Total synthesis of thiaplakortone A: Derivatives as metabolically stable leads for the treatment of malaria

ACS Medicinal Chemistry Letters

Volumn 5, Issue 2, 2014, Pages 178-182

  Pouwer, Rebecca H ^a   Deydier, Sophie M ^a   Le, Phuc Van ^a   Schwartz, Brett D ^a   Franken, Nicole C ^a   Davis, Rohan A ^a   Coster, Mark J ^a   Charman, Susan A ^b   Edstein, Michael D ^c   Skinner Adams, Tina S ^a   Andrews, Katherine T ^a   Jenkins, Ian D ^a   Quinn, Ronald J ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c AUSTRALIAN ARMY MALARIA INSTITUTE   (Australia)

Author keywords

Malaria; natural products; total synthesis

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; MEFLOQUINE; NATURAL PRODUCT; NITROGEN; THIAPLAKORTONE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIVER MICROSOME; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 84894040918     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400447v     Document Type: Article

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