Antioxidants and vision health: Facts and fiction

Molecular and Cellular Biochemistry

Volumn 388, Issue 1-2, 2014, Pages 173-183

  Grover, Ashok K ^a   Samson, Sue E ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Age related macular degeneration; Alternative medicine; Cataract; Eye diseases; Glaucoma; Nutritional supplements

Indexed keywords

ANTIOXIDANTS; BLINDNESS; CATARACT; DIETARY SUPPLEMENTS; EYE DISEASES; EYE INFECTIONS; GLAUCOMA; HUMANS; LUTEIN; MACULAR DEGENERATION; REACTIVE OXYGEN SPECIES; RETINITIS PIGMENTOSA; VISION, OCULAR; VITAMINS;

EID: 84893876187     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1908-z     Document Type: Article

References (65)

1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, Mariotti SP (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82:844-851 (Pubitemid 39573742)
2. Congdon N, O'Colmain B, Klaver CC, Klein R, Munoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P (2004) Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 122:477-485 (Pubitemid 38456282)
3. Gunasekera V, Ernst E, Ezra DG (2008) Systematic internet-based review of complementary and alternative medicine for glaucoma. Ophthalmology 115:435-439 (Pubitemid 351305322)
4. Walia M, Kwan CY, Grover AK (2003) Effects of free radicals on coronary artery. Med Princ Pract 12:1-9 (Pubitemid 36164647)
5. Romano AD, Serviddio G, de Matthaeis A, Bellanti F, Vendemiale G (2010) Oxidative stress and aging. J Nephrol 23(Suppl 15):S29-S36
6. Oliveira BF, Nogueira-Machado JA, Chaves MM (2010) The role of oxidative stress in the aging process. Sci World J 10:1121-1128
7. Varma SD, Kovtun S, Hegde KR (2011) Role of ultraviolet irradiation and oxidative stress in cataract formation-medical prevention by nutritional antioxidants and metabolic agonists. Eye Contact Lens 37:233-245
8. Babizhayev MA, Burke L, Micans P, Richer SP (2009) N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population. Clin Interv Aging 4:31-50
9. Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A (2009) N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients. Am J Ther 16:517-533
10. Misner B (2012) What are the effects of topical N-acetylcarnosine [eye drops] on cataract-inhibited vision in an elderly subject? - a case report. Web Med Central http://webmedcentral.com/article-view/3214
11. Ha JW, Schwahn AB, Downard KM (2010) Ability of N-acetylcarnosine to protect lens crystallins from oxidation and oxidative damage by radical probe mass spectrometry (RP-MS). Rapid Commun Mass Spectrom 24:2900-2908
12. Gritz DC, Srinivasan M, Smith SD, Kim U, Lietman TM, Wilkins JH, Priyadharshini B, Aravind S, Prajna NV, Smolin G, Thulasiraj RD, Selvaraj S, Whitcher JP (2006) Antioxidants in prevention of cataracts in South India: methodology and baseline data. Ophthalmic Epidemiol 13:97-107
13. Gritz DC, Srinivasan M, Smith SD, Kim U, Lietman TM, Wilkins JH, Priyadharshini B, John RK, Aravind S, Prajna NV, Duraisami TR, Whitcher JP (2006) The Antioxidants in Prevention of Cataracts Study: effects of antioxidant supplements on cataract progression in South India. Br J Ophthalmol 90:847-851 (Pubitemid 43973994)
14. Toh T, Morton J, Coxon J, Elder MJ (2007) Medical treatment of cataract. Clin Experiment Ophthalmol 35:664-671 (Pubitemid 47491225)
15. Fernandez MM, Afshari NA (2008) Nutrition and the prevention of cataracts. Curr Opin Ophthalmol 19:66-70 (Pubitemid 350307564)
16. Mathew MC, Ervin AM, Tao J, Davis RM (2012) Antioxidant vitamin supplementation for preventing and slowing the progression of age-related cataract. Cochrane Database Syst Rev 6:CD004567
17. Agte V, Tarwadi K (2010) The importance of nutrition in the prevention of ocular disease with special reference to cataract. Ophthalmic Res 44:166-172
18. Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I (2012) Definition of glaucoma: clinical and experimental concepts. Clin Experiment Ophthalmol 40:341-349
