Whole-blood cultures from patients with chronic periodontitis respond differently to porphyromonas gingivalis but not escherichia coli lipopolysaccharide

Journal of Periodontology

Volumn 85, Issue 2, 2014, Pages

  Nogueira Filho, Getulio ^a   Rosa, Bruno Trevisan ^b   Santos, Patricia Ferreira ^b   Unes, Urbino Rocha ^b   Freire, Songeli Menezes ^c   Meyer, Roberto ^c   Darveau, Richard P ^d  

^a UNIVERSITY OF TORONTO   (Canada)

^b Bahian School of Medicine and Public Health   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Cytokines; Lipopolysaccharides; Molecular biology; Periodontitis; Porphyromonas gingivalis

Indexed keywords

AUTACOID; CYTOKINE; GAMMA INTERFERON; IL10 PROTEIN, HUMAN; INTERLEUKIN 10; LIPID A; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; BLOOD; BLOOD CELL; CHRONIC PERIODONTITIS; CLASSIFICATION; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; DRUG EFFECTS; ESCHERICHIA COLI; FEMALE; HUMAN; MALE; MIDDLE AGED; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; TOOTH PLAQUE;

ADULT; AGED; BLOOD CELLS; CHRONIC PERIODONTITIS; CROSS-SECTIONAL STUDIES; CYTOKINES; DENTAL PLAQUE INDEX; ESCHERICHIA COLI; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-10; LIPID A; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PORPHYROMONAS GINGIVALIS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84893868961     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2013.120735     Document Type: Article

References (28)

1. Persson GR. Immune responses and vaccination against periodontal infections. J Clin Periodontol 2005;32(Suppl. 6):39-53.
2. Silva TA, Garlet GP, Fukada SY, Silva JS, Cunha FQ. Chemokines in oral inflammatory diseases: Apical periodontitis and periodontal disease. J Dent Res 2007;86:306-319.
3. Mogensen TH. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 2009;22:240-273.
4. Berezow AB, Jin LJ, Darveau RP. The molecular basis of host defense mechanisms in oral disease. In: Rogers AH, ed. Molecular Oral Microbiology. Norwich UK: Caister Academic Press/Horizon Scientific Press; 2008:237-255.
5. Darveau RP, Cunningham MD, Bailey T, et al. Ability of bacteria associated with chronic inflammatory disease to stimulate E-selectin expression and promote neutrophil adhesion. Infect Immun 1995;63:1311-1317.
6. Darveau RP, Belton CM, Reife RA, Lamont RJ. Local chemokine paralysis, a novel pathogenic mechanism for Porphyromonas gingivalis. Infect Immun 1998;66: 1660-1665.
7. Al-Qutub MN, Braham PH, Karimi-Naser LM, Liu X, Genco CA, Darveau RP. Hemin-dependent modulation of the lipid A structure of Porphyromonas gingivalis lipopolysaccharide. Infect Immun 2006;74:4474-4485.
8. Jain S, Coats SR, Chang AM, Darveau RP. A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis. Infect Immun 2013;81:1277-1286.
9. Reife RA, Coats SR, Al-Qutub M, et al. Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity: Differential activities of tetra-and penta-acylated lipid A structures on E-selectin expression and TLR4 recognition. Cell Microbiol 2006;8:857-868.
10. Lu Q, Darveau RP, Samaranayake LP, Wang CY, Jin L. Differential modulation of human beta-defensins expression in human gingival epithelia by Porphyromo-nas gingivalis lipopolysaccharide with tetra-and penta-acylated lipid A structures. Innate Immun 2009; 15:325-335.
11. Herath TD, Wang Y, Seneviratne CJ, et al. Porphyr-omonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts. J Clin Peri-odontol 2011;38:694-701.
12. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
13. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975;25:229-235.
14. Mühlemann HR, Son S. Gingival sulcus bleeding-A leading symptom in initial gingivitis. Helv Odontol Acta 1971;15:107-113.
15. Engler WO, Ramfjord SP, Hiniker JJ. Development of epithelial attachment and gingival sulcus in rhesus monkeys. J Periodontol 1965;36:44-56.
16. Gibbs CH, Hirschfeld JW, Lee JG, et al. Description and clinical evaluation of a new computerized periodontal probe-The Florida probe. J Clin Periodontol 1988;15: 137-144.
17. Wilson BM, Severn A, Rapson NT, Chana J, Hopkins P. A convenient human whole blood culture system for studying the regulation of tumour necrosis factor release by bacterial lipopolysaccharide. J Immunol Methods 1991;139:233-240.
18. Schytte Blix IJ, Helgeland K, Hvattum E, Lyberg T. Lipopolysaccharide from Actinobacillus actinomyce-temcomitans stimulates production of interleukin-1beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-1 receptor antagonist in human whole blood. J Periodontal Res 1999;34:34-40.
19. Nakamura T, Nitta H, Ishikawa I. Effect of low dose Actinobacillus actinomycetemcomitans lipopolysac-charide pretreatment on cytokine production by human whole blood. J Periodontal Res 2004;39:129-135.
20. Nemoto E, Darveau RP, Foster BL, Nogueira-Filho GR, Somerman MJ. Regulation of cementoblast function by P. gingivalis lipopolysaccharide via TLR2. J Dent Res 2006;85:733-738.
21. Loppnow H, Dürrbaum I, Brade H, et al. Lipid A, the immunostimulatory principle of lipopolysaccharides? Adv Exp Med Biol 1990;256:561-566.
22. Dixon DR, Darveau RP. Lipopolysaccharide heterogeneity: Innate host responses to bacterial modification of lipid a structure. J Dent Res 2005;84:584-595.
23. Ogawa T, Yagi T. Bioactive mechanism of Porphyr-omonas gingivalis lipid A. Periodontol 2000 2010; 54:71-77.
24. Liu R, Desta T, Raptis M, Darveau RP, Graves DT. P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers. J Periodontol 2008;79:1241-1247.
25. Darveau RP, Hajishengallis G, Curtis MA. Porphyromo-nas gingivalis as a potential community activist for disease. J Dent Res 2012;91:816-820.
26. Herath TD, Darveau RP, Seneviratne CJ, Wang CY, Wang Y, Jin L. Tetra-and penta-acylated lipid A structures of Porphyromonas gingivalis LPS differentially activate TLR4-mediated NF-kB signal transduc-tion cascade and immuno-inflammatory response in human gingival fibroblasts. PLoS One 2013;8:e58496.
27. Grenier D, Mayrand D. Functional characterization of extracellular vesicles produced by Bacteroides gingi-valis. Infect Immun 1987;55:111-117.
28. Uehara A, Takada H. Functional TLRs and NODs in human gingival fibroblasts. J Dent Res 2007;86: 249-254.