-
1
-
-
84869475394
-
Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma
-
Maluccio M, Covey A. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA Cancer J. Clin. 62, 394-399 (2012).
-
(2012)
CA Cancer J. Clin.
, vol.62
, pp. 394-399
-
-
Maluccio, M.1
Covey, A.2
-
2
-
-
47949116252
-
SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V et al.; SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl. J. Med. 359, 378-390 (2008).
-
(2008)
N Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
3
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A Phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a Phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 10, 25-34 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
4
-
-
84859973897
-
Improved chemotherapy for hepatocellular carcinoma
-
Cao H, Phan H, Yang LX. Improved chemotherapy for hepatocellular carcinoma. Anticancer Res. 32, 1379-1386 (2012).
-
(2012)
Anticancer Res.
, vol.32
, pp. 1379-1386
-
-
Cao, H.1
Phan, H.2
Yang, L.X.3
-
6
-
-
84860252717
-
Hepatocellular carcinoma: Towards personalized medicine
-
Miki D, Ochi H, Hayes CN, Aikata H, Chayama K. Hepatocellular carcinoma: towards personalized medicine. Cancer Sci. 103, 846-850 (2012).
-
(2012)
Cancer Sci.
, vol.103
, pp. 846-850
-
-
Miki, D.1
Ochi, H.2
Hayes, C.N.3
Aikata, H.4
Chayama, K.5
-
7
-
-
34250020201
-
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
-
DOI 10.1053/j.gastro.2007.04.061, PII S0016508507007998
-
El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132, 2557-2576 (2007). (Pubitemid 46890874)
-
(2007)
Gastroenterology
, vol.132
, Issue.7
, pp. 2557-2576
-
-
El-Serag, H.B.1
Rudolph, K.L.2
-
8
-
-
33745527481
-
Viral hepatitis and liver cancer: The case of hepatitis C
-
DOI 10.1038/sj.onc.1209562, PII 1209562
-
Levrero M. Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene 25, 3834-3847 (2006). (Pubitemid 43980479)
-
(2006)
Oncogene
, vol.25
, Issue.27
, pp. 3834-3847
-
-
Levrero, M.1
-
9
-
-
34548321204
-
Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis
-
DOI 10.1002/hep.21802
-
Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46, 590-597 (2007). (Pubitemid 47344795)
-
(2007)
Hepatology
, vol.46
, Issue.2
, pp. 590-597
-
-
Elsharkawy, A.M.1
Mann, D.A.2
-
10
-
-
70349849505
-
Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences
-
Nakagawa H, Maeda S, Yoshida H et al. Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences. Int. J. Cancer 125, 2264-2269 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, pp. 2264-2269
-
-
Nakagawa, H.1
Maeda, S.2
Yoshida, H.3
-
11
-
-
77956627711
-
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
-
Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 29, 4989-5005 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 4989-5005
-
-
Whittaker, S.1
Marais, R.2
Zhu, A.X.3
-
12
-
-
0034283772
-
Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma
-
Chung YH, Kim JA, Song BC et al. Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma. Cancer 89, 977-982 (2000).
-
(2000)
Cancer
, vol.89
, pp. 977-982
-
-
Chung, Y.H.1
Kim, J.A.2
Song, B.C.3
-
13
-
-
1842428601
-
Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
-
DOI 10.1073/pnas.0306068101
-
Huh CG, Factor VM, Sanchez A et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl Acad. Sci. USA 101, 4477-4482 (2004). (Pubitemid 38437436)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.13
, pp. 4477-4482
