Enamel matrix derivative: Protein components and osteoinductive properties

Journal of Periodontology

Volumn 85, Issue 2, 2014, Pages

  Stout, Bradshaw M ^a   Alent, Brian J ^a   Pedalino, Peter ^a   Holbrook, Ryan ^a   Gluhak Heinrich, Jelica ^b   Cui, Yong ^b   Harris, Marie A ^b   Gemperli, Anja C ^c   Cochran, David L ^b   Deas, David E ^b   Harris, Stephen E ^b  

^a WILFORD HALL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c INSTITUT STRAUMANN AG   (Switzerland)

Author keywords

Ameloblastin protein; Amelogenin; Enamel matrix proteins; Human; Osteogenesis; Proteomics; Tuftelin

Indexed keywords

AMBN PROTEIN, MOUSE; AMELOGENIN; BONE MORPHOGENETIC PROTEIN; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; LEUCINE-RICH AMELOGENIN PEPTIDE; OSTERIX PROTEIN, MOUSE; PROTEOME; SMAD1 PROTEIN; SMAD1 PROTEIN, MOUSE; SMAD5 PROTEIN; SMAD5 PROTEIN, MOUSE; SMAD8 PROTEIN; SMAD9 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL; ANIMAL MODEL; BONE DEVELOPMENT; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; GEL CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; PERIOSTEUM; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; SKULL;

AMELOGENIN; ANIMALS; BONE MORPHOGENETIC PROTEINS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DENTAL ENAMEL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MASS SPECTROMETRY; MICE; MODELS, ANIMAL; MOLECULAR WEIGHT; OSTEOGENESIS; PARIETAL BONE; PERIOSTEUM; PROTEOME; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84893862720     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2013.130264     Document Type: Article

References (28)

1. Heijl L, Heden G, Svärdström G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997;24:705-714.
2. Mellonig JT, Valderrama P, Gregory HJ, Cochran DL. Clinical and histologic evaluation of non-surgical periodontal therapy with enamel matrix derivative: A report of four cases. J Periodontol 2009;80:1534-1540.
3. Cochran DL, Jones A, Heijl L, Mellonig JT, Schoolfield J, King GN. Periodontal regeneration with a combination of enamel matrix proteins and autogenous bone grafting. J Periodontol 2003;74:1269-1281.
4. Grandin HM, Gemperli AC, Dard M. Enamel matrix derivative: A review of cellular effects in vitro and a model of molecular arrangement and functioning. Tissue Eng Part B Rev 2012;18:181-202.
5. Brookes SJ, Robinson C, Kirkham J, Bonass WA. Biochemistry and molecular biology of amelogenin proteins of developing dental enamel. Arch Oral Biol 1995;40:1-14.
6. Hammarström L. The role of enamel matrix proteins in the development of cementum and periodontal tissues. Ciba Found Symp 1997;205:246-260.
7. Carinci F, Piattelli A, Guida A, et al. Effects of Emdo-gain on osteoblast gene expression. Oral Dis 2006;12: 329-342.
8. Gestrelius S, Lyngstadaas SP, Hammarström L. Emdogain-Periodontal regeneration based on bio-mimicry. Clin Oral Investig 2000;4:120-125.
9. Zeichner-David M, Chen L-S, Hsu Z, Reyna J, Caton J, Bringas P. Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells. Eur J Oral Sci 2006;114(Suppl. 1):244-253, discussion 254-256, 381-382.
10. Hu CC, Fukae M, Uchida T, et al. Sheathlin: Cloning, cDNA/polypeptide sequences, and immunolocaliza-tion of porcine enamel sheath proteins. J Dent Res 1997a;76:648-657.
11. Hu CC, Fukae M, Uchida T, et al. Cloning and characterization of porcine enamelin mRNAs. J Dent Res 1997;76:1720-1729.
12. Fukae M, Tanabe T, Uchida T, et al. Enamelysin (matrix metalloproteinase-20): Localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis. J Dent Res 1998;77:1580-1588.
13. Takayanagi K, Osawa G, Nakaya H, Cochran DL, Kamoi K, Oates TW. Effects of enamel matrix derivative on bone-related mRNA expression in human periodontal ligament cells in vitro. J Periodontol 2006; 77:891-898.
14. Schwartz Z, Carnes DL Jr., Pulliam R, et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteo-blast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000;71:1287-1296.
15. Amin HD, Olsen I, Knowles JC, Donos N. Differential effect of amelogenin peptides on osteogenic differentiation in vitro: Identification of possible new drugs for bone repair and regeneration. Tissue Eng Part A 2012; 18:1193-1202.
16. Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24: 658-668.
17. Zhao M, Harris SE, Horn D, et al. Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation. J Cell Biol 2002; 157:1049-1060.
18. Yang W, Guo D, Harris MA, et al. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci 2013;126:4085-4098.
19. UCSF Mass Spectrometry Facility. Protein Prospector. Available at: http://prospector2.ucsf.edu. Accessed January 16, 2014.
20. Zhang C. Molecular mechanisms of osteoblast-specific transcription factor osterix effect on bone formation. Beijing Da Xue Xue Bao 2012;44:659-665.
21. Tang W, Yang F, Li Y, et al. Transcriptional regulation of vascular endothelial growth factor (VEGF) by osteoblast-specific transcription factor osterix (Osc) in osteoblasts. J Biol Chem 2012;287: 1671-1678.
22. Kanazashi M, Gomi K, Nagano T, Tanabe T, Arai T, Fukae M. The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs. J Periodontal Res 2006;41:193-199.
23. Nakayama Y, Yang L, Mezawa M, et al. Effects of porcine 25 kDa amelogenin and its proteolytic derivatives on bone sialoprotein expression. J Periodontal Res 2010;45:602-611.
24. Haze A, Taylor AL, Haegewald S, et al. Regeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis. J Cell Mol Med 2009;13:1110-1124.
25. Tamburstuen MV, Reppe S, Spahr A, et al. Ameloblas-tin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators. Eur J Oral Sci 2010;118:451-459.
26. Yang W, Harris MA, Cui Y, Mishina Y, Harris SE, Gluhak-Heinrich J. Bmp2 is required for odontoblast differentiation and pulp vasculogenesis. J Dent Res 2012;91:58-64.
27. Rakian A, Yang W, Gluhak-Heinrich J, et al. Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the peri-odontium. Int J Oral Sci 2013;5:75-84.
28. Liu Y, Berendsen AD, Jia S, et al. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest 2012;122: 3101-3113.