메뉴 건너뛰기




Volumn 97, Issue 1, 2014, Pages 64-71

"Herbal incense": Designer drug blends as cannabimimetics and their assessment by drug discrimination and other in vivo bioassays

Author keywords

Bioassays; Drug discrimination; Synthetic marijuana; THC

Indexed keywords

BIOASSAYS; DRUG DISCRIMINATION; SYNTHETIC MARIJUANA; THC;

EID: 84894038511     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.07.011     Document Type: Review
Times cited : (19)

References (90)
  • 1
    • 0031935011 scopus 로고    scopus 로고
    • Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain
    • I.B. Adams, D.R. Compton, and B.R. Martin Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain J Pharmacol Exp Ther 284 1998 1209 1217 (Pubitemid 28130853)
    • (1998) Journal of Pharmacology and Experimental Therapeutics , vol.284 , Issue.3 , pp. 1209-1217
    • Adams, I.B.1    Compton, D.R.2    Martin, B.R.3
  • 2
    • 84894102172 scopus 로고
    • Symposium on the chemistry and biological activity of cannabis
    • S. Agurell, J.L.G. Nilsson
    • S. Agurell, and J.L.G. Nilsson Symposium on the chemistry and biological activity of cannabis S. Agurell, J.L.G. Nilsson, Acta Pharmaceutica Suecica 1971 671 706
    • (1971) Acta Pharmaceutica Suecica , pp. 671-706
    • Agurell, S.1    Nilsson, J.L.G.2
  • 3
    • 0022921460 scopus 로고
    • 1- tetrahydrocannabinol and other cannabinoids with emphasis on man
    • S. Agurell, M. Halldin, J.E. Lindgren, A. Ohlsson, M. Widman, and H. Gillespie et al. Pharmacokinetics and metabolism of delta-1-tetrahydrocannabinol and other cannabinoids with emphasis on man Pharmacol Rev 38 1986 21 43 (Pubitemid 16077324)
    • (1986) Pharmacological Reviews , vol.38 , Issue.1 , pp. 21-43
    • Agurell, S.1    Halldin, M.2    Lindgren, J.-E.3
  • 4
    • 0026516004 scopus 로고
    • 9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication
    • 9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication Neurosci Biobehav Rev 16 1992 55 62
    • (1992) Neurosci Biobehav Rev , vol.16 , pp. 55-62
    • Balster, R.L.1    Prescott, W.R.2
  • 5
    • 79960003774 scopus 로고    scopus 로고
    • Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity
    • L.K. Brents, E.E. Reichard, S.M. Zimmerman, J.H. Moran, W.E. Fantegrossi, and P.L. Prather Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity PLoS One 6 2011 e21917
    • (2011) PLoS One , vol.6 , pp. 21917
    • Brents, L.K.1    Reichard, E.E.2    Zimmerman, S.M.3    Moran, J.H.4    Fantegrossi, W.E.5    Prather, P.L.6
  • 6
    • 84857372061 scopus 로고    scopus 로고
    • Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
    • L.K. Brents, A. Gallus-Zawada, A. Radominska-Pandya, T. Vasiljevik, T.E. Prisinzano, and W.E. Fantegrossi et al. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity Biochem Pharmacol 83 2012 952 961
    • (2012) Biochem Pharmacol , vol.83 , pp. 952-961
    • Brents, L.K.1    Gallus-Zawada, A.2    Radominska-Pandya, A.3    Vasiljevik, T.4    Prisinzano, T.E.5    Fantegrossi, W.E.6
  • 8
    • 80051712075 scopus 로고    scopus 로고
    • Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine
    • K.C. Chimalakonda, C.L. Moran, P.D. Kennedy, G.W. Endres, A. Uzieblo, and P.J. Dobrowolski et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine Anal Chem 83 2011 6381 6388
    • (2011) Anal Chem , vol.83 , pp. 6381-6388
    • Chimalakonda, K.C.1    Moran, C.L.2    Kennedy, P.D.3    Endres, G.W.4    Uzieblo, A.5    Dobrowolski, P.J.6
  • 9
    • 0037393956 scopus 로고    scopus 로고
