Protective effects of dexmedetomidine-ketamine combination against ventilator-induced lung injury in endotoxemia rats

Journal of Surgical Research

Volumn 167, Issue 2, 2011, Pages

  Yang, Chih Lin ^a   Chen, Cay Huyen ^c,d   Tsai, Pei Shan ^b   Wang, Tao Yeuan ^a   Huang, Chun Jen ^c,d  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^d TZU CHI UNIVERSITY   (Taiwan)

Author keywords

chemokine; cyclooxygenase 2; cytokine; high tidal volume ventilation; inducible nitric oxide synthase

Indexed keywords

CYCLOOXYGENASE 2; DEXMEDETOMIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; KETAMINE; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; NITRIC OXIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL GAS; ARTICLE; CELL COUNT; CELL INFILTRATION; ENDOTOXEMIA; ENZYME ACTIVITY; HISTOPATHOLOGY; LEUKOCYTE; LOADING DRUG DOSE; LUNG FLUID; LUNG HEMODYNAMICS; LUNG LAVAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; VENTILATOR INDUCED LUNG INJURY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DEXMEDETOMIDINE; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; ENDOTOXEMIA; HYPNOTICS AND SEDATIVES; KETAMINE; LEUKOCYTES; LIPOPOLYSACCHARIDES; LUNG; LUNG INJURY; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; VENTILATORS, MECHANICAL;

EID: 79954591061     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.02.020     Document Type: Article

References (30)

1. P. Delong, J.A. Murray, and C.K. Cook Mechanical ventilation in the management of acute respiratory distress syndrome Semin Dial 19 2006 517
2. J.D. Ricard, D. Dreyfuss, and G. Saumon Ventilator-induced lung injury Eur Respir J Suppl 42 2003 2s
3. J.A. Frank, P.E. Parsons, and M.A. Matthay Pathogenetic significance of biological markers of ventilator-associated lung injury in experimental and clinical studies Chest 130 2006 1906
4. H. Imanaka, M. Shimaoka, and N. Matsuura Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-β1 mRNA up-regulation in rat lungs Anesth Analg 92 2001 428
5. E.A. Kirchner, G. Mols, and G. Hermle Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs Br J Anaesth 94 2005 530
6. D.B. Coursin, D.B. Coursin, and G.A. Maccioli Dexmedetomidine Curr Opin Crit Care 7 2001 221
7. M.G. Annetta, D. Iemma, and C. Garisto Ketamine: New indications for an old drug Curr Drug Targets 6 2005 789
8. Z. Tosun, A. Akin, and G. Guler Dexmedetomidine-ketamine and propofol-ketamine combinations for anesthesia in spontaneously breathing pediatric patients undergoing cardiac catheterization J Cardiothorac Vasc Anesth 20 2006 515
9. T. Taniguchi, Y. Kidani, and H. Kanakura Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats Crit Care Med 32 2004 1322
10. J.W. Suliburk, K.S. Helmer, and E.A. Gonzalez Ketamine attenuates liver injury attributed to endotoxemia: Role of cyclooxygenase-2 Surgery 138 2005 34
11. C.H. Yang, P.S. Tsai, and T.Y. Wang Dexmedetomidine-ketamine combination mitigates acute lung injury in hemorrhagic shock rats Resuscitation 80 2009 1204
12. B. Walder, E. Fontao, and M. Totsch Time and tidal volume-dependent ventilator-induced lung injury in healthy rats Eur J Anaesthesiol 22 2005 785
13. T.Y. Huang, P.S. Tsai, and T.Y. Wang Hyperbaric oxygen attenuation of lipopolysaccharide-induced acute lung injury involves heme oxygenase-1 Acta Anaesthesiol Scand 49 2005 1293
14. C. Szabo Alterations in nitric oxide production in various forms of circulatory shock New Horiz 3 1995 2
15. Z. Yan, P.P. Stapleton, and T.A. Freeman Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-κB mechanisms Cell Immunol 232 2004 116
16. T.S. Blackwell, and J.W. Christman The role of nuclear factor-κB in cytokine gene regulation Am J Respir Cell Mol Biol 17 1997 3
17. C. Chen, Y.H. Chen, and W.W. Lin Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages Immunology 97 1999 124
18. R.D. Ramnath, J. Sun, and S. Adhikari Effect of mitogen-activated protein kinases on chemokine synthesis induced by substance P in mouse pancreatic acinar cells J Cell Mol Med 11 2007 1326
19. Q.M. Ning, and X.R. Wang Activations of mitogen-activated protein kinase and nuclear factor-κB by mechanical stretch result in ventilation-induced lung injury Med Hypotheses 68 2007 356
20. J. Sun, F. Li, and J. Chen Effect of ketamine on NF-κB activity and TNF-α production in endotoxin-treated rats Ann Clin Lab Sci 34 2004 181
21. Y. Chang, J.J. Lee, and C.Y. Hsieh Inhibitory effects of ketamine on lipopolysaccharide-induced microglial activation Mediators Inflamm 2009 2009 705379
22. N.R. MacIntyre Ventilator-associated pneumonia: The role of ventilator management strategies Respir Care 50 2005 766
23. P.E. Parsons, M.D. Eisner, and B.T. Thompson Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury Crit Care Med 33 2005 1
24. N. Petrucci, and W. Iacovelli Lung protective ventilation strategy for the acute respiratory distress syndrome Cochrane Database Syst Rev 2007 CD003844
25. T.J. Ebert, J.E. Hall, and J.A. Barney The effects of increasing plasma concentrations of dexmedetomidine in humans Anesthesiology 93 2000 382
26. Y.C. Lai, P.S. Tsai, and C.J. Huang Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages J Surg Res 154 2009 212
27. M. Yu, D. Shao, and R. Yang Effects of ketamine on pulmonary inflammatory responses and survival in rats exposed to polymicrobial sepsis J Pharm Pharm Sci 10 2007 434
28. F.L. Yang, C.H. Li, and B.G. Hsu The reduction of tumor necrosis factor-alpha release and tissue damage by pentobarbital in the experimental endotoxemia model Shock 28 2007 309
29. H.M. Shaprio, S.R. Wyte, and A.B. Harris Ketamine anaesthesia in patients with intracranial pathology Br J Anaesth 44 1972 1200
30. A. Bourgoin, J. Albanese, and N. Wereszczynski Safety of sedation with ketamine in severe head injury patients: Comparison with sufentanil Crit Care Med 31 2003 711