Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats

Psychopharmacology

Volumn 198, Issue 4, 2008, Pages 467-478

  Järbe, Torbjörn U C ^a,c   Li, Chen ^b   Vadivel, Subramanian K ^b,c   Makriyannis, Alexandros ^b,c  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c NORTHEASTERN UNIVERSITY   (United States)

Author keywords

9 THC; Cannabinoid agonists; Cannabinoid antagonists; Drug discrimination; Methanandamide rats; Rimonabant AM251 AM281 SR144528 AM630

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; DRONABINOL; LITHIUM CHLORIDE; METHANANDAMIDE; RIMONABANT; SACCHARIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DRINKING; DRUG DISCRIMINATION; DRUG EFFECT; LIQUID; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TASTE AVERSION; TRAINING;

ANIMALS; ARACHIDONIC ACIDS; AVOIDANCE LEARNING; BORNANES; DISCRIMINATION (PSYCHOLOGY); DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; HALLUCINOGENS; INDOLES; INJECTIONS, INTRAPERITONEAL; LITHIUM CHLORIDE; MALE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; TASTE; TETRAHYDROCANNABINOL;

EID: 44549088560     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1076-0     Document Type: Article

References (58)

1. Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG, Makriyannis A (1994) (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem 37:1889-1893
2. Balster RL, Prescott WR (1992) Δ9-Tetrahydrocannabinol discrimination in rats as a model for cannabis intoxication. Neurosci Biobehav Rev 16:55-62
3. 1 knockout and wild-type mice. J Pharmacol Exp Ther 309:86-91
4. Colpaert FC, Niemegeers CJ, Janssen PA (1980) Factors regulating drug cue sensitivity: the effect of training dose in fentanyl-saline discrimination. Neuropharmacology 19:705-713
5. 1 receptor ligands in a drug discrimination paradigm. Behav Pharmacol 14:471-476
6. 1 receptors in vivo. J Neurochem 70:417-423
7. Gong JP, Onaivi ES, Ishiguro H, Liu QR, Tagliaferro PA, Brusco A, Uhl GR (2006) Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 1071:10-23
8. Greenberg I, Kuhn DM, Appel JB (1975) Behaviorally induced sensitivity to the discriminable properties of LSD. Psychopharmacologia 43:229-232
9. Hàjos N, Freund TF (2002) Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers. Neuropharmacology 43:503-510
10. 1 receptor-mediated signal transduction. Br J Pharmacol 142:1209-1218
11. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International union of pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
12. Järbe TUC (1989) Discrimination learning with drug stimuli: methods and applications. In: Boulten AA, Baker GB, Greenshaw AJ (eds) Neuromethods, vol 13. Psychopharmacology, Humana Press, Clifton, NJ, pp 513-563
13. Järbe TUC, Lamb RJ (1995) Discriminated conditioned taste aversion for studying multi-elemental stimulus control. Behav Pharmacol 6:149-155
14. Järbe TUC, Lamb RJ (1999) Effects of lithium dose (UCS) on the acquisition and extinction of a discriminated morphine aversion: tests with morphine and Δ9-THC. Behav Pharmacol 10:349-358
15. Järbe TUC, Mathis DA (1992) Dissociative and discriminative stimulus functions of cannabinoids and cannabimimetics. In: Bartke A, Murphy L (eds) Marijuana/cannabinoids: neurobiology and neurophysiology. CRC Press, Boca Raton, FL, pp 425-459
16. Järbe TUC, Swedberg MDB (1998) Discriminative stimulus functions of CNS sedative drugs assessed by drug versus drug discrimination procedures in gerbils. Psychopharmacology (Berl) 135:201-212
17. Järbe TUC, Sheppard R, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A (1998) Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats. Behav Pharmacol 9:169-174
18. Järbe TUC, Lamb RJ, Lin S, Makriyannis A (2001) (R)-methanandamide and Δ9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide. Psychopharmacology (Berl) 156:369-380
19. 1 receptor antagonist SR-141716 in rats: open-field revisited. Pharmacol Biochem Behav 73:911-919
20. Järbe TUC, DiPatrizio NV, Li C, Makriyannis A (2003a) The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats. Pharmacol Biochem Behav 75:809-821
21. Järbe TUC, Lamb RJ, Liu Q, Makriyannis A (2003b) (R)-methanandamide and Δ9-THC induced operant rate decreases in rats are not readily antagonized by SR-141716A. Eur J Pharmacol 466:121-127
22. 1 receptor antagonist. Psychopharmacology (Berl) 177:35-45
23. 1R selective anandamide analog in rats trained with Δ9-THC or (R)-methanandamide (AM-356). Psychopharmacology (Berl) 188:315-323
24. Järbe TUC, Liu Q, Makriyannis A (2006b) Antagonism of discriminative stimulus effects of Δ9-THC and (R)-methanandamide in rats. Psychopharmacology (Berl) 184:36-45
25. Kautz MA, Geter B, McBride SA, Mastropaolo JP, Riley AL (1989) Naloxone as a stimulus for drug discrimination learning. Drug Dev Res 16:317-326