19. Grant J, Tran V, Bhattacharya SK, Bianchi L (2013) Ionic currents of human trabecular meshwork cells from control and glaucoma subjects. J Membr Biol 246:167-175
20. Shoshani YZ, Harris A, Shoja MM, Rusia D, Siesky B, Arieli Y, Wirostko B (2012) Endothelin and its suspected role in the pathogenesis and possible treatment of glaucoma. Curr Eye Res 37:1-11
21. Anwar Z, Wellik SR, Galor A (2013) Glaucoma therapy and ocular surface disease: current literature and recommendations. Curr Opin Ophthalmol 24:136-143
22. Zanon-Moreno V, Ciancotti-Olivares L, Asencio J, Sanz P, Ortega-Azorin C, Pinazo-Duran MD, Corella D (2011) Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population. Mol Vis 17:2997-3004
23. Yuki K, Murat D, Kimura I, Ohtake Y, Tsubota K (2010) Reduced-serum vitamin C and increased uric acid levels in normal-tension glaucoma. Graefes Arch Clin Exp Ophthalmol 248:243-248
24. Zanon-Moreno V, Garcia-Medina JJ, Gallego-Pinazo R, Vinuesa-Silva I, Moreno-Nadal MA, Pinazo-Duran MD (2009) Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma. Eur J Ophthalmol 19:565-571
25. Izzotti A, Sacca SC, Di Marco B, Penco S, Bassi AM (2008) Antioxidant activity of timolol on endothelial cells and its relevance for glaucoma course. Eye (Lond) 22:445-453 (Pubitemid 351404474)
26. Wang SY, Singh K, Lin SC (2013) Glaucoma and vitamins A, C, and E supplement intake and serum levels in a population-based sample of the United States. Eye (Lond) 27:487-494
27. Ramdas WD, Wolfs RC, Kiefte-de Jong JC, Hofman A, de Jong PT, Vingerling JR, Jansonius NM (2012) Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. Eur J Epidemiol 27:385-393
28. Giaconi JA, Yu F, Stone KL, Pedula KL, Ensrud KE, Cauley JA, Hochberg MC, Coleman AL (2012) The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Am J Ophthalmol 154:635-644
29. Kang JH, Pasquale LR, Willett W, Rosner B, Egan KM, Faberowski N, Hankinson SE (2003) Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol 158:337-346 (Pubitemid 41288801)
30. Chung HS, Harris A, Kristinsson JK, Ciulla TA, Kagemann C, Ritch R (1999) Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther 15:233-240 (Pubitemid 29262980)
31. Shim SH, Kim JM, Choi CY, Kim CY, Park KH (2012) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. J Med Food 15:818-823
32. Park JW, Kwon HJ, Chung WS, Kim CY, Seong GJ (2011) Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma. Korean J Ophthalmol 25:323-328
33. Quaranta L, Bettelli S, Uva MG, Semeraro F, Turano R, Gandolfo E (2003) Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology 110:359-362 (Pubitemid 36184342)
34. de Jong PT (2006) Age-related macular degeneration. N Engl J Med 355:1474-1485 (Pubitemid 44511562)
35. The Age-Related Eye Disease Study 1(AREDS1) Research Group (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119:1417-1436
36. The Age-Related Eye Disease Study 2(AREDS2) Research Group (2013) Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA 309:2005-2015
37. Evans JR, Lawrenson JG (2012) Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst Rev 6:CD000253
38. Evans JR, Lawrenson JG (2012) Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 11:CD000254
39. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH (2007) Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 335:755 (Pubitemid 47612631)
40. Piccardi M, Marangoni D, Minnella AM, Savastano MC, Valentini P, Ambrosio L, Capoluongo E, Maccarone R, Bisti S, Falsini B (2012) A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: sustained benefits to central retinal function. Evid Based Complement Alternat Med 2012:429124
41. Madsen-Bouterse SA, Kowluru RA (2008) Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 9:315-327
42. Williams M, Hogg RE, Chakravarthy U (2013) Antioxidants and diabetic retinopathy. Curr Diab Rep 13:481-487
43. Saugstad OD (2006) Oxygen and retinopathy of prematurity. J Perinatol 26(Suppl 1):S46-S50
