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Volumn 11, Issue 2, 2011, Pages 66-68

Rapamycin for treatment of epilepsy: Antiseizure, antiepileptogenic, both, or neither?

(1)  Wong, Michael a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN;

EID: 84858006041     PISSN: 15357597     EISSN: 15357511     Source Type: Journal    
DOI: 10.5698/1535-7511-11.2.66     Document Type: Note
Times cited : (20)

References (14)
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    • Franz DN. mTOR in tuberous sclerosis and other neurological disorders. Epilepsia 2007;48:1630-1631.
    • (2007) Epilepsia , vol.48 , pp. 1630-1631
    • Franz, D.N.1
  • 2
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    • Mammalian target of rapamycin (mTOR) inhibition as potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies
    • Wong M. Mammalian target of rapamycin (mTOR) inhibition as potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia 2010;51:27-36.
    • (2010) Epilepsia , vol.51 , pp. 27-36
    • Wong, M.1
  • 3
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    • Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function
    • Meikle L, Pollizzi K, Egnor A, Kramvis I, Lane H, Sahin M, Kwiatkowski DJ. Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: Effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci 2008;28:5422-5432.
    • (2008) J Neurosci , vol.28 , pp. 5422-5432
    • Meikle, L.1    Pollizzi, K.2    Egnor, A.3    Kramvis, I.4    Lane, H.5    Sahin, M.6    Kwiatkowski, D.J.7
  • 4
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol 2008;63:444-453.
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 6
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    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, Sinton C, Powell CM, Parada LF. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci 2009;29:1773-1783.
    • (2009) J Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.H.4    Zhang, W.5    Sinton, C.6    Powell, C.M.7    Parada, L.F.8
  • 7
    • 68349100270 scopus 로고    scopus 로고
    • Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    • Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech 2009;2:389-398.
    • (2009) Dis Model Mech , vol.2 , pp. 389-398
    • Ljungberg, M.C.1    Sunnen, C.N.2    Lugo, J.N.3    Anderson, A.E.4    D'Arcangelo, G.5
  • 9
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    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • Zeng LH, Rensing NR, Wong M. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci 2009;29:6964-6972.
    • (2009) J Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 10
    • 67649382228 scopus 로고    scopus 로고
    • Inhibition of the mammaliantarget of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy
    • Buckmaster PS, Ingram EA, Wen X. Inhibition of the mammaliantarget of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci 2009;29:8259-8269.
    • (2009) J Neurosci , vol.29 , pp. 8259-8269
    • Buckmaster, P.S.1    Ingram, E.A.2    Wen, X.3
  • 12
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    • Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    • Ruegg S, Baybis M, Juul H, Dichter M, Crino PB. Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy Res 2007;77:85-92.
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  • 13
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    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • Buckmaster PS, Lew FH. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci 2011;2337-2347.
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    • Buckmaster, P.S.1    Lew, F.H.2
  • 14
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    • Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR):A double-edged sword?
    • Zeng LH, McDaniel SS, Rensing N, Wong M. Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR):A double-edged sword? Cell Cycle 2010;9:2281-2285.
    • (2010) Cell Cycle , vol.9 , pp. 2281-2285
    • Zeng, L.H.1    McDaniel, S.S.2    Rensing, N.3    Wong, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.