Successful simultaneous liver-kidney transplant in an adult with atypical hemolytic uremic syndrome associated with a mutation in complement factor H

American Journal of Kidney Diseases

Volumn 58, Issue 1, 2011, Pages 109-112

  Wilson, Colin ^a,e   Torpey, Nick ^b   Jaques, Bryon ^a   Strain, Lisa ^c   Talbot, David ^a   Manas, Derek ^a   Goodship, Tim ^a,c,d  

^a NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

^c NEWCASTLE UPON TYNE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e FREEMAN HOSPITAL   (United Kingdom)

Author keywords

complement; factor H; Hemolytic uremic syndrome; kidney transplantation; liver transplantation

Indexed keywords

ACETYLSALICYLIC ACID; ADENINE; AMINO ACID; BASILIXIMAB; COMPLEMENT FACTOR H; COMPLEMENTARY DNA; FRESH FROZEN PLASMA; HEPARIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEOTIDE; PREDNISONE; TACROLIMUS; THREONINE;

ADULT; ANALGESIA; ANASTOMOSIS; ARTICLE; ATYPICAL HEMOLYTIC UREMIC SYNDROME; BILE DUCT OBSTRUCTION; CASE REPORT; DIARRHEA; DISEASE COURSE; GASTROINTESTINAL ENDOSCOPE; GENE; GENE MUTATION; GLOMERULUS FILTRATION RATE; HEMODIALYSIS; HEMOLYTIC UREMIC SYNDROME; HETEROZYGOSITY; HOSPITAL DISCHARGE; HUMAN; KIDNEY BIOPSY; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALAISE; MALE; MUTATION; PLASMA TRANSFUSION; PLASMAPHERESIS; POSTOPERATIVE PERIOD; SINGLE DRUG DOSE; STENT; THROMBOSIS; TREATMENT OUTCOME; ULTRASOUND;

COMPLEMENT FACTOR H; HEMOLYTIC-UREMIC SYNDROME; HUMANS; KIDNEY TRANSPLANTATION; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MUTATION; TREATMENT OUTCOME;

EID: 79959342153     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2011.04.008     Document Type: Article

References (25)

1. M. Noris, and G. Remuzzi Atypical hemolytic-uremic syndrome N Engl J Med 361 2009 1676 1687
2. M. Noris, J. Caprioli, and E. Bresin Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype Clin J Am Soc Nephrol 5 2010 1844 1859
3. A.L. Sellier-Leclerc, V. Fremeaux-Bacchi, and M.A. Dragon-Durey Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome J Am Soc Nephrol 18 2007 2392 2400 (Pubitemid 47203855)
4. E. Bresin, E. Daina, and M. Noris Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background Clin J Am Soc Nephrol 1 2006 88 99
5. G. Remuzzi, P. Ruggenenti, and D. Codazzi Combined kidney and liver transplantation for familial haemolytic uraemic syndrome Lancet 359 2002 1671 1672 (Pubitemid 34518531)
6. H.I. Cheong, B.S. Lee, and H.G. Kang Attempted treatment of factor H deficiency by liver transplantation Pediatr Nephrol 19 2004 454 458 (Pubitemid 38477414)
7. G. Remuzzi, P. Ruggenenti, and M. Colledan Hemolytic uremic syndrome: a fatal outcome after kidney and liver transplantation performed to correct factor H gene mutation Am J Transplant 5 2005 1146 1150 (Pubitemid 40571267)
8. J.M. Saland, S.H. Emre, and B.L. Shneider Favorable long-term outcome after liver-kidney transplant for recurrent hemolytic uremic syndrome associated with a factor H mutation Am J Transplant 6 2006 1948 1952 (Pubitemid 44024968)
9. H. Jalanko, S. Peltonen, and A. Koskinen Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor H Am J Transplant 8 2008 216 221
10. J.M. Saland, B.L. Shneider, and J.S. Bromberg Successful split liver-kidney transplant for factor H associated hemolytic uremic syndrome Clin J Am Soc Nephrol 4 2009 201 206
11. W. Haller, D.V. Milford, T.H. Goodship, K. Sharif, D.F. Mirza, and P.J. McKiernan Successful isolated liver transplantation in a child with atypical hemolytic uremic syndrome and a mutation in complement factor H Am J Transplant 10 2010 2142 2147
12. The Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 2007 661 678
13. P.R. Burton, D.G. Clayton, and L.R. Cardon Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Nat Genet 39 2007 1329 1337 (Pubitemid 350041542)
14. J.M. Saland, P. Ruggenenti, and G. Remuzzi Liver-kidney transplantation to cure atypical hemolytic uremic syndrome J Am Soc Nephrol 20 2009 940 949
15. C. Loirat, M. Noris, and V. Fremeaux-Bacchi Complement and the atypical hemolytic uremic syndrome in children Pediatr Nephrol 23 2008 1957 1972
16. C.M. Taylor, S. Machin, S.J. Wigmore, and T.H. Goodship Clinical practice guidelines for the management of atypical haemolytic uraemic syndrome in the United Kingdom Br J Haematol 148 2010 37 47
17. G. Ariceta, N. Besbas, and S. Johnson Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome Pediatr Nephrol 24 2009 687 696
18. A. Richards, M.R. Buddles, and R.L. Donne Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition Am J Hum Genet 68 2001 485 490 (Pubitemid 32147817)
19. T. Manuelian, J. Hellwage, and S. Meri Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome J Clin Invest 111 2003 1181 1190 (Pubitemid 36519935)
20. J. Zuber, M. Le Quintrec, R. Sberro-Soussan, C. Loirat, V. Fremeaux-Bacchi, and C. Legendre New insights into postrenal transplant hemolytic uremic syndrome Nat Rev Nephrol 7 2011 23 35
21. J.C. Davin, L. Strain, and T.H. Goodship Plasma therapy in atypical haemolytic uremic syndrome: lessons from a family with a factor H mutation Pediatr Nephrol 23 2008 1517 1521
22. P. Hirt-Minkowski, S. Schaub, and M. Mayr Haemolytic uraemic syndrome caused by factor H mutation: is single kidney transplantation under intensive plasmatherapy an option? Nephrol Dial Transplant 24 2009 3548 3551
23. L.B. Zimmerhackl, J. Hofer, and G. Cortina Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome N Engl J Med 362 2010 1746 1748
24. J.C. Davin, V. Gracchi, A. Bouts, J. Groothoff, L. Strain, and T. Goodship Maintenance of kidney function following treatment with eculizumab and discontinuation of plasma exchange after a third kidney transplant for atypical hemolytic uremic syndrome associated with a CFH mutation Am J Kidney Dis 55 4 2010 708 711
25. N.V. Jamieson A 20-year experience of combined liver/kidney transplantation for primary hyperoxaluria (PH1): the European PH1 transplant registry experience 1984-2004 Am J Nephrol 25 2005 282 289 (Pubitemid 41202752)