Unraveling new roles for serotonin receptor 2B in development: Key findings from Xenopus

International Journal of Developmental Biology

Volumn 57, Issue 9-10, 2013, Pages 707-714

  Ori, Michela ^a   De Lucchini, Stefania ^b   Marras, Giulia ^a   Nardi, Irma ^a  

^a UNIVERSITY OF PISA   (Italy)

^b SCUOLA NORMALE SUPERIORE   (Italy)

Author keywords

5 HT2B; Craniofacial morphogenesis; Eye; Neural crest cell; SSRI

Indexed keywords

ANIMALS; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAD; HEART; HEART DEFECTS, CONGENITAL; PREGNANCY; RECEPTORS, SEROTONIN, 5-HT2; RETINA; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

EID: 84894101273     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.130204mo     Document Type: Article

References (73)

1. ANDREAZZOLI M (2009). Molecular regulation of vertebrate retina cell fate. Birth Defects Research (Part C) 87: 284-295.
2. ANSORGE MS, MORELLI E, GINGRICH JA (2008). Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28: 199-207.
3. BERGER M, GRAY JA, ROTH BL (2009). The expanded biology of serotonin. Annu Rev Med 60: 355-366.
4. BELLISSIMA V, VERVERS TFF, VISSER GHA, GAZZOLO D (2012). Selective serotonin reuptake inhibitors in pregnancy. Curr Med Chem 19: 4554-4561
5. BERTON O, NESTLER EJ (2006). New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7: 137-151.
6. BEVILACQUA L, DOLY S, KAPRIO J, YUAN Q, TIKKANEN R, PAUNIO T, ZHOU Z, WEDENOJA J, MAROTEAUX L, DIAZ S, BELMER A, HODGKINSON CA, DELL'OSSO L, SUVISAARI J, COCCARO E, ROSE RJ, PELTONEN L, VIRKKUNEN M, GOLDMAN D (2010). A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468: 1061-6. Erratum in: Nature 2011, 470: 424.
7. BEYER T, DANILCHICK M, THUMBERGER T, VICK P, TISLER M, SCHNEIDER I, BOGUSCH S, ANDRE P, ULMER B, WALENTEK P, NIESLER B, BLUM M, SCHWEICKERT A (2012). Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus. Curr Biol 22: 33-39.
8. BHASIN N, LA MANTIA AS, LAUDER JM (2004). Opposing regulation of cell proliferation by retinoic acid and the serotonin 2B receptor in the mouse frontonasal mass. Anat Embryol 208: 135-143.
9. BLANPAIN C, LE POUL E, PARMA J, KNOOP C, DETHEUX M, PARMENTIER M, VASSART G, ABRAMOWICZ MJ (2003). Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension. Cardiovasc Res 60: 518-28.
10. BONNIN A, TORII M, WANG L, RAKIC P, LEVITT P (2007). Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 10: 588-597.
11. BONNIN A, GOEDEN N, CHEN K, WILSON ML, KING J, SHIH JC, BLAKELY RD, DENERIS ES, LEVITT P (2011). A transient placental source of serotonin for the fetal forebrain. Nature 472: 347-350.
12. BORCHERS A, EPPERLEIN HH, WEDLICH D (2000). An assay system to study migratory behavior of cranial neural crest cells in Xenopus. Dev Genes Evol 210: 217-222.
13. BUZNIKOV GA (2007). Preneural transmitters as regulators of embryogenesis. Current state of the problem. Russ J. Dev Biol 38: 213-220.
14. CASES O, VITALIS T, SEIF I, DE MAEYER E, SOTELO C, GASPAR P (1996). Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 16: 297-307.
15. CHAMBERS C D, HERNANDEZ-DIAZ S, VAN MARTER L J, WERLER M M, LOUIK C, JONES KL, MITCHELL AA (2006). Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 354: 579-587.
16. CHOI DS, WARD SJ, MESSADDEQ N, LAUNAY JM, MAROTEAUX L (1997). 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development 124: 1745-1755.
