The metabolic changes caused by dexamethasone in the adjuvant-induced arthritic rat

Molecular and Cellular Biochemistry

Volumn 302, Issue 1-2, 2007, Pages 87-98

  Caparroz Assef, Silvana M ^a   Bersani Amado, Ciomar A ^a   Kelmer Bracht, Ana M ^a   Bracht, Adelar ^a   Ishii Iwamoto, Emy L ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Arthritis; Dexamethasone; Gluconeogenesis; L Alanine metabolism; Perfused rat liver

Indexed keywords

ALANINE; CARBON; DEXAMETHASONE; FREUND ADJUVANT; GLUCOSE; GLYCOGEN; INSULIN;

ADJUVANT ARTHRITIS; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DIET RESTRICTION; DISEASE COURSE; DRUG RESPONSE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOGEN ANALYSIS; GLYCOGEN SYNTHESIS; INSULIN BLOOD LEVEL; LIVER METABOLISM; LIVER PERFUSION; MALE; METABOLIC PARAMETERS; NONHUMAN; PAW EDEMA; PREVALENCE; RAT; WEIGHT GAIN; WEIGHT REDUCTION;

ALANINE; AMMONIA; ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOOD GLUCOSE; BODY WEIGHT; DEXAMETHASONE; FASTING; FEEDING BEHAVIOR; FREUND'S ADJUVANT; GLYCOGEN; INFLAMMATION; INSULIN; LACTATES; MALE; OXYGEN; PERFUSION; PYRUVATES; RATS; UREA; WEIGHT GAIN;

RATTUS;

EID: 34547644680     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9430-9     Document Type: Article

References (68)

