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Volumn 24, Issue 2, 2013, Pages 136-143

Glaucoma therapy and ocular surface disease: Current literature and recommendations

Author keywords

Benzalkonium Chloride; Glaucoma; Ocular Surface Disease; Preservatives; Recommendations

Indexed keywords

BENZALKONIUM CHLORIDE; BRIMONIDINE; COSOPT PF; DORZOLAMIDE PLUS TIMOLOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; LATANOPROST; POLIDRONIUM CHLORIDE; SOFZIA; TAFLUPROST; TIMOLOL; TRAVOPROST; UNCLASSIFIED DRUG;

EID: 84876210030     PISSN: 10408738     EISSN: 15317021     Source Type: Journal    
DOI: 10.1097/ICU.0b013e32835c8aba     Document Type: Review
Times cited : (83)

References (60)
  • 1
    • 80053299068 scopus 로고    scopus 로고
    • An assessment of the health and economic burdens of glaucoma
    • Varma R, Lee PP, Goldberg I, Kotak S. An assessment of the health and economic burdens of glaucoma. Am J Ophthalmol 2011; 152:515-522.
    • (2011) Am J Ophthalmol , vol.152 , pp. 515-522
    • Varma, R.1    Lee, P.P.2    Goldberg, I.3    Kotak, S.4
  • 2
    • 34548774065 scopus 로고    scopus 로고
    • Adherence in glaucoma: Objective measurements of once-daily and adjunctive medication use
    • Robin AL, Novack GD, Covert DW, et al. Adherence in glaucoma: objective measurements of once-daily and adjunctive medication use. Am J Ophthalmol 2007; 144:533-540.
    • (2007) Am J Ophthalmol , vol.144 , pp. 533-540
    • Robin, A.L.1    Novack, G.D.2    Covert, D.W.3
  • 3
    • 57149134057 scopus 로고    scopus 로고
    • Prevalence of ocular surface disease in glaucoma patients
    • Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J Glaucoma 2008; 17:350-355.
    • (2008) J Glaucoma , vol.17 , pp. 350-355
    • Leung, E.W.1    Medeiros, F.A.2    Weinreb, R.N.3
  • 4
    • 83555164899 scopus 로고    scopus 로고
    • Ocular surface disease and quality of life in patients with glaucoma
    • Assessed the quality of life in patients with OSD and glaucoma. This study was able to demonstrate a poorer quality of life in glaucoma patients with OSD with statistical significance. Furthermore, predictors of OSD in these patients were identified
    • Skalicky SE, Goldberg I, McCluskey P. Ocular surface disease and quality of life in patients with glaucoma. Am J Ophthalmol 2012; 153:1-9. Assessed the quality of life in patients with OSD and glaucoma. This study was able to demonstrate a poorer quality of life in glaucoma patients with OSD with statistical significance. Furthermore, predictors of OSD in these patients were identified.
    • (2012) Am J Ophthalmol , vol.153 , pp. 1-9
    • Skalicky, S.E.1    Goldberg, I.2    McCluskey, P.3
  • 5
    • 77952956785 scopus 로고    scopus 로고
    • Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressurelowering medications
    • Fechtner RD, Godfrey DG, Budenz D, et al. Prevalence of ocular surface complaints in patients with glaucoma using topical intraocular pressurelowering medications. Cornea 2010; 29:618-621.
    • (2010) Cornea , vol.29 , pp. 618-621
    • Fechtner, R.D.1    Godfrey, D.G.2    Budenz, D.3
  • 6
    • 79953183017 scopus 로고    scopus 로고
    • Effects of common topical antiglaucoma medications on the ocular surface, eyelids and periorbital tissue
    • Servat JJ, Bernardino CR. Effects of common topical antiglaucoma medications on the ocular surface, eyelids and periorbital tissue. Drugs Aging 2011; 28:267-282.