    • Discovering risperidone: The LSD model of psychopathology
    • F.C. Colpaert Discovering risperidone: the LSD model of psychopathology Nat Rev Drug Discov 2 2003 315 320 (Pubitemid 37361689)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.4 , pp. 315-320
    • Colpaert, F.C.1
  • 12
    • 0020326178 scopus 로고
    • Use of a potential rabbit model for structure-behavioral activity studies of cannabinoids
    • DOI 10.1021/jm00347a021
    • P. Consroe, A.R. Martin, and B.S. Fish Use of a potential rabbit model for structure-behavioral activity studies of cannabinoids J Med Chem 25 1982 596 599 (Pubitemid 12051988)
    • (1982) Journal of Medicinal Chemistry , vol.25 , Issue.5 , pp. 596-599
    • Consroe, P.1    Martin, A.R.2    Schneiderman Fish, B.3
  • 13
    • 0037146921 scopus 로고    scopus 로고
    • Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist
    • DOI 10.1016/S0014-2999(02)02697-3, PII S0014299902026973
    • J. De Vry, and K.R. Jentzsch Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist Eur J Pharmacol 457 2002 147 152 (Pubitemid 35447656)
    • (2002) European Journal of Pharmacology , vol.457 , Issue.2-3 , pp. 147-152
    • De Vry, J.1    Jentzsch, K.R.2
  • 14
    • 8844248621 scopus 로고    scopus 로고
    • 2 receptor partial agonist BAY 59-3074 in the rat
    • DOI 10.1016/j.ejphar.2004.10.012, PII S001429990401163X
    • 2 receptor partial agonist BAY 59-3074 in the rat Eur J Pharmacol 505 2004 127 133 (Pubitemid 39535684)
    • (2004) European Journal of Pharmacology , vol.505 , Issue.1-3 , pp. 127-133
    • De Vry, J.1    Jentzsch, K.R.2
  • 19
    • 84894046542 scopus 로고
    • The physiological action of the alkaloids derived from Anhalonium Lewinii
    • W.E. Dixon The physiological action of the alkaloids derived from Anhalonium Lewinii J Physiol 25 1899 69 86
    • (1899) J Physiol , vol.25 , pp. 69-86
    • Dixon, W.E.1
  • 20
    • 84894075863 scopus 로고
    • Pharmacological approaches to the study of the cannabis problem
    • J.R. do Valle Pharmacological approaches to the study of the cannabis problem Int J Addict 4 1969 623 647
    • (1969) Int J Addict , vol.4 , pp. 623-647
    • Do Valle, J.R.1
  • 22
    • 84855507862 scopus 로고    scopus 로고
    • Beyond THC: The new generation of cannabinoid designer drugs
    • L. Fattore, and W. Fratta Beyond THC: the new generation of cannabinoid designer drugs Front Behav Neurosci 5 60 2011 1 12
    • (2011) Front Behav Neurosci , vol.5 , Issue.60 , pp. 1-12
    • Fattore, L.1    Fratta, W.2
  • 23
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Y. Gaoni, and R. Mechoulam Isolation, structure and partial synthesis of an active constituent of hashish J Am Chem Soc 86 1964 1646
    • (1964) J Am Chem Soc , vol.86 , pp. 1646
    • Gaoni, Y.1    Mechoulam, R.2
  • 25
    • 34250954491 scopus 로고
    • Pharmakologische wertbestimmung von orientalischem haschish und herba cannabis indicae
    • H. Gayer Pharmakologische wertbestimmung von orientalischem haschish und herba cannabis indicae Arch exp Path Pharmak 129 1928 312 318
    • (1928) Arch Exp Path Pharmak , vol.129 , pp. 312-318
    • Gayer, H.1
  • 26
    • 84055219353 scopus 로고    scopus 로고
    • JWH-018 and JWH-073: Delta(9)-tetrahydrocannabinol-like discriminative stimulus effects in monkeys
    • B.C. Ginsburg, D.R. Schulze, L. Hruba, and L.R. McMahon JWH-018 and JWH-073: delta(9)-tetrahydrocannabinol-like discriminative stimulus effects in monkeys J Pharmacol Exp Ther 340 2012 37 45
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 37-45