-
-
Huh, C.-G.1
Factor, V.M.2
Sanchez, A.3
Uchida, K.4
Conner, E.A.5
Thorgeirsson, S.S.6
-
14
-
-
0036217866
-
Invasive growth: From development to metastasis
-
DOI 10.1172/JCI200215392
-
Comoglio PM, Trusolino L. Invasive growth: from development to metastasis. J. Clin. Invest. 109, 857-862 (2002). (Pubitemid 34275105)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.7
, pp. 857-862
-
-
Comoglio, P.M.1
Trusolino, L.2
-
15
-
-
0027954225
-
C-met mRNA overexpression in human hepatocellular carcinoma
-
DOI 10.1016/0270-9139(94)90057-4
-
Boix L, Rosa JL, Ventura F et al. c-Met mRNA overexpression in human hepatocellular carcinoma. Hepatology 19, 88-91 (1994). (Pubitemid 24020476)
-
(1994)
Hepatology
, vol.19
, Issue.1
, pp. 88-91
-
-
Boix, L.1
Rosa, J.L.2
Ventura, F.3
Castells, A.4
Bruix, J.5
Rodes, J.6
Bartrons, R.7
-
16
-
-
0027967963
-
Expression of the c-met protooncogene in human hepatocellular carcinoma
-
DOI 10.1016/0270-9139(94)90762-5
-
Suzuki K, Hayashi N, Yamada Y et al. Expression of the c-met protooncogene in human hepatocellular carcinoma. Hepatology 20, 1231-1236 (1994). (Pubitemid 24323571)
-
(1994)
Hepatology
, vol.20
, Issue.5
, pp. 1231-1236
-
-
Suzuki, K.1
Hayashi, N.2
Yamada, Y.3
Yoshihara, H.4
Miyamoto, Y.5
Ito, Y.6
Ito, T.7
Katayama, K.8
Sasaki, Y.9
Ito, A.10
Kisida, Y.11
Kashiwagi, T.12
Fusamoto, H.13
Kamada, T.14
-
17
-
-
33748508832
-
The clinical value of hepatocyte growth factor and its receptor-c-met for liver cancer patients with hepatectomy
-
DOI 10.1016/j.dld.2006.03.007, PII S1590865806000995
-
Wu F, Wu L, Zheng S et al. The clinical value of hepatocyte growth factor and its receptor c-Met for liver cancer patients with hepatectomy. Dig. Liver Dis. 38, 490-497 (2006). (Pubitemid 44356232)
-
(2006)
Digestive and Liver Disease
, vol.38
, Issue.7
, pp. 490-497
-
-
Wu, F.1
Wu, L.2
Zheng, S.3
Ding, W.4
Teng, L.5
Wang, Z.6
Ma, Z.7
Zhao, W.8
-
18
-
-
33745220780
-
Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
-
Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS. Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J. Clin. Invest. 116, 1582-1595 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1582-1595
-
-
Kaposi-Novak, P.1
Lee, J.S.2
Gomez-Quiroz, L.3
Coulouarn, C.4
Factor, V.M.5
Thorgeirsson, S.S.6
-
19
-
-
47749103018
-
Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: A retrospective study
-
Wang ZL, Liang P, Dong BW, Yu XL, Yu de J. Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: a retrospective study. J. Gastrointest. Surg. 12, 327-337 (2008).
-
(2008)
J. Gastrointest. Surg.
, vol.12
, pp. 327-337
-
-
Wang, Z.L.1
Liang, P.2
Dong, B.W.3
Yu, X.L.4
De J, Y.5
-
20
-
-
64349104998
-
MTOR inhibitors for hepatocellular cancer: A forward-moving target
-
Treiber G. mTOR inhibitors for hepatocellular cancer: a forward-moving target. Expert Rev. Anticancer Ther. 9, 247-261 (2009).
-
(2009)
Expert Rev. Anticancer Ther.
, vol.9
, pp. 247-261
-
-
Treiber, G.1
-
21
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
Villanueva A, Chiang DY, Newell P et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 135, 1972-1983 (2008).
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
-
22
-
-
2542473135
-
Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: Its role in tumor progression and apoptosis
-
Huynh H, Nguyen TT, Chow KH, Tan PH, Soo KC, Tran E. Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterology 3, 19 (2003).