    • (2011) Drugs Aging , vol.28 , pp. 267-282
    • Servat, J.J.1    Bernardino, C.R.2
  • 8
    • 0025763133 scopus 로고
    • Long-term treatment with pilogel/beta-blocker in glaucoma patients
    • Maas S, Ros FE, De Heer LJ, De Keizer RJ. Long-term treatment with Pilogel/beta-blocker in glaucoma patients. Int Ophthalmol 1991; 15:281-284.
    • (1991) Int Ophthalmol , vol.15 , pp. 281-284
    • Maas, S.1    Ros, F.E.2    De Heer, L.J.3    De Keizer, R.J.4
  • 9
    • 84855462450 scopus 로고    scopus 로고
    • Long-term effect of bak-free travoprost on ocular surface and intraocular pressure in glaucoma patients after transition from latanoprost
    • This crossover study evaluated SPK in patients who were transitioned to preservative-free therapy who were followed up to 12 months
    • Aihara M, Otani S, Kozaki J, et al. Long-term effect of BAK-free travoprost on ocular surface and intraocular pressure in glaucoma patients after transition from latanoprost. J Glaucoma 2012; 21:60-64. This crossover study evaluated SPK in patients who were transitioned to preservative-free therapy who were followed up to 12 months.
    • (2012) J Glaucoma , vol.21 , pp. 60-64
    • Aihara, M.1    Otani, S.2    Kozaki, J.3
  • 10
    • 0344305392 scopus 로고    scopus 로고
    • Ocular factors relevant to antiglaucomatous eyedrop-related keratoepitheliopathy
    • Inoue K, Okugawa K, Kato S, et al. Ocular factors relevant to antiglaucomatous eyedrop-related keratoepitheliopathy. J Glaucoma 2003; 12:480-485.
    • (2003) J Glaucoma , vol.12 , pp. 480-485
    • Inoue, K.1    Okugawa, K.2    Kato, S.3
  • 11
    • 34447129594 scopus 로고    scopus 로고
    • Ocular symptoms and signs with preserved and preservative-free glaucoma medications
    • Jaenen N, Baudouin C, Pouliquen P, et al. Ocular symptoms and signs with preserved and preservative-free glaucoma medications. Eur J Ophthalmol 2007; 17:341-349.
    • (2007) Eur J Ophthalmol , vol.17 , pp. 341-349
    • Jaenen, N.1    Baudouin, C.2    Pouliquen, P.3
  • 12
    • 0036222151 scopus 로고    scopus 로고
    • Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication
    • Pisella PJ, Pouliquen P, Baudouin C. Prevalence of ocular symptoms and signs with preserved and preservative free glaucoma medication. Br J Ophthalmol 2002; 86:418-423.
    • (2002) Br J Ophthalmol , vol.86 , pp. 418-423
    • Pisella, P.J.1    Pouliquen, P.2    Baudouin, C.3
  • 14
    • 84866344918 scopus 로고    scopus 로고
    • Effects of long-term topical antiglaucoma medications on meibomian glands
    • This study assessed abnormal meibomian gland function and morphology in addition to tear-film abnormalities in patients on long-term glaucoma therapy
    • Arita R, Itoh K, Maeda S, et al. Effects of long-term topical antiglaucoma medications on meibomian glands. Graefes Arch Clin Exp Ophthalmol 2012; 250:1181-1185. This study assessed abnormal meibomian gland function and morphology in addition to tear-film abnormalities in patients on long-term glaucoma therapy.
    • (2012) Graefes Arch Clin Exp Ophthalmol , vol.250 , pp. 1181-1185
    • Arita, R.1    Itoh, K.2    Maeda, S.3
  • 15
    • 84867395622 scopus 로고    scopus 로고
    • Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands
    • Arita R, Itoh K, Maeda S, et al. Comparison of the long-term effects of various topical antiglaucoma medications on meibomian glands. Cornea 2012; 31:1229-1234.
