Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases

AAPS PharmSciTech

Volumn 8, Issue 3, 2007, Pages

  El Kamel, Amal Hassan ^a   Ashri, Lubna Y ^a   Alsarra, Ibrahim A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Chitosan; Correlation; Metronidazole benzoate; Mucoadhesive; Periodontal; Poly( caprolactone)

Indexed keywords

CHITOSAN; METRONIDAZOLE; POLYCAPROLACTONE; WATER; ANTIINFECTIVE AGENT; AQUAPLAST, CAPROLACTONE; POLYESTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SALIVA LEVEL; DRUG STRUCTURE; FEMALE; FILM COATING; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NORMAL HUMAN; PARTICLE SIZE; PERIODONTAL DISEASE; SLOW DRUG RELEASE; TENSILE STRENGTH; THERMAL ANALYSIS; WATER ABSORPTION; WATER TRANSPORT; ADHESION; CHEMISTRY; DELAYED RELEASE FORMULATION; METABOLISM; MOLECULAR WEIGHT; MOUTH MUCOSA; SALIVA; SOLUBILITY; WETTABILITY;

ADHESIVENESS; ANTI-INFECTIVE AGENTS; CHITOSAN; DELAYED-ACTION PREPARATIONS; HUMANS; METRONIDAZOLE; MOLECULAR WEIGHT; MOUTH MUCOSA; PARTICLE SIZE; PERIODONTAL DISEASES; POLYESTERS; SALIVA; SOLUBILITY; WETTABILITY;

EID: 35148875270     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt0803051     Document Type: Article

References (36)