1. Walsmith J, Roubenoff R (2002) Cachexia in rheumatoid arthritis. Int J Cardiol 85:89-99
2. Rosenthale ME (1970) A comparative study of the Lewis and Sprague Dawley rat in adjuvant arthritis. Arch Int Pharmacodyn Ther 188:14-22
3. Caparroz-Assef SM, Bersani-Amado CA, Nascimento EA, Kelmer-Bracht AM, Ishii-Iwamoto EL (1998) Effects of the nonsteroidal anti-inflammatory drug nimesulide on energy metabolism in livers from adjuvant-induced arthritic rats. Res Commun Mol Pathol Pharmacol 99:93-116
4. Fedatto-Júnior Z, Ishii-Iwamoto EL, Amado CB, Vicentini G, D'Urso-Panerari A, Bracht A, Kelmer-Bracht AM (1999) Gluconeogenesis in the liver of arthritic rats. Cell Biochem Funct 17:271-278
5. Fedatto-Júnior Z, Ishii-Iwamoto EL, Caparroz-Assef SM, Vicentini GE, Bracht A, Kelmer-Bracht AM (2002) Glycogen levels and glycogen catabolism in livers from arthritic rats. Mol Cell Biochem 229:1-7
6. Fedatto-Júnior Z, Ishii-Iwamoto EL, Amado CB, Maciel ERM, Bracht A, Kelmer-Bracht AM (2000) Glucose phosphorylation capacity and glycolysis in the liver of arthritic rats. Inflamm Res 49:128-132
7. Yassuda Filho P, Bracht A, Ishii-Iwamoto EL, Lousano SH, Bracht L, Kelmer-Bracht A (2003) The urea cycle in the liver of arthritic rats. Mol Cell Biochem 243:97-106
8. Da Silva JAP, Bijlsma JWJ (2000) Optimizing glucocorticoid therapy of rheumatoid arthritis. Rheum Dis Clin North Am 26:859-880
9. Moreland LW, O'Deal JR (2002) Glucocorticoids and rheumatoid arthritis: back to the future? Arthritis Rheum 46:2553-2563
10. O'Dell JR (2004) Therapeutic strategies for rheumatoid arthritis. New Engl J Med 350:2591-2602
11. + subsets. J Immunol 155:3322-3328
12. Bendele AM, McComb J, Gould T, Frazier J, Chlipala ES, Seely J, Kieft G, Wolf J, Edwards CK III (1999) Combination benefit of PEGylated soluble tumor necrosis factor receptor type I (PEGsTNF-TI) and dexamethasone or indomethacin in adjuvant arthritic rats. Inflamm Res 48:453-460
13. Amano Y, Lee SW, Allison AC (1992) Inhibition by glucocorticoids of the formation of interleukin-1α, interleukin-1β, interleukin-6: mediation by decreased mRNA stability. Mol Pharmacol 43:176-182
14. Caldenhoven E, Liden J, Wissink S, Van de Stolpe A, Raaijmakers J, Koenderman L, Okret S, Gustafsson JA, Van der Saag PT (1995) Negative cross-talk between RelA and the glucocorticoid receptor: A possible mechanism for the anti-inflammatory action of glucocorticoid. Mol Endocrinol 9:401-412
15. Lavagno L, Gunella G, Bardelli C, Soina S, Fresu LG, Viano I, Brunelleschi S (2004) Anti-inflammatory drugs and tumor necrosis factors-α production: Role of transcription factor NF-κB and implication for rheumatoid arthritis therapy. Eur J Pharmacol 501:199-208
16. Dirlewanger M, Schneiter PH, Paquot N, Jequier E, Rey V, Tappy L (2000) Effects of glucocorticoids on hepatic sensitivity to insulin and glucagon in man. Clin Nutr 19:29-34
17. Boyle PJ (1993) Cushing's disease, glucocorticoid excess, glucocorticoid deficieny, and diabetes. Diabetes Res 1:301-308
18. Wang M (2005) The role of glucocorticoid action in the pathophysiology of the metabolic syndrome. Nutr Metab 2:3
19. Walsmith J, Abad L, Snydman L, Lundgren N, Roubenoff R (2000) Interleukin 1-β and tumor necrosis factor-α exhibit different metabolic effects in rheumatoid arthritis. FASEB J 14:A525
20. Choy EHS, Panayi GS (2001) Cytokine pathways and joint inflammation in rheumatoid arthritis. New Engl J Med 344:907-916
21. Allison AC, Lee SW (1989) The mode of action of anti-rheumatic drugs. I. Anti-inflammatory and immunosuppressive effects of glucocorticoids. Prog Drug Res 33:63-81
22. Simon LS (1999) Role and regulation of cyclooxygenase-2 during inflammation. Am J Med 106:37S-42S
23. Scholz R, Bücher T (1965) Hemoglobin-free perfusion of rat liver. In: Chance B, Estabrook RW, Williamson JR (eds) Control of energy metabolism. Academic Press, New York, pp 393-414
24. Bergmeyer HU, Bernt E (1974) Glucose determination with glucose oxidase and peroxidase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1205-1212
25. +. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1464-1468
26. Czok R, Lamprecht W (1974) Pyruvate, phosphoenolpyruvate and glycerate-2-phosphate. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1446-1451
27. Bergmeyer HU (1974) Determination of urea with glutamate dehydrogenase as indicator enzyme. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1794-1801
28. Kun F, Kearney EB (1974) Ammonia. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 1801-1806
29. Goldstein RE, Wasserman DH, McGuinness OP, Lacy DB, Cherrington AD, Abumrad NN (1992) Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am J Physiol Endocrinol Metab 264:E119-E127
30. Kobayashi T, Iwai H, Uchimoto R, Ohta M, Shiota M, Sugano T (1989) Gluconeogenesis in perfused livers from dexamethasone-treated chickens. Am J Physiol Regul Integr Comp Physiol 256:R907-R914
31. Kimmig R, Mauch TJ, Kerzl W, Schwabe U, Scholz R (1983) Actions of glucagon on flux rates in perfused rat liver. 1. Kinetics of the inhibitory effect on glycolysis and the stimulatory effect on glycogenolysis. Eur J Biochem 136:609-616
32. Jin JY, DuBois DC, Alman RR, Jusko WJ (2004) Receptor/Gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver. J Pharmacol Exp Ther 309:328-339
33. Jones CG, Hothi SK, Titheradge A (1993) Effect of dexamethasone on gluconeogenesis, piruvate kinase, pyruvate carboxylase and pyruvate dehydrogenase flux in isolated hepatocytes. Biochem J 289:821-828
34. Burlini N, Morandi S, Pellegrini R, Tortora P, Guerritore A (1989) Studies on the degradative mechanism of phosphoenolpyruvate carboxykinase from yeast Saccharomyces cerevisiae. Biochem Biophys Acta 1014:153-161
35. O'Brien RM, Granner DK (1990) PEPCK gene as model of inhibitory effects of insulin on gene transcription. Diabetes Care 13:327-339