    • Ginsburg, B.C.1    Schulze, D.R.2    Hruba, L.3    McMahon, L.R.4
  • 28
    • 84862768861 scopus 로고    scopus 로고
    • "Spice" and "k2" herbal highs: A case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans
    • E.W. Gunderson, H.M. Haughey, N. Ait-Daoud, A.S. Joshi, and C.L. Hart "Spice" and "K2" herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans Am J Addict 21 2012 320 326
    • (2012) Am J Addict , vol.21 , pp. 320-326
    • Gunderson, E.W.1    Haughey, H.M.2    Ait-Daoud, N.3    Joshi, A.S.4    Hart, C.L.5
  • 29
    • 28044470532 scopus 로고    scopus 로고
    • The marijuana withdrawal syndrome: Diagnosis and treatment
    • M. Haney The marijuana withdrawal syndrome: diagnosis and treatment Curr Psychiatry Rep 7 2005 360 366 (Pubitemid 41684183)
    • (2005) Current Psychiatry Reports , vol.7 , Issue.5 , pp. 360-366
    • Haney, M.1
  • 32
    • 62249219871 scopus 로고    scopus 로고
    • Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids
    • L.O. Hanus Pharmacological and therapeutic secrets of plant and brain (endo)cannabinoids Med Res Rev 29 2009 213 271
    • (2009) Med Res Rev , vol.29 , pp. 213-271
    • Hanus, L.O.1
  • 33
    • 84886051469 scopus 로고    scopus 로고
    • Perceptual drug discriminative aspects of the endocannabinoid signaling system in animals and man
    • R.A. Glennon, R. Young, John Wiley & Sons Hoboken, N.J.
    • T.U.C. Järbe Perceptual drug discriminative aspects of the endocannabinoid signaling system in animals and man R.A. Glennon, R. Young, Drug discrimination: applications to medicinal chemistry and drug studies 2011 John Wiley & Sons Hoboken, N.J. 241 285
    • (2011) Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies , pp. 241-285
    • Järbe, T.U.C.1
  • 34
    • 0016226715 scopus 로고
    • Discriminative response control produced with hashish, tetrahydrocannabinols (delta-8-THC and delta-9-THC), and other drugs
    • T.U.C. Järbe, and B.G. Henriksson Discriminative response control produced with hashish, tetrahydrocannabinols (delta-8-THC and delta-9-THC), and other drugs Psychopharmacologia 40 1974 1 16
    • (1974) Psychopharmacologia , vol.40 , pp. 1-16
    • Järbe, T.U.C.1    Henriksson, B.G.2
  • 35
    • 0017129444 scopus 로고
    • Characteristics of tetrahydrocannabinol (THC)-produced discrimination in rats
    • T.U.C. Järbe, J.O. Johansson, and B.G. Henriksson Characteristics of tetrahydrocannabinol (THC)-produced discrimination in rats Psychopharmacology (Berl) 48 1976 181 187
    • (1976) Psychopharmacology (Berl) , vol.48 , pp. 181-187
    • Järbe, T.U.C.1    Johansson, J.O.2    Henriksson, B.G.3
  • 37
    • 0022473089 scopus 로고
    • 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons
    • DOI 10.1016/0091-3057(86)90015-8
    • T.U.C. Järbe, A.J. Hiltunen, N. Lander, and R. Mechoulam Cannabimimetic activity (delta-1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons Pharmacol Biochem Behav 25 1986 393 399 (Pubitemid 16045863)
    • (1986) Pharmacology Biochemistry and Behavior , vol.25 , Issue.2 , pp. 393-399
    • Jarbe, T.U.C.1    Hiltunen, A.J.2    Lander, N.3    Mechoulam, R.4
  • 39
    • 12144250603 scopus 로고    scopus 로고
    • 1 receptor antagonist
    • DOI 10.1007/s00213-004-1916-5
    • T.U.C. Järbe, M.Y. Harris, C. Li, Q. Liu, and A. Makriyannis Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist Psychopharmacology (Berl) 177 2004 35 45 (Pubitemid 40109912)
    • (2004) Psychopharmacology , vol.177 , Issue.1-2 , pp. 35-45
    • Jarbe, T.U.C.1    Harris, M.Y.2    Li, C.3    Liu, Q.4    Makriyannis, A.5
