Dexmedetomidine regulates inflammatory molecules contributing to ventilator-induced lung injury in dogs

Journal of Surgical Research

Volumn 187, Issue 1, 2014, Pages 211-218

  Chen, Chang ^a   Zhang, Zongze ^a   Chen, Kai ^a   Zhang, Fan ^b   Peng, Mian ^a   Wang, Yanlin ^a  

^a WUHAN UNIVERSITY   (China)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

2 adrenergic receptors; Dexmedetomidine; Inflammatory factor; Ventilator induced lung injury

Indexed keywords

DEXMEDETOMIDINE; INFLAMMATORY FACTOR; VENTILATOR-INDUCED LUNG INJURY; Α2-ADRENERGIC RECEPTORS;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BLOOD GAS ANALYSIS; DEXMEDETOMIDINE; DISEASE MODELS, ANIMAL; DOGS; LUNG; NEUTROPHILS; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; ORGAN SIZE; PEROXIDASE; RANDOM ALLOCATION; RESPIRATION, ARTIFICIAL; TUMOR NECROSIS FACTOR-ALPHA; VENTILATOR-INDUCED LUNG INJURY;

EID: 84894072614     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.09.018     Document Type: Article

References (20)

1. P.R. Rocco, C. Dos Santos, and P. Pelosi Pathophysiology of ventilator-associated lung injury Curr Opin Anaesthesiol 25 2012 123
2. J.A. Frank, P.E. Parsons, and M.A. Matthay Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies Chest 130 2006 1906
3. J.A. Tan, and K.M. Ho Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis Intensive Care Med 36 2010 926
4. X. Wu, X. Song, and N. Li et al. Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats J Trauma Acute Care Surg 74 2013 524
5. C.L. Yang, C.H. Chen, and P.S. Tsai et al. Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats J Surg Res 167 2011 273
6. L. Xu, H. Bao, and Y. Si et al. Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice Inflamm Res 62 2013 507
7. T. Taniguchi, A. Kurita, and K. Kobayashi et al. Dose-and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats J Anesth 22 2008 221
8. S. Yao, D. Feng, and Q. Wu et al. Losartan attenuates ventilator-induced lung injury J Surg Res 145 2008 25
9. J. Gu, P. Sun, and H. Zhao et al. Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice Crit Care 15 2011 153
10. M.T. Kuipers, T. van der Poll, and M.J. Schultz et al. Bench-to-bedside review: damage-associated molecular patterns in the onset of ventilator-induced lung injury Crit Care 15 2011 235
11. K.N. Khan, M. Kitajima, and A. Fujishita et al. Toll-like receptor system and endometriosis J Obstet Gynaecol Res 39 2013 1281
12. M. Contreras, B. Ansari, and G. Curley et al. Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB- dependent mechanism Crit Care Med 40 2012 2622
13. S.R. Chorney, M.E. Gooch, and M.T. Oberdier et al. The safety and efficacy of dexmedetomidine for postoperative sedation in the cardiac surgery intensive care unit HSR Proc Intensive Care Cardiovasc Anesth 5 2013 17
14. Y. Terao, T. Ichinomiya, and U. Higashijima et al. Comparison between propofol and dexmedetomidine in postoperative sedation after extensive cervical spine surgery J Anesth 26 2012 179
15. T. Kunisawa, M. Ueno, and A. Kurosawa et al. Dexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass J Anesth 25 2011 818
16. Y. Wu, Y. Liu, and H. Huang et al. Dexmedetomidine inhibits inflammatory reaction in lung tissues of septic rats by suppressing TLR4/NF-κB pathway Mediators Inflamm 2013 2013 562154
17. Y. Si, H. Bao, and L. Han et al. Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation J Transl Med 11 2013 141
18. J. Gu, J. Chen, and P. Xia et al. Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice Acta Anaesthesiol Scand 55 2011 1272
19. M.A. Hegeman, S.N. Hemmes, and M.T. Kuipers et al. The extent of ventilator-induced lung injury in mice partly depends on duration of mechanical ventilation Crit Care Res Pract 2013 2013 435236
20. J. Villar, N.E. Cabrera, and M. Casula et al. Mechanical ventilation modulates TLR4 and IRAK-3 in a non-infectious, ventilator-induced lung injury model Respir Res 11 2010 27