Proteases and small intestinal barrier function in health and disease

Current Opinion in Gastroenterology

Volumn 30, Issue 2, 2014, Pages 147-153

  Giuffrida, Paolo ^a   Biancheri, Paolo ^a   MacDonald, Thomas T ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Epithelial cell; Inflammatory bowel disease; Protease

Indexed keywords

EPITHELIAL CELLS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MAST CELLS; PEPTIDE HYDROLASES;

EID: 84894061920     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000042     Document Type: Review

References (45)

1. Rescigno M. The intestinal epithelial barrier in the control of homeostasis and immunity. Trends Immunol 2011; 32:256-264
2. Turner JR. Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 2009; 9:799-809
3. Bevins CL, Salzman NH. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 2011; 9:356-368
4. MacDonald TT, Monteleone I, Fantini MC, Monteleone G. Regulation of homeostasis and inflammation in the intestine. Gastroenterology 2011; 140:1768-1775
5. Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT. Proteases and the gut barrier. Cell Tissue Res 2013; 351:269-280
6. Huxley-Jones J, Clarke TK, Beck C, et al. The evolution of the vertebrate metzincins; insights from Ciona intestinalis and Danio rerio. BMC Evol Biol 2007; 7:63
7. Pender SL, MacDonald TT. Matrix metalloproteinases and the gut: New roles for old enzymes. Curr Opin Pharmacol 2004; 4:546-550
8. Edwards DR, Handsley MM, Pennington CJ. The ADAM metalloproteinases. Mol Aspects Med 2008; 29:258-289
9. Scheller J, Chalaris A, Garbers C, Rose-John S. ADAM17: A molecular switch to control inflammation and tissue regeneration. Trends Immunol 2011; 32:380-387
10. MacDonald TT, Pender SL. Mechanisms of tissue injury. In: Sartor RB, Sandborn WJ, editors. Kirsner's inflammatory bowel disease. London: Saunders; 2004. pp. 163-178
11. Villadangos JA, Bryant RA, Deussing J, et al. Proteases involved in MHC class II antigen presentation. Immunol Rev 1999; 172:109-120
12. Menzel K, Hausmann M, Obermeier F, et al. Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo. Clin Exp Immunol 2006; 146:169-180
13. Ravi A, Garg P, Sitaraman SV. Matrix metalloproteinases in inflammatory bowel disease: Boon or a bane? Inflamm Bowel Dis 2007; 13:97-107
14. Baumgart DC, Sandborn WJ. Crohn's disease. Lancet 2012; 380:1590-1605
15. Ordás I, Eckmann L, Talamini M, et al. Ulcerative colitis. Lancet 2012; 380:1606-1619
16. Monteleone G, Neurath MF, MacDonald TT. Inflammatory bowel disease. In: Smith PD, MacDonald TT, Blumberg RS, editors. Principles of mucosal immunology. London and New York: Garland Science, Taylor & Francis Group; 2012. pp. 473-487
17. Buzza MS, Martin EW, Driesbaugh KH, et al. Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway. J Biol Chem 2013; 288:10328-10337
18. Buzza MS, Netzel-Arnett S, Shea-Donohue T, et al. Membrane-Anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A 2010; 107:4200-4205
19. Liu H, Patel NR, Walter L, et al. Constitutive expression of MMP9 in intestinal epithelium worsens murine acute colitis and is associated with increased levels of proinflammatory cytokine Kc. Am J Physiol Gastrointest Liver Physiol 2013; 304:G793-G803
20. Sina C, Lipinski S, Gavrilova O, et al. Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut 2013; 62:520-530
21. Motta JP, Magne L, Descamps D, et al. Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis. Gastroenterology 2011; 140:1272-1282
22. Groschwitz KR, Wu D, Osterfeld H, et al. Chymase-mediated intestinal epithelial permeability is regulated by a protease-Activating receptor/matrix metalloproteinase-2-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 2013; 304:G479-G489
23. Wilcz-Villega EM, McClean S, O'Sullivan MA. Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: Implications for the mechanisms of barrier dysfunction in irritable bowel syndrome. Am J Gastroenterol 2013; 108:1140-1151
24. List K, Kosa P, Szabo R, et al. Epithelial integrity is maintained by a matriptasedependent proteolytic pathway. Am J Pathol 2009; 175:1453-1463
25. Prasad S, Mingrino R, Kaukinen K, et al. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 2005; 85:1139-1162
26. Netzel-Arnett S, Buzza MS, Shea-Donohue T, et al. Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis 2012; 18:1303-1314
27. Franzè E, Caruso R, Stolfi C, et al. High expression of the 'A Disintegrin And Metalloprotease' 19 (ADAM19), a sheddase for TNF-A in the mucosa of patients with inflammatory bowel diseases. Inflamm Bowel Dis 2013; 19:501-511
28. Blaydon DC, Biancheri P, Di WL, et al. Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med 2011; 365:1502-1508
29. Monteleone I, Federici M, Sarra M, et al. Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine. Gastroenterology 2012; 143:1277-1287
30. Vandenbroucke RE, Dejonckheere E, Van Hauwermeiren F, et al. Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med 2013; 5:932-948
31. Zitta K, Meybohm P, Bein B, et al. Serum from patients undergoing remote ischemic preconditioning protects cultured human intestinal cells from hypoxia-induced damage: Involvement of matrixmetalloproteinase-2 and -9. Mol Med 2012; 18:29-37
32. Rodrigues DM, Sousa AJ, Hawley SP, et al. Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis. BMC Microbiol 2012; 12:105
33. Arampatzidou M, Schütte A, Hansson GC, et al. Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol Chem 2012; 393:1391-1403
34. Motta JP, Bermúdez-Humarán LG, Deraison C, et al. Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis. Sci Transl Med 2012; 4:158ra144
35. Uchiyama K, Naito Y, Takagi T, et al. Serpin B1 protects colonic epithelial cell via blockage of neutrophil elastase activity and its expression is enhanced in patients with ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 2012; 302:G1163-G1170
36. Schmid M, Fellermann K, Fritz P, et al. Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease. J Leukoc Biol 2007; 81:907-915
37. Morohoshi Y, Matsuoka K, Chinen H, et al. Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis. J Gastroenterol 2006; 41:318-324
38. Groschwitz KR, Ahrens R, Osterfeld H, et al. Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism. Proc Natl Acad Sci U S A 2009; 106:22381-22386
39. Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med 2007; 204:3067-3076
40. Wu S, Lim KC, Huang J, et al. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin. Proc Natl Acad Sci U S A 1998; 95:14979-14984
41. Steck N, Hoffmann M, Sava IG, et al. Enterococcus faecalis metalloprotease compromises epithelial barrier and contributes to intestinal inflammation. Gastroenterology 2011; 141:959-971
42. Lidell ME, Moncada DM, Chadee K, Hansson GC. Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-Terminal domain and dissolve the protective colonic mucus gel. Proc Natl Acad Sci U S A 2006; 103:9298-9303
43. Hasnain SZ, McGuckin MA, Grencis RK, Thornton DJ. Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis 2012; 6:e1856
44. Becker C, Watson AJ, Neurath MF. Complex roles of caspases in the pathogenesis of inflammatory bowel disease. Gastroenterology 2013; 144:283-293
45. Günther C, Martini E, Wittkopf N, et al. Caspase-8 regulates TNF-A-induced epithelial necroptosis and terminal ileitis. Nature 2011; 477:335-339