    • (2012) Cornea , vol.31 , pp. 1229-1234
    • Arita, R.1    Itoh, K.2    Maeda, S.3
  • 16
    • 0026710222 scopus 로고
    • Ocular surface alteration after long-term treatment with an antiglaucomatous drug
    • Herreras JM, Pastor JC, Calonge M, Asensio VM. Ocular surface alteration after long-term treatment with an antiglaucomatous drug. Ophthalmology 1992; 99:1082-1088.
    • (1992) Ophthalmology , vol.99 , pp. 1082-1088
    • Herreras, J.M.1    Pastor, J.C.2    Calonge, M.3    Asensio, V.M.4
  • 17
    • 79956355134 scopus 로고    scopus 로고
    • Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects
    • Terai N, Muller-Holz M, Spoerl E, Pillunat LE. Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects. Clin Ophthalmol 2011; 5:517-525.
    • (2011) Clin Ophthalmol , vol.5 , pp. 517-525
    • Terai, N.1    Muller-Holz, M.2    Spoerl, E.3    Pillunat, L.E.4
  • 18
    • 84857015690 scopus 로고    scopus 로고
    • Effects of preservative-free tafluprost on tear film osmolarity, tolerability, and intraocular pressure in previously treated patients with open-angle glaucoma
    • This crossover study measured tear-film parameters in patients transitioned to preservative-free therapy. Hyperosmolarity, which is difficult to monitor clinically, was notably included in this study
    • Januleviciene I, Derkac I, Grybauskiene L, et al. Effects of preservative-free tafluprost on tear film osmolarity, tolerability, and intraocular pressure in previously treated patients with open-angle glaucoma. Clin Ophthalmol 2012; 6:103-109. This crossover study measured tear-film parameters in patients transitioned to preservative-free therapy. Hyperosmolarity, which is difficult to monitor clinically, was notably included in this study.
    • (2012) Clin Ophthalmol , vol.6 , pp. 103-109
    • Januleviciene, I.1    Derkac, I.2    Grybauskiene, L.3
  • 19
    • 34347243555 scopus 로고    scopus 로고
    • Definition and classification subcommittee of the international dry eye work shop. The definition and classification of dry eye disease: Report of the definition and classification subcommittee of the international dry eye work shop (2007)
    • Definition and Classification Subcommittee of the International Dry Eye Work Shop. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye Work Shop (2007). Ocul Surf 2007; 5:75-92.
    • (2007) Ocul Surf , vol.5 , pp. 75-92
  • 20
    • 25144432279 scopus 로고    scopus 로고
    • Allergic reaction to topical eyedrops
    • Baudouin C. Allergic reaction to topical eyedrops. Curr Opin Allergy Clin Immunol 2005; 5:459-463.
    • (2005) Curr Opin Allergy Clin Immunol , vol.5 , pp. 459-463
    • Baudouin, C.1
  • 21
    • 77953359918 scopus 로고    scopus 로고
    • Preservatives in eyedrops: The good, the bad and the ugly
    • Baudouin C, Labbe A, Liang H, et al. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res 2010; 29:312-334.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 312-334
    • Baudouin, C.1    Labbe, A.2    Liang, H.3
  • 24
    • 33845682137 scopus 로고    scopus 로고
    • Allergic contact dermatitis due to beta-blockers in eye drops: A retrospective analysis of multicentre surveillance data 1993-2004
    • Jappe U, Uter W, Menezes de Padua CA, et al. Allergic contact dermatitis due to beta-blockers in eye drops: a retrospective analysis of multicentre surveillance data 1993-2004. Acta Derm Venereol 2006; 86:509-514.
    • (2006) Acta Derm Venereol , vol.86 , pp. 509-514
    • Jappe, U.1    Uter, W.2    Menezes De Padua, C.A.3
  • 25
    • 0032901575 scopus 로고    scopus 로고
    • Brimonidine tartrate 0.2% twice daily vs timolol 0.5% twice daily:1-year results in glaucoma patients. Brimonidine study group
    • Katz LJ. Brimonidine tartrate 0.2% twice daily vs timolol 0.5% twice daily:1-year results in glaucoma patients. Brimonidine Study Group. Am J Ophthalmol 1999; 127:20-26.
