Isothiocoumarin-3-carboxylic acid derivatives: Synthesis, anticancer and antitrypanosomal activity evaluation

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 57-66

  Kaminskyy, Danylo ^a   Kryshchyshyn, Anna ^a   Nektegayev, Ihor ^a   Vasylenko, Olexandr ^b   Grellier, Philippe ^c   Lesyk, Roman ^a  

^a DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^b INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY   (Ukraine)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

5 Ylidenerhodanines; Anticancer activity; Antitrypanosomal activity; Isothiocoumarins; Synthesis

Indexed keywords

1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (3 TRIFLUOROMETHYLPHENYL) AMIDE; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 PHENYLTHIAZOL 2 YL) AMIDE; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 SULFAMOYLPHENYL) AMIDE; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (5 METHYLISOXAZOL 3 YL) AMIDE; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID ETHYL ESTER; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID ISOPROPYL ESTER; 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID NAPHTHALEN 1 YLAMIDE; 3 (AZEPANE 1 CARBONYL) 7,8 DIMETHOXY ISOTHIOCHROMEN 1 ONE; 3 (MORPHOLINE 4 CARBONYL) ISOTHIOCHROMEN 1 ONE; 4 [(7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBONYL) AMINO] BENZOIC ACID ETHYL ESTER; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOCXYLIC ACID (4 CHLOROPHENYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (2 HYDROXYETHYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (2 TRIFLUOROMETHYLPHENYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (3 TRIFLUOROMETHYLPHENYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 FLUOROPHENYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 HYDROXYPHENYL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 PHENYLTHIAZOL 2 YL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (5 METHYLISOXAZOL 3 YL) AMIDE; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID ISOPROPYL ESTER; 7,8 DIMETHOXY 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID NAPHTHALEN 1 YLAMIDE; 7,8 DIMETHOXY 3 (MORPHOLINE 4 CARBONYL) ISOTHIOCHROMEN 1 ONE; 7,8 DIMETHYL 1 OXO 1H ISOTHIOCHROMENE 3 CARBOXYLIC ACID (4 SULFAMOYLPHENYL) AMIDE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ANTITRYPANOSOMAL AGENT; CARBOXYLIC ACID DERIVATIVE; ISOCOUMARIN DERIVATIVE; UNCLASSIFIED DRUG; [(1 OXO 1H ISOTHIOCHROMENE 3 CARBONYL) AMINO] ACETIC ACID;

ANTINEOPLASTIC ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

5-YLIDENERHODANINES; ANTICANCER ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ISOTHIOCOUMARINS; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBOXYLIC ACIDS; CELL LINE, TUMOR; COUMARINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; PARASITIC SENSITIVITY TESTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS;

EID: 84893979896     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.028     Document Type: Article

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