Effect of renin-angiotensin system blockade on the expression of the angiotensinogen gene and induction of hypertrophy in rat kidney proximal tubular cells

Experimental Nephrology

Volumn 9, Issue 2, 2001, Pages 109-117

  Zhang, Shao Ling ^a   To, Catherine ^a   Chen, Xing ^a   Filep, Janos G ^a   Tang, Shiow Shih ^b   Ingelfinger, Julie R ^b   Carrière, Serge ^c   Chan, John S D ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Servier Amérique   (Canada)

Author keywords

Angiotensinogen; Hyperglycemia; Kidney and hypertrophy

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSINOGEN; CAPTOPRIL; CELL PROTEIN; GLUCOSE; LOSARTAN; MATRIX PROTEIN; MESSENGER RNA; PERINDOPRIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; HYPERGLYCEMIA; KIDNEY HYPERTROPHY; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035160293     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: 10.1159/000052601     Document Type: Article

References (27)

1. High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule
2. Angiotensin II induces cellular hypertrophy in cultured murine tubular cells
3. The influence of glucose concentration of angiotensin II-induced hypertrophy of proximal tubular cells in culture
4. Intracellular signalling of transcription and secretion of type IV collagen after angiotensin II-induced cellular hypertrophy in cultured proximal tubular cells
5. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule
6. 1 receptor
7. Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-β
8. Angiotensin-converting enzyme inhibitors and the progression of diabetic nephropathy
9. The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy
10. Will angiotensin II receptor antagonists be renoprotective in humans?
11. Losartan blocks aldosterone and renal vascular responses to angiotensin II in humans
12. In situ hybridization evidence for angiotensinogen mRNA in the rat proximal tubule. A hypothesis for the intrarenal renin angiotensin system
13. Angiotensin II as a hypertrophogenic cytokine for proximal tubular cells
14. Renin and renin mRNA in proximal tubule of the rat kidney
15. Temperature-sensitive SV40 immortalized rat proximal tubule cell line has functional renin-angiotensin system
16. Synergistic effect of dexamethasone and isoproterenol on the expression of angiotensinogen in immortalized rat proximal tubular cells
17. Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells
18. Rat proximal tubule cell line transformed with origin-defective SV40 DNA: Autocrine Ang II feedback
19. Control of growth hormone synthesis in cultured GH cells by 3,5,3′-triiodo-L-thyronine and glucocorticoid agonists and antagonists: Studies on the independent and synergistic regulation of the growth hormone response
20. Cloning and sequence analysis of cDNA for rat angiotensinogen
21. The nucleotide sequence of the rat cytoplasmic β-acting gene
22. Protein determination in membrane and lipoprotein samples: Manual and automated procedures
23. + exchanger is not required for induction of hypertrophy in cells in vitro
24. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat
25. Proximal tubular secretion of angiotensin II in rats
26. Tubular fluid concentrations and kidney contents of angiotensin I and II in anesthesized rats
27. Reciprocal feedback regulation of kidney angiotensinogen and renin mRNA expressions by Ang II