    • (1999) Am J Ophthalmol , vol.127 , pp. 20-26
    • Katz, L.J.1
  • 26
    • 0030877607 scopus 로고    scopus 로고
    • A1-year study of brimonidine twice daily in glaucoma and ocular hypertension. A controlled, randomized, multicenter clinical trial. Chronic brimonidine study group
    • Schuman JS, Horwitz B, Choplin NT, et al. A1-year study of brimonidine twice daily in glaucoma and ocular hypertension. A controlled, randomized, multicenter clinical trial. Chronic Brimonidine Study Group. Arch Ophthalmol 1997; 115:847-852.
    • (1997) Arch Ophthalmol , vol.115 , pp. 847-852
    • Schuman, J.S.1    Horwitz, B.2    Choplin, N.T.3
  • 27
    • 0346157379 scopus 로고    scopus 로고
    • Mucous membrane pemphigoid and pseudopemphigoid
    • Thorne JE, Anhalt GJ, Jabs DA. Mucous membrane pemphigoid and pseudopemphigoid. Ophthalmology 2004; 111:45-52.
    • (2004) Ophthalmology , vol.111 , pp. 45-52
    • Thorne, J.E.1    Anhalt, G.J.2    Jabs, D.A.3
  • 28
    • 0036176650 scopus 로고    scopus 로고
    • Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma
    • Kroll DM, Schuman JS. Reactivation of herpes simplex virus keratitis after initiating bimatoprost treatment for glaucoma. Am J Ophthalmol 2002; 133:401-403.
    • (2002) Am J Ophthalmol , vol.133 , pp. 401-403
    • Kroll, D.M.1    Schuman, J.S.2
  • 30
    • 0036512438 scopus 로고    scopus 로고
    • Corneal decompensation in patients with endothelial compromise treated with topical dorzolamide
    • Domingo Gordo B, Urcelay Segura JL, Conejero Arroyo J, et al. Corneal decompensation in patients with endothelial compromise treated with topical dorzolamide. Arch Soc Esp Oftalmol 2002; 77:139-144.
    • (2002) Arch Soc Esp Oftalmol , vol.77 , pp. 139-144
    • Domingo Gordo, B.1    Urcelay Segura, J.L.2    Conejero Arroyo, J.3
  • 31
    • 0033119461 scopus 로고    scopus 로고
    • Irreversible corneal decompensation in patients treated with topical dorzolamide
    • Konowal A, Morrison JC, Brown SV, et al. Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol 1999; 127: 403-406.
    • (1999) Am J Ophthalmol , vol.127 , pp. 403-406
    • Konowal, A.1    Morrison, J.C.2    Brown, S.V.3
  • 32
    • 80051771373 scopus 로고    scopus 로고
    • Preservative use in topical glaucoma medications
    • Tressler CS, Beatty R, Lemp MA. Preservative use in topical glaucoma medications. Ocul Surf 2011; 9:140-158.
    • (2011) Ocul Surf , vol.9 , pp. 140-158
    • Tressler, C.S.1    Beatty, R.2    Lemp, M.A.3
  • 33
    • 84863305056 scopus 로고    scopus 로고
    • The preservative polyquaternium-1 increases cytoxicity and nf-kappab linked inflammation in human corneal epithelial cells
    • Paimela T, Ryhanen T, Kauppinen A, et al. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis 2012; 18:1189-1196.
    • (2012) Mol Vis , vol.18 , pp. 1189-1196
    • Paimela, T.1    Ryhanen, T.2    Kauppinen, A.3
  • 34
    • 84860850886 scopus 로고    scopus 로고
    • Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro
    • This in-vitro study demonstrated the importance of hyperosmolarity in corneal and conjunctival toxicity
    • Clouzeau C, Godefroy D, Riancho L, et al. Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro. Mol Vis 2012; 18:851-863. This in-vitro study demonstrated the importance of hyperosmolarity in corneal and conjunctival toxicity.