-
(2003)
BMC Gastroenterology
, vol.3
, pp. 19
-
-
Huynh, H.1
Nguyen, T.T.2
Chow, K.H.3
Tan, P.H.4
Soo, K.C.5
Tran, E.6
-
23
-
-
0034881019
-
Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals
-
Ballif BA, Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 12, 397-408 (2001). (Pubitemid 32762689)
-
(2001)
Cell Growth and Differentiation
, vol.12
, Issue.8
, pp. 397-408
-
-
Ballif, B.A.1
Blenis, J.2
-
24
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1148-1159
-
-
Esteller, M.1
-
25
-
-
31444437920
-
Epigenetics provides a new generation of oncogenes and tumour-suppressor genes
-
DOI 10.1038/sj.bjc.6602918, PII 6602918
-
Esteller M. Epigenetics provides a new generation of oncogenes and tumour-suppressor genes. Br. J. Cancer 94, 179-183 (2006). (Pubitemid 43151531)
-
(2006)
British Journal of Cancer
, vol.94
, Issue.2
, pp. 179-183
-
-
Esteller, M.1
-
26
-
-
0041924707
-
Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
-
Yang B, Guo M, Herman JG, Clark DP. Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am. J. Pathol. 163, 1101-1107 (2003). (Pubitemid 37040145)
-
(2003)
American Journal of Pathology
, vol.163
, Issue.3
, pp. 1101-1107
-
-
Yang, B.1
Guo, M.2
Herman, J.G.3
Clark, D.P.4
-
27
-
-
0041695472
-
Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas
-
Zhong S, Yeo W, Tang MW, Wong N, Lai PB, Johnson PJ. Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas. Clin. Cancer Res. 9, 3376-3382 (2003). (Pubitemid 37086674)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.9
, pp. 3376-3382
-
-
Zhong, S.1
Yeo, W.2
Tang, M.W.3
Wong, N.4
Lai, P.B.S.5
Johnson, P.J.6
-
28
-
-
33748147734
-
Angiogenesis and anti-angiogenesis in hepatocellular carcinoma
-
DOI 10.1016/j.ctrv.2006.06.002, PII S0305737206001137
-
Ribatti D, Vacca A, Nico B, Sansonno D, Dammacco F. Angiogenesis and anti-angiogenesis in hepatocellular carcinoma. Cancer Treat. Rev. 32, 437-444 (2006). (Pubitemid 44309250)
-
(2006)
Cancer Treatment Reviews
, vol.32
, Issue.6
, pp. 437-444
-
-
Ribatti, D.1
Vacca, A.2
Nico, B.3
Sansonno, D.4
Dammacco, F.5
-
29
-
-
0034219429
-
Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues
-
Yamaguchi R, Yano H, Nakashima Y et al. Expression and localization of vascular endothelial growth factor receptors in human hepatocellular carcinoma and non-HCC tissues. Oncol. Rep. 7, 725-729 (2000).
-
(2000)
Oncol. Rep.
, vol.7
, pp. 725-729
-
-
Yamaguchi, R.1
Yano, H.2
Nakashima, Y.3
-
30
-
-
0043163428
-
Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
-
DOI 10.1245/ASO.2003.10.002
-
Chao Y, Li CP, Chau GY et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann. Surg. Oncol. 10, 355-362 (2003). (Pubitemid 40486931)
-
(2003)
Annals of Surgical Oncology
, vol.10
, Issue.4
, pp. 355-362
-
-
Chao, Y.1
Li, C.-P.2
Chau, G.-Y.3
Chen, C.-P.4
King, K.-L.5
Lui, W.-Y.6
Yen, S.-H.7
Chang, F.-Y.8
Chan, W.-K.9
Lee, S.-D.10
-
31
-
-
4043169060
-
Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma
-
DOI 10.1136/jcp.2003.015784
-
Messerini L, Novelli L, Comin CE. Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma. J. Clin. Pathol. 57, 867-871 (2004). (Pubitemid 39061438)
-
(2004)
Journal of Clinical Pathology
, vol.57
, Issue.8
, pp. 867-871
-
-
Messerini, L.1
Novelli, L.2
Comin, C.E.3
-
32
-
-
1542685212
-
Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: A prospective study
-
Jeng KS, Sheen IS, Wang YC et al. Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study. World J. Gastroenterol. 10, 643-648 (2004).
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 643-648
-
-
Jeng, K.S.1
Sheen, I.S.2
Wang, Y.C.3
-
33
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
DOI 10.1002/bjs.4594
-
Poon RT, Ho JW, Tong CS et al. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br. J. Surg. 91, 1354-1360 (2004). (Pubitemid 39331462)
-
(2004)
British Journal of Surgery
, vol.91
, Issue.10
, pp. 1354-1360
-
-
Poon, R.T.P.1
Ho, J.W.Y.2
Tong, C.S.W.3
Lau, C.4
Ng, I.O.L.5
Fan, S.-T.6
-
34
-
-
45549092607
-
Cancer immunology
-
Finn OJ. Cancer immunology. N. Engl. J. Med. 358, 2704-2715 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2704-2715
-
-
Finn, O.J.1
-
35
-
-
63949083417
-
Spontaneous regression of hepatocellular carcinoma: Three case reports and a categorized review of the literature
-
Oquiñena S, Iñarrairaegui M, Vila JJ, Alegre F, Zozaya JM, Sangro B. Spontaneous regression of hepatocellular carcinoma: three case reports and a categorized review of the literature. Dig. Dis. Sci. 54, 1147-1153 (2009).
-
(2009)
Dig. Dis. Sci.