1. Piovano S. Bacteriology of most frequent oral anaerobic infections. Anaerobe. 1999;5:221-227.
2. Perioli L, Ambrogi V, Rubini D, et al. Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. J Control Release. 2004;95:521-533.
3. Schwach-Abdellaoui K, Vivien-Castioni N, Gurny R. Local delivery of antimicrobial agents for the treatment of periodontal diseases. Eur J Pharm Biopharm. 2000;50:83-99.
4. Vyas SP, Sihorkar V, Mishra V. Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases. J Clin Pharm Ther. 2000;25:21-42.
5. Brackett MG, Drisko CL, Thompson AL, Waller JL, Marshall DL, Schuster GS. Penetration of fluids into periodontal pockets using a powered toothbrush/irrigator device. J Contemp Dent Pract. 2006; 7:30-39.
6. Ahuja A, Ali J, Rahman S. Biodegradable periodontal intrapocket device containing metronidazole and amoxycillin: formulation and characterisation. Pharmazie. 2006;61:25-29.
7. Barat R, Srinatha A, Pandit JK, et al. Niridazole biodegradable inserts for local long-term treatment of periodontitis: possible new life for an orphan drug. Drug Deliv. 2006; 13:365-373.
8. Samati Y, Yuksel N, Tarimci N. Preparation and characterization of poly (D,L-lactic-co-glycolic acid) microspheres containing flurbiprofen sodium. Drug Deliv. 2006;13:105-111.
9. Liebana J, Castillo AM, Alvarez M. Periodontal diseases: microbiological considerations. Med Oral Patol Oral Cir Bucal. 2004;9:82-91.
10. Zheng LY, Zhu JF. Study on antimicrobial activity of chitosan with different molecular weights. Carbohydr Polym. 2003;54:527-530.
11. Perugini P, Genta I, Conti B, Modena T, Pavanetto F. Periodontal delivery of ipriflavone: new chitosan/PLGA film delivery system for a lipophilic drug. Int J Pharm. 2003;252:1-9.
12. USP. US Pharmacopeia National Formulary. vol. 21. Rockville, MD: USP; 1999.
13. Patty PJ, Frisken BJ. Direct determination of the number-weighted mean radius and polydispersity from dynamic light-scattering data. Appl Opt. 2006;45:2209-2216.
14. Peh KK, Wong CF. Polymeric films as vehicle for buccal delivery: swelling, mechanical, and bioadhesive properties. J Pharm Pharm Sci. 1999;2:53-61.
15. Baro M, Sanchez E, Delgado A, Perera A, Evora C. In vitro-in vivo characterization of gentamicin bone implants. J Control Release. 2002;83:353-364.
16. Ponchel G, Touchard F, Duchene D, Peppas NA. Bioadhesive analysis of controlled-release systems, I: fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J Control Release. 1987;5:129-141.
17. Wong CF, Yuen KH, Peh KK. Formulation and evaluation of controlled release Eudragit buccal patches. Int J Pharm. 1999; 178:11-22.
18. Padula CP, Colombo G, Nicoli S, Catellani PL, Massimo G, Santi P. Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behavior. J Control Release. 2003;88:277-285.
19. Ritger PL, Peppas NA. A simple equation for description of solute release, II: Fickian and anomalous release from swellable devices. J Control Release. 1987;5:37-42.
20. Metz P, Kohlhepp SJ, Gilbert DN. Study of different off-line sample processing procedures and the measurement of antibiotic and antiviral levels in human serum by high-performance liquid chromatography. J Chromatogr B. 2002;773:159-166.
21. Sarasam A, Madihally SV. Characterization of chitosan-polycaprolactone blends for tissue engineering applications. Biomaterials. 2005:26:5500-5508.
22. Roldo M, Hornof M, Caliceti P, Bernkop-Schnurch A. Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation. Eur J Pharm Biopharm. 2004;57: 115-121.
23. Wenling C, Duohui J, Jiamou L, Yandao G, Nanming Z, Xiufang Z. Effects of the degree of deacetylation on the physicochemical properties and Schwann cell affinity of chitosan films. J Biomater Appl. 2005; 20:157-177.
24. Needleman IG, Smales FC. In vitro assessment of bioadhesion for periodontal and buccal drug delivery. Biomaterials. 1995;16:617-624.
25. Harding SE. Trends in mucoadhesive analysis. Trends Food Sci Tech. 2006;17:255-262.
26. Ikinci G, Senel S, Akincibay H, et al. Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis. Int J Pharm. 2002; 235:121-127.
27. Dhanikula AB, Panchagnula R. Development and characterization of biodegradable chitosan films for local delivery of paclitaxel. AAPS J. 2004;6:Article 27.
28. Martin AN, ed. Polymer science. In: Physical Pharmacy: Physical Chemical Principles in the Pharmaceutical Sciences. 4th ed. Philadelphia, PA: Lea & Febiger; 1993:575-578.
29. Lorenzo-Lamosa ML, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Design of microencapsulated chitosan microspheres for colonic drug delivery. J Control Release. 1998;52:109-118.
30. Sarasam AR, Krishnaswamy RK, Madihally SV. Blending chitosan with polycaprolactone: effects on physicochemical and antibacterial properties. Biomacromolecules. 2006;7:1131-1138.
31. Colombo P, Santi P, Bettini R, Brazel CS. Drug release from swelling controlled systems. In: Wise DL, ed. Handbook of Pharmaceutical Controlled Release Technology. vol. 9. New York, NY: Marcel Dekker; 2000:183-209.
32. Khanna F, Agarwal SP, Ahuja A. Mucoadhesive buccal tablets of clotimazole for oral candidiasis. Drug Dev Ind Pharm. 1997; 23:1-7.
33. Mody SSB, Mody PD, Doshi MM, inventors. Pharmaceutical dental formulation for topical application of metronidazole benzoate and chlorhexidine gluconate. US patent 6 017 516. January 25, 2000.
34. Parfitt K. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press; 1999.
35. Milazzo I, Blandino G, Musumeci F, Nicoletti G, Lo Bue AM, Speciale A. Antibacterial activity of moxifloxacin against periodontal anaerobic pathogens involved in systemic infections. Int J Antimicrob Agent. 2002;20:451-456.
36. Mckellar QA, Sanchez Bruni SF, Jones DG. Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary medicine. J Vet Pharmacol Ther. 2004;27:503-514.