    • (2012) Mol Vis , vol.18 , pp. 851-863
    • Clouzeau, C.1    Godefroy, D.2    Riancho, L.3
  • 35
    • 84856120314 scopus 로고    scopus 로고
    • The cytotoxic effects of preserved and preservative-free prostaglandin analogs on human corneal and conjunctival epithelium in vitro and the distribution of benzalkonium chloride homologs in ocular surface tissues in vivo
    • Pellinen P, Huhtala A, Tolonen A, et al. The cytotoxic effects of preserved and preservative-free prostaglandin analogs on human corneal and conjunctival epithelium in vitro and the distribution of benzalkonium chloride homologs in ocular surface tissues in vivo. Curr Eye Res 2012; 37:145-154.
    • (2012) Curr Eye Res , vol.37 , pp. 145-154
    • Pellinen, P.1    Huhtala, A.2    Tolonen, A.3
  • 36
    • 80755136762 scopus 로고    scopus 로고
    • Role of benzalkonium chloride in dna strand breaks in human corneal epithelial cells
    • This study provided one molecular mechanism to benzalkonium chloride toxicity by evaluating single-and double-stranded DNA breaks from exposure
    • Ye J, Wu H, Zhang H, et al. Role of benzalkonium chloride in DNA strand breaks in human corneal epithelial cells. Graefes Arch Clin Exp Ophthalmol 2011; 249:1681-1687. This study provided one molecular mechanism to benzalkonium chloride toxicity by evaluating single-and double-stranded DNA breaks from exposure.
    • (2011) Graefes Arch Clin Exp Ophthalmol , vol.249 , pp. 1681-1687
    • Ye, J.1    Wu, H.2    Zhang, H.3
  • 37
    • 80053279479 scopus 로고    scopus 로고
    • Effects of glaucoma medications and preservatives on cultured human trabecular meshwork and nonpigmented ciliary epithelial cell lines
    • Ammar DA, Kahook MY. Effects of glaucoma medications and preservatives on cultured human trabecular meshwork and nonpigmented ciliary epithelial cell lines. Br J Ophthalmol 2011; 95:1466-1469.
    • (2011) Br J Ophthalmol , vol.95 , pp. 1466-1469
    • Ammar, D.A.1    Kahook, M.Y.2
  • 38
    • 79960727543 scopus 로고    scopus 로고
    • Effects of benzalkonium chloride-or polyquadpreserved fixed combination glaucoma medications on human trabecular meshwork cells
    • Ammar DA, Kahook MY. Effects of benzalkonium chloride-or polyquadpreserved fixed combination glaucoma medications on human trabecular meshwork cells. Mol Vis 2011; 17:1806-1813.
    • (2011) Mol Vis , vol.17 , pp. 1806-1813
    • Ammar, D.A.1    Kahook, M.Y.2
  • 39
    • 79956363646 scopus 로고    scopus 로고
    • Toxicological evaluation of preservativecontaining and preservative-free topical prostaglandin analogues on a threedimensional-reconstituted corneal epithelium system
    • Liang H, Pauly A, Riancho L, et al. Toxicological evaluation of preservativecontaining and preservative-free topical prostaglandin analogues on a threedimensional-reconstituted corneal epithelium system. Br J Ophthalmol 2011; 95:869-875.
    • (2011) Br J Ophthalmol , vol.95 , pp. 869-875
    • Liang, H.1    Pauly, A.2    Riancho, L.3
  • 40
    • 79958206256 scopus 로고    scopus 로고
    • Effects of benzalkonium chloride-and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells
    • This in-vitro study compared multiple preservative (benzalkonium chloride, Polyquad, and SofZia) toxicity in corneal and conjunctival epithelial cells
    • Ammar DA, Noecker RJ, Kahook MY. Effects of benzalkonium chloride-and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells. Adv Ther 2011; 28:501-510. This in-vitro study compared multiple preservative (benzalkonium chloride, Polyquad, and SofZia) toxicity in corneal and conjunctival epithelial cells.
