메뉴 건너뛰기




Volumn 24, Issue 1, 2014, Pages 54-62

Investigation of the dose-dependency of citicoline effects on nerve regeneration and functional recovery in a rat model of sciatic nerve injury

Author keywords

Citicoline; Peripheral nerve; Regeneration

Indexed keywords

CITICOLINE; NOOTROPIC AGENT;

EID: 84894073364     PISSN: 10195149     EISSN: None     Source Type: Journal    
DOI: 10.5137/1019-5149.JTN.8451-13.0     Document Type: Article
Times cited : (28)

References (40)
  • 1
    • 0042672758 scopus 로고    scopus 로고
    • Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia
    • Adibhatla RM, Hatcher JF: Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia. J Neurol Res 73:308-315, 2003
    • (2003) J Neurol Res , vol.73 , pp. 308-315
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 2
    • 13844264515 scopus 로고    scopus 로고
    • Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders
    • Adibhatla RM, Hatcher JF: Cytidine 5'-diphosphocholine (CDP-choline) in stroke and other CNS disorders. Neurochem Res 30:15-23, 2005
    • (2005) Neurochem Res , vol.30 , pp. 15-23
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 3
    • 0034788227 scopus 로고    scopus 로고
    • Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia
    • Adibhatla RM, Hatcher JF, Dempsey RJ: Effects of citicoline on phospholipid and glutathione levels in transient cerebral ischemia. Stroke 32:2376-2381, 2001
    • (2001) Stroke , vol.32 , pp. 2376-2381
    • Adibhatla, R.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 4
    • 0036270432 scopus 로고    scopus 로고
    • Citicoline: Neuroprotective mechanisms in cerebral ischemia
    • Adibhatla RM, Hatcher JF, Dempsey RJ: Citicoline: Neuroprotective mechanisms in cerebral ischemia. J Neurochem 80:12-23, 2002
    • (2002) J Neurochem , vol.80 , pp. 12-23
    • Adibhatla, R.M.1    Hatcher, J.F.2    Dempsey, R.J.3
  • 5
    • 0027451394 scopus 로고
    • Oral cytidine 5'-diphosphate choline administration to rats increases brain phospholipid levels
    • Agut J, Lopez IG, Ortiz JA, Wurtman RJ: Oral cytidine 5'-diphosphate choline administration to rats increases brain phospholipid levels. Ann NY Acad Sci 695:318-320, 1993
    • (1993) Ann NY Acad Sci , vol.695 , pp. 318-320
    • Agut, J.1    Lopez, I.G.2    Ortiz, J.A.3    Wurtman, R.J.4
  • 6
    • 79960488003 scopus 로고    scopus 로고
    • CDP-choline and its endogenous metabolites, cytidine and choline, promote the nevre regeneration and improve the functional recovery of injured rat sciatic nerves
    • Arslan E, Kocaeli H, Bekar A, Tolunay S, Ulus IH: CDP-choline and its endogenous metabolites, cytidine and choline, promote the nevre regeneration and improve the functional recovery of injured rat sciatic nerves. Neurol Res 33:766-773, 2011
    • (2011) Neurol Res , vol.33 , pp. 766-773
    • Arslan, E.1    Kocaeli, H.2    Bekar, A.3    Tolunay, S.4    Ulus, I.H.5
  • 7
    • 1042301370 scopus 로고    scopus 로고
    • Pathophysiology of cerebral ischemia and brain trauma: Similarities and differences
    • Bramlett HM, Dietrich WD: Pathophysiology of cerebral ischemia and brain trauma: Similarities and differences. J Cereb Blood Flow Metab 24:133-150, 2004
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 133-150
    • Bramlett, H.M.1    Dietrich, W.D.2
  • 8
    • 0029937643 scopus 로고    scopus 로고
    • The use of cultured schwann cells in nerve repair in rabbit hind-limb model
    • Brown RE, Detlev E, Lyons SF, Suchy H: The use of cultured schwann cells in nerve repair in rabbit hind-limb model. J Reconstr Microsurg 12:149-152, 1996
    • (1996) J Reconstr Microsurg , vol.12 , pp. 149-152
    • Brown, R.E.1    Detlev, E.2    Lyons, S.F.3    Suchy, H.4
  • 9
    • 84859308948 scopus 로고    scopus 로고
    • Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury
