Choline or CDP-choline alters serum lipid responses to endotoxin in dogs and rats: Involvement of the peripheral nicotinic acetylcholine receptors

Shock

Volumn 32, Issue 3, 2009, Pages 286-294

  Ilcol, Yesim Ozarda ^a   Yilmaz, Zeki ^a   Cansev, Mehmet ^a   Ulus, Ismail H ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

CDP choline; Choline; Dog; Endotoxin; Hypertriglyceridemia; LPS; Rat; Serum lipids; Serum phospholipids

Indexed keywords

ATROPINE; CHOLINE; CITICOLINE; ENDOTOXIN; FATTY ACID DERIVATIVE; HEXAMETHONIUM; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NICOTINIC RECEPTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOSE RESPONSE; ENDOTOXEMIA; EXPERIMENTAL DOG; KIDNEY INJURY; LIPID METABOLISM; LIVER INJURY; NONHUMAN; RAT; SEPTIC SHOCK; SURVIVAL RATE;

ANIMALS; ATROPINE; CHOLESTEROL; CHOLINE; CYTIDINE DIPHOSPHATE CHOLINE; DOGS; ENDOTOXINS; FATTY ACIDS, NONESTERIFIED; FEMALE; HEXAMETHONIUM; KIDNEY; LIPID METABOLISM; LIPIDS; LIVER; MALE; NICOTINIC ANTAGONISTS; PHOSPHOLIPIDS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; SHOCK, SEPTIC; TRIGLYCERIDES;

EID: 69549096230     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181971b02     Document Type: Article

References (35)

