메뉴 건너뛰기




Volumn 30, Issue 2, 2014, Pages 227-240

Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: Results of 7 children from a cohort of 86

Author keywords

Children; Epilepsy; Rapamycin; Tuberous sclerosis complex

Indexed keywords

ANTIBIOTICS, ANTINEOPLASTIC; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; HUMANS; INFANT; MALE; RETROSPECTIVE STUDIES; SIROLIMUS; TREATMENT OUTCOME; TUBEROUS SCLEROSIS; YOUNG ADULT;

EID: 84893959443     PISSN: 02567040     EISSN: 14330350     Source Type: Journal    
DOI: 10.1007/s00381-013-2185-6     Document Type: Article
Times cited : (38)

References (73)
  • 2
    • 48549098902 scopus 로고    scopus 로고
    • The pathogenesis and imaging of the tuberous sclerosis complex
    • 18414839 10.1007/s00247-008-0832-y
    • Baskin HJ Jr (2008) The pathogenesis and imaging of the tuberous sclerosis complex. Pediatr Radiol 38:936-952
    • (2008) Pediatr Radiol , vol.38 , pp. 936-952
    • Baskin, Jr.H.J.1
  • 3
    • 49649118165 scopus 로고    scopus 로고
    • Tuberous sclerosis
    • 1:CAS:528:DC%2BD1cXhtVagu7jN 18722871 10.1016/S0140-6736(08)61279-9
    • Curatolo P, Bombardieri R, Jozwiak S (2008) Tuberous sclerosis. Lancet 372:657-668
    • (2008) Lancet , vol.372 , pp. 657-668
    • Curatolo, P.1    Bombardieri, R.2    Jozwiak, S.3
  • 4
    • 0032438210 scopus 로고    scopus 로고
    • Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria
    • 1:STN:280:DyaK1M%2FpsFylsg%3D%3D 9881533 10.1177/088307389801301206
    • Roach ES, Gomez MR, Northrup H (1998) Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol 13:624-628
    • (1998) J Child Neurol , vol.13 , pp. 624-628
    • Roach, E.S.1    Gomez, M.R.2    Northrup, H.3
  • 5
    • 0034023746 scopus 로고    scopus 로고
    • National Institutes of Health consensus conference: Tuberous sclerosis complex
    • 1:STN:280:DC%2BD3c3ntlaltA%3D%3D 10815131 10.1001/archneur.57.5.662
    • Hyman MH, Whittemore VH (2000) National Institutes of Health consensus conference: tuberous sclerosis complex. Arch Neurol 57:662-665
    • (2000) Arch Neurol , vol.57 , pp. 662-665
    • Hyman, M.H.1    Whittemore, V.H.2
  • 6
    • 8844231735 scopus 로고    scopus 로고
    • Diagnosis of tuberous sclerosis complex
    • 15563009
    • Roach ES, Sparagana SP (2004) Diagnosis of tuberous sclerosis complex. J Child Neurol 19:643-649
    • (2004) J Child Neurol , vol.19 , pp. 643-649
    • Roach, E.S.1    Sparagana, S.P.2
  • 7
    • 33847057994 scopus 로고    scopus 로고
    • Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States
    • 1:CAS:528:DC%2BD2sXhslCmt7o%3D 17304050 10.1097/GIM.0b013e31803068c7
    • Au KS, Williams AT, Roach ES et al (2007) Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med 9:88-100
    • (2007) Genet Med , vol.9 , pp. 88-100
    • Au, K.S.1    Williams, A.T.2    Roach, E.S.3
  • 8
    • 77954529084 scopus 로고    scopus 로고
    • The natural history of epilepsy in tuberous sclerosis complex
    • 3065368 20041940 10.1111/j.1528-1167.2009.02474.x
    • Chu-Shore CJ, Major P, Camposano S, Muzykewicz D, Thiele EA (2010) The natural history of epilepsy in tuberous sclerosis complex. Epilepsia 51:1236-1241
    • (2010) Epilepsia , vol.51 , pp. 1236-1241
    • Chu-Shore, C.J.1    Major, P.2    Camposano, S.3    Muzykewicz, D.4    Thiele, E.A.5
  • 9
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • European Chromosome 16 Tuberous Sclerosis Consortium 10.1016/0092- 8674(93)90618-Z
    • European Chromosome 16 Tuberous Sclerosis Consortium (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305-1315
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 10
    • 0030879277 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
