The L-kynurenine-probenecid combination reduces neuropathic pain in rats

European Journal of Pain (United Kingdom)

Volumn 17, Issue 9, 2013, Pages 1365-1373

  Pineda Farias, J B ^a   Perez Severiano F ^b   Gonzalez Esquivel D F ^b   Barragan Iglesias P ^a   Bravo Hernandez M ^a   Cervantes Duran C ^a   Aguilera, P ^b   Rios C ^b   Granados Soto, Vinicio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; DRUG THERAPY, COMBINATION; FEMALE; HYPERALGESIA; KYNURENINE; MOTOR ACTIVITY; NEURALGIA; PAIN MEASUREMENT; PROBENECID; RATS; RATS, WISTAR; SPINAL CORD;

EID: 84894142920     PISSN: 10903801     EISSN: 15322149     Source Type: Journal    
DOI: 10.1002/j.1532-2149.2013.00305.x     Document Type: Article

References (50)

1. Bacciottini, L., Pellegrini-Giampietro, D.E., Bongianni, F., de Luca, G., Beni, M., Politi, V., Moroni, F. (1987). Biochemical and behavioural studies on indole-pyruvic acid: A keto-analogue of tryptophan. Pharmacol Res Commun 19, 803-817.
2. Caram-Salas, N.L., Reyes-García, G., Bartoszyk, G.D., Araiza-Saldaña, C.I., Ambriz-Tututi, M., Rocha-González, H.I., Arreola-Espino, R., Cruz, S.L., Granados-Soto, V. (2007). Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol 573, 75-83.
3. Carpenedo, R., Chiarugi, A., Russi, P., Lombardi, G., Carlà, V., Pellicciari, R., Mattoli, L., Moroni, F. (1994). Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience 61, 237-243.
4. Carpenedo, R., Pittaluga, A., Cozzi, A., Attucci, S., Galli, A., Raiteri, M., Moroni, F. (2001). Presynaptic kynurenate-sensitive receptors inhibit glutamate release. Eur J Neurosci 13, 2141-2147.
5. Chaplan, S.R., Bach, F.W., Pogrel, J.W., Chung, J.M., Yaksh, T.L. (1994). Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53, 55-63.
6. Chaplan, S.R., Malmberg, A.B., Yaksh, T.L. (1997). Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther 280, 829-838.
7. Chen, Y., Guillemin, G.J. (2009). Kynurenine pathway metabolites in humans: Disease and healthy States. Int J Tryptophan Res 2, 1-19.
8. Coderre, T.J., Van Empel, I. (1994). The utility of excitatory amino acid (EAA) antagonists as analgesic agents. II. Assessment of the antinociceptive activity of combinations of competitive and noncompetitive NMDA antagonists with agents acting at allosteric-glycine and polyamine receptor sites. Pain 59, 353-359.
9. Cosi, C., Mannaioni, G., Cozzi, A., Carlà, V., Sili, M., Cavone, L., Maratea, D., Moroni, F. (2011). G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast. Neuropharmacology 60, 1227-1231.
10. Cunningham, R.F., Israili, Z.H., Dayton, P.G. (1981). Clinical pharmacokinetics of probenecid. Clin Pharmacokinet 6, 135-151.
11. Dixon, W.J. (1980). Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20, 441-462.
12. Du, F., Schmidt, W., Okuno, E., Kido, R., Köhler, C., Schwarcz, R. (1992). Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus. J Comp Neurol 321, 477-487.
13. Erhardt, S., Hajos, M., Lindberg, A., Engberg, G. (2000). Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid. Synapse 37, 104-108.
14. Finnerup, N.B., Sindrup, S.H., Jensen, T.S. (2010). The evidence for pharmacological treatment of neuropathic pain. Pain 150, 573-581.
15. Geber, C., Baumgärtner, U., Schwab, R., Müller, H., Stoeter, P., Dieterich, M., Sommer, C., Birklein, F., Treede, R.D. (2009). Revised definition of neuropathic pain and its grading system: An open case series illustrating its use in clinical practice. Am J Med 122, S3-S12.
16. Guidetti, P., Hoffman, G.E., Melendez-Ferro, M., Albuquerque, E.X., Schwarcz, R. (2007). Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia 55, 78-92.
17. Guidetti, P., Okuno, E., Schwarcz, R. (1997). Characterization of rat brain kynurenine aminotransferases I and II. J Neurosci Res 50, 457-465.
18. Guo, J., Williams, D.J., Puhl, H.L., Ikeda, S.R. (2008). Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons. J Pharmacol Exp Ther 324, 342-351.
19. Hao, J.X., Xu, X.J. (1996). Treatment of a chronic allodynia-like response in spinally injured rats: Effects of systemically administered excitatory amino acid receptor antagonists. Pain 66, 279-285.
20. Heyliger, S.O., Goodman, C.B., Ngong, J.M., Soliman, K.F. (1998). The analgesic effects of tryptophan and its metabolites in the rat. Pharmacol Res 38, 243-250.
21. Hilmas, C., Pereira, E.F., Alkondon, M., Rassoulpour, A., Schwarcz, R., Albuquerque, E.X. (2001). The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: Physiopathological implications. J Neurosci 21, 7463-7473.
22. Kapoor, R., Okuno, E., Kido, R., Kapoor, V. (1997). Immuno-localization of kynurenine aminotransferase (KAT) in the rat medulla and spinal cord. Neuroreport 8, 3619-3623.
23. Kim, S.H., Chung, J.M. (1992). An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50, 355-363.
24. Knyihár-Csillik, E., Toldi, J., Krisztin-Péva, B., Chadaide, Z., Németh, H., Fenyo, R., Vécsei, L. (2007a). Prevention of electrical stimulationinduced increase of c-fos immunoreaction in the caudal trigeminal nucleus by kynurenine combined with probenecid. Neurosci Lett 418, 122-126.
25. Knyihár-Csillik, E., Toldi, J., Mihály, A., Krisztin-Péva, B., Chadaide, Z., Németh, H., Fenyo, R., Vécsei, L. (2007b). Kynurenine in combination with probenecid mitigates the stimulation-induced increase of c-fos immunoreactivity of the rat caudal trigeminal nucleus in an experimental migraine model. J Neural Transm 114, 417-421.
26. LoPachin, R.M., Rudy, T.A., Yaksh, T.L. (1981). An improved method for chronic catheterization of the rat spinal subarachnoid space. Physiol Behav 27, 559-561.
27. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J Biol Chem 193, 265-275.
28. Mao, J., Price, D.D., Hayes, R.L., Lu, J., Mayer, D.J. (1992). Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res 598, 271-278.
29. McQuay, H.J., Tramèr, M., Nye, B.A., Carroll, D., Wiffen, P.J., Moore, R.A. (1996). A systematic review of antidepressants in neuropathic pain. Pain 68, 217-227.
30. Mecs, L., Tuboly, G., Nagy, E., Benedek, G., Horvath, G. (2009). The peripheral antinociceptive effects of endomorphin-1 and kynurenic acid in the rat inflamed joint model. Anesth Analg 109, 1297-1304.
31. Medvedev, I.O., Malyshkin, A.A., Belozertseva, I.V., Sukhotina, I.A., Sevostianova, N.Y., Aliev, K., Zvartau, E.E., Parsons, C.G., Danysz, W., Bespalov, A.Y. (2004). Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. Neuropharmacology 47, 175-183.
32. Moroni, F. (1999). Tryptophan metabolism and brain function: Focus on kynurenine and other indole metabolites. Eur J Pharmacol 375, 87-100.
33. Moroni, F., Pellegrini-Giampietro, D.E., Alesiani, M., Cherici, G., Mori, F., Galli, A. (1989). Glycine and kynurenate modulate the glutamate receptors in the myenteric plexus and in cortical membranes. Eur J Pharmacol 163, 123-126.
34. Moroni, F., Russi, P., Carlà, V., De Luca, G., Politi, V. (1991). The regulation of brain kynurenic acid content: Focus on indole-3-pyruvic acid. Adv Exp Med Biol 294, 299-308.
35. Németh, H., Toldi, J., Vécsei, L. (2005). Role of kynurenines in the central and peripheral nervous systems. Curr Neurovasc Res 2, 249-260.
36. Nozaki, K., Beal, M.F. (1992). Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats. J Cereb Blood Flow Metab 12, 400-407.
37. Ohshiro, H., Tonai-Kachi, H., Ichikawa, K. (2008). GPR35 is a functional receptor in rat dorsal root ganglion neurons. Biochem Biophys Res Commun 365, 344-348.
38. Okuno, E., Nakamura, M., Schwarcz, R. (1991). Two kynurenine aminotransferases in human brain. Brain Res 542, 307-312.
39. Pellegrini-Giampietro, D.E., Galli, A., Alesiani, M., Cherici, G., Moroni, F. (1989). Quinoxalines interact with the glycine recognition site of NMDA receptors: Studies in guinea-pig myenteric plexus and in rat cortical membranes. Br J Pharmacol 98, 1281-1286.
40. Perkins, M.N., Stone, T.W. (1985). Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo. Exp Neurol 88, 570-579.
41. Rivera-Mancía, S., Ríos, C., Montes, S. (2012). Manganese and ammonia interactions in the brain of cirrhotic rats: Effects on brain ammonia metabolism. Neurochem Res 37, 1074-1084.
42. Schwarcz, R., Pellicciari, R. (2002). Manipulation of brain kynurenines: Glial targets, neuronal effects, and clinical opportunities. J Pharmacol Exp Ther 303, 1-10.
43. Sindrup, S.H., Jensen, T.S. (1999). Efficacy of pharmacological treatments of neuropathic pain: An update and effect related to mechanism of drug action. Pain 83, 389-400.
44. Stone, T.W. (1993). Neuropharmacology of quinolinic and kynurenic acids. Pharmacol Rev 45, 309-379.
45. Stone, T.W., Addae, J.I. (2002). The pharmacological manipulation of glutamate receptors and neuroprotection. Eur J Pharmacol 447, 285-296.
46. Uwai, Y., Honjo, H., Iwamoto, K. (2012). Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3. Pharmacol Res 65, 254-260.
47. Vámos, E., Párdutz, A., Varga, H., Bohár, Z., Tajti, J., Fülöp, F., Toldi, J., Vécsei, L. (2009). L-kynurenine combined with probenecid and the novel synthetic kynurenic acid derivative attenuate nitroglycerininduced nNOS in the rat caudal trigeminal nucleus. Neuropharmacology 57, 425-429.
48. Wang, J., Simonavicius, N., Wu, X., Swaminath, G., Reagan, J., Tian, H., Ling, L. (2006). Kynurenic acid as a ligand for orphan G proteincoupled receptor GPR35. J Biol Chem 281, 22021-22028.
49. Zhang, Y.Q., Ji, G.C., Wu, G.C., Zhao, Z.Q. (2003). Kynurenic acid enhances electroacupuncture analgesia in normal and carrageenaninjected rats. Brain Res 966, 300-307.
50. Zimmermann, M. (1983). Ethical guidelines for investigations on experimental pain in conscious animals. Pain 16, 109-110.