CDP-choline and its endogenous metabolites, cytidine and choline, promote the nerve regeneration and improve the functional recovery of injured rat sciatic nerves

Neurological Research

Volumn 33, Issue 7, 2011, Pages 766-773

  Aslan, Erhan ^a   Kocaeli, Hasan ^a   Bekar, Ahmet ^a   Tolunay, ŞAhsine ^a   Ulus, Ismail H ^b  

^a ULUDAG UNIVERSITY   (Turkey)

^b ACIBADEM UNIVERSITY   (Turkey)

Author keywords

Citicoline; Peripheral nerve; Scarring

Indexed keywords

CHOLINE; CITICOLINE; CYTIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; NERVE FIBER GROWTH; NERVE INJURY; NERVE REGENERATION; NONHUMAN; RAT; SCAR FORMATION; SCIATIC NERVE; TREATMENT DURATION; TREATMENT RESPONSE;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHOLINE; CYTIDINE; CYTIDINE DIPHOSPHATE CHOLINE; DISEASE MODELS, ANIMAL; FEMALE; NERVE REGENERATION; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SCIATIC NEUROPATHY; TRAUMA SEVERITY INDICES;

EID: 79960488003     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/1743132811Y.0000000004     Document Type: Article

References (45)

1. Adibhatla RM Hatcher. Cytidine 59-diphosphocholine (CDPcholine) in stroke and other CNS disorders. Neurochem Res 2005;30:15-23.
2. Saver JL. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Rev Neurol Dis 2008;5:167-77.
3. Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review, 2006 update. Methods Find Exp Clin Pharmacol 2006;28(Supp B):1-56.
4. Aronowski J, Strong R, Grotta JC. Citicoline for treatment of experimental focal ischemia: histological and behavioral outcome. Neurol Res 1996;18:570-4.
5. Fresta M, Puglisi G. Survival rate improvement in a rat ischemia model by long circulating liposomes containing cytidine 59-diphosphate choline. Life Sci 1997;61:1227-35.
6. Hamdorf G, Cervos-Navarro J, Muller R. Increase survival time in experimental model hipoxia by cytidine diphosphate choline. Arzeimittelforschung 1992;42:421-4.
7. Dixon CE, Ma XC, Marion DW. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J Neurotrauma 1997;14:161-9.
8. Başkaya MK, Doǧan A, Rao AM, Dempsey RJ. Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg 2000;92:448-52.
9. Alkan T, Kahveci N, Gören B, Korfali E, Ozluk K. Ischemic brain injury caused by interrupted versus uninterrupted occlusion in hypotensive rats with subarachnoid hemorrhage: neuroprotective effects of citicoline. Arch Physiol Biochem 2001;109:161-7.
10. Alvarez XA, Laredo M, Corzo D, Ferna ́ndez-Novoa L, Mouzo R, Perea JE, et al. Citicoline improves memory performance in elderly subjects. Method Find Exp Clin Pharmacol 1997;19:201-10.
11. Spiers PA, Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8.
12. Clark WM, Warach SJ, Pettigrew LC, Gammans RE, Sabounjian LA. A randomized dose-response trial of citicoline in acute ischemic stroke patients. Neurology 1997;49:671-8.
13. Clark WM, Williams BJ, Selzer KA, Zweifler RM, Sabounjian LA, Gammans RE. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke 1999;30:2592-7.
14. D'Orlanda KJ, Sandage BW, Jr. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurol Res 1995;17;281-4.
15. Hazama T, Hasegawa T, Ueda S, Sakuma A. Evaluation of the effect of CDP-choline on poststroke hemiplegia employing a double-blind controlled trial: assessed by a new rating scale for recovery in hemiplegia. Int J Neurosci 1980;11:211-25.
16. Tazaki Y, Sakai F, Otomo E, Kutsuzawa T, Kameyama M, Omae T, et al. Treatment of acute cerebral infarction with a choline precursor in a multicenter double-blind placebocontrolled study. Stroke 1988;19:211-6.
17. Warach S, Pettigrew LC, Dashe JF, Pullicino P, Lefkowitz DM, Sabounjian L, et al. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators. Ann Neurol 2000;48:713-22.
18. Özay R, Bekar A, Kocaeli H, Karli N, Filiz G, Ulus IH. Citicoline improves functional recovery, promotes nerve regeneration, and reduces postoperative scarring after peripheral nerve surgery in rats. Surg Neurol 2007;68:615-22.
19. Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res 2006;1088:83-92.
20. López-Coviella I, Agut J, Savci V, Ortiz JA, Wurtman RJ. Evidence that 59-cytidinediphosphocholine can affect brain phospholipids composition by increasing choline and cytidine plasma levels. J Neurochem 1995;65:889-94.
