Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome

New England Journal of Medicine

Volumn 362, Issue 18, 2010, Pages 1746-1748

  Zimmerhackl, Lothar Bernd ^a   Hofer, Johannes ^a   Cortina, Gérard ^a   Mark, Walter ^a   Würzner, Reinhard ^a   Jungraithmayr, Therese C ^a   Khursigara, Gus ^b   Kliche, Kay O ^b   Radauer, Wolfgang ^c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b ALEXION PHARMACEUTICALS   (United States)

^c Children's Hospital Salzburg   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ECULIZUMAB; HAPTOGLOBIN;

CASE REPORT; CHILD; DISEASE COURSE; DISEASE SEVERITY; GRAFT FAILURE; GRAFT REJECTION; HEMOLYTIC UREMIC SYNDROME; HIGH RISK PATIENT; HUMAN; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LETTER; MENINGOCOCCOSIS; MUTATION; NEISSERIA MENINGITIDIS; PERITONEAL DIALYSIS; PLASMAPHERESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPHYLAXIS; SEPTICEMIA; THROMBOCYTE COUNT; URINE VOLUME;

EID: 77951876953     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1001060     Document Type: Letter

References (6)

1. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med 2009;361:1676-1687
2. Sellier-Leclerc AL, Fremeaux-Bacchi V, Dragon-Durey MA, et al. Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome. J Am Soc Nephrol 2007;18:2392-2400 (Pubitemid 47203855)
3. Zimmerhackl LB, Scheiring J, Prüfer F, Taylor CM, Loirat C. Renal transplantation in HUS patients with disorders of complement regulation. Pediatr Nephrol 2007;22:10-16 (Pubitemid 46138353)
4. Prüfer F, Scheiring J, Sautter S, et al. Terminal complement complex (C5b-9) in children with recurrent hemolytic uremic syndrome. Semin Thromb Hemost 2006;32:121-127
5. Chatelet V, Frémeaux-Bacchi V, Lobbedez T, Ficheux M, de Ligny BH. Safety and long-term efficacy of eculizumab in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome. Am J Transplant 2009;9:2644-2645
6. Nürnberger J, Witzke O, Opazo Saez A, et al. Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med 2009;360:542-544 [Erratum, N Engl J Med 2009;360:2487.]