    • 9242607 10.1126/science.277.5327.805
    • van Slegtenhorst M, de Hoogt R, Hermans C et al (1997) Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277:805-808
    • (1997) Science , vol.277 , pp. 805-808
    • Van Slegtenhorst, M.1    De Hoogt, R.2    Hermans, C.3
  • 11
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • 1:CAS:528:DC%2BD3sXktlWnsrk%3D 12771962 10.1038/ncb999
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578-581
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 12
    • 33745924695 scopus 로고    scopus 로고
    • Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons
    • 1:CAS:528:DC%2BD28XmsVagur0%3D 16651266 10.1074/jbc.M512524200
    • Gong R, Park CS, Abbassi NR, Tang SJ (2006) Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J Biol Chem 281:18802-18815
    • (2006) J Biol Chem , vol.281 , pp. 18802-18815
    • Gong, R.1    Park, C.S.2    Abbassi, N.R.3    Tang, S.J.4
  • 13
    • 33749639034 scopus 로고    scopus 로고
    • Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
    • 1:CAS:528:DC%2BD28XhtVCiurvN 17023663 10.1126/science.1131693
    • Raab-Graham KF, Haddick PC, Jan YN, Jan LY (2006) Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314:144-148
    • (2006) Science , vol.314 , pp. 144-148
    • Raab-Graham, K.F.1    Haddick, P.C.2    Jan, Y.N.3    Jan, L.Y.4
  • 14
    • 28044456974 scopus 로고    scopus 로고
    • Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
    • 1:CAS:528:DC%2BD2MXht1Gis77M 16286931 10.1038/nn1566
    • Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8:1727-1734
    • (2005) Nat Neurosci , vol.8 , pp. 1727-1734
    • Tavazoie, S.F.1    Alvarez, V.A.2    Ridenour, D.A.3    Kwiatkowski, D.J.4    Sabatini, B.L.5
  • 15
    • 33645738458 scopus 로고    scopus 로고
    • Complexity of the TOR signaling network
    • 1:CAS:528:DC%2BD28Xjs1Grur4%3D 16516475 10.1016/j.tcb.2006.02.002
    • Inoki K, Guan KL (2006) Complexity of the TOR signaling network. Trends Cell Biol 16:206-212
    • (2006) Trends Cell Biol , vol.16 , pp. 206-212
    • Inoki, K.1    Guan, K.L.2
  • 16
    • 78650987740 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: Neurological, renal and pulmonary manifestations
    • 1:CAS:528:DC%2BC3MXjsFOhs7g%3D 21210335 10.1055/s-0030-1269906
    • Franz DN, Bissler JJ, McCormack FX (2010) Tuberous sclerosis complex: neurological, renal and pulmonary manifestations. Neuropediatrics 41:199-208
    • (2010) Neuropediatrics , vol.41 , pp. 199-208
    • Franz, D.N.1    Bissler, J.J.2    McCormack, F.X.3
  • 17
    • 81455151255 scopus 로고    scopus 로고
    • The tuberous sclerosis complex
    • 1:CAS:528:DC%2BD2sXisVGit7c%3D 17005952 10.1056/NEJMra055323
    • Crino PB, Nathanson KL, Henske EP (2006) The tuberous sclerosis complex. N Engl J Med 355:1345-1356
    • (2006) N Engl J Med , vol.355 , pp. 1345-1356
    • Crino, P.B.1    Nathanson, K.L.2    Henske, E.P.3
  • 18
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • 1:CAS:528:DyaE28Xis1eruw%3D%3D 10.7164/antibiotics.28.721
    • Vezina C, Kudelski A, Sehgal SN (1975) Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 28:721-726
    • (1975) J Antibiot (Tokyo) , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 19
    • 33947193386 scopus 로고    scopus 로고
    • Use of sirolimus in solid organ transplantation
    • 1:CAS:528:DC%2BD2sXkvFehsb4%3D 17335296 10.2165/00003495-200767030-00004
    • Augustine JJ, Bodziak KA, Hricik DE (2007) Use of sirolimus in solid organ transplantation. Drugs 67:369-391
    • (2007) Drugs , vol.67 , pp. 369-391
    • Augustine, J.J.1    Bodziak, K.A.2    Hricik, D.E.3
  • 20
