Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design

Journal of Medicinal Chemistry

Volumn 57, Issue 3, 2014, Pages 849-860

  Carson, Matthew W ^a   Luz, John G ^a   Suen, Chen ^a   Montrose, Chahrzad ^a   Zink, Richard ^a   Ruan, Xiaoping ^a   Cheng, Christine ^a   Cole, Harlan ^a   Adrian, Mary D ^a   Kohlman, Dan T ^a   Mabry, Thomas ^a   Snyder, Nancy ^a   Condon, Brad ^a   Maletic, Milan ^a   Clawson, David ^a   Pustilnik, Anna ^a   Coghlan, Michael J ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; BENZOXEPINS; BINDING SITES; CARRAGEENAN; CELL LINE; CHRONIC DISEASE; COLLAGEN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; EDEMA; HUMANS; INFLAMMATION; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84894090667     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401616g     Document Type: Article

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