17. CÔTÉ F, FLIGNY C, BAYARD E, LAUNAY JM, GERSHON MD, MALLET J. VODJDANI G (2007). Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci USA 104: 329-334.
18. DE LUCCHINI S, MARRACCI S, NARDI I (2001). The serotonin 5-HT2B receptor from the puffer fish Tetraodon fluviatilis: cDNA cloning, genomic organization and alternatively spliced variants. Brain Res Mol Brain Res 97: 89-93.
19. DE LUCCHINI S, ORI M, NARDINI M, MARRACCI S, NARDI I (2003). Expression of 5-HT2B and 5-HT2C receptor genes is associated with proliferative regions of Xenopus developing brain and eye. Brain Res. Mol. Brain Res 115: 196-201.
20. DE LUCCHINI S, ORI M, CREMISI F, NARDINI M, NARDI I (2005). 5-HT2B mediated serotonin signaling is required for eye morphogenesis in Xenopus. Mol Cell Neurosci 29: 299-312.
21. DERAET M, MANIVET P, JANOSHAZI A, CALLEBERT J, GUENTHER S, DROUET L, LAUNAY JM, MAROTEAUX L (2005). The natural mutation encoding a C-terminus truncated 5-HT2B receptor is a gain of proliferative functions. Molec. Pharmacol. 67: 983-991.
22. DIAZ S L, DOLY S, NARBOUX-NÊME N, FERNÁNDEZ S, MAZOT P, M BANAS SM, BOUTOURLINSKY K, MOUTKINE I, BELMER A, ROUMIER A, AND MAROTEAUX L (2012). 5-HT2B receptors are required for serotonin-selective antidepressant actions. Mol Psychiatry 17: 154-163.
23. FARRA C, YUNIS K, MIKATI M, YAZBECK N, MAJDALANI M, AWWAD J (2010). Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence? Birth Defects Res A Clin Mol Teratol 88: 582-5.
24. FISCHER S, LÜDECKE HJ, WIECZOREK D, BÖHRINGER S, GILLESSEN-KAESBACH G, HORSTHEMKE B (2006). Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. Hum Mol Genet 15: 581-587.
25. FREDERICK JM, RAYBORN ME, HOLLYFIELD JG (1989). Serotoninergic neurons in the retina of Xenopus laevis: selective staining, identification, development, and content. J. Comp. Neurol. 281: 516-531.
26. FUKUMOTO T, KEMA IP, LEVIN M (2005). Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Curr Biol 15: 794-803.
27. GAGE PJ, RHOADES W, PRUCKA SK, HJALT T (2005). Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci 46: 4200-4208.
28. GASPAR P, CASES O, MAROTEAUX L (2003). The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002-1012.
29. GASTINGER MJ, TIAN N, HORVATH T, MARSHAK DW (2006). Retinopetal axons in mammals: emphasis on histamine and serotonin. Curr Eye Res 31: 655-667.
30. GREEN CB, CAHILL GM, BESHARSE JC (1995). Tryptophan hydroxylase is expressed by photoreceptors in Xenopus laevis retina. Vis. Neurosci. 12: 663-670
31. HANLEY GE, BRAIN U, OBERLANDER TF (2013). Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect. Early Hum Dev, Feb 2. pii: S0378-3782(13)00015-7. doi: 10.1016/j.earlhumdev.2012.12.012. [Epub ahead of print]
32. HUANG S, MOODY SA (1997). Three types of serotonin-containing amacrine cells in tadpole retina have distinct clonal origins. J Comp Neurol 387: 42-52
33. LAUDER JM (1993). Neurotransmitters as growth regulatory signals: role of receptors and second messengers. Trends Neurosci 16: 233-240.
34. LAUDER JM, ZIMMERMAN EF 1988. Sites of serotonin uptake in epithelia of the developing mouse palate, oral cavity, and face: possible role in morphogenesis. J Craniofac Genet Dev Biol 8: 265-76.