    • (2011) Adv Ther , vol.28 , pp. 501-510
    • Ammar, D.A.1    Noecker, R.J.2    Kahook, M.Y.3
  • 41
    • 84863348090 scopus 로고    scopus 로고
    • Research on the stability of a rabbit dry eye model induced by topical application of the preservative benzalkonium chloride
    • This in-vivo study simulated the additive and prolonged exposure of benzalkonium chloride and measured tear film and cell morphology abnormalities
    • Li C, Song Y, Luan S, et al. Research on the stability of a rabbit dry eye model induced by topical application of the preservative benzalkonium chloride. PLoS One 2012; 7:e33688. This in-vivo study simulated the additive and prolonged exposure of benzalkonium chloride and measured tear film and cell morphology abnormalities.
    • (2012) PLoS One , vol.7
    • Li, C.1    Song, Y.2    Luan, S.3
  • 42
    • 84862639350 scopus 로고    scopus 로고
    • Corneal neurotoxicity due to topical benzalkonium chloride
    • This animal study evaluated benzalkonium chloride corneal neurotoxicity and subsequent patterns of nerve fiber regrowth during recovery
    • Sarkar J, Chaudhary S, Namavari A, et al. Corneal neurotoxicity due to topical benzalkonium chloride. Invest Ophthalmol Vis Sci 2012; 53:1792-1802. This animal study evaluated benzalkonium chloride corneal neurotoxicity and subsequent patterns of nerve fiber regrowth during recovery.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 1792-1802
    • Sarkar, J.1    Chaudhary, S.2    Namavari, A.3
  • 43
    • 80054861741 scopus 로고    scopus 로고
    • Polyoxyethylene hydrogenated castor oil modulates benzalkonium chloride toxicity: Comparison of acute corneal barrier dysfunction induced by travoprost z and travoprost
    • Uematsu M, Kumagami T, Shimoda K, et al. Polyoxyethylene hydrogenated castor oil modulates benzalkonium chloride toxicity: comparison of acute corneal barrier dysfunction induced by travoprost Z and travoprost. J Ocul Pharmacol Ther 2011; 27:437-444.
    • (2011) J Ocul Pharmacol Ther , vol.27 , pp. 437-444
    • Uematsu, M.1    Kumagami, T.2    Shimoda, K.3
  • 44
    • 79960032358 scopus 로고    scopus 로고
    • Effects of benzalkonium chloride on the ocular surface of the rabbit
    • Kim JR, Oh TH, Kim HS. Effects of benzalkonium chloride on the ocular surface of the rabbit. Jpn J Ophthalmol 2011; 55:283-293.
    • (2011) Jpn J Ophthalmol , vol.55 , pp. 283-293
    • Kim, J.R.1    Oh, T.H.2    Kim, H.S.3
  • 45
    • 79958184765 scopus 로고    scopus 로고
    • Polyquad-preserved travoprost/timolol, benzalkonium chloride (bak)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: A rabbit ocular surface study
    • Liang H, Brignole-Baudouin F, Pauly A, et al. Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: a rabbit ocular surface study. Adv Ther 2011; 28:311-325.
    • (2011) Adv Ther , vol.28 , pp. 311-325
    • Liang, H.1    Brignole-Baudouin, F.2    Pauly, A.3
  • 46
    • 33847414439 scopus 로고    scopus 로고
    • The dilution of benzalkonium chloride (bak) in the tear film
    • Friedlaender MH, Breshears D, Amoozgar B, et al. The dilution of benzalkonium chloride (BAK) in the tear film. Adv Ther 2006; 23:835-841.
    • (2006) Adv Ther , vol.23 , pp. 835-841
    • Friedlaender, M.H.1    Breshears, D.2    Amoozgar, B.3
  • 47
    • 0016512985 scopus 로고
    • Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy
    • Tonjum AM. Effects of benzalkonium chloride upon the corneal epithelium studied with scanning electron microscopy. Acta Ophthalmol (Copenh) 1975; 53:358-366.
