Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma

Journal of Medicinal Food

Volumn 15, Issue 9, 2012, Pages 818-823

  Shim, Seong Hee ^a   Kim, Joon Mo ^a   Choi, Chul Young ^a   Kim, Chan Yun ^b   Park, Ki Ho ^c,d  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Seoul National University Biomedical Research Institute   (South Korea)

Author keywords

anthocyanins; antioxidants; bilberry; gingko

Indexed keywords

ANTHOCYANIN; GINKGO BILOBA EXTRACT; GLUCOSE;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; HUMAN; INTRAOCULAR PRESSURE; LOW TENSION GLAUCOMA; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; OPTIC NERVE INJURY; OUTCOME ASSESSMENT; PERIMETRY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TREATMENT DURATION; VISION; VISUAL ACUITY;

ADULT; AGED; AGED, 80 AND OVER; ANTHOCYANINS; ANTIOXIDANTS; DIETARY SUPPLEMENTS; FEMALE; FOLLOW-UP STUDIES; GINKGO BILOBA; HUMANS; LOW TENSION GLAUCOMA; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RETROSPECTIVE STUDIES; VACCINIUM MYRTILLUS; VISUAL ACUITY; VISUAL FIELDS; VISUAL PATHWAYS; YOUNG ADULT;

GINKGO (GENUS); GINKGO BILOBA; VACCINIUM MYRTILLUS;

EID: 84865695999     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.2241     Document Type: Article

References (49)