35. LAUDER J M, WILKIE MB, WU C, SINGH S (2000). Expression of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors in the mouse embryo. Int J Dev Neurosci 18: 653-662.
36. LAUNAY JM, SCHNEIDER B, LORIC S, DA PRADA M, KELLERMAN O (2006). Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J 20: 1843-54.
37. LEVIN M, BUZNIKOV GA, LAUDER JM (2006). Of minds and embryos: left-right asymmetry and the serotonergic controls of pre-neural morphogenesis. Dev Neurosci 28: 171-185.
38. MARRACCI S, CINI D, NARDI I (1997). Cloning and developmental expression of 5-HT1A receptor gene in Xenopus laevis. Brain Res Mol Brain Res 47: 67-77.
39. MARSELLA M, UBALDINI E, SOLINAS A, GUERRINI P (2010). Prenatal exposure to serotonin reuptake inhibitors: a case report. Ital. J. Pediatrics 36: 27-29.
40. MARTINS RA, PEARSON RA (2008). Control of cell proliferation by neurotransmitters in the developing vertebrate retina. Brain Res 1192: 37-60.
41. MIGLIARINI S, PACINI G, PELOSI B, LUNARDI G, PASQUALETTI M (2012). Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Molec. Psychiatry Sep 25, 1-13 doi: 10.1038/mp.2012.128. [Epub ahead of print]
42. MILLER CT, YELON D, STAINIER DY, KIMMEL CB (2003). Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Development 130: 1353-1365.
43. MINOUX M, RIJLI FM (2010). Molecular mechanisms of cranial neural crest cell migration and patterning in craniofacial development. Development 137: 2605-21.
44. MOISEIWITSCH JR (2000). The role of serotonin and neurotransmitters during craniofacial development. Crit Rev Oral Biol Med 11: 230-239.
45. NARBOUX-NÊME N, PAVONE LM, AVALLONE L, ZHUANG X, GASPAR P (2008). Serotonin transporter transgenic (SERTcre) mouse line reveals developmental targets of serotonin specific reuptake inhibitors (SSRIs). Neuropharmacology 55: 994-1005.
46. NEBIGIL CG, CHOI DS, DIERICH A, HICKEL P, LE MEUR M, MESSADDEQ N, LAUNAY JM, MAROTEAUX L (2000). Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci USA 97: 9508-9513.
47. NEBIGIL CG, MAROTEAUX L (2001). A novel role for serotonin in heart. Trends Cardiovasc Med 11: 329-335.
48. NEBIGIL CG, ETIENNE N, MESSADDEQ N, MAROTEAUX L (2003). Serotonin is a novel survival factor of cardiomyocytes: mitochondria as a target of 5-HT2B receptor signaling. FASEB J 17: 1373-1375
49. NEWMAN C S, GROW MW, CLEAVER O, CHIA F, KRIEG P (1997). Xbap, a vertebrate gene related to bagpipe, is expressed in developing craniofacial structures and in anterior gut muscle. Dev Biol 181: 223-233.
50. NIKISHIN DA, KREMNYOV SV, KONDUKTOROVA VV, SHMUKLER YB (2012). Expression of serotonergic system components during early Xenopus embryogenesis. Int J Dev Biol 56: 385-91.
51. OBERLANDER TF, GINGRICH JA, ANSORGE MS (2009). Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidence. Clin Pharmacol Ther 86: 672-677
52. PERSICO AM, MENGUAL E, MOESSNER R, HALL FS, REVAY RS, SORA I, ARELLANO J, DEFELIPE J, GIMENEZ-AMAYA JM, CONCIATORI M, MARINO R, BALDI A, CABIB S, PASCUCCI T, UHL GR, MURPHY DL, LESCH KP, KELLER F (2001). Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 21: 6862-6873.
53. RAYMOND JR, MUKHIN YV, GELASCO A, TURNER J, COLLINSWORTH G, GETTYS TW, GREWAL JS, GARNOVSKAYA MN (2001). Multiplicity of mechanisms of serotonin receptor signal transduction. Pharmacol Ther 92: 179-212.