    • 33846236407 scopus 로고    scopus 로고
    • Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex
    • 17223050 10.1016/j.ejim.2006.07.017
    • Herry I, Neukirch C, Debray MP, Mignon F, Crestani B (2007) Dramatic effect of sirolimus on renal angiomyolipomas in a patient with tuberous sclerosis complex. Eur J Intern Med 18:76-77
    • (2007) Eur J Intern Med , vol.18 , pp. 76-77
    • Herry, I.1    Neukirch, C.2    Debray, M.P.3    Mignon, F.4    Crestani, B.5
  • 21
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • 1:CAS:528:DC%2BD28XjtV2ltr8%3D 16453317 10.1002/ana.20784
    • Franz DN, Leonard J, Tudor C et al (2006) Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 59:490-498
    • (2006) Ann Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 22
    • 47549093135 scopus 로고    scopus 로고
    • The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis
    • 1:CAS:528:DC%2BD1cXhtVCqs7bO 18547304 10.1111/j.1365-2133.2008.08677.x
    • Hofbauer GF, Marcollo-Pini A, Corsenca A et al (2008) The mTOR inhibitor rapamycin significantly improves facial angiofibroma lesions in a patient with tuberous sclerosis. Br J Dermatol 159:473-475
    • (2008) Br J Dermatol , vol.159 , pp. 473-475
    • Hofbauer, G.F.1    Marcollo-Pini, A.2    Corsenca, A.3
  • 23
    • 77958178123 scopus 로고    scopus 로고
    • Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient
    • 20954988 10.3109/0886022X.2010.517345
    • Micozkadioglu H, Koc Z, Ozelsancak R, Yildiz I (2010) Rapamycin therapy for renal, brain, and skin lesions in a tuberous sclerosis patient. Ren Fail 32:1233-1236
    • (2010) Ren Fail , vol.32 , pp. 1233-1236
    • Micozkadioglu, H.1    Koc, Z.2    Ozelsancak, R.3    Yildiz, I.4
  • 24
    • 66149169973 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • 1:CAS:528:DC%2BD1MXmvVGisL0%3D 2727061 19474323 10.1523/JNEUROSCI.0066- 09.2009
    • Zeng LH, Rensing NR, Wong M (2009) The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 29:6964-6972
    • (2009) J Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 25
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a Mouse model of tuberous sclerosis complex
    • 1:CAS:528:DC%2BD1cXmsFGqt7c%3D 18389497 10.1002/ana.21331
    • Zeng LH, Xu L, Gutmann DH, Wong M (2008) Rapamycin prevents epilepsy in a Mouse model of tuberous sclerosis complex. Ann Neurol 63:444-453
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 26
    • 64249118425 scopus 로고    scopus 로고
    • Rapamycin reduces seizure frequency in tuberous sclerosis complex
    • 3072696 19151365 10.1177/0883073808324535
    • Muncy J, Butler IJ, Koenig MK (2009) Rapamycin reduces seizure frequency in tuberous sclerosis complex. J Child Neurol 24:477
    • (2009) J Child Neurol , vol.24 , pp. 477
    • Muncy, J.1    Butler, I.J.2    Koenig, M.K.3
  • 27
    • 84855163851 scopus 로고    scopus 로고
    • Surgical timing of the subependymal giant cell astrocytoma (SEGA) with the patients of tuberous sclerosis complex
    • 21845566
    • Ekici MA, Kumandas S, Per H et al (2011) Surgical timing of the subependymal giant cell astrocytoma (SEGA) with the patients of tuberous sclerosis complex. Turk Neurosurg 21:315-324
    • (2011) Turk Neurosurg , vol.21 , pp. 315-324
    • Ekici, M.A.1    Kumandas, S.2    Per, H.3
  • 28
    • 0036263937 scopus 로고    scopus 로고
    • Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex
    • 12023313 10.1093/brain/awf124
    • Bolton PF, Park RJ, Higgins JN, Griffiths PD, Pickles A (2002) Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex. Brain 125:1247-1255
    • (2002) Brain , vol.125 , pp. 1247-1255