, vol.54
, pp. 1147-1153
-
-
Oquiñena, S.1
Iñarrairaegui, M.2
Vila, J.J.3
Alegre, F.4
Zozaya, J.M.5
Sangro, B.6
-
36
-
-
33846465547
-
Immunostimulatory monoclonal antibodies for cancer therapy
-
DOI 10.1038/nrc2051, PII NRC2051
-
Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nat. Rev. Cancer 7, 95-106 (2007). (Pubitemid 46160986)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.2
, pp. 95-106
-
-
Melero, I.1
Hervas-Stubbs, S.2
Glennie, M.3
Pardoll, D.M.4
Chen, L.5
-
37
-
-
46449091500
-
Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
-
Siegel AB, Cohen EI, Ocean A et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J. Clin. Oncol. 26, 2992-2998 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2992-2998
-
-
Siegel, A.B.1
Cohen, E.I.2
Ocean, A.3
-
38
-
-
84871294854
-
Efficacy and safety of bevacizumab for the treatment of advanced hepatocellular carcinoma: A systematic review of Phase II trials
-
Fang P, Hu JH, Cheng ZG et al. Efficacy and safety of bevacizumab for the treatment of advanced hepatocellular carcinoma: a systematic review of Phase II trials. PLoS One 7, e49717 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Fang, P.1
Hu, J.H.2
Cheng, Z.G.3
-
39
-
-
84860254547
-
A Phase II study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC)
-
Abstract 4083
-
Zhu AX, Finn RS, Mulcahy MF et al. A Phase II study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 28(s15), Abstract 4083 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.15 S
-
-
Zhu, A.X.1
Finn, R.S.2
Mulcahy, M.F.3
-
40
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: An open-label, multicentre, Phase II study
-
Faivre S, Raymond E, Boucher E et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, Phase II study. Lancet Oncol. 10, 794-800 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
-
41
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: A Phase II study
-
Zhu AX, Sahani DV, Duda DG et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a Phase II study. J. Clin. Oncol. 27, 3027-3035 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
-
42
-
-
77950546450
-
Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter II trial (SAKK 77/06)
-
Koeberle D, Montemurro M, Samaras P et al. Continuous sunitinib treatment in patients with advanced hepatocellular carcinoma: a Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) multicenter II trial (SAKK 77/06). Oncologist 15, 285-292 (2010).
-
(2010)
Oncologist
, vol.15
, pp. 285-292
-
-
Koeberle, D.1
Montemurro, M.2
Samaras, P.3
-
43
-
-
84891915708
-
Sunitinib versus sorafenib in advanced hepatocellular cancer: Results of a randomized Phase III trial
-
Cheng AL, Kang YK, Lin DY et al. Sunitinib versus sorafenib in advanced hepatocellular cancer: results of a randomized Phase III trial. J. Clin. Oncol. 31, 4067-4076 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 4067-4076
-
-
Cheng, A.L.1
Kang, Y.K.2
Lin, D.Y.3
-
44
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, Phase 3 trial
-
CORRECT Study Group
-
Grothey A, Van Cutsem E, Sobrero A et al.; CORRECT Study Group. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, Phase 3 trial. Lancet 381, 303-312 (2013).
-
(2013)
Lancet
, vol.381
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
-
45
-
-
84872892692
-
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, Phase 3 trial
-
Demetri GD, Reichardt P, Kang YK et al. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, Phase 3 trial. Lancet 381, 295-302 (2013).
-
(2013)
Lancet
, vol.381
, pp. 295-302
-
-
Demetri, G.D.1
Reichardt, P.2
Kang, Y.K.3
-
46
-
-
79954499886
-
Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
-
Wilhelm SM, Dumas J, Adnane L et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int. J. Cancer 129, 245-255 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 245-255
-
-
Wilhelm, S.M.1
Dumas, J.2
Adnane, L.3
-
47
-
-
84885172911
-
Continuous-dose regorafenib (REG) in hepatocellular carcinoma (HCC): Phase i safety and pharmacokinetic (PK) study
-
Abstract 300
-
Finn RS, Blumenschein GR, Tolcher AW, Leong S, Boix O, Diefenbach K. Continuous-dose regorafenib (REG) in hepatocellular carcinoma (HCC): Phase I safety and pharmacokinetic (PK) study. J. Clin. Oncol. 30(s34), Abstract 300 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.34 S
-
-
Finn, R.S.1
Blumenschein, G.R.2
Tolcher, A.W.3
Leong, S.4
Boix, O.5
Diefenbach, K.6
-
48
-
-
84885173677
-
Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: Multicentre, open-label, Phase II safety study
-
Bