Dexamethasone inhibits inflammation and cartilage damage in a new model of post-traumatic osteoarthritis

Journal of Orthopaedic Research

Volumn 32, Issue 4, 2014, Pages 566-572

  Huebner, Kyla D ^a,b   Shrive, Nigel G ^a,b   Frank, Cyril B ^a,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c FOOTHILLS HOSPITAL   (Canada)

Author keywords

cartilage; corticosteroids; dexamethasone; knee; OA

Indexed keywords

CARTILAGE; CORTICOSTEROIDS; DEXAMETHASONE; KNEE; OA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; FEMALE; INJECTIONS, INTRA-ARTICULAR; LEG INJURIES; OSTEOARTHRITIS; RABBITS; RANDOM ALLOCATION; REAL-TIME POLYMERASE CHAIN REACTION; SYNOVIAL MEMBRANE;

EID: 84893873401     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22568     Document Type: Article

References (35)

1. The Arthritis Foundation. [cited 2012; Available from: http://www.arthritis.org/what-is-osteoarthritis.php
2. The Arthritis Society [Cited 2013; Available from: http://arthritis.ca/ page.aspx?pid=6225 Facts and Figures Factsheet
3. Daniel DM, Stone ML, Dobson BE, et al. 1994. Fate of the ACL-injured patient. A prospective outcome study. Am J Sports Med 22: 632-644. (Pubitemid 24280036)
4. Ringdahl E, Pandit S., 2011. Treatment of knee osteoarthritis. Am Fam Physician 83: 1287-1292.
5. Joyce DA, Steer JH, Kloda A., 1996. Dexamethasone antagonizes IL-4 and IL-10-induced release of IL-1RA by monocytes but augments IL-4-, IL-10-, and TGF-beta-induced suppression of TNF-alpha release. J Interferon Cytokine Res 16: 511-517. (Pubitemid 26306952)
6. Brattsand R, Linden M., 1996. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment Pharmacol Ther 10: 81-90; discussion 1-2. (Pubitemid 26341300)
7. Stove J, Schoniger R, Huch K, et al. 2002. Effects of dexamethasone on proteoglycan content and gene expression of IL-1beta-stimulated osteoarthrotic chondrocytes in vitro. Acta Orthop Scand 73: 562-567. (Pubitemid 35252466)
8. Lu YC, Evans CH, Grodzinsky AJ., 2011. Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. Arthritis Res Ther 13: R142.
9. Huebner KD, Shrive NG, Frank CB., 2013. New surgical model of post-traumatic osteoarthritis: isolated intra-articular bone injury in the rabbit. J Orthop Res 31: 914-920.
10. Kydd AS, Reno C, Sorbetti JM, et al. 2005. Influence of a single systemic corticosteroid injection on mRNA levels for a subset of genes in connective tissues of the rabbit knee: a comparison of steroid types and effect of skeletal maturity. J Rheumatol 32: 307-319. (Pubitemid 40209131)
11. Caparroz-Assef SM, Bersani-Amado CA, Kelmer-Bracht AM, et al. 2007. The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat. Mol Cell Biochem 302: 87-98. (Pubitemid 47202324)
12. Reno C, Marchuk L, Sciore P, et al. 1997. Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues. Biotechniques 22: 1082-1086. (Pubitemid 27248981)
13. Huebner KD, O'Brien EJ, Heard BJ, et al. 2012. Post-natal molecular adaptations in anteromedial and posterolateral bundles of the ovine anterior cruciate ligament: one structure with two parts or two distinct ligaments ? Connect Tissue Res 53: 277-284.
14. Cederlof S, Jonson G., 1966. Intraarticular prednisolone injection for osteoarthritis of the knee. A double blind test with placebo. Acta Chir Scand 132: 532-537.
15. Hochberg MC, Altman RD, April KT, et al. 2012. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 64: 465-474.
16. Akinbo SR, Aiyejusunle CB, Akinyemi OA, et al. 2007. Comparison of the therapeutic efficacy of phonophoresis and iontophoresis using dexamethasone sodium phosphate in the management of patients with knee osteoarthritis. Niger Postgrad Med J 14: 190-194.