    • Bolton, P.F.1    Park, R.J.2    Higgins, J.N.3    Griffiths, P.D.4    Pickles, A.5
  • 29
    • 12244298162 scopus 로고    scopus 로고
    • Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex
    • 1:STN:280:DC%2BD3s7gvFeruw%3D%3D 12622312 10.1017/S0033291702007092
    • Joinson C, O'Callaghan FJ, Osborne JP, Martyn C, Harris T, Bolton PF (2003) Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex. Psychol Med 33:335-344
    • (2003) Psychol Med , vol.33 , pp. 335-344
    • Joinson, C.1    O'Callaghan, F.J.2    Osborne, J.P.3    Martyn, C.4    Harris, T.5    Bolton, P.F.6
  • 30
    • 0031897224 scopus 로고    scopus 로고
    • Poor mental development in patients with tuberous sclerosis complex: Clinical risk factors
    • 1:STN:280:DyaK1c7nvVygtg%3D%3D 9520012 10.1001/archneur.55.3.379
    • Jozwiak S, Goodman M, Lamm SH (1998) Poor mental development in patients with tuberous sclerosis complex: clinical risk factors. Arch Neurol 55:379-384
    • (1998) Arch Neurol , vol.55 , pp. 379-384
    • Jozwiak, S.1    Goodman, M.2    Lamm, S.H.3
  • 31
    • 22544488406 scopus 로고    scopus 로고
    • Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex
    • 16043792 10.1212/01.wnl.0000168908.78118.99
    • Goh S, Kwiatkowski DJ, Dorer DJ, Thiele EA (2005) Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex. Neurology 65:235-238
    • (2005) Neurology , vol.65 , pp. 235-238
    • Goh, S.1    Kwiatkowski, D.J.2    Dorer, D.J.3    Thiele, E.A.4
  • 32
    • 0033991818 scopus 로고    scopus 로고
    • Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients
    • 1:CAS:528:DyaK1MXnvFensbg%3D 10642043 10.1016/S0920-1211(99)00082-0
    • Jambaque I, Chiron C, Dumas C, Mumford J, Dulac O (2000) Mental and behavioural outcome of infantile epilepsy treated by vigabatrin in tuberous sclerosis patients. Epilepsy Res 38:151-160
    • (2000) Epilepsy Res , vol.38 , pp. 151-160
    • Jambaque, I.1    Chiron, C.2    Dumas, C.3    Mumford, J.4    Dulac, O.5
  • 33
    • 39749141046 scopus 로고    scopus 로고
    • Neuroimaging correlation with neurological severity in tuberous sclerosis complex
    • 17869556 10.1016/j.ejpn.2007.07.002
    • Chou IJ, Lin KL, Wong AM et al (2008) Neuroimaging correlation with neurological severity in tuberous sclerosis complex. Eur J Paediatr Neurol 12:108-112
    • (2008) Eur J Paediatr Neurol , vol.12 , pp. 108-112
    • Chou, I.J.1    Lin, K.L.2    Wong, A.M.3
  • 34
    • 0032052110 scopus 로고
    • CT and MR imaging of cerebral tuberous sclerosis
    • 10.1016/S0387-7604(98)00022-9
    • Inoue Y, Nemoto Y, Murata R et al (1988) CT and MR imaging of cerebral tuberous sclerosis. Brain Dev 20:209-221
    • (1988) Brain Dev , vol.20 , pp. 209-221
    • Inoue, Y.1    Nemoto, Y.2    Murata, R.3
  • 35
    • 33947098824 scopus 로고    scopus 로고
    • Neuroimaging in tuberous sclerosis complex
    • 1:CAS:528:DC%2BD2sXkvFegtr4%3D 17351483 10.1097/WCO.0b013e3280895d93
    • Luat AF, Makki M, Chugani HT (2007) Neuroimaging in tuberous sclerosis complex. Curr Opin Neurol 20:142-150
    • (2007) Curr Opin Neurol , vol.20 , pp. 142-150
    • Luat, A.F.1    Makki, M.2    Chugani, H.T.3
  • 36
    • 84878502738 scopus 로고    scopus 로고
    • Subependymal nodules and giant cell tumours in tuberous sclerosis complex patients: Prevalence on MRI in relation to gene mutation
    • 22936080 10.1007/s00381-012-1892-8
    • Michelozzi C, Di Leo G, Galli F et al (2013) Subependymal nodules and giant cell tumours in tuberous sclerosis complex patients: prevalence on MRI in relation to gene mutation. Childs Nerv Syst 29:249-254
    • (2013) Childs Nerv Syst , vol.29 , pp. 249-254
    • Michelozzi, C.1    Di Leo, G.2    Galli, F.3
  • 37
