Screen for small molecules increasing the mitochondrial membrane potential

Journal of Biomolecular Screening

Volumn 19, Issue 3, 2014, Pages 387-398

  Montague, Christine R ^a   Fitzmaurice, Aileen ^a   Hover, Bradley M ^a,b   Salazar, Noe A ^a   Fey, Julien P ^a  

^a Agave BioSystems   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell based assays; membrane potential; mitochondria; yeast screening

Indexed keywords

ADENOSINE TRIPHOSPHATE; AGENTS AFFECTING METABOLISM; FERRITIN; GLUCOSE 6 PHOSPHATASE; KLOTHO PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RETINOIC ACID RECEPTOR ALPHA; SOMATOMEDIN BINDING PROTEIN 1; ST 003709; ST 003711; ST 005192; ST 005213; ST 0053241; ST 0053256; ST 006407; ST 032288; ST 038830; ST 053241; ST 053256; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRAIN 3T3; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG STRUCTURE; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; LIVER CELL; MAMMAL CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOTUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; PC12 CELL; PRIORITY JOURNAL; YEAST;

CELL-BASED ASSAYS; MEMBRANE POTENTIAL; MITOCHONDRIA; YEAST SCREENING;

ADENOSINE TRIPHOSPHATE; ANIMALS; DRUG DISCOVERY; GENE EXPRESSION PROFILING; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTEOMICS; SMALL MOLECULE LIBRARIES; YEASTS;

EID: 84893864315     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113495295     Document Type: Article

References (26)

1. Dykens J. A., Marroquin L. D., Will Y. Strategies to Reduce Late-Stage Drug Attrition Due to Mitochondrial Toxicity. Expert Rev. Mol. Diagn. 2007 ; 7: 161-175
2. Ferrin G., Linares C. I., Muntané J. Mitochondrial Drug Targets in Cell Death and Cancer. Curr. Pharm. Des. 2011 ; 17: 2002-2016
3. Gogvadze V. Targeting Mitochondria in Fighting Cancer. Curr. Pharm. Des. 2011 ; 17: 4034-4046
4. Toogood P. L. Mitochondrial Drugs. Curr. Opin. Chem. Biol. 2008 ; 12: 457-463
5. Moreira P. I., Cardoso S. M., Pereira C. M., et al. Mitochondria as a Therapeutic Target in Alzheimer's Disease and Diabetes. CNS Neurol. Disord. Drug Targets. 2009 ; 8: 492-511
6. Victor V. M., Rocha M., Bañuls C., et al. Mitochondrial Dysfunction and Targeted Drugs: A Focus on Diabetes. Curr. Pharm. Des. 2011 ; 17: 1986-2001
7. Scatena R. Mitochondria and Drugs. Adv. Exp. Med. Biol. 2012 ; 942: 329-346
8. Smith R. A., Hartley R. C., Cochemé H. M., et al. Mitochondrial Pharmacology. Trends Pharmacol. Sci. 2012 ; 33: 341-352
9. Wagner B., Kitami T., Gilbert T., et al. V. Large-Scale Chemical Dissection of Mitochondrial Function. Nat. Biotech. 2008 ; 26: 343-351
10. Nadanaciva S., Murray J., Wilson C., et al. High-Throughput Assays for Assessing Mitochondrial Dysfunction Caused by Compounds That Impair mtDNA-Encoded Protein Levels in Eukaryotic Cells. Curr. Protoc. Toxicol. 2011 ;:
11. Kim J. A., Han E., Eun C. J., et al. Real-Time Concurrent Monitoring of Apoptosis, Cytosolic Calcium, and Mitochondria Permeability Transition for Hypermulticolor High-Content Screening of Drug-Induced Mitochondrial Dysfunction-Mediated Hepatotoxicity. Toxicol. Lett. 2012 ; 214: 175-181
12. Kitami T., Logan D. J., Negri J., et al. A Chemical Screen Probing the Relationship between Mitochondrial Content and Cell Size. PLoS One. 2012 ; 7: e33755
13. Tolosa L., Pinto S., Donato M. T., et al. Development of a Multiparametric Cell-Based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs. Toxicol. Sci. 2012 ; 127: 187-198
14. Barberis A., Gunde T., Berset C., et al. Yeast as a Screening Tool. Drug Discov. Today: Technologies. 2005 ; 2: 187-192
15. Middendorp O., Ortler C., Neumann U., et al. Yeast Growth Selection System for the Identification of Cell-Active Inhibitors of Beta-Secretase. Biochim. Biophys. Acta. 2004 ; 1674: 29-39
16. Chrebet G. L., Wisniewski D., Perkins A. L., et al. Cell-Based Assays to Detect Inhibitors of Fungal mRNA Capping Enzymes and Characterization of Sinefungin as a Cap Methyltransferase Inhibitor. J. Biomol. Screen. 2005 ; 10: 355-364
17. Cottier V., Barberis A., Lüthi U. Novel Yeast Cell-Based Assay to Screen for Inhibitors of Human Cytomegalovirus Protease in a High-Throughput Format. Antimicrob. Agents Chemother. 2006 ; 50: 565-571
18. Marjanovic J., Chalupska D., Patenode C., et al. Recombinant Yeast Screen for New Inhibitors of Human Acetyl-CoA Carboxylase 2 Identifies Potential Drugs to Treat Obesity. Proc. Natl. Acad. Sci. U. S. A. 2010 ; 107: 9093-9098
19. Fernández-Acero T., Rodríguez-Escudero I., Vicente F., et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors. J. Biomol. Screen. 2012 ; 17: 1018-1029
20. Minic J., Sautel M., Salesse R., et al. Yeast System as a Screening Tool for Pharmacological Assessment of G Protein Coupled Receptors. Curr. Med. Chem. 2005 ; 12: 961-969
21. Cohen Y., Schuldiner M. Advanced Methods for High-Throughput Microscopy Screening of Genetically Modified Yeast Libraries. Methods Mol. Biol. 2011 ; 781: 127-159
22. Cheng W. C., Leach K. M., Hardwick J. M. Mitochondrial Death Pathways in Yeast and Mammalian Cells. Biochim. Biophys. Acta. 2008 ; 1783: 1272-1279
23. Couplan E., Aiyar R. S., Kucharczyk R., et al. A Yeast-Based Assay Identifies Drugs Active against Human Mitochondrial Disorders. Proc. Natl. Acad. Sci. U. S. A. 2011 ; 108: 11989-11994
24. Yang Y., Qiang X., Owsiany K., et al. Evaluation of Different Multidimensional LC-MS/MS Pipelines for Isobaric Tags for Relative and Absolute Quantitation (iTRAQ)-Based Proteomic Analysis of Potato Tubers in Response to Cold Storage. J. Proteome Res. 2011 ; 10: 4647-4660
25. Cohen J. S., Fox T. D. Expression of Green Fluorescent Protein from a Recoded Gene Inserted into Saccharomyces cerevisiae Mitochondrial DNA. Mitochondrion. 2001 ; 1: 181-189
26. Miyakawa I., Higo K., Osaki F., et al. Double Staining of Mitochondria and Mitochondrial Nucleoids in the Living Yeast during the Life Cycle. J. Gen. Appl. Microbiol. 1994 ; 40: 1-14