Interleukin-17A antagonist attenuates radiation-induced lung injuries in mice

Experimental Lung Research

Volumn 40, Issue 2, 2014, Pages 77-85

  Wang, Bao Zhong ^a,b   Wang, Li Ping ^b   Han, Hui ^b   Cao, Fang Li ^b   Li, Guang Yao ^b   Xu, Jun Long ^b   Wang, Xiu Wen ^a   Wang, Le Xin ^b,c  

^a SHANDONG UNIVERSITY   (China)

^b TAISHAN MEDICAL UNIVERSITY   (China)

^c CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Fibrosis; Interleukin 17A; Irradiation; Lung injury; Mortality

Indexed keywords

ANIMALS; ANTIBODIES, NEUTRALIZING; BRONCHOALVEOLAR LAVAGE FLUID; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; INTERLEUKIN-17; LUNG; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; PULMONARY FIBROSIS; RADIATION INJURIES, EXPERIMENTAL; SURVIVAL RATE;

EID: 84894123534     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.3109/01902148.2013.872210     Document Type: Article

References (42)

1. Kelly P, Balter PA, Rebueno N, Sharp HJ, Liao Z, Komaki R, Chang JY: Stereotactic body radiation therapy for patients with lung cancer previously treated with thoracic radiation. Int J Radiat Oncol Biol Phys. 2010;78:1387-1393.
2. Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M: Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat Res. 2010;173:590-601.
3. Anscher MS, Vujaskovic Z: Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Semin Oncol. 2005;32:S86-S91.
4. Madani I, De Ruyck K, Goeminne H, De Neve W, Thierens H, Van Meerbeeck J: Predicting risk of radiation-induced lung injury. J Thorac Oncol. 2007;2:864-874.
5. Kim JY, Kim YS, Kim YK, Park HJ, Kim SJ, Kang JH, Wang YP, Jang HS, Lee SN, Yoon SC: The TGF-beta1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients. Radiat Oncol. 2009;4:59.
6. Mehta V. Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: Pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys. 2005;63:5-24.
7. Flechsig P, Dadrich M, Bickelhaupt S, Jenne J, Hauser K, Timke C, Peschke P, Hahn EW, Grone HJ, Yingling J, Lahn M, Wirkner U, Huber PE: LY2109761 attenuates radiationinduced pulmonary murine fibrosis via reversal of TGF-beta and BMP-associated proinflammatory and proangiogenic signals. Clin Cancer Res. 2012;18:3616-3627.
8. Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P: Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002;12:26-33.
9. Chen Y, Hyrien O,Williams J, Okunieff P, Smudzin T, Rubin P: Interleukin (IL)-1A and IL-6: Applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2005;62:260-266.
10. Arpin D, Perol D, Blay JY, Falchero L, Claude L, Vuillermoz- Blas S, Martel-Lafay I, Ginestet C, Alberti L, Nosov D, Etienne-Mastroianni B, Cottin V, Perol M, Guerin JC, Cordier JF, Carrie C: Early variations of circulating interleukin-6 and interleukin-10 levels during thoracic radiotherapy are predictive for radiation pneumonitis. J Clin Oncol. 2005;23:8748- 8756.
11. Johnston CJ, Williams JP, Okunieff P, Finkelstein JN: Radiation-induced pulmonary fibrosis: Examination of chemokine and chemokine receptor families. Radiat Res. 2002;157:256-265.
12. Stenmark MH, Cai XW, Shedden K, Hayman JA, Yuan S, Ritter T, Ten Haken RK, Lawrence TS, Kong FM: Combining physical and biologic parameters to predict radiation-induced lung toxicity in patients with non-small-cell lung cancer treated with definitive radiation therapy. Int J Radiat Oncol Biol Phys. 2012;84:e217-e222.
13. Wang L, Bi N: TGF-beta1 gene polymorphisms for anticipating radiation-induced pneumonitis in non-small-cell lung cancer: Different ethnic association. J Clin Oncol. 2010;28: E621-e622.
14. Anscher MS: Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy. Oncologist. 2010;15:350-359.
15. Sakai M, Iwakawa M, Iwakura Y, Ohta T, Tsujii H, Imai T: CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation. J Radiat Res. 2008;49: 409-416.
16. Zhang M, Qian J, Xing X, Kong FM, Zhao L, Chen M, Lawrence TS: Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung. Clin Cancer Res. 2008;14:1868-1876.
17. PuthawalaK,Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS: Inhibition of integrin alpha (v) beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis. Am J Respir Crit Care Med. 2008;177:82-90.