1. Nolan JP, Ali MV: Endotoxin and the liver. Toxicity in rats with choline deficient fatty livers. Proc Soc Exp Biol Med 129:29-33, 1968.
2. Eastin CE, McClain CJ, Lee EY, Bagby GJ, Chawla RK: Choline deficiency augments and antibody to tumor necrosis factor-alpha attenuates endotoxin-induced hepatic injury. Alcohol Clin Exp Res 21:1037-1041, 1997.
3. Rivera CA, Wheeler MD, Enomoto N, Thurman RG: A choline rich diet improves survival in a rat model of endotoxin shock. Am J Physiol 275:862-867, 1998. (Pubitemid 128733591)
4. Savci V, Ulus IH: Cardiovascular effects of central choline during endotoxin shock in the rat. J Cardiovasc Pharmacol 30:667-675, 1997. (Pubitemid 27524508)
5. Ilcol YO, Yilmaz Z, Ulus IH: Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs. Shock 24:288-293, 2005. (Pubitemid 41279495)
6. Yilmaz Z, Ilcol YO, Torun S, Ulus IH: Intravenous administration of choline or CDP-choline improves platelet count and platelet closure times in endotoxin-treated dogs. Shock 25:73-79, 2006. (Pubitemid 43755990)
7. Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang L, Hudson LQ, Lin X, Patel N, Johnson SM, et al.: Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine-mediated signaling. Mol Med 14:567-574, 2008.
8. Harris HW, Gosnell JE, Kumwenda ZL: The lipemia of sepsis: triglyceriderich lipoproteins as agents of innate immunity. J Endotoxin Res 6:421-430, 2001.
9. Wu A, Hinds CJ, Thiermermann C: High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications. Shock 21:210-221, 2004.
10. Zeisel SH: Choline: critical role during fetal development and dietary requirements in adults. Ann Rev Nutr 26:229-250, 2006.
11. Maldonado EN, Romero JR, Ochoa B, Aveldano MI: Lipid and fatty acid composition of canine lipoproteins. Comp Biochem Physiol Part B 128:719-729, 2003.
12. Gordon BR, Parker TS, Levine DM, Feuerbach F, Saal ST, Sloan B-J, Chu C, Stenzel KH, Parrillo JE, Rubin AL: Neutralization of endotoxin by a phospholipid emulsion in healthy volunteers. J Infect Dis 191:1515-1522, 2005. (Pubitemid 40563364)
13. Ulus IH, Millington WR, Buyukuysal RL, Kiran BK: Choline as an agonist: determination of its agonistic potency on cholinergic receptors. Biochem Pharmacol 14:2747-2755, 1988.
14. Ilcol YO, Gurun MS, Taga Y, Ulus IH: Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated acetylcholine release from the rat minced pancreas in vitro. Eur J Biochem 270:991-999, 2003. (Pubitemid 36315342)
15. Ilcol YO, Gurun MS, Taga Y, Ulus IH: Intraperitoneal administration of choline increases serum glucose in rat: involvement of the sympatho-adrenal system. Horm Metab Res 34:341-347, 2002. (Pubitemid 34761720)
16. llcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH: Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. Arch Physiol Biochem 113:186-201, 2007.
17. llcol YO, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH: Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions. Neurosci Lett 431:71-76, 2008.
18. Cansev M, Yilmaz MS, llcol YO, Hamurtekin E, Ulus IH: Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system. Eur J Pharmacol 577:129-142, 2007. (Pubitemid 47632525)
19. Cansev M, Ilcol YO, Yilmaz MS, Hamurtekin E, Ulus IH: Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. Auton Autacoid Pharmacol 28:41-58, 2008. (Pubitemid 351197444)
20. Nance DM, Sanders VM: Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun 21:736-745, 2007.
21. Tracey KJ: Physiology and immunology of the cholinergic anti-inflammatory pathway. J Clin Invest 117:289-296, 2007. (Pubitemid 46203953)
22. Gallowitsch-Puerto M, Pavlov VA: Neuro-immune interactions via the cholinergic anti-inflammatory pathway. Life Sci 80:2325-2329, 2007. (Pubitemid 46818256)
23. Yilmaz Z, Ilcol YO, Ulus IH: Endotoxin increases plasma leptin and ghrelin levels in dogs. Crit Care Med 36:828-833, 2008.
24. Lanza-Jacoby S, Tabares A: Triglyceride kinetics, tissue lipoprotein lipase and liver lipogenesis in septic rat. Am J Physiol 258:E675-E68, 1990.
25. Memon RA, Grunfeld C, Moser AH, Feingold KR: Tumor necrosis factor mediates the effects of endotoxin on cholesterol and triglyceride metabolism in mice. Endocrinology 132:2246-2253, 1991. (Pubitemid 23133278)
26. Feingold KR, Staprans I, Memon RA, Moser AH, Shigenaga JK, Doerrler W, Dinarello CA, Grunfeld C: Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance. J Lipid Res 33:1765-1776, 1992. (Pubitemid 23006653)
27. Nonogaki K, Moser AH, Feingold KR, Grunfeld C: α-Adrenergic receptors mediate the hypertriglyceridemia induced by endotoxin, but not tumor necrosis factor, in rats. Endocrinology 135:2644-2650, 1994. (Pubitemid 24377427)
28. de Vasconcelos PRL, Kettlewell MGW, Gibbons GF, Williamson DH: Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rat in vivo: evidence for the possible involvement of insulin. Clin Sci 76:205-211, 1989.
29. Kumwenda ZL, Wong CB, Johnson JA, Gosnell JE, Welch WJ, Harris HW: Cyclomicron-bound endotoxin selectively inhibits NF-kappaB activation in rat hepatocytes. Shock 18:182-188, 2002.
30. Read TE, Grunfeld C, Kumwenda ZL, Calhoun MC, Kane JP, Feingold KR, Rapp JH: Triglyceride-rich lipoproteins prevents septic death in rats. J Exp Med 182:267-272, 1995.
31. Fujii T, Takata-Takatori Y, Kawashima K: Basic and clinical aspects of nonneuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J Pharmacol Sci 106:186-192, 2008.
32. Fuentes JM, Fulton WB, Nino D, Talamini MA, Maio AD: Atropine treatment modifies LPS-induced inflammatory response and increases survival. Inflamm Res 57:111-117, 2008.
33. Buhling F, Lieder N, Kuhlmann UC, Waldburg N, Welte T: Tiotropium suppresses acetylcholine-induced release of chemotactic mediators. Resp Med 101:2386-2394, 2007. (Pubitemid 47471396)
34. Chien J-Y, Jerng J-S, Yu C-J, yang P-C: Low serum level of high-density lipoprotein cholesterol is a poor prognostic factor for severe sepsis. Crit Care Med 33:1688-1693, 2005.
35. Hudgins LC, Parker TS, Levine DM, Gordon BR, Saal SD, Jiang X-C, Seidman CE, Tremaroli JD, Lai J, Rubin AL: A single intravenous dose of endotoxin rapidly alters serum lipoproteins and lipid transfer proteins in normal volunteers. J Lipid Res 44:1489-1498, 2003. (Pubitemid 37279593)