    • (1975) Acta Ophthalmol (Copenh) , vol.53 , pp. 358-366
    • Tonjum, A.M.1
  • 48
    • 78649320252 scopus 로고    scopus 로고
    • Effects of benzalkonium chloridepreserved, polyquad-preserved, and sofzia-preserved topical glaucoma medications on human ocular epithelial cells
    • Ammar DA, Noecker RJ, Kahook MY. Effects of benzalkonium chloridepreserved, polyquad-preserved, and sofZia-preserved topical glaucoma medications on human ocular epithelial cells. Adv Ther 2010; 27:837-845.
    • (2010) Adv Ther , vol.27 , pp. 837-845
    • Ammar, D.A.1    Noecker, R.J.2    Kahook, M.Y.3
  • 49
    • 79955111191 scopus 로고    scopus 로고
    • Tear osmolarity in the diagnosis and management of dry eye disease
    • e791
    • Lemp MA, Bron AJ, Baudouin C, et al. Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 2011; 151:792-798; e791.
    • (2011) Am J Ophthalmol , vol.151 , pp. 792-798
    • Lemp, M.A.1    Bron, A.J.2    Baudouin, C.3
  • 50
    • 62649134213 scopus 로고    scopus 로고
    • An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology
    • e721
    • Martone G, Frezzotti P, Tosi GM, et al. An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology. Am J Ophthalmol 2009; 147:725-735; e721.
    • (2009) Am J Ophthalmol , vol.147 , pp. 725-735
    • Martone, G.1    Frezzotti, P.2    Tosi, G.M.3
  • 51
    • 78650694957 scopus 로고    scopus 로고
    • Toxicity of antiglaucoma drugs with and without benzalkonium chloride to cultured human corneal endothelial cells
    • Ayaki M, Iwasawa A, Inoue Y. Toxicity of antiglaucoma drugs with and without benzalkonium chloride to cultured human corneal endothelial cells. Clin Ophthalmol 2010; 4:1217-1222.
    • (2010) Clin Ophthalmol , vol.4 , pp. 1217-1222
    • Ayaki, M.1    Iwasawa, A.2    Inoue, Y.3
  • 52
    • 84860484141 scopus 로고    scopus 로고
    • Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: A randomized clinical trial
    • This clinical study demonstrated a novel clinical manifestation of benzalkonium chloride. Inflammatory changes in the anterior chamber from benzalkonium chloride were compared with the fellow eye using a flare meter
    • Stevens AM, Kestelyn PA, De Bacquer D, Kestelyn PG. Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial. Acta Ophthalmol 2012; 90:e221-e224. This clinical study demonstrated a novel clinical manifestation of benzalkonium chloride. Inflammatory changes in the anterior chamber from benzalkonium chloride were compared with the fellow eye using a flare meter.
    • (2012) Acta Ophthalmol , vol.90
    • Stevens, A.M.1    Kestelyn, P.A.2    De Bacquer, D.3    Kestelyn, P.G.4
  • 53
    • 80054794909 scopus 로고    scopus 로고
    • Comparison of a travoprost bak-free formulation preserved with polyquaternium-1 with bak-preserved travoprost in ocular hypertension or open-angle glaucoma
    • This crossover clinical study is one of the more recent trials that did not find changes in OSD in patients after switching to benzalkonium chloride-free therapy
    • Gandolfi S, Paredes T, Goldberg I, et al. Comparison of a travoprost BAK-free formulation preserved with polyquaternium-1 with BAK-preserved travoprost in ocular hypertension or open-angle glaucoma. Eur J Ophthalmol 2012; 22:34-44. This crossover clinical study is one of the more recent trials that did not find changes in OSD in patients after switching to benzalkonium chloride-free therapy.