    • 0032941743 scopus 로고    scopus 로고
    • Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis
    • 1:STN:280:DyaK1M7ot1Shug%3D%3D 10084537 10.1136/jnnp.66.3.370
    • Nabbout R, Santos M, Rolland Y, Delalande O, Dulac O, Chiron C (1999) Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis. J Neurol Neurosurg Psychiatry 66:370-375
    • (1999) J Neurol Neurosurg Psychiatry , vol.66 , pp. 370-375
    • Nabbout, R.1    Santos, M.2    Rolland, Y.3    Delalande, O.4    Dulac, O.5    Chiron, C.6
  • 38
    • 36249023723 scopus 로고    scopus 로고
    • Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    • 3474316 17983731 10.1016/j.eplepsyres.2007.09.009
    • Rüegg S, Baybis M, Juul H, Dichter M, Crino PB (2007) Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy Res 77:85-92
    • (2007) Epilepsy Res , vol.77 , pp. 85-92
    • Rüegg, S.1    Baybis, M.2    Juul, H.3    Dichter, M.4    Crino, P.B.5
  • 40
    • 38049169559 scopus 로고    scopus 로고
    • Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    • 1:CAS:528:DC%2BD1cXltFWrtg%3D%3D 3398441 18184959 10.1056/NEJMoa063564
    • Bissler JJ, McCormack FX, Young LR et al (2008) Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 358:140-151
    • (2008) N Engl J Med , vol.358 , pp. 140-151
    • Bissler, J.J.1    McCormack, F.X.2    Young, L.R.3
  • 41
    • 79551594354 scopus 로고    scopus 로고
    • Fetal and neonatal cardiac rhabdomyomas: Clinical presentation, outcome and association with tuberous sclerosis complex
    • 21434532
    • Atalay S, Aypar E, Uçar T et al (2010) Fetal and neonatal cardiac rhabdomyomas: clinical presentation, outcome and association with tuberous sclerosis complex. Turk J Pediatr 52:481-487
    • (2010) Turk J Pediatr , vol.52 , pp. 481-487
    • Atalay, S.1    Aypar, E.2    Uçar, T.3
  • 42
    • 8844285191 scopus 로고    scopus 로고
    • Managing epilepsy in tuberous sclerosis complex
    • 15563014
    • Thiele E (2004) Managing epilepsy in tuberous sclerosis complex. J Child Neurol 19:680-686
    • (2004) J Child Neurol , vol.19 , pp. 680-686
    • Thiele, E.1
  • 43
    • 33845927451 scopus 로고    scopus 로고
    • Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: Specialized minimal access technique of balloon dilation
    • 1:STN:280:DC%2BD28jis1GitQ%3D%3D 17163349 10.1055/s-2006-950391
    • Levine NB, Collins J, Franz DN, Crone KR (2006) Gradual formation of an operative corridor by balloon dilation for resection of subependymal giant cell astrocytomas in children with tuberous sclerosis: specialized minimal access technique of balloon dilation. Minim Invasive Neurosurg 49:317-320
    • (2006) Minim Invasive Neurosurg , vol.49 , pp. 317-320
    • Levine, N.B.1    Collins, J.2    Franz, D.N.3    Crone, K.R.4
  • 44
    • 1642618108 scopus 로고    scopus 로고
    • A controlled study of vigabatrin and visual abnormalities
    • 10.1136/bjo.84.5.499
    • Manuchehri K, Goodman S, Siviter L, Nightingale S (2008) A controlled study of vigabatrin and visual abnormalities. Br J Ophthalmol 84:499-505
    • (2008) Br J Ophthalmol , vol.84 , pp. 499-505
    • Manuchehri, K.1    Goodman, S.2    Siviter, L.3    Nightingale, S.4
  • 45
    • 0032721611 scopus 로고    scopus 로고
    • Visual field defects associated with vigabatrin therapy
    • 1:STN:280:DC%2BD3c%2Fjs1OitQ%3D%3D 10567485 10.1136/jnnp.67.6.716
    • Lawden MC, Eke T, Degg C, Harding GF, Wild JM (1999) Visual field defects associated with vigabatrin therapy. J Neurol Neurosurg Psychiatry 67:716-722
    • (1999) J Neurol Neurosurg Psychiatry , vol.67 , pp. 716-722
    • Lawden, M.C.1    Eke, T.2    Degg, C.3    Harding, G.F.4    Wild, J.M.5