    • Caner B, Kafa MI, Bekar A, Kurt MA, Karli N, Cansev M, Ulus IH: Intraperitoneal administration of CDP-choline or a combination of cytidine plus choline improves nerve regeneration and functional recovery in a rat model of sciatic nerve injury. Neurol Res 34:238-245, 2012
    • (2012) Neurol Res , vol.34 , pp. 238-245
    • Caner, B.1    Kafa, M.I.2    Bekar, A.3    Kurt, M.A.4    Karli, N.5    Cansev, M.6    Ulus, I.H.7
  • 10
    • 38849167380 scopus 로고    scopus 로고
    • Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations
    • Cansev M, Ilcol YO, Yilmaz MS, Hamurtekin E, Ulus IH: Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. Auton Autacoid Pharmacol 28:41-58, 2008
    • (2008) Auton Autacoid Pharmacol , vol.28 , pp. 41-58
    • Cansev, M.1    Ilcol, Y.O.2    Yilmaz, M.S.3    Hamurtekin, E.4    Ulus, I.H.5
  • 11
    • 47549099175 scopus 로고    scopus 로고
    • Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system
    • Cansev M, Ilcol YO, Yilmaz MS, Hamurtekin E, Ulus IH: Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system. Eur J Pharmacol 589:315-322, 2008
    • (2008) Eur J Pharmacol , vol.589 , pp. 315-322
    • Cansev, M.1    Ilcol, Y.O.2    Yilmaz, M.S.3    Hamurtekin, E.4    Ulus, I.H.5
  • 12
    • 35449003300 scopus 로고    scopus 로고
    • Cardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous system
    • Cansev M, Yilmaz MS, Ilcol YO, Hamurtekin E, Ulus IH: Cardiovascular effects of CDP-choline and its metabolites: Involvement of peripheral autonomic nervous system. Eur J Pharmacol 577:129-142, 2007
    • (2007) Eur J Pharmacol , vol.577 , pp. 129-142
    • Cansev, M.1    Yilmaz, M.S.2    Ilcol, Y.O.3    Hamurtekin, E.4    Ulus, I.H.5
  • 13
    • 0032873649 scopus 로고    scopus 로고
    • Long term effects of a single dose of brain-derived neurotropic factor on motorneuron survival following spinal root avulsion in the adult rat
    • Chai H, Wu W, So KF, Prevette DM, Oppenheim RW: Long term effects of a single dose of brain-derived neurotropic factor on motorneuron survival following spinal root avulsion in the adult rat. Neurosci Lett 274:147-150, 1999
    • (1999) Neurosci Lett , vol.274 , pp. 147-150
    • Chai, H.1    Wu, W.2    So, K.F.3    Prevette, D.M.4    Oppenheim, R.W.5
  • 14
    • 0344305407 scopus 로고    scopus 로고
    • Phospholipase A2 plays important role in myelin breakdown and phagocytosis during wallerian degeneration
    • De S, Trigueros MA, Kalyvas A, David S: Phospholipase A2 plays important role in myelin breakdown and phagocytosis during wallerian degeneration. Mol Cell Neurosci 24:753-765, 2003
    • (2003) Mol Cell Neurosci , vol.24 , pp. 753-765
    • De, S.1    Trigueros, M.A.2    Kalyvas, A.3    David, S.4
  • 15
    • 0031063473 scopus 로고    scopus 로고
    • The cellular and molecular basis of peripheral nevre regeneration
    • Fu SY, Gordon T: The cellular and molecular basis of peripheral nevre regeneration. Mol Neurobiol 14:67-116, 1997
    • (1997) Mol Neurobiol , vol.14 , pp. 67-116
    • Fu, S.Y.1    Gordon, T.2
  • 16
    • 0029904013 scopus 로고    scopus 로고
    • Sciatic function index, nevre conduction tests, muscle contraction, and axon morphometry asindicators of regeneration
    • Fuminori K, John CF, Warren CB: Sciatic function index, nevre conduction tests, muscle contraction, and axon morphometry asindicators of regeneration. Plast Reconstr Surg 98:1264-1271, 1996
    • (1996) Plast Reconstr Surg , vol.98 , pp. 1264-1271
    • Fuminori, K.1    John, C.F.2    Warren, C.B.3
  • 18
    • 37549039845 scopus 로고    scopus 로고
    • Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: Involvement of the sympathoadrenal system
    • Ilcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH: Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: Involvement of the sympathoadrenal system. Arch Physiol Biochem 113:186-201, 2007
    • (2007) Arch Physiol Biochem , vol.113 , pp. 186-201