44. Garcia-Medina JJ, Pinazo-Duran MD, Garcia-Medina M, Zanon-Moreno V, Pons-Vazquez S (2011) A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy. Eur J Ophthalmol 21:637-643
45. Millen AE, Klein R, Folsom AR, Stevens J, Palta M, Mares JA (2004) Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study. Am J Clin Nutr 79:865-873 (Pubitemid 41103889)
46. Raju TN, Langenberg P, Bhutani V, Quinn GE (1997) Vitamin E prophylaxis to reduce retinopathy of prematurity: a reappraisal of published trials. J Pediatr 131:844-850 (Pubitemid 28027608)
47. Brion LP, Bell EF, Raghuveer TS (2003) Vitamin E supplementation for prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev 4:CD003665
48. Johnson L, Schaffer D, Quinn G, Goldstein D, Mathis MJ, Otis C, Boggs TR Jr (1982) Vitamin E supplementation and the retinopathy of prematurity. Ann N Y Acad Sci 393:473-495 (Pubitemid 13206932)
49. Dani C, Lori I, Favelli F, Frosini S, Messner H, Wanker P, De Marini S, Oretti C, Boldrini A, Massimiliano C, Bragetti P, Germini C (2012) Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study. J Matern Fetal Neonatal Med 25:523-527
50. Parad RB, Allred EN, Rosenfeld WN, Davis JM (2012) Reduction of retinopathy of prematurity in extremely low gestational age newborns treated with recombinant human Cu/Zn superoxide dismutase. Neonatology 102:139-144
51. Baumgartner WA (2000) Etiology, pathogenesis, and experimental treatment of retinitis pigmentosa. Med Hypotheses 54:814-824 (Pubitemid 30327673)
52. Hartong DT, Berson EL, Dryja TP (2006) Retinitis pigmentosa. Lancet 368:1795-1809 (Pubitemid 44739028)
53. Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C, Moser A, Brockhurst RJ, Hayes KC, Johnson CA, Anderson EJ, Gaudio AR, Willett WC, Schaefer EJ (2004) Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. Arch Ophthalmol 122:1306-1314 (Pubitemid 39180850)
54. Pasantes-Morales H, Quiroz H, Quesada O (2002) Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study. Metab Brain Dis 17:183-197 (Pubitemid 35034418)
55. Berson EL, Rosner B, Sandberg MA, Weigel-DiFranco C, Willett WC (2012) Omega-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. Arch Ophthalmol 130:707-711
56. Jacobson SG, Cideciyan AV (2010) Treatment possibilities for retinitis pigmentosa. N Engl J Med 363:1669-1671
57. Berson EL, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C, Willett W (1993) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch Ophthalmol 111:761-772 (Pubitemid 23170587)
58. Amza A, Goldschmidt P, Einterz E, Huguet P, Olmiere C, Bensaid P, Bella-Assumpta L (2010) Elimination of active trachoma after two topical mass treatments with azithromycin 1.5 % eye drops. PLoS Negl Trop Dis 4:e895
59. Katabarwa MN, Eyamba A, Nwane P, Enyong P, Kamgno J, Kuete T, Yaya S, Aboutou R, Mukenge L, Kafando C, Siaka C, Mkpouwoueiko S, Ngangue D, Biholong BD, Andze GO (2013) Fifteen years of annual mass treatment of onchocerciasis with ivermectin have not interrupted transmission in the west region of cameroon. J Parasitol Res 2013:420928
60. van Rooij J, Schwartzenberg SG, Mulder PG, Baarsma SG (1999) Oral vitamins C and E as additional treatment in patients with acute anterior uveitis: a randomised double masked study in 145 patients. Br J Ophthalmol 83:1277-1282 (Pubitemid 29511813)
61. Read RW (2006) Uveitis: advances in understanding of pathogenesis and treatment. Curr Rheumatol Rep 8:260-266 (Pubitemid 44623952)
62. Nussenblatt RB, Kim J, Thompson DJ, Davis MD, Chew E, Ferris FL, Buggage R (2006) Vitamin E in the treatment of uveitis-associated macular edema. Am J Ophthalmol 141:193-194 (Pubitemid 43016195)
63. Bartlett H, Eperjesi F (2003) Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic Physiol Opt 23:383-399 (Pubitemid 41711055)
64. Rathore M (2009) Nutrient content of important fruit trees from arid zone of Rajasthan. J Hortic For 1:103-108
65. Weller P, Breithaupt DE (2003) Identification and quantification of zeaxanthin esters in plants using liquid chromatography-mass spectrometry. J Agric Food Chem 51:7044-7049