26. Kirk RE (1968) Experimental design: procedures for the behavioral sciences, 2nd edn. Brooks/Cole, Belmont, CA
27. Lamb RJ, Järbe TUC (1997) Multielemental stimulus control: effects of saccharin concentration on a discriminated morphine-saccharin taste aversion. Exp Clin Psychopharmacol 5:123-129
28. Lucki I (1988) Rapid discrimination of the stimulus properties of 5-hydroxytryptamine agonists using conditioned taste aversion. J Pharmacol Exp Ther 247:1120-1127
29. Lan R, Liu Q, Fan P, Lin S, Fernando SR, McCallion D, Pertwee RG, Makriyannis A (1999) Structure-activity relationship of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem 42:776-779
30. McMahon LR (2006a) Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Δ9-tetrahydrocannabinol. J Pharmacol Exp Ther 319:1211-1218
31. 1 antagonist SR 141716A in rhesus monkeys pretreated with Δ9-tetrahydrocannabinol. Psychopharmacology (Berl) 188:306-314
32. McMahon LR, Koek W (2007) Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice. Eur J Pharmacol 569:70-76
33. Mastropaolo J, Riley AL (1990) Drug discrimination studies in animals. In: Deutsch SI, Weizman A, Weizman R (eds) Application of basic neuroscience to child psychiatry. Plenum, New York, pp 125-140
34. 2 cannabinoid receptor-mediated peripheral antinociception. Pain 93:239-245
35. 1 receptor antagonist SR141716A on the behavior of pigeons and rats. Psychopharmacology (Berl) 124:315-322
36. Melton PM, Kopman JA, Riley AL (1993) Cholecystokinin as a stimulus in drug discrimination learning. Pharmacol Biochem Behav 44:249-252
37. National Institutes of Health (1996) Principles of animal laboratory care. National Academy Press, Washington, DC
38. Overton DA (1979) Drug discrimination training with progressively lowered doses. Science 205:720-721
39. Overton DA, Leonard WR, Merkle DA (1986) Methods for measuring the strength of discriminable drug effects. Neurosci Biobehav Rev 10:251-263
40. Oz M (2006) Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids. Pharmacol Ther 111:114-144
41. Pacher P, Batkai S, Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389-462
42. 1 antagonist, SR 141716A. Behav Pharmacol 7:65-71
43. Pertwee R, Griffin G, Fernando S, Li X, Hill A, Makriyannis A (1995) AM630, a competitive cannabinoid antagonist. Life Sci 56:1949-1955
44. Riley AL (1997) Drug discrimination learning: assessment of opioid receptor pharmacology. In: Learning, motivation, and cognition: the functional behaviorism of Robert C. Bolles. American Psychological Association, Washington, DC, pp 225-254
45. Rinaldi-Carmona M, Barth F, Héaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Néliat G, Caput D, Ferrara P, Soubrié P, Breliére JC, LeFur G (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244
46. 2 cannabinoid receptor. J Pharmacol Exp Ther 284:644-650
47. 1 receptor antagonist, in plus-maze-naive and plus-maze-experienced mice. Behav Pharmacol 16:405-413
48. Sidman M (1960) Tactics of scientific research-evaluating experimental data in psychology. Basic Books, New York, NY
49. Solinas M, Panlilio LV, Justinova Z, Yasar S, Goldberg SR (2006) Using drug-discrimination techniques to study the abuse-related effects of psychoactive drugs in rats. Nat Protoc 1:1194-1206
50. Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D, Vadivel SK, Makriyannis A, Goldberg SR (2007) The endogenous cannabinoid anandamide produces Δ9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. J Pharmacol Exp Ther 321:370-380
51. Stevenson GW, Pournaghash S, Riley AL (1992) Antagonism of drug discrimination learning within the conditioned taste aversion procedure. Pharmacol Biochem Behav 41:245-249
52. Swedberg MDB, Järbe TUC (1982) Morphine cue saliency: limits of discriminability and third state perception by pigeons. In: Colpaert FC, Slangen JL (eds) Drug discrimination: applications in CNS pharmacology. Elsevier, Amsterdam, pp 147-164
53. Vann RE, Cook CD, Martin BR, Wiley JL (2007) Cannabimimetic properties of ajulemic acid. J Pharmacol Exp Ther 320:678-686
54. 2 receptors. Science 310:329-332
55. 1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat. Psychopharmacology (Berl) 179:498-508
56. Wiley JL (1999) Cannabis: discrimination of "internal bliss"? Pharmacol Biochem Behav 64:257-260
57. Wiley JL, Lowe JA, Balster RL, Martin BR (1995) Antagonism of the discriminative stimulus effects of Δ9-tetrahydrocannabinol in rats and rhesus monkeys. J Pharmacol Exp Ther 275:1-6
58. Wiley JL, LaVecchia KL, Karp NE, Kulasegram S, Mahadevan A, Razdan RK, Martin BR (2004) A comparison of the discriminative stimulus effects of Δ9-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats. Exp Clin Psychopharmacol 12:173-179