    • Ilcol, Y.O.1    Cansev, M.2    Yilmaz, M.S.3    Hamurtekin, E.4    Ulus, I.H.5
  • 19
    • 38049072149 scopus 로고    scopus 로고
    • Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: Muscarinic and nicotinic acetylcholine receptors are both involved in their actions
    • Ilcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH: Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: Muscarinic and nicotinic acetylcholine receptors are both involved in their actions. Neurosci Lett 431:71-76, 2008
    • (2008) Neurosci Lett , vol.431 , pp. 71-76
    • Ilcol, Y.O.1    Cansev, M.2    Yilmaz, M.S.3    Hamurtekin, E.4    Ulus, I.H.5
  • 20
    • 69549096230 scopus 로고    scopus 로고
    • Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors
    • Ilcol YO, Yilmaz Z, Cansev M, Ulus IH: Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors. Shock 32:286-294, 2009
    • (2009) Shock , vol.32 , pp. 286-294
    • Ilcol, Y.O.1    Yilmaz, Z.2    Cansev, M.3    Ulus, I.H.4
  • 21
    • 0000749205 scopus 로고
    • The function of cytidine coenzymes in the biosynthesis of phospholipides
    • Kennedy EP, Weiss SB: The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem 222:193-214, 1956
    • (1956) J Biol Chem , vol.222 , pp. 193-214
    • Kennedy, E.P.1    Weiss, S.B.2
  • 23
    • 0031913965 scopus 로고    scopus 로고
    • Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair
    • Labrador RO, Buti M, Navarro X: Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair. Exp Neurol 149:243-252, 1998
    • (1998) Exp Neurol , vol.149 , pp. 243-252
    • Labrador, R.O.1    Buti, M.2    Navarro, X.3
  • 24
    • 0034193047 scopus 로고    scopus 로고
    • 25 th Anniversary Presentation.A 25-Year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance
    • Lundborg G: 25 th Anniversary Presentation. A 25-Year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance. J Hand Surg 25A:391-414, 2000
    • (2000) J Hand Surg , vol.25 A , pp. 391-414
    • Lundborg, G.1
  • 25
    • 20444431911 scopus 로고    scopus 로고
    • Molecular mechanisms in successful peripheral regeneration
    • Makwana M, Raivich G: Molecular mechanisms in successful peripheral regeneration. FEBS J 272:2628-2638, 2005
    • (2005) FEBS J , vol.272 , pp. 2628-2638
    • Makwana, M.1    Raivich, G.2
  • 26
    • 20444439462 scopus 로고    scopus 로고
    • Overall assessment of regeneration in peripheral nerve lesion repair using fibrin glue, suture, or a combination of the 2 techniques in a rat model. Which is the ideal choice?
    • Martins RS, Siqueira MG, Da Silva CF, Plese JPP: Overall assessment of regeneration in peripheral nerve lesion repair using fibrin glue, suture, or a combination of the 2 techniques in a rat model. Which is the ideal choice? Surg Neurol 64:10-16, 2005
    • (2005) Surg Neurol , vol.64 , pp. 10-16
    • Martins, R.S.1    Siqueira, M.G.2    Da Silva, C.F.3    Plese, J.P.P.4
  • 27
    • 0032951834 scopus 로고    scopus 로고
    • Focally administered nerve growth factor supresses molecular regenerative responses of axotomized peripheral afferent in rats
    • Mohiuddin L, Delcroix D, Fernyhough P, Tomlinson R: Focally administered nerve growth factor supresses molecular regenerative responses of axotomized peripheral afferent in rats. Neuroscience 91:265-271, 1999
    • (1999) Neuroscience , vol.91 , pp. 265-271
    • Mohiuddin, L.1    Delcroix, D.2    Fernyhough, P.3    Tomlinson, R.4
  • 29
    • 0022352223 scopus 로고
    • Nerve regeneration and pharmacological suppresion of the scar reaction at the suture site
    • Nachemson AK, Lundborg G, Myrhage R, Kank F: Nerve regeneration and pharmacological suppresion of the scar reaction at the suture site. Scand J Plast Reconstr Surg 19:255-260, 1985
    • (1985) Scand J Plast Reconstr Surg , vol.19 , pp. 255-260
    • Nachemson, A.K.1    Lundborg, G.2    Myrhage, R.3    Kank, F.4
  • 30
    • 77249109884 scopus 로고    scopus 로고