  • 40
    • 44549088560 scopus 로고    scopus 로고
    • Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats
    • T.U.C. Järbe, C. Li, S.K. Vadivel, and A. Makriyannis Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats Psychopharmacology (Berl) 198 2008 467 478
    • (2008) Psychopharmacology (Berl) , vol.198 , pp. 467-478
    • Järbe, T.U.C.1    Li, C.2    Vadivel, S.K.3    Makriyannis, A.4
  • 43
    • 79961172900 scopus 로고    scopus 로고
    • Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB(1) receptor antagonist rimonabant in rats
    • T.U.C. Järbe, B.J. Lemay, V.K. Vemuri, S.K. Vadivel, A. Zvonok, and A. Makriyannis Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB(1) receptor antagonist rimonabant in rats Psychopharmacology (Berl) 216 2011 355 365
    • (2011) Psychopharmacology (Berl) , vol.216 , pp. 355-365
    • Järbe, T.U.C.1    Lemay, B.J.2    Vemuri, V.K.3    Vadivel, S.K.4    Zvonok, A.5    Makriyannis, A.6
  • 44
    • 84858450136 scopus 로고    scopus 로고
    • AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice
    • T.U.C. Järbe, S. Tai, B.J. Lemay, S.P. Nikas, V.G. Shukla, and A. Zvonok et al. AM2389, a high-affinity, in vivo potent CB(1)-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice Psychopharmacology (Berl) 220 2012 417 426
    • (2012) Psychopharmacology (Berl) , vol.220 , pp. 417-426
    • Järbe, T.U.C.1    Tai, S.2    Lemay, B.J.3    Nikas, S.P.4    Shukla, V.G.5    Zvonok, A.6
  • 48
    • 0001090531 scopus 로고
    • Studies on the pharmacology and acute toxicity of compounds with marihuana activity
    • S. Loewe Studies on the pharmacology and acute toxicity of compounds with marihuana activity J Pharmacol Exp Ther 88 1946 154 161
    • (1946) J Pharmacol Exp Ther , vol.88 , pp. 154-161
    • Loewe, S.1
  • 49
    • 0029933318 scopus 로고    scopus 로고
    • Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats
    • R.S. Mansbach, C.C. Rovetti, E.N. Winston, and J.A. Lowe 3rd. Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats Psychopharmacology (Berl) 124 1996 315 322 (Pubitemid 26149916)
    • (1996) Psychopharmacology , vol.124 , Issue.4 , pp. 315-322
    • Mansbach, R.S.1    Rovetti, C.C.2    Winston, E.N.3    Lowe III, J.A.4
  • 50
    • 0017316407 scopus 로고
    • Cannabinoid induced behavioral convulsions in rabbits
    • P. Martin, and P. Consroe Cannabinoid induced behavioral convulsions in rabbits Science 194 1976 965 967
    • (1976) Science , vol.194 , pp. 965-967
    • Martin, P.1    Consroe, P.2
  • 52
    • 0024589729 scopus 로고
    • Conditioned taste aversions as a behavioral baseline for drug discrimination learning: An assessment with phencyclidine
    • DOI 10.1016/0091-3057(89)90203-7
    • J.P. Mastropaolo, K.H. Moskowitz, R.J. Dacanay, and A.L. Riley Conditioned taste aversions as a behavioral baseline for drug discrimination learning: an assessment with phencyclidine Pharmacol Biochem Behav 32 1989 1 8 (Pubitemid 19125908)
    • (1989) Pharmacology Biochemistry and Behavior , vol.32 , Issue.1 , pp. 1-8
    • Mastropaolo, J.P.1    Moskowitz, K.H.2    Dacanay, R.J.3    Riley, A.L.4
  • 54
    • 33748663275 scopus 로고    scopus 로고
    • 9- tetrahydrocannabinol
    • DOI 10.1007/s00213-006-0500-6
    • 9- tetrahydrocannabinol Psychopharmacology (Berl) 188 2006 306 314 (Pubitemid 44387458)
    • (2006) Psychopharmacology , vol.188 , Issue.3 , pp. 306-314
    • McMahon, L.R.1
  • 55
    • 0009116694 scopus 로고
    • Structure-activity relationships in the cannabinoid series
