High glucose induces activation of the local renin-angiotensin system in glomerular endothelial cells

Molecular Medicine Reports

Volumn 9, Issue 2, 2014, Pages 450-456

  Peng, Hui ^a   Xing, Yan Fang ^b   Ye, Zeng Chun ^a   Li, Can Ming ^a   Luo, Peng Li ^a   Li, Ming ^a   Lou, Tan Qi ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin II; Diabetic kidney disease; Glomerular endothelial cell; Renin angiotensin

Indexed keywords

ANGIOTENSIN II; ANGIOTENSINOGEN; ANIMALS; CELLS, CULTURED; DIABETIC NEPHROPATHIES; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; KIDNEY; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER;

EID: 84893862055     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1855     Document Type: Article

References (35)

1. Wolf G: Molecular mechanisms of angiotensin II in the kidney: emerging role in the progression of renal disease: beyond haemodynamics. Nephrol Dial Transplant 13: 1131-1142, 1998.
2. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V and Egido J: Inflammation and angiotensin II. Int J Biochem Cell Biol 35: 881-900, 2003.
3. Seikaly MG, Arant BS Jr and Seney FD Jr: Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 86: 1352-1357, 1990.
4. Zhang SL, To C, Chen X, et al: Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat kidney proximal tubular cells. Exp Nephrol 9: 109-117, 2001.
5. Cristovam PC, Arnoni CP, de Andrade MC, et al: ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells. Exp Biol Med (Maywood) 233: 1035-1043, 2008.
6. Durvasula RV and Shankland SJ: Activation of a local renin angiotensin system in podocytes by glucose. Am J Physiol Renal Physiol 294: F830-F839, 2008.
7. Lee LK, Meyer TW, Pollock AS and Lovett DH: Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96: 953-964, 1995.
8. Satchell SC and Tooke JE: What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium? Diabetologia 51: 714-725, 2008.
9. Ballermann BJ: Contribution of the endothelium to the glomerular permselectivity barrier in health and disease. Nephron Physiol 106: 19-25, 2007.
10. Zanatta CM, Canani LH, Silveiro SP, Burttet L, Nabinger G and Gross JL: Endothelin system function in diabetic nephropathy. Arq Bras Endocrinol Metabol 52: 581-588, 2008 (In Portuguese).
11. Jefferson JA, Shankland SJ and Pichler RH: Proteinuria in diabetic kidney disease: a mechanistic viewpoint. Kidney Int 74: 22-36, 2008.
12. Jaimes EA, Hua P, Tian RX and Raij L: Human glomerular endothelium: interplay among glucose, free fatty acids, angiotensin II, and oxidative stress. Am J Physiol Renal Physiol 298: F125-F132, 2010.
13. Adler S: Integrin receptors in the glomerulus: potential role in glomerular injury. Am J Physiol
14. Peng H, Luo P, Li Y, Wang C, Liu X, et al: Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1. PLoS One 8: e80009, 2013.
15. Peng H, Wang C, Ye ZC, et al: How increased VEGF induces glomerular hyperpermeability: a potential signaling pathway of Rac1 activation. Acta Diabetol 47 (Suppl 1): 57-63, 2010.
16. Durvasula RV, Petermann AT, Hiromura K, et al: Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney Int 65: 30-39, 2004.
17. Li M, Liu K, Michalicek J, et al: Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. J Clin Invest 114: 112-120, 2004.
18. Sadjadi J, Kramer GL, Yu CH, Burress Welborn M III, Chappell MC and Gregory Modrall J: Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. J Surg Res 127: 65-69, 2005.
19. Homma T, Sonoda H, Manabe K, et al: Activation of renal angiotensin type 1 receptor contributes to the pathogenesis of progressive renal injury in a rat model for chronic cardiorenal syndrome. Am J Physiol Renal Physiol 302: F750-F761, 2012.
20. Filipeanu CM, Henning RH, de Zeeuw D and Nelemans A: Intracellular Angiotensin II and cell growth of vascular smooth muscle cells. Br J Pharmacol 132: 1590-1596, 2001.
21. Cook JL, Zhang Z and Re RN: In vitro evidence for an intracellular site of angiotensin action. Circ Res 89: 1138-1146, 2001.
22. Kumar R, Singh VP and Baker KM: The intracellular renin-angiotensin system: a new paradigm. Trends Endocrinol Metab 18: 208-214, 2007.
23. Singh R, Singh AK, Alavi N and Leehey DJ: Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J Am Soc Nephrol 14: 873-880, 2003.
24. Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N and Boim MA: High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol 286: F1039-F1045, 2004.
25. Singh VP, Le B, Bhat VB, Baker KM and Kumar R: High-glucose-induced regulation of intracellular Ang II synthesis and nuclear redistribution in cardiac myocytes. Am J Physiol Heart Circ Physiol 293: H939-H948, 2007.
26. Heikkila HM, Latti S, Leskinen MJ, Hakala JK, Kovanen PT and Lindstedt KA: Activated mast cells induce endothelial cell apoptosis by a combined action of chymase and tumor necrosis factor-alpha. Arterioscler Thromb Vasc Biol 28: 309-314, 2008.
27. Kumar R, Singh VP and Baker KM: The intracellular renin-angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens 17: 168-173, 2008.
28. Singh VP, Baker KM and Kumar R: Activation of the intracellular renin-angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production. Am J Physiol Heart Circ Physiol 294: H1675-H1684, 2008.
29. Takahashi H, Ichihara A, Kaneshiro Y, et al: Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade. J Am Soc Nephrol 18: 2054-2061, 2007.
30. Matsusaka T, Nishimura H, Utsunomiya H, et al: Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest 98: 1867-1877, 1996.
31. Schunkert H, Ingelfinger JR, Jacob H, Jackson B, Bouyounes B and Dzau VJ: Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by angiotensin II. Am J Physiol 263: E863-E869, 1992.
32. Muller MW, Todorov V, Kramer BK and Kurtz A: Angiotensin II inhibits renin gene transcription via the protein kinase C pathway. Pflugers Arch 444: 499-505, 2002.
33. Wasse H, Rivera AA, Huang R, et al: Increased plasma chymase concentration and mast cell chymase expression in venous neointimal lesions of patients with CKD and ESRD. Semin Dial 24: 688-693, 2011.
34. Huang XR, Chen WY, Truong LD and Lan HY: Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J Am Soc Nephrol 14: 1738-1747, 2003.
35. Amiri F and Garcia R: Regulation of angiotensin II receptors and PKC isoforms by glucose in rat mesangial cells. Am J Physiol 276: F691-F699, 1999.