  • 46
    • 3042825407 scopus 로고    scopus 로고
    • Combined treatment with vigabatrin and topiramate in West syndrome
    • 15224711 10.1177/088307380401900512
    • Buoni S, Zannolli R, Strambi M, Fois A (2004) Combined treatment with vigabatrin and topiramate in West syndrome. J Child Neurol 19:385-386
    • (2004) J Child Neurol , vol.19 , pp. 385-386
    • Buoni, S.1    Zannolli, R.2    Strambi, M.3    Fois, A.4
  • 47
    • 79958184395 scopus 로고    scopus 로고
    • A pulse rapamycin therapy for infantile spasms and associated cognitive decline
    • 1:CAS:528:DC%2BC3MXnsFWhtbY%3D 3114281 21504792 10.1016/j.nbd.2011.03.021
    • Raffo E, Coppola A, Ono T, Briggs SW, Galanopoulou AS (2011) A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis 43:322-329
    • (2011) Neurobiol Dis , vol.43 , pp. 322-329
    • Raffo, E.1    Coppola, A.2    Ono, T.3    Briggs, S.W.4    Galanopoulou, A.S.5
  • 49
    • 84858006041 scopus 로고    scopus 로고
    • Rapamycin for treatment of epilepsy: Antiseizure, antiepileptogenic, both, or neither?
    • 3117496 21852879 10.5698/1535-7511-11.2.66
    • Wong M (2011) Rapamycin for treatment of epilepsy: antiseizure, antiepileptogenic, both, or neither? Epilepsy Curr 11:66-68
    • (2011) Epilepsy Curr , vol.11 , pp. 66-68
    • Wong, M.1
  • 50
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • 1:CAS:528:DC%2BD1MXotFKgu74%3D 2819377 19553465 10.1523/JNEUROSCI.4179- 08.2009
    • Buckmaster PS, Ingram EA, Wen X (2009) Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci 29:8259-8269
    • (2009) J Neurosci , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 51
    • 84856372774 scopus 로고    scopus 로고
    • Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
    • 1:CAS:528:DC%2BC38XhvVGgtro%3D 22227620 10.1016/j.neulet.2011.12.051
    • Sliwa A, Plucinska G, Bednarczyk J, Lukasiuk K (2012) Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Neurosci Lett 509:105-109
    • (2012) Neurosci Lett , vol.509 , pp. 105-109
    • Sliwa, A.1    Plucinska, G.2    Bednarczyk, J.3    Lukasiuk, K.4
  • 52
    • 84857648355 scopus 로고    scopus 로고
    • American Epilepsy Society Basic Science Committee and the International League Against Epilepsy Working Group on Recommendations for Preclinical Epilepsy Drug Discovery. Identification of new epilepsy treatments: Issues in preclinical methodology
    • 3551973 22292566 10.1111/j.1528-1167.2011.03391.x
    • Galanopoulou AS, Buckmaster PS, Staley KJ et al (2012) American Epilepsy Society Basic Science Committee and The International League Against Epilepsy Working Group on Recommendations for Preclinical Epilepsy Drug Discovery. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia 53:571-582
    • (2012) Epilepsia , vol.53 , pp. 571-582
    • Galanopoulou, A.S.1    Buckmaster, P.S.2    Staley, K.J.3
  • 53
    • 68349100270 scopus 로고    scopus 로고
    • Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    • 1:CAS:528:DC%2BD1MXhtVahs7bO 2707106 19470613 10.1242/dmm.002386
    • Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G (2009) Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech 2:389-398
    • (2009) Dis Model Mech , vol.2 , pp. 389-398
    • Ljungberg, M.C.1    Sunnen, C.N.2    Lugo, J.N.3    Anderson, A.E.4    D'Arcangelo, G.5
  • 54
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • 1:CAS:528:DC%2BD1MXit1Witbo%3D 3904448 19211884 10.1523/JNEUROSCI.5685- 08.2009
    • Zhou J, Blundell J, Ogawa S et al (2009) Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci 29:1773-1783
    • (2009) J Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3
  • 55
    • 77955845741 scopus 로고    scopus 로고
    • Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    • 1:CAS:528:DC%2BC3cXhtVGrt7zP 2926303 20566381 10.1016/j.nbd.2010.05.024
    • Huang X, Zhang H, Yang J et al (2010) Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol Dis 40:193-199
    • (2010) Neurobiol Dis , vol.40 , pp. 193-199
    • Huang, X.1    Zhang, H.2    Yang, J.3
  • 56
    • 84863727156 scopus 로고    scopus 로고
    • Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target
    • 1:CAS:528:DC%2BC38Xht1KksbzF 3389589 22578218 10.1111/j.1528-1167.2012. 03506.x
    • Galanopoulou AS, Gorter JA, Cepeda C (2012) Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. Epilepsia 53:1119-1130
    • (2012) Epilepsia , vol.53 , pp. 1119-1130
    • Galanopoulou, A.S.1    Gorter, J.A.2    Cepeda, C.3
  • 57
    • 0032498882 scopus 로고    scopus 로고
    • + channel is modulated by FK506 and rapamycin
    • 1:CAS:528:DyaK1cXitlSlt7Y%3D 9555045 10.1016/S0006-8993(97)01435-2
    • + channel is modulated by FK506 and rapamycin. Brain Res 786:255-258
    • (1998) Brain Res , vol.786 , pp. 255-258
    • Terashima, A.1    Nakai, M.2    Hashimoto, T.3
  • 58
    • 33646391271 scopus 로고    scopus 로고
    • A role for the mTOR pathway in surface expression of AMPA receptors
    • 1:CAS:528:DC%2BD28Xks1Oltbg%3D 16677760 10.1016/j.neulet.2006.03.011
    • Wang Y, Barbaro MF, Baraban SC (2006) A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett 401:35-39
    • (2006) Neurosci Lett , vol.401 , pp. 35-39
    • Wang, Y.1    Barbaro, M.F.2    Baraban, S.C.3
  • 59
    • 38349090475 scopus 로고    scopus 로고
    • Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities
    • 1:CAS:528:DC%2BD1cXpvV2ksg%3D%3D 18162540 10.1073/pnas.0710424105
    • Ruan B, Pong K, Jow F et al (2008) Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci USA 105:33-38
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 33-38
    • Ruan, B.1    Pong, K.2    Jow, F.3
  • 60
    • 34247111348 scopus 로고    scopus 로고
    • Rapamycin: Brain excitability studied in vitro
    • 1:CAS:528:DC%2BD2sXlsVWgtrs%3D 17284292 10.1111/j.1528-1167.2006.00976.x
    • Daoud D, Scheld HH, Speckmann EJ, Gorji A (2007) Rapamycin: brain excitability studied in vitro. Epilepsia 48:834-836
    • (2007) Epilepsia , vol.48 , pp. 834-836
    • Daoud, D.1    Scheld, H.H.2    Speckmann, E.J.3    Gorji, A.4
  • 61
    • 81955160719 scopus 로고    scopus 로고
    • Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex
    • 1:CAS:528:DC%2BC3MXhsFGqsLnO 3225687 21889982 10.1016/j.nbd.2011.08.015
    • Cepeda C, Andre VM, Hauptman JS et al (2012) Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex. Neurobiol Dis 45:310-321
    • (2012) Neurobiol Dis , vol.45 , pp. 310-321
    • Cepeda, C.1    Andre, V.M.2    Hauptman, J.S.3
  • 62
    • 76249084241 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    • 1:CAS:528:DC%2BC3cXhsFCms7s%3D 3022513 19817806 10.1111/j.1528-1167.2009. 02341.x
    • Wong M (2010) Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies. Epilepsia 51:27-36
    • (2010) Epilepsia , vol.51 , pp. 27-36
    • Wong, M.1
  • 63
    • 84877589482 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations
    • Wong M (2011) Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations. Exp Neurol 244:22-26
    • (2011) Exp Neurol , vol.244 , pp. 22-26
    • Wong, M.1
  • 64
    • 78049510428 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    • 1:CAS:528:DC%2BC3cXhtl2gsbbP 21047224 10.1056/NEJMoa1001671
    • Krueger DA, Care MM, Holland K et al (2010) Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med 363:1801-1811
    • (2010) N Engl J Med , vol.363 , pp. 1801-1811