    • R. Mechoulam, Academic Press New York
    • R. Mechoulam, and H. Edery Structure-activity relationships in the cannabinoid series R. Mechoulam, Marijuana 1973 Academic Press New York 101 136
    • (1973) Marijuana , pp. 101-136
    • Mechoulam, R.1    Edery, H.2
  • 56
    • 0014189130 scopus 로고
    • Recent advances in the chemistry of hashish
    • R. Mechoulam, and Y. Gaoni Recent advances in the chemistry of hashish Fortschr Chem Org Naturst 25 1967 175 213
    • (1967) Fortschr Chem Org Naturst , vol.25 , pp. 175-213
    • Mechoulam, R.1    Gaoni, Y.2
  • 57
    • 0014208456 scopus 로고
    • A stereospecific synthesis of (-)-delta-1- and (-)-delta-1(6)- tetrahydrocannabinols
    • R. Mechoulam, P. Braun, and Y. Gaoni A stereospecific synthesis of (-)-delta-1- and (-)-delta-1(6)-tetrahydrocannabinols J Am Chem Soc 89 1967 4552 4554
    • (1967) J Am Chem Soc , vol.89 , pp. 4552-4554
    • Mechoulam, R.1    Braun, P.2    Gaoni, Y.3
  • 58
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • R. Mechoulam, S. Ben-Shabat, L. Hanus, M. Ligumsky, N.E. Kaminski, and A.R. Schatz et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Biochem Pharmacol 50 1995 83 90
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 60
    • 79957951018 scopus 로고    scopus 로고
    • Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine
    • C.L. Moran, V.H. Le, K.C. Chimalakonda, A.L. Smedley, F.D. Lackey, and S.N. Owen et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine Anal Chem 83 2011 4228 4236
    • (2011) Anal Chem , vol.83 , pp. 4228-4236
    • Moran, C.L.1    Le, V.H.2    Chimalakonda, K.C.3    Smedley, A.L.4    Lackey, F.D.5    Owen, S.N.6
  • 61
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • DOI 10.1038/365061a0
    • S. Munro, K.L. Thomas, and M. Abu-Shaar Molecular characterization of a peripheral receptor for cannabinoids Nature 365 1993 61 65 (Pubitemid 23305569)
    • (1993) Nature , vol.365 , Issue.6441 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 63
    • 77957906973 scopus 로고    scopus 로고
    • Novel 1′,1′-chain substituted hexahydrocannabinols: 9beta-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist
    • S.P. Nikas, S.O. Alapafuja, I. Papanastasiou, C.A. Paronis, V.G. Shukla, and D.P. Papahatjis et al. Novel 1′,1′-chain substituted hexahydrocannabinols: 9beta-hydroxy-3-(1-hexyl-cyclobut-1-yl)- hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist J Med Chem 53 2010 6996 7010
    • (2010) J Med Chem , vol.53 , pp. 6996-7010
    • Nikas, S.P.1    Alapafuja, S.O.2    Papanastasiou, I.3    Paronis, C.A.4    Shukla, V.G.5    Papahatjis, D.P.6
  • 64
    • 0037337169 scopus 로고    scopus 로고
    • Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea
    • L.A. Parker, R. Mechoulam, C. Schlievert, L. Abbott, M.L. Fudge, and P. Burton Effects of cannabinoids on lithium-induced conditioned rejection reactions in a rat model of nausea Psychopharmacology (Berl) 166 2003 156 162 (Pubitemid 36313122)
    • (2003) Psychopharmacology , vol.166 , Issue.2 , pp. 156-162
    • Parker, L.A.1    Mechoulam, R.2    Schlievert, C.3    Abbott, L.4    Fudge, M.L.5    Burton, P.6
  • 66
  • 68
    • 0015445325 scopus 로고
    • The ring test: A quantitative method for assessing the 'cataleptic' effect of cannabis in mice
    • R.G. Pertwee The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice Br J Pharmacol 46 1972 753 763
    • (1972) Br J Pharmacol , vol.46 , pp. 753-763
    • Pertwee, R.G.1
  • 69
    • 30444457225 scopus 로고    scopus 로고