    • Scar less: A review of methods of scar reduction at sites of peripheral nerve repair
    • Ngeow WC: Scar less: A review of methods of scar reduction at sites of peripheral nerve repair. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:357-366, 2010
    • (2010) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.109 , pp. 357-366
    • Ngeow, W.C.1
  • 31
    • 36348987717 scopus 로고    scopus 로고
    • Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats
    • Ozay R, Bekar A, Kocaeli H, Karli N, Filiz G, Ulus IH: Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats. Surg Neurol 68: 615-622, 2007
    • (2007) Surg Neurol , vol.68 , pp. 615-622
    • Ozay, R.1    Bekar, A.2    Kocaeli, H.3    Karli, N.4    Filiz, G.5    Ulus, I.H.6
  • 32
    • 0037304831 scopus 로고    scopus 로고
    • Effects of human amniotic fluid on peripheral nevre scarring and regeneration in rats
    • Ozgenel GY, Filiz G: Effects of human amniotic fluid on peripheral nevre scarring and regeneration in rats. J Neurosurg 98:371-377, 2003
    • (2003) J Neurosurg , vol.98 , pp. 371-377
    • Ozgenel, G.Y.1    Filiz, G.2
  • 34
    • 0037720339 scopus 로고    scopus 로고
    • Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: Effect is mediated by central cholinergic activation
    • Savci V, Goktalay G, Cansev M, Cavun S, Yilmaz MS, Ulus IH: Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: Effect is mediated by central cholinergic activation. Eur J Pharmacol 468:129-139, 2003
    • (2003) Eur J Pharmacol , vol.468 , pp. 129-139
    • Savci, V.1    Goktalay, G.2    Cansev, M.3    Cavun, S.4    Yilmaz, M.S.5    Ulus, I.H.6
  • 36
    • 0000801169 scopus 로고
    • Endoneurial tube shrinkage in the distal segment of a severed nerve
    • Sunderland S, Bradley KC: Endoneurial tube shrinkage in the distal segment of a severed nerve. J Comp Neurol 93:411-420, 1950
    • (1950) J Comp Neurol , vol.93 , pp. 411-420
    • Sunderland, S.1    Bradley, K.C.2
  • 37
    • 0142151019 scopus 로고    scopus 로고
    • Fibroblast growth factor-inducible-14 is induced in axotomized neurons and neurite outgrowth
    • Tanabe K, Bonilla I, Winkles JA, Strittmatter SM: Fibroblast growth factor-inducible-14 is induced in axotomized neurons and neurite outgrowth. J Neurosci 23:9675-9686, 2003
    • (2003) J Neurosci , vol.23 , pp. 9675-9686
    • Tanabe, K.1    Bonilla, I.2    Winkles, J.A.3    Strittmatter, S.M.4
  • 38
    • 0031027478 scopus 로고    scopus 로고
    • Leukemia inhibitory factor enhances the regeneration of transected rat sciatic nerve and the function of reinnervated muscle
    • Tham S, Dowsing B, Finkelstein D, Donato R, Cheema SS, Bartlett PF, Morrison WA: Leukemia inhibitory factor enhances the regeneration of transected rat sciatic nerve and the function of reinnervated muscle. J Neurosci Res 47:208-215, 1997
    • (1997) J Neurosci Res , vol.47 , pp. 208-215
    • Tham, S.1    Dowsing, B.2    Finkelstein, D.3    Donato, R.4    Cheema, S.S.5    Bartlett, P.F.6    Morrison, W.A.7
  • 39
    • 0028896412 scopus 로고
    • Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline
    • Weiss GB: Metabolism and actions of CDP-choline as an endogenous compound and administered exogenously as citicoline. Life Sci 56:637-660, 1995
    • (1995) Life Sci , vol.56 , pp. 637-660
    • Weiss, G.B.1
  • 40
    • 77951911170 scopus 로고    scopus 로고
    • Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia
    • Yilmaz Z, Ozarda Y, Cansev M, Eralp O, Kocaturk M, Ulus IH: Choline or CDP-choline attenuates coagulation abnormalities and prevents the development of acute disseminated intravascular coagulation in dogs during endotoxemia. Blood Coagul Fibrinolysis 21:339-348, 2010
    • (2010) Blood Coagul Fibrinolysis , vol.21 , pp. 339-348
    • Yilmaz, Z.1    Ozarda, Y.2    Cansev, M.3    Eralp, O.4    Kocaturk, M.5    Ulus, I.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.