    • (2012) Eur J Ophthalmol , vol.22 , pp. 34-44
    • Gandolfi, S.1    Paredes, T.2    Goldberg, I.3
  • 54
    • 80052623756 scopus 로고    scopus 로고
    • Travoprost 0.004%/timolol 0.5%-fixed combination with and without benzalkonium chloride: A prospective, randomized, doubled-masked comparison of safety and efficacy
    • Kitazawa Y, Smith P, Sasaki N, et al. Travoprost 0.004%/timolol 0.5%-fixed combination with and without benzalkonium chloride: a prospective, randomized, doubled-masked comparison of safety and efficacy. Eye (Lond) 2011; 25:1161-1169.
    • (2011) Eye (Lond) , vol.25 , pp. 1161-1169
    • Kitazawa, Y.1    Smith, P.2    Sasaki, N.3
  • 55
    • 77951758581 scopus 로고    scopus 로고
    • Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication
    • Uusitalo H, Chen E, Pfeiffer N, et al. Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol 2010; 88:329-336.
    • (2010) Acta Ophthalmol , vol.88 , pp. 329-336
    • Uusitalo, H.1    Chen, E.2    Pfeiffer, N.3
  • 56
    • 78649694589 scopus 로고    scopus 로고
    • Efficacy and tolerability of preservativefree eye drops containing a fixed combination of dorzolamide and timolol in glaucoma patients
    • Renieri G, Fuhrer K, Scheithe K, et al. Efficacy and tolerability of preservativefree eye drops containing a fixed combination of dorzolamide and timolol in glaucoma patients. J Ocul Pharmacol Ther 2010; 26:597-603.
    • (2010) J Ocul Pharmacol Ther , vol.26 , pp. 597-603
    • Renieri, G.1    Fuhrer, K.2    Scheithe, K.3
  • 57
    • 77954208628 scopus 로고    scopus 로고
    • Ocular surface tolerability of prostaglandin analogs in patients with glaucoma or ocular hypertension
    • Whitson JT, Trattler WB, Matossian C, et al. Ocular surface tolerability of prostaglandin analogs in patients with glaucoma or ocular hypertension. J Ocul Pharmacol Ther 2010; 26:287-292.
    • (2010) J Ocul Pharmacol Ther , vol.26 , pp. 287-292
    • Whitson, J.T.1    Trattler, W.B.2    Matossian, C.3
  • 58
    • 78650682979 scopus 로고    scopus 로고
    • Ocular surface disease in patients with glaucoma or ocular hypertension treated with either bakpreserved latanoprost or bak-free travoprost
    • Katz G, Springs CL, Craven ER, Montecchi-Palmer M. Ocular surface disease in patients with glaucoma or ocular hypertension treated with either BAKpreserved latanoprost or BAK-free travoprost. Clin Ophthalmol 2010; 4:1253-1261.
    • (2010) Clin Ophthalmol , vol.4 , pp. 1253-1261
    • Katz, G.1    Springs, C.L.2    Craven, E.R.3    Montecchi-Palmer, M.4
  • 59
    • 84862783754 scopus 로고    scopus 로고
    • Impact of ocular surface symptoms on quality of life in a united states veterans affairs population
    • e1063
    • Pouyeh B, Viteri E, Feuer W, et al. Impact of ocular surface symptoms on quality of life in a United States veterans affairs population. Am J Ophthalmol 2012; 153:1061-1066; e1063.
    • (2012) Am J Ophthalmol , vol.153 , pp. 1061-1066
    • Pouyeh, B.1    Viteri, E.2    Feuer, W.3
  • 60
    • 68149132520 scopus 로고    scopus 로고
    • Dry eye syndrome-related quality of life in glaucoma patients
    • Rossi GC, Tinelli C, Pasinetti GM, et al. Dry eye syndrome-related quality of life in glaucoma patients. Eur J Ophthalmol 2009; 19:572-579.
    • (2009) Eur J Ophthalmol , vol.19 , pp. 572-579
    • Rossi, G.C.1    Tinelli, C.2    Pasinetti, G.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.