36. Nielsen MF, Caumo A, Chandramouli V, Schumann WC, Cobelli C, Landau BR, Vilstrup H, Rizza RA, Schmitz O (2004) Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis during short-term hypercortisolemia in healthy subjects. Am J Physiol Endocrinol Metab 286:E102-E110
37. Smith OK, Long CNH (1967) Effect of cortisol on the plasma amino nitrogen of eviscerated adrenalectomized-diabetic rats. Endocrinology 80:561-566
38. Sutherland EW III, Haynes RC Jr (1967) Increased release of aminoacids from rats thymus after cortisol administration. Endocrinology 80:288-296
39. Wise JK, Hendler R, Felig P (1973) Influence of glucocortocoids on glucagon secretion and plasma aminoacid concentration in man. J Clin Invest 52:2774-2782
40. Kuwajima M, Golden S, Katz J, Unger RH, Foster DW, McGarry JD (1986) Active hepatic glycogen synthesis from gluconeogenic precursors despite high tissue levels of fructose 2,6-bisphosphate. J Biol Chem 261:2632-2337
41. Magnusson I, Rothman DL, Jucker B, Cline GW, Shulman RG, Shulman GI (1994) Liver glycogen turnover in fed and fasted humans. Am J Physiol Endocrinol Metab 266:E796-E803
42. Roden M, Perseghin G, Petersen KF, Hwang JH, Clive GW, Gerow K, Rothman DJ, Shulman GI (1996) The role of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 97:642-648
43. Hellerstein MK, Neese RA, Linfoot P, Christiansen M, Turner S, Letscher A (1997) Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. J Clin Invest 100:1305-1319
44. Pilkis SJ, Granner DK (1992) Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Ann Rev Physiol 54:885-909
45. Petersen KF, Laurent D, Rothman DL, Cline GW, Shulman GI (1998) Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J Clin Invest 101:1203-1209
46. Klein HH, Ullmann S, Drenckhan M, Grimmsmann T, Unthan-Fechner K, Probst I (2002) Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes. J Hepatol 37:432-440
47. Reynolds RM, Walker BR (2003) Human insulin resistance: The role of glucocorticoids. Diabetes Obes Metab 5:5-12
48. Amatruda JM, Danahy SA, Chang CL (1982) The effect of glucocorticoids on insulin-stimulated lipogenesis in primary cultures of rat hepatocytes. Biochem J 212:135-141
49. Probst I, Jungermann K (1983) Short-term regulation of glycolysis by insulin and dexamethasone in cultured rat hepatocytes. Eur J Biochem 135:151-156
50. Fleig WE, Nöther-Fleig G, Steudter S, Enderle D, Ditschuneit H (1985) Regulation of insulin binding and glycogenolysis by insulin and dexamethasone in culture hepatocytes. Biochem Biophys Acta 847:352-361
51. Mokuda O, Sakamoto Y, Ikeda T, Mashiba H (1991) Sensitivity and responsiveness of glucose output to insulin in isolated perfused liver from dexamethasone-treated rats. Horm Metab Res 23:53-55
52. Silva JCR, Rocha MFG, Lima AAM, Brito GAC, de Menezes DB, Rao VSN (2000) Effects of pentoxifylline and nabumetone on the serum levels of IL-1β and TNFα in rats with adjuvant arthritis. Inflamm Res 49:14-19
53. Broetto-Biazon AC, Ishii-Iwamoto EL, Kelmer-Bracht AM, Bracht A (2006) Low doses of tumor necrosis factor alpha and interleukin 1 beta diminish hepatic gluconeogenesis from alanine in vivo. Basic Clin Pharmacol Toxicol 99:335-339
54. Rebuffe-Scrive M, Walsh UA, McEwen B, Rodin J (1992) Effect of stress and exogenous glucocorticoid on regional fat distribution and metabolism. Physiol Behav 52:583-590
55. Tataranni PA, Larson DE, Sniker S, Young JB, Flatt JP, Ravussi E (1996) Effects of glucocorticoids on energy metabolism and food intake in human. Am J Physiol 271:E317-E325
56. Green PK, Wilkinson CW, Woods SC (1992) Intraventricular corticosterone increases the rate of body weight gain in underweight adrenalectomized rats. Endocrinology 130:269-275
57. Obeid OA, Boukarim LK, Al Awar RM, Hwalla N (2006) Postprandial glycogen and lipid synthesis in prednisole-treated rats maintained on high-protein diets with varied carbohydrate levels. Nutrition 22:288-294
58. Odebra BR, Bates PC, Minard DJ (1983) Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochem J 214:617-627
59. Mokuda O, Sakamoto Y (1997) Increased glucagon action on lactate gluconeogenesis in perfused liver of dexamethasone-treated rats. Biochem Mol Med 62:65-69
60. Dumas JF, Simard G, Roussel D, Douay O, Foussard F, Malthiery Y, Ritz P (2003) Mitochondrial energy metabolism in a model of undernutriton induced by dexamethasone. Br J Nutr 90:969-977
61. Roussel D, Dumas JF, Augeraud A, Douay O, Foussard F, Malthhéry Y, Simard G, Titz P (2003) Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett 54:75-79
62. Woodward CJH, Emery PW (1989) Energy balance in rats given chronic hormone treatment. 2. effects of corticosterone. Br J Nutr 61:445-452
63. Minet-Quinard R, Moinard C, Walrand S, Villie F, Normand B, Vasson NP, Chopineau J, Cynober L (2000) Induction of a catabolic state in rats by dexamethasone: Dose or time dependency? J Parenter Enteral Nutr 24:30-36
64. Roubenoff R, Freemann LM, Smith DE, Abad LW, Dinarello CA, Kehayias JJ (1997) Adjuvant arthritis as a model of inflammatory cachexia. Arthritis Rheum 40:534-539
65. Hamada K, Vannier E, Smith DE, Abad LW, Roubenoff R (2000) Inflammatory cachexia induces sarcoactive cytokine gene expression in a rat model of adjuvant arthritis. FASEP J 14:A572
66. Roubenoff R, Roubenoff RA, Cannon JG, Kehayias JJ (1994) Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 93:2379-2386
67. Bendele AM, Chlipala ES, Schereer J, Frazier J, Sennello G, Rich WJ, Edwards CK III (2000) Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis. Arthritis Rheum 43:2648-2659
68. Fathalla B, Hamada K, Vannier E, Smith D, Edwards C, Roubenoff R (2004) Effects of aging and cytokine blockade on inflammatory cachexia. Clin Exp Rheumatol 22:85-90