Gene expression analysis of peripheral cells for subclassification of pediatric inflammatory bowel disease in remission

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Van Lierop, Pieter P E ^a,d   Swagemakers, Sigrid M ^b   De Bie, Charlotte I ^a   Middendorp, Sabine ^a,d   Van Baarlen, Peter ^c   Samsom, Janneke N ^a   Van IJcken, Wilfred F J ^b   Escher, Johanna C ^a   Van Der Spek, Peter J ^b   Nieuwenhuis, Edward E S ^a,d  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATORY BOWEL DISEASES; MALE;

EID: 84894168446     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079549     Document Type: Article

References (35)

1. Nieuwenhuis EE, Escher JC (2008) Early onset IBD: What's the difference? Dig Liver Dis 40: 12-15. (Pubitemid 350246388)
2. Levine A, Karban A, Eliakim R, Shaoul R, Reif S, et al. (2005) A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease. Am J Gastroenterol 100: 407-413. (Pubitemid 40314528)
3. Damen GM, Hol J, de Ruiter L, Bouquet J, Sinaasappel M, et al. (2006) Chemokine production by buccal epithelium as a distinctive feature of pediatric Crohn disease. J Pediatr Gastroenterol Nutr 42: 142-149.
4. Turunen P, Ashorn M, Auvinen A, Iltanen S, Huhtala H, et al. (2009) Longterm health outcomes in pediatric inflammatory bowel disease: a population-based study. Inflamm Bowel Dis 15: 56-62.
5. Hyams JS, Ferry GD, Mandel FS, Gryboski JD, Kibort PM, et al. (1991) Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 12: 439-447.
6. Turner D, Otley AR, Mack D, Hyams J, de Bruijne J, et al. (2007) Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study. Gastroenterology 133: 423-432. (Pubitemid 47193130)
7. Yamamoto T, Nakahigashi M, Umegae S, Kitagawa T, Matsumoto K (2005) Impact of elemental diet on mucosal inflammation in patients with active Crohn's disease: cytokine production and endoscopic and histological findings. Inflamm Bowel Dis 11: 580-588. (Pubitemid 40826346)
8. Rutgeerts P, Vermeire S, Van Assche G (2007) Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target? Gut 56: 453-455. (Pubitemid 46580492)
9. Froslie KF, Jahnsen J, Moum BA, Vatn MH (2007) Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 133: 412-422. (Pubitemid 47187355)
10. Yamamoto T, Umegae S, Kitagawa T, Matsumoto K (2005) Systemic and local cytokine production in quiescent ulcerative colitis and its relationship to future relapse: a prospective pilot study. Inflamm Bowel Dis 11: 589-596. (Pubitemid 40826347)
11. Diamanti A, Colistro F, Basso MS, Papadatou B, Francalanci P, et al. (2008) Clinical role of calprotectin assay in determining histological relapses in children affected by inflammatory bowel diseases. Inflammatory bowel diseases 14: 1229-1235.
12. Consigny Y, Modigliani R, Colombel JF, Dupas JL, Lemann M, et al. (2006) A simple biological score for predicting low risk of short-term relapse in Crohn's disease. Inflamm Bowel Dis 12: 551-557. (Pubitemid 43977735)
13. Weersma RK, Stokkers PC, van Bodegraven AA, van Hogezand RA, Verspaget HW, et al. (2009) Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut 58: 388-395.
14. Vermeire S, Van Assche G, Rutgeerts P (2006) Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut 55: 426-431. (Pubitemid 43268284)
15. IBD Working Group of the European Society for Paediatric Gastroenterology HaN (2005) Inflammatory bowel disease in children and adolescents: recommendations for diagnosis-the Porto criteria. J Pediatr Gastroenterol Nutr 41: 1-7.
16. Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, et al. (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350: 1617-1628. (Pubitemid 38528701)
17. Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98: 5116-5121. (Pubitemid 32397092)
18. Wu F, Dassopoulos T, Cope L, Maitra A, Brant SR, et al. (2007) Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm Bowel Dis 13: 807-821. (Pubitemid 47203859)
19. Matsuda R, Koide T, Tokoro C, Yamamoto T, Godai T, et al. (2008) Quantitive cytokine mRNA expression profiles in the colonic mucosa of patients with steroid naive ulcerative colitis during active and quiescent disease. Inflamm Bowel Dis.
20. Arsenescu R, Bruno ME, Rogier EW, Stefka AT, McMahan AE, et al. (2008) Signature biomarkers in Crohn's disease: toward a molecular classification. Mucosal Immunol 1: 399-411.
21. Burczynski ME, Peterson RL, Twine NC, Zuberek KA, Brodeur BJ, et al. (2006) Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. J Mol Diagn 8: 51-61. (Pubitemid 43257434)
22. Lawrance IC, Fiocchi C, Chakravarti S (2001) Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet 10: 445-456. (Pubitemid 32181667)
23. Olsen J, Gerds TA, Seidelin JB, Csillag C, Bjerrum JT, et al. (2009) Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data. Inflamm Bowel Dis 15: 1032-1038.
24. Canto E, Ricart E, Monfort D, Gonzalez-Juan D, Balanzo J, et al. (2006) TNF alpha production to TLR2 ligands in active IBD patients. Clin Immunol 119: 156-165.
25. Marks DJ, Harbord MW, MacAllister R, Rahman FZ, Young J, et al. (2006) Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 367: 668-678. (Pubitemid 43289157)
26. Damen GM, van Lierop P, de Ruiter L, Escher JC, Donders R, et al. (2008) Production of IL12p70 and IL23 by monocyte-derived dendritic cells in children with inflammatory bowel disease. Gut 57: 1480.
27. Hedl M, Li J, Cho JH, Abraham C (2007) Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci U S A.
28. Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, et al. (2009) Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med.
29. Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, et al. (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43: 246-252.
30. Doecke JD, Simms LA, Zhao ZZ, Huang N, Hanigan K, et al. (2013) Genetic susceptibility in IBD: overlap between ulcerative colitis and Crohn's disease. Inflammatory bowel diseases 19: 240-245.
31. van Lierop PP, Damen GM, Escher JC, Samsom JN, Nieuwenhuis EE (2006) Defective acute inflammation in Crohn's disease. Lancet 368: 578.
32. Katsuta T, Lim C, Shimoda K, Shibuta K, Mitra P, et al. (2000) Interleukin-8 and SDF1-alpha mRNA expression in colonic biopsies from patients with inflammatory bowel disease. Am J Gastroenterol 95: 3157-3164.
33. Damen GM, Hol J, de Ruiter L, Bouquet J, Sinaasappel M, et al. (2006) Chemokine Production by Buccal Epithelium as a Distinctive Feature of Pediatric Crohn Disease. J Pediatr Gastroenterol Nutr 42: 142-149.
34. Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, et al. (2007) Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 3: e58.
35. Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA, et al. (2007) Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39: 830-832. (Pubitemid 47014496)