Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7071-7074

  Zelisko, Nataliya ^a   Atamanyuk, Dmytro ^a   Vasylenko, Olexandr ^b   Grellier, Philippe ^c   Lesyk, Roman ^a  

^a DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY   (Ukraine)

^b INSTITUTE OF BIOORGANIC CHEMISTRY AND PETROCHEMISTRY   (Ukraine)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Antitrypanosomal activity; Human African trypanosomiasis; Thiopyrano 2,3 d 1,3 thiazoles; Trypanosoma brucei

Indexed keywords

(3,4 DIMETHOXYPHENYL) 1 (4 CHLOROPHENYL) 3',7' DIHYDRO 2H,2'H,5H SPIRO[PYROLIDIN 3,6' THIOPYRANO[2,3DEXTRO]THIAZOL] 2,2',5 TRIONE; 2,6 DIOXO 3,5A,6,11B TETRAHYDRO 2H,5H CROMENOL[4',3':4,5]THIOPYRANO[2,3 DEXTRO]THIAZOL 5A YL]ACETIC ACID; 3',7' DIHYDRO 2H,2'H,5H SPIRO[PYROLIDIN 3,6' THIOPYRANO[2,3 DEXTRO]THIAZOL] 2,2' 5 TRIONE; 7 ARYL 6 CARBOXYMETHYL 2 OXO 3,5,6,7 TETRAHYDRO 2H THIOPYRANO[2,3DEXTRO][1,3]THIAZOLE 6 CARBOXYLIC ACID; ANTITRYPANOSOMAL AGENT; RESAZURIN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CYCLOADDITION; DRUG DEVELOPMENT; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; PROTON TRANSPORT; STEREOCHEMISTRY; TRYPANOSOMA BRUCEI; TRYPANOSOMA GAMBIENSE;

HUMANS; PYRANS; PYRROLIDINES; SULFHYDRYL COMPOUNDS; THIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI GAMBIENSE;

TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI GAMBIENSE;

EID: 84869090244     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.091     Document Type: Article

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