17. Shrader MW, Draganich LF, Pottenger LA, et al. 2004. Effects of knee pain relief in osteoarthritis on gait and stair-stepping. Clin Orthop Relat Res 188-193. (Pubitemid 38579737)
18. Hepper CT, Halvorson JJ, Duncan ST, et al. 2009. The efficacy and duration of intra-articular corticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg 17: 638-646.
19. Malfait AM, Tortorella M, Thompson J, et al. 2009. Intra-articular injection of tumor necrosis factor-alpha in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation. Osteoarthritis Cartilage 17: 627-635.
20. Guerne PA, Desgeorges A, Jaspar JM, et al. 1999. Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone. Matrix Biol 18: 253-260. (Pubitemid 29324740)
21. Livne E, Weiss A, Silbermann M., 1989. Articular chondrocytes lose their proliferative activity with aging yet can be restimulated by PTH-(1-84), PGE1, and dexamethasone. J Bone Miner Res 4: 539-548. (Pubitemid 19224554)
22. Braun HJ, Wilcox-Fogel N, Kim HJ, et al. 2012. The effect of local anesthetic and corticosteroid combinations on chondrocyte viability. Knee Surg Sports Traumatol Arthrosc 20: 1689-1695.
23. Dragoo JL, Danial CM, Braun HJ, et al. 2012. The chondrotoxicity of single-dose corticosteroids. Knee Surg Sports Traumatol Arthrosc 20: 1809-1814.
24. Vento R, Torregrossa MV, Guiliano M, et al. 1990. Effects of dexamethasone on human synovial fibroblast-like cells, from osteoarthritic joints, in culture. Life Sci 47: 2199-2205.
25. Achari Y, Reno CR, Frank CB, et al. 2012. Carrageenan-induced transient inflammation in a rabbit knee model: molecular changes consistent with an early osteoarthritis phenotype. Inflamm Res 61: 907-914.
26. Crofford LJ, Wilder RL, Ristimaki AP, et al. 1994. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 93: 1095-1101.
27. DiBattista JA, Martel-Pelletier J, Wosu LO, et al. 1991. Glucocorticoid receptor mediated inhibition of interleukin-1 stimulated neutral metalloprotease synthesis in normal human chondrocytes. J Clin Endocrinol Metab 72: 316-326. (Pubitemid 21921694)
28. Kubota E, Imamura H, Kubota T, et al. 1997. Interleukin 1 beta and stromelysin (MMP3) activity of synovial fluid as possible markers of osteoarthritis in the temporomandibular joint. J Oral Maxillofac Surg 55: 20-27; discussion 7-8.
29. Zhu W, Meng L, Jiang C, et al. 2011. Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts. Arthritis Res Ther 13: R103.
30. Garnero P, Mazieres B, Gueguen A, et al. 2005. Cross-sectional association of 10 molecular markers of bone, cartilage, and synovium with disease activity and radiological joint damage in patients with hip osteoarthritis: the ECHODIAH cohort. J Rheumatol 32: 697-703. (Pubitemid 40524704)
31. Berenbaum F, Eymard F, Houard X., 2013. Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol 25: 114-118.
32. Vincenti MP, Brinckerhoff CE., 2002. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 4: 157-164. (Pubitemid 34460754)
33. Guicciardi E, Little K., 1967. Some observations on the effects of blood and a fibrinolytic enzyme on articular cartilage in the rabbit. J Bone Joint Surg Br 49: 342-350.
34. Volpin G, Dowd GS, Stein H, et al. 1990. Degenerative arthritis after intra-articular fractures of the knee. Long-term results. J Bone Joint Surg Br 72: 634-638. (Pubitemid 20221116)
35. Su S, Dehnade F, Zafarullah M., 1996. Regulation of tissue inhibitor of metalloproteinases-3 gene expression by transforming growth factor-beta and dexamethasone in bovine and human articular chondrocytes. DNA Cell Biol 15: 1039-1048.