Mitochondrial uncoupling reduces exercise capacity despite several skeletal muscle metabolic adaptations

Journal of Applied Physiology

Volumn 116, Issue 4, 2014, Pages 364-375

  Schlagowski, A I ^a,b   Singh, F ^a   Charles, A L ^a   Gali Ramamoorthy, T ^c   Favret, F ^a,b   Piquard, F ^a,b   Geny, B ^a,b   Zoll, J ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b HÔPITAL CIVIL   (France)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

2,4 dinitrophenol; Exhaustive exercise; Gas exchanges; Maximal oxygen uptake; Maximal running speed; Mitochondrial uncoupling

Indexed keywords

2,4 DINITROPHENOL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PPARGC1A PROTEIN, RAT; TFAM PROTEIN, RAT; TRANSCRIPTION FACTOR; UNCOUPLING PROTEIN;

ADAPTATION; ANIMAL; ARTICLE; CELL LINE; DRUG EFFECT; ENERGY METABOLISM; EXERCISE; EXERCISE TOLERANCE; EXHAUSTIVE EXERCISE; GAS EXCHANGES; GENE EXPRESSION REGULATION; GENETICS; KINETICS; MALE; MAXIMAL OXYGEN UPTAKE; MAXIMAL RUNNING SPEED; METABOLISM; MITOCHONDRIAL DYNAMICS; MUSCLE CONTRACTION; MUSCLE MITOCHONDRION; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; RAT; RUNNING; SKELETAL MUSCLE; WISTAR RAT;

2,4-DINITROPHENOL; EXHAUSTIVE EXERCISE; GAS EXCHANGES; MAXIMAL OXYGEN UPTAKE; MAXIMAL RUNNING SPEED; MITOCHONDRIAL UNCOUPLING;

2,4-DINITROPHENOL; ADAPTATION, PHYSIOLOGICAL; ANIMALS; CELL LINE; ENERGY METABOLISM; EXERCISE TOLERANCE; GENE EXPRESSION REGULATION; KINETICS; MALE; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; MITOCHONDRIAL TURNOVER; MUSCLE CONTRACTION; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHYSICAL EXERTION; RATS; RATS, WISTAR; RNA, MESSENGER; RUNNING; TRANSCRIPTION FACTORS; UNCOUPLING AGENTS;

EID: 84894247285     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01177.2013     Document Type: Article

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