    • Cannabinoid pharmacology: The first 66 years
    • DOI 10.1038/sj.bjp.0706406, PII 0706406
    • R.G. Pertwee Cannabinoid pharmacology: the first 66 years Br J Pharmacol 147 Suppl. 1 2006 S163 S171 (Pubitemid 43077274)
    • (2006) British Journal of Pharmacology , vol.147 , Issue.SUPPL. 1
    • Pertwee, R.G.1
  • 70
    • 0015070245 scopus 로고
    • Chemistry of synthetic cannabis derivatives
    • T. Petrzilka Chemistry of synthetic cannabis derivatives Bull Schweiz Akad Med Wiss 27 1971 22 30
    • (1971) Bull Schweiz Akad Med Wiss , vol.27 , pp. 22-30
    • Petrzilka, T.1
  • 71
    • 0014198698 scopus 로고
    • Synthesis of (-)-delta6,1-3,4-trans-tetrahydrocannabinol, as well as (+)-delta 6,1-3,4-trans-tetrahydrocannabinol
    • T. Petrzilka, and C. Sikemeier Synthesis of (-)-delta6,1-3,4-trans- tetrahydrocannabinol, as well as (+)-delta 6,1-3,4-trans-tetrahydrocannabinol Helv Chim Acta 50 1967 1416 1419
    • (1967) Helv Chim Acta , vol.50 , pp. 1416-1419
    • Petrzilka, T.1    Sikemeier, C.2
  • 72
    • 0022885592 scopus 로고
    • Structure-activity relationships in cannabinoids
    • R.K. Razdan Structure-activity relationships in cannabinoids Pharmacol Rev 38 1986 75 149 (Pubitemid 16001328)
    • (1986) Pharmacological Reviews , vol.38 , Issue.2 , pp. 75-149
    • Razdan, R.K.1
  • 73
    • 84881548345 scopus 로고    scopus 로고
    • Human drug discrimination: Methodological considerations and application to elucidating the neuropharmacology of amphetamines
    • R.A. Glennon, R. Young, John Wiley & Sons Hoboken, N.J.
    • C.R. Rush, A.R. Vansickel, and W.W. Stoops Human drug discrimination: methodological considerations and application to elucidating the neuropharmacology of amphetamines R.A. Glennon, R. Young, Drug discrimination: applications to medicinal chemistry and drug studies 2011 John Wiley & Sons Hoboken, N.J. 431 461
    • (2011) Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies , pp. 431-461
    • Rush, C.R.1    Vansickel, A.R.2    Stoops, W.W.3
  • 75
    • 79953228493 scopus 로고    scopus 로고
    • Marijuana-based drugs: Innovative therapeutics or designer drugs of abuse?
    • K.A. Seely, P.L. Prather, L.P. James, and J.H. Moran Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? Mol Interv 11 2011 36 51
    • (2011) Mol Interv , vol.11 , pp. 36-51
    • Seely, K.A.1    Prather, P.L.2    James, L.P.3    Moran, J.H.4
  • 79
    • 77954954841 scopus 로고    scopus 로고
    • Spice drugs as a new trend: Mode of action, identification and legislation
    • I. Vardakou, C. Pistos, and C. Spiliopoulou Spice drugs as a new trend: mode of action, identification and legislation Toxicol Lett 197 2010 157 162
    • (2010) Toxicol Lett , vol.197 , pp. 157-162
    • Vardakou, I.1    Pistos, C.2    Spiliopoulou, C.3
  • 80
    • 84879064644 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse
    • T. Vasiljevik, L.N. Franks, B.M. Ford, J.T. Douglas, P.L. Prather, and W.E. Fantegrossi et al. Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse J Med Chem 56 2013 4537 4550
    • (2013) J Med Chem , vol.56 , pp. 4537-4550
    • Vasiljevik, T.1    Franks, L.N.2    Ford, B.M.3    Douglas, J.T.4    Prather, P.L.5    Fantegrossi, W.E.6
  • 81
    • 84876280355 scopus 로고    scopus 로고
    • Novel 3-substituted rimonabant analogues lack Delta(9)- tetrahydrocannabinol-like abuse-related behavioural effects in mice
    • D. Walentiny, R. Vann, A. Mahadevan, R. Kottani, R. Gujjar, and J. Wiley Novel 3-substituted rimonabant analogues lack Delta(9)-tetrahydrocannabinol-like abuse-related behavioural effects in mice Br J Pharmacol 169 2013 10 20