18. Korn T, Bettelli E, Oukka M, Kuchroo VK: IL-17 and Th17 Cells. Annu Rev Immunol. 2009;27:485-517.
19. Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA: Bleomycin and IL-1betamediated pulmonary fibrosis is IL-17A dependent. J ExpMed. 2010;207:535-552.
20. Mi S, Li Z, Yang HZ, Liu H, Wang JP, Ma YG, Wang X X, Liu HZ, Sun W, Hu ZW: Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGFbeta1- dependent and -independent mechanisms. J Immunol. 2011;187:3003-3014.
21. Schnyder-Candrian S, Togbe D, Couillin I, Mercier I, Brombacher F, Quesniaux V, Fossiez F, Ryffel B, Schnyder B: Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med. 2006;203:2715-2725.
22. Haston CK, Begin M, Dorion G, Cory SM: Distinct loci influence radiation-induced alveolitis from fibrosing alveolitis in the mouse. Cancer Res. 2007;67:10796-10803.
23. Ashcroft T, Simpson JM, Timbrell V: Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988;41:467-470.
24. Yavas G, Yavas C, Acar H, Toy H, Yuce D, Ata O: Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: Results of an experimental study. Support Care Cancer. 2013;21:811-817.
25. Knapp S, Florquin S, Golenbock DT, van der Poll T: Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. J Immunol. 2006;176:3189-3195.
26. Edwards CA, O'Brien WD, Jr: Modified assay for determination of hydroxyproline in a tissue hydrolyzate. Clin Chim Acta. 1980;104:161-167.
27. Yang HZ, Cui B, Liu HZ, Chen ZR, Yan HM, Hua F, Hu ZW: Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment. J Immunol. 2009;182:692-702.
28. Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, Muroi E, Hara T, Ogawa F, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S: Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J Immunol. 2010;185:2502-2515.
29. Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Cihakova D: Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy. Circ Res. 2010;106:1646-1655.
30. Smith E, Prasad KM, Butcher M, Dobrian A, Kolls JK, Ley K, Galkina E: Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2010;121:1746-1755.
31. Genovese MC, Van den Bosch F, Roberson SA, Bojin S, Biagini IM, Ryan P, Sloan-Lancaster J: LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum. 2010;62:929- 939.
32. Lubberts E, Koenders MI, Oppers-Walgreen B, van den Bersselaar L, Coenen-de Roo CJ, Joosten LA, van den Berg WB: Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion. Arthritis Rheum. 2004;50:650-659.
33. Miossec P, Kolls JK: Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 2012;11:763-776.
34. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen CT, LaRiviere PJ, MauceriH, Sammani S, Husain AN,Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JG: Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol. 2011;44:415-422.
35. Eldh T, Heinzelmann F, Velalakan A, Budach W, Belka C, Jendrossek V: Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- And dose-dependent. Strahlenther Onkol. 2012;188:274-281.
36. Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medhora M: Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. Radiat Res. 2010;173:545-556.
37. Rube CE, Wilfert F, Palm J, Konig J, Burdak-Rothkamm S, Liu L, Schuck A, Willich N, Rube C: Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung. Strahlenther Onkol. 2004;180:442-448.
38. Yao Z, Painter SL, Fanslow WC, Ulrich D, Macduff BM, Spriggs MK, Armitage RJ: Human IL-17: A novel cytokine derived from T cells. J Immunol. 1995;155:5483-5486.
39. Fossiez F, Djossou O, Chomarat P, Flores-Romo L, Ait- Yahia S, Maat C, Pin JJ, Garrone P, Garcia E, Saeland S, Blanchard D, Gaillard C, Das Mahapatra B, Rouvier E, Golstein P, Banchereau J, Lebecque S: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J ExpMed. 1996;183:2593- 2603.
40. Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P: Circulating IL-6 as a predictor of radiation pneumonitis Int J Radiat Oncol Biol Phys. 2001;49:641- 648.
41. Rube CE, Uthe D, Wilfert F, Ludwig D, Yang K, Konig J, Palm J, Schuck A, WillichN, Remberger K, Rube C: The bronchiolar epithelium as a prominent source of pro-inflammatory cytokines after lung irradiation. Int J Radiat Oncol Biol Phys. 2005;61:1482-1492.
42. Ahmed KM, Li JJ: NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radic Biol Med. 2008;44:1-13.