1. Levene RZ: Low tension glaucoma: a critical review and new material. Surv Ophthalmol 1980;24:621-664. (Pubitemid 10069333)
2. Coleman AL: Glaucoma. Lancet 1999;354:1803-1810.
3. Collaborative Normal-Tension Glaucoma Study Group: Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures [published erratum appears in Am J Ophthalmol 1999;127:120]. Am J Ophthalmol 1998;126: 487-497.
4. Anderson DR, Hendrickson A: Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest Ophthalmol 1974;13:771-783.
5. Lucas DR, Newhouse JP: The toxic effect of sodium L-glutamate on the inner layers of the retina. Arch Ophthalmol 1957;58:193-201.
6. Dreyer EB, Zurakowski D, Schumer RA, Podos SM, Lipton SA: Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol 1996;114:299-305. (Pubitemid 26086736)
7. Sucher NJ, Wong LA, Lipton SA: Redox modulation of NMDA receptor-mediated Ca2 + flux in mammalian central neurons. Neuroreport 1990;1:29-32.
8. Sucher NJ, Aizenmann E, Lipton SA: N-methyl-D-aspartate antagonists prevent kainite neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci 1991;11:966-971.
9. Siliprandi R, Canella R, Carmignoto G, et al.: N-methyl-Daspartate- induced neurotoxicity in the adult rat retina. Vis Neurosci 1992;8:567-573.
10. Flammer J, Orgul S, Costa VP, et al.: The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 2002;21:359-393. (Pubitemid 34879080)
11. Aslan M, Cort A, Yucel I: Oxidative and nitrative stress markers in glaucoma. Free Radic Biol Med 2008;45:367-376.
12. Wax MB, Barrett DA, Pestronk A: Increased incidence of paraproteinemia and autoantibodies in patients with normalpressure glaucoma. Am J Ophthalmol 1994;117:561-568. (Pubitemid 24150722)
13. Yan X, Tezel G, Wax MB, Edward DP: Matrix metalloproteinases and tumor necrosis factor alpha in glaucomatous optic nerve head. Arch Ophthalmol 2000;118:666-673. (Pubitemid 30327344)
14. Kleijnen J, Knipschild P: Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 1992;34:352-358.
15. No authors listed: Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 2001;6:500-504.
16. Head KA: Natural therapies for ocular disorders part two: cataracts and glaucoma. Altern Med Rev 2001;6:141-166. (Pubitemid 32323368)
17. Salvayre R, Braquet P, Perruchot T, Douste-Blazy L: Flavonoids and Bioflavonoids 1981. Elsevier Press, Amsterdam-Oxford-New York, 1982, pp. 437-442.
18. Harvsteen B: Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol 1983;32:1141-1148.
19. Gabor M: Pharmacologic effects of flavonoids on blood vessels. Angiologica 1972;9:355-374.
20. Mian E, Curri SB, Lietti A, Bombardelli E: Anthocyanosides and the walls of the microvessels: further aspects of the mechanism of action of their protective effect in syndromes due to abnormal capillary fragility. Minerva Med 1977;68:3565-3581. (Pubitemid 8226869)
21. Bottecchia D, Bettini V, Martino R, et al.: Preliminary reports on the inhibitory effect of Vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8. (Pubitemid 17086402)
22. Amella M, Bronner C, Briancon F, et al.: Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Med 1985;51:16-20. (Pubitemid 15146406)
23. Bever B, Zahnd G: Plants with oral hypoglycemic action. Quart J Crude Drug Res 1979;17:139-196.
24. Quaranta L, Bettelli S, Uva MG, et al.: Effect of Ginkgo biloba extract on preexisting visual field damage in normal tension glaucoma. Ophthalmology 2003;110:359-362. (Pubitemid 36184342)
25. Huang SY, Jeng C, Kao SC, Yu JJ, Liu DZ: Improved haemorrheological properties by Ginkgo biloba extract (Egb 761) in type 2 diabetes mellitus complicated with retinopathy. Clin Nutr 2004;23:615-621. (Pubitemid 39107040)
26. Smith SD, Katz J, Quigley HA: Analysis of progressive change in automated visual fields in glaucoma. Invest Ophthalmol Vis Sci 1996;37:1419-1428. (Pubitemid 26177317)
27. Holladay JT: Proper method for calculating average visual acuity. J Refract Surg 1997;13:388-391. (Pubitemid 27369067)
28. Colantuoni A, Bertuglia S, Magistretti MJ, Donato L: Effects of Vaccinium myrtillus anthocyanosides on arterial vasomotion. Arzneimittelforschung 1991;41:905-909.
29. Ghiringhelli C, Gregoratti L, Marastoni F: Capillarotropic activity of anthocyanosides in high doses in phlebopathic stasis. Minerva Cardioangiol 1978;26:255-276. (Pubitemid 8366881)
30. Bratman S, Kroll D: The Natural Pharmacist: Clinical Evaluation of Medicinal Herbs and Other Therapeutic Natural Products. Prima Publishing, Rocklin, CA, 1999.
31. Chung HS, Harris A, Kristinsson JK, et al.: Ginkgo biloba extract increases ocular blood flow velocity. J Ocul Pharmacol Ther 1999;15:233-240. (Pubitemid 29262980)
32. Lee DJ, Ahn HB, Rho SH: The effect of Ginkgo biloba to retinal microcirculation. J Korean Ophthalmol Soc 2002;43:1522-1527.
33. Park JW, Kwon HJ, Chung WS, Kim CY, Seong GJ: Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma. J Korean Ophthalmol Soc 2011;25:323-328.
34. Hassimotto NM, Lajolo FM: Antioxidant status in rats after longterm intake of anthocyanins and ellagitannins from blackberries. J Sci Food Agric 2011;91:523-531.
35. Stefanovits-Ba'nyai E, Szentmiha'lyi K, Hegedus A, et al.: Metal ion and antioxidant alterations in leaves between different sexes of Ginkgo biloba L. Life Sci 2006;78:1049-1056. (Pubitemid 43143461)
36. Eckert A, Keil U, Kressmann S, et al.: Effects of EGb 761 Ginkgo biloba extract on mitochondrial function and oxidative stress. Pharmacopsychiatry 2003;36(Suppl 1):S15-S23. (Pubitemid 37047004)
37. Eckert A, Keil U, Scherping I, Hauptmann S, Mu ller W: Stabilization of mitochondrial membrane potential and improvement of neuronal energy metabolism by Ginkgo biloba extract EGb 761. Ann NY Acad Sci 2005;1056:474-485. (Pubitemid 43031000)
38. Hirooka K, Tokuda M, Miyamoto O, et al.: The Ginkgo biloba extract (EGb 761) provides a neuroprotective effect on retinal ganglion cells in a rat model of chronic glaucoma. Curr Eye Res 2004;28:153-157. (Pubitemid 38365818)
39. Yan LJ, Droy-Lefaix MT, Packer L: Ginkgo biloba extract (EGb 761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem Biophys Res Commun 1995;212:360-366.
40. Le Bars PL, Katz MM, Berman N, et al.: A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American Study EGb Group. JAMA 1997;278: 1327-1332. (Pubitemid 27449692)
41. Stroman GA, Stewart WC, Golnik KC, Curé JK, Olinger RE: Magnetic resonance imaging in patients with low-tension glaucoma. Arch Ophthalmol 1995;113:168-172.
42. Kim M, Park KH, Kwon JW, et al.: Retinal nerve fiber layer defect and cerebral small vessel disease. Invest Ophthalmol Vis Sci 2011;52:6882-6886.
43. Ritch R: Potential role for Ginkgo biloba extract in the treatment of glaucoma. Med Hypotheses 2000;54:221-235. (Pubitemid 30170967)
44. Tsoyi K, Park HB, Kim YM, et al.: Anthocyanins from black soybean seed coats inhibit UVB-induced inflammatory cyclooxygenase- 2 gene expression and PGE2 production through regulation of the nuclear factor-kappaB and phosphatidylinositol 3-kinase/Akt pathway. J Agric Food Chem 2008;56:8969-8974.
45. Srivastava A, Akoh CC, Fischer J, Krewer G: Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. J Agric Food Chem 2007;55:3180-3185. (Pubitemid 46668332)
46. Pan MH, Ghai G, Ho CT: Food bioactives, apoptosis, and cancer. Mol Nutr Food Res 2008;52:43-52. (Pubitemid 351211801)
47. Lee J, Lee HK, Kim CY, et al.: Purified high-dose anthocyanoside oligomer administration improves nocturnal vision and clinical symptoms in myopia subjects. Br J Nutr 2005;93: 895-899. (Pubitemid 43899568)
48. McKenna DJ, Jones K, Hughes K: Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern Ther Health Med 2001;7:70-86.
49. Eandi M: Post marketing investigation on Tegens-preparation with respect to side effects. Unpublished results. Cited by: Morazzoni P, Bombardelli E: Vaccinium myrtillus. Fitoterapia 1996;67:3-29.