    • Krueger, D.A.1    Care, M.M.2    Holland, K.3
  • 65
    • 33745481867 scopus 로고    scopus 로고
    • The diverse clinical manifestations of tuberous sclerosis complex: A review
    • 16818173 10.1016/j.spen.2006.01.008
    • Rosser T, Panigrahy A, McClintock W (2006) The diverse clinical manifestations of tuberous sclerosis complex: a review. Semin Pediatr Neurol 13:27-36
    • (2006) Semin Pediatr Neurol , vol.13 , pp. 27-36
    • Rosser, T.1    Panigrahy, A.2    McClintock, W.3
  • 66
    • 8844240684 scopus 로고    scopus 로고
    • Behavioral and cognitive aspects of tuberous sclerosis complex
    • 15563012
    • Prather P, de Vries PJ (2004) Behavioral and cognitive aspects of tuberous sclerosis complex. J Child Neurol 19:666-674
    • (2004) J Child Neurol , vol.19 , pp. 666-674
    • Prather, P.1    De Vries, P.J.2
  • 67
    • 0014978690 scopus 로고
    • Renal angiomyolipoma (hamartoma): Review of the literature and report of 7 cases
    • 1:STN:280:DyaE3M7gvVyhuw%3D%3D 5100869
    • McCullough DL, Scott R Jr, Seybold HM (1971) Renal angiomyolipoma (hamartoma): review of the literature and report of 7 cases. J Urol 105:32-44
    • (1971) J Urol , vol.105 , pp. 32-44
    • McCullough, D.L.1    Scott, Jr.R.2    Seybold, H.M.3
  • 68
    • 0023270237 scopus 로고
    • Renal lesions in tuberous sclerosis
    • 1:STN:280:DyaL2szhtF2juw%3D%3D 3625844
    • Stillwell TJ, Gomez MR, Kelalis PP (1987) Renal lesions in tuberous sclerosis. J Urol 138:477-481
    • (1987) J Urol , vol.138 , pp. 477-481
    • Stillwell, T.J.1    Gomez, M.R.2    Kelalis, P.P.3
  • 69
    • 0027758317 scopus 로고
    • The natural history of renal angiomyolipoma
    • 1:STN:280:DyaK2c%2FkslCjug%3D%3D 8230504
    • Steiner MS, Goldman SM, Fishman EK, Marshall FF (1993) The natural history of renal angiomyolipoma. J Urol 150:1782-1786
    • (1993) J Urol , vol.150 , pp. 1782-1786
    • Steiner, M.S.1    Goldman, S.M.2    Fishman, E.K.3    Marshall, F.F.4
  • 70
    • 0036830140 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: Renal imaging findings
    • 12409579 10.1148/radiol.2252011584
    • Casper KA, Donnelly LF, Chen B, Bissler JJ (2002) Tuberous sclerosis complex: renal imaging findings. Radiology 225:451-456
    • (2002) Radiology , vol.225 , pp. 451-456
    • Casper, K.A.1    Donnelly, L.F.2    Chen, B.3    Bissler, J.J.4
  • 71
    • 79958284085 scopus 로고    scopus 로고
    • Effects of rapamycin on angiomyolipomas in patients with tuberous sclerosis
    • 21629335
    • Cabrera Lopez C, Marti T, Catala V et al (2011) Effects of rapamycin on angiomyolipomas in patients with tuberous sclerosis. Nefrologia 31:292-298
    • (2011) Nefrologia , vol.31 , pp. 292-298
    • Cabrera Lopez, C.1    Marti, T.2    Catala, V.3
  • 72
    • 84856546231 scopus 로고    scopus 로고
    • Facial angiofibromas treated with topical rapamycin: An excellent choice with fast response
    • 22301052
    • Truchuelo T, Díaz-Ley B, Ríos L, Alcántara J, Jaén P (2012) Facial angiofibromas treated with topical rapamycin: an excellent choice with fast response. Dermatol Online J 18:15
    • (2012) Dermatol Online J , vol.18 , pp. 15
    • Truchuelo, T.1    Díaz-Ley, B.2    Ríos, L.3    Alcántara, J.4    Jaén, P.5
  • 73
    • 41449112167 scopus 로고    scopus 로고
    • Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
    • 2266897 18226258 10.1186/1471-5945-8-1
    • Rauktys A, Lee N, Lee L, Dabora SL (2008) Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model. BMC Dermatol 8:1
    • (2008) BMC Dermatol , vol.8 , pp. 1
    • Rauktys, A.1    Lee, N.2    Lee, L.3    Dabora, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.