21. Richardson UI, Watkins CJ, Pierre C, Ulus IH, Wurtman RJ. Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells. Brain Res 2003;971:161-7.
22. Ulus IH, Watkins CJ, Cansev M, Wurtman RJ. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis and release. Cell Mol Neurobiol 2006;26:563-77.
23. Wurtman RJ, Reagan M, Ulus IH, Yu L. Effect of oral CDPcholine on plasma choline and uridine levels in humans. Biochem Pharmacol 2000;60:989-92.
24. Pooler AM, Guez DH, Benedictus R, Wurtman RJ. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12 [corrected]. Neuroscience 2005;134:207-14.
25. Cansev M, Watkins CJ, van der Beek EM, Wurtman RJ. Oral uridine-59-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res 2005;1058:101-8.
26. Cansev M, Wurtman RJ, Sakamoto T, Ulus IH. Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapsis. Alzheimers Dement 2008;4(1 Suppl 1):S153-8.
27. Sakamoto T, Cansev M, Wurtman RJ. Oral supplementation with docosahexaenoic acid and uridine-59-monophosphate increases dentritic spine density in adult gerbil hippocampus. Brain Res 2007;1182:50-9.
28. Cansev M, I lçö l YÖ, Yilmaz MS, Hamurtekin E, Ulus IH. Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations. Auton Autocoid Pharmacol 2008;28:41-58.
29. Cansev M, Yilmaz MS, I lçö l YÖ, Hamurtekin E, Ulus IH. Cardiovascular effects of CDP-choline and its metabolites: involvement of peripheral autonomic nervous system. Eur J Pharmacol 2007;577:129-42.
30. Ilçö l YÖ, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH. Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. Arch Physiol Biochem 2007;113:186-201.
31. I lçö l YÖ, Cansev M, Yilmaz MS, Hamurtekin E, Ulus IH. Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: muscarinic and nicotinic acetylcholine receptors are both involved in their actions. Neurosci Lett 2008;431:71-6.
32. İlçöl YÖ, Yilmaz Z, Ulus IH. Endotoxin alters serum-free choline and phospholipid-bound choline concentrations, and choline administration attenuates endotoxin-induced organ injury in dogs. Shock 2005;24:288-93.
33. İlçöl YÖ, Yilmaz Z, Cansev M, Ulus IH. Choline or CDPcholine alters serum lipid responses to endotoxin in dogs and rats: involvement of the peripheral nicotinic acetylcholine receptors. Shock 2009;32:286-94.
34. Özgenel GY. Effects of hyaluronic acid on peripheral nerve scarring and regeneration in rats. Microsurgery 2003;23:575-81.
35. Ö zgenel GY, Filiz G. Effects of human amniotic fluid on peripheral nerve scarring and regeneration in rats. J Neurosurg 2003;98:371-7.
36. Hare GM, Evans PJ, Mackinnon SE, Best TJ, Bain JR, Szalai JP, et al. Walking track analysis: a long-term assessment of peripheral nerve recovery. Plast Reconstr Surg 1992;89:251-8.
37. Kanaya F, Firrell JC, Breidenbach WC. Sciatic function index, nerve conduction tests, muscle contraction, and axon morphometry as indicators of regeneration. Plast Reconstr Surg 1996;98:1264-74.
38. Petersen J, Russell L, Andrus K, MacKinnon M, Silver J, Kliot M. Reduction of extraneural scarring by ADCON-T/N after surgical intervention. Neurosurgery 1996;38:976-83.
39. Brown RE, Erdman D, Lyons SF, Suchy H. The use of cultured Schwann cells in nerve repair in a rabbit hind-limb model. J Reconstr Microsurg 1996;12:149-52.
40. Görgü lü A, I mer M, Şimşek O, Sencer A, Kutlu K, Cobanoǧlu S. The effect of aprotinin on extraneural scarring in peripheral nerve surgery: an experimental study. Acta Neurochir (Wien) 1998;140:1303-7.
41. Görgü lü A, Uzal C, Doǧanay L, Imer M, Eliuz K, Cobanoǧlu S. The effect of low-dose extraneural scarring after peripheral nerve surgery in rats. Neurosurgery 2003;53:1389-95.
42. Kennedy EM, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipids. J Biol Chem 1956;222:193-214.
43. Wurtman RJ, Cansev M, Sakamoto T, Ulus IH. Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dentritic spines in rodent brain. World Rev Nutr Diet 2009;99:71-96.
44. Cansev M, Ulus IH, Wang L, Maher TJ, Wurtman RJ. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. Neurosci Res 2008;62:206-9.
45. Cansev M, Marzloff G, Sakamoto T, Ulus IH, Wurtman RJ. Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Dev Neurosci 2009;31:181-92.