    • (2013) Br J Pharmacol , vol.169 , pp. 10-20
    • Walentiny, D.1    Vann, R.2    Mahadevan, A.3    Kottani, R.4    Gujjar, R.5    Wiley, J.6
  • 82
    • 10544248503 scopus 로고
    • Generalization of the discriminative stimulus properties of delta-9-tetrahydrocannabinol to cannabinoids with therapeutic potential
    • F.C. Colpaert, J.A. Rosecrans, Elsevier/North Holland Biomed. Press Amsterdam
    • A. Weissman Generalization of the discriminative stimulus properties of delta-9-tetrahydrocannabinol to cannabinoids with therapeutic potential F.C. Colpaert, J.A. Rosecrans, Stimulus properties of drugs: ten years of progress 1978 Elsevier/North Holland Biomed. Press Amsterdam 99 122
    • (1978) Stimulus Properties of Drugs: Ten Years of Progress , pp. 99-122
    • Weissman, A.1
  • 84
    • 84869211772 scopus 로고    scopus 로고
    • Inhalation exposure to smoke from synthetic "marijuana" produces potent cannabimimetic effects in mice
    • J.M. Wiebelhaus, J.L. Poklis, A. Poklis, R.E. Vann, A.H. Lichtman, and L.E. Wise Inhalation exposure to smoke from synthetic "marijuana" produces potent cannabimimetic effects in mice Drug Alcohol Depend 126 2012 316 323
    • (2012) Drug Alcohol Depend , vol.126 , pp. 316-323
    • Wiebelhaus, J.M.1    Poklis, J.L.2    Poklis, A.3    Vann, R.E.4    Lichtman, A.H.5    Wise, L.E.6
  • 87
    • 33751342255 scopus 로고    scopus 로고
    • Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice
    • DOI 10.1016/j.lfs.2006.08.017, PII S0024320506006539
    • J.L. Wiley, R.K. Razdan, and B.R. Martin Evaluation of the role of the arachidonic acid cascade in anandamide's in vivo effects in mice Life Sci 80 2006 24 35 (Pubitemid 44809295)
    • (2006) Life Sciences , vol.80 , Issue.1 , pp. 24-35
    • Wiley, J.L.1    Razdan, R.K.2    Martin, B.R.3
  • 88
    • 84944610747 scopus 로고    scopus 로고
    • Hijacking of basic research: The case of synthetic cannabinoids
    • RTI Press 10.3768/rtipress.2011.op.0007.1111
    • J.L. Wiley, J.A. Marusich, J.W. Huffman, R.L. Balster, and B.F. Thomas Hijacking of basic research: the case of synthetic cannabinoids Methods report 2011 RTI Press 10.3768/rtipress.2011.op.0007.1111
    • (2011) Methods Report
    • Wiley, J.L.1    Marusich, J.A.2    Huffman, J.W.3    Balster, R.L.4    Thomas, B.F.5
  • 89
    • 84862955862 scopus 로고    scopus 로고
    • 3-Substituted pyrazole analogs of the cannabinoid type 1 (CB(1)) receptor antagonist rimonabant: Cannabinoid agonist-like effects in mice via non-CB(1), non-CB(2) mechanism
    • J.L. Wiley, D.E. Selley, P. Wang, R. Kottani, S. Gadthula, and A. Mahadeven 3-Substituted pyrazole analogs of the cannabinoid type 1 (CB(1)) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB(1), non-CB(2) mechanism J Pharmacol Exp Ther 340 2012 433 444
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 433-444
    • Wiley, J.L.1    Selley, D.E.2    Wang, P.3    Kottani, R.4    Gadthula, S.5    Mahadeven, A.6
  • 90
    • 0017129553 scopus 로고
    • 9-Nor-9-hydroxyhexahydrocannabinols. Synthesis, some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols
    • R.S. Wilson, E.L. May, B.R. Martin, and W.L. Dewey 9-Nor-9- hydroxyhexahydrocannabinols. Synthesis, some behavioral and analgesic properties, and comparison with the tetrahydrocannabinols J Med Chem 19 1976 1165 1167
    • (1976) J Med Chem , vol.19 , pp. 1165-1167
    • Wilson, R.S.1    May, E.L.2    Martin, B.R.3    Dewey, W.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.