54. REISOLI E, DE LUCCHINI S, ANELLI, BIAGIONI S, NARDI I., ORI M (2008). Overexpression of 5-HT2B receptor results in retinal dysplasia and defective ocular morphogenesis in Xenopus embryos. Brain Res 9: 32-39
55. REISOLI E, DE LUCCHINI S, NARDI I., ORI M (2010). Serotonin 2B receptor signaling is required for craniofacial morphogenesis and jaw joint formation in Xenopus Development 137: 2927-2937.
56. SADLER T W (2011). Selective serotonin reuptake inhibitors (SSRIs) and heart defects: potential mechanisms for the observed associations. Reprod Toxicol 32: 484-9.
57. SALTYS HA, JONZ MG, NURSE CA (2006). Comparative study of gill neuroepithelial cells and their innervation in teleosts and Xenopus tadpoles. Cell Tissue Res 323: 1-10.
58. SAUKA-SPENGLER T, BRONNER-FRASER M (2008). A gene regulatory network orchestrates neural crest formation. Nat Rev Mol Cell Biol 9: 557-568.
59. SHAFER WR (1999). How do antidepressants work? Prospects for genetic analysis of drug mechanisms. Cell 98: 551-554
60. SHARIF NA, SENCHYNA M (2006). Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR. Mol Vis 12: 1040-7.
61. SHUEY DL, SADLER TW, LAUDER JM (1992). Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors. Teratology 46: 367-378.
62. TSAPAKIS EM, GAMIE Z, TRAN GT, ADSHEAD S, LAMPARD A, MANTALARIS A, TSIRIDIS E (2012). The adverse skeletal effects of selective serotonin reuptake inhibitors. Eur. Psychiatry 27: 156-169
63. TUCCORI M, TESTI A, ANTONIOLI L, FORNAI M, MONTAGNANI S, GHISU N, COLUCCI R, CORONA T, BLANDIZZI C, DEL TACCA M (2009). Safety concerns associated with the use of serotonin reuptake inhibitors and other serotonergic/noradrenergic antidepressants during pregnancy: a review. Clin Ther 31: 1426-53.
64. TUCKER A S, WATSON RP, LETTICE LA, YAMADA G, HILL RE (2004). Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Development 131: 1235-1245.
65. VAN MIER P, JOOSTEN HW, VAN RHEDEN R, TEN DONKELAAR HJ (1986). The development of serotonergic raphespinal projections in Xenopus laevis. Int J Dev Neurosci 4: 465-75.
66. VANDENBERG LN, LEMIRE JM, LEVIN M (2013). Serotonin has early, cilia-independent roles in Xenopus left-right patterning. Disease Mod. Mech. 6: 261-268
67. WALKER MB, MILLER CT, SWARTZ ME, EBERHART JK, KIMMEL CB (2007). Phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Dev Biol 304: 194-207.
68. WHEELER GN, BRÄNDLI AW (2009). Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. Dev Dyn 238: 1287-308.
69. WHITAKER-AZMITIA PM 2001. Serotonin and brain development: role in human developmental diseases. Brain Res Bull 56: 479-485.
70. WOGELIUS P M, NORGAARD M, GISLUM L, PEDERSEN E, MUNK P B, MORTENSEN PB, LIPWORTH L, SØRENSEN HT (2006). Maternal use of selective serotonin reuptake inhibitors and risk of congenital malformations. Epidemiology 17: 701-704.
71. ZHANG S, LI B, LOVATT D, XU J, SONG D, GOLDMAN SA, NEDERGAARD M, HERTZ L, PENG L (2010). 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotoninspecific reuptake inhibitors'. Neuron Glia Biol 6: 113-125.
72. ZHU B, STRAZNICKY C (1992). Large serotonin-like immunoreactive amacrine cells in the retina of developing Xenopus laevis. Brain Res., Dev. Brain Res. 69: 109-116.
73. ZHU B, GÁBRIEL R, STRAZNICKY C (1992). Serotonin synthesis and accumulation by neurons of the anuran retina. Vis Neurosci 9: 377-388.