Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines

Arthritis Research and Therapy

Volumn 13, Issue 5, 2011, Pages

  Lu, Yihong C S ^a   Evans, Christopher H ^b   Grodzinsky, Alan J ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECANASE; CYTOKINE; DEX; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR ANTAGONIST; GLYCOSAMINOGLYCAN; GROWTH FACTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; MIFEPRISTONE; PROTEINASE; PROTEOGLYCAN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CARTILAGE MATRIX PROTEIN; GLUCOCORTICOID; GLYCOPROTEIN; SCLEROPROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CARTILAGE INJURY; CARTILAGE MATRIX; CATABOLISM; CONTROLLED STUDY; COW; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; EXPLANT; FEMALE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; METABOLISM; NONHUMAN; OSTEOARTHRITIS; PROTEOGLYCAN SYNTHESIS; TRANSCRIPTION REGULATION; ANIMAL; ARTICULAR CARTILAGE; BIOSYNTHESIS; CATTLE; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; INJURY; MECHANICAL STRESS; MIDDLE AGED; TREATMENT OUTCOME;

ANIMALS; CARTILAGE, ARTICULAR; CATTLE; CHONDROCYTES; CYTOKINES; DEXAMETHASONE; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; GLYCOPROTEINS; HUMANS; INFLAMMATION MEDIATORS; MIDDLE AGED; STRESS, MECHANICAL; TREATMENT OUTCOME;

EID: 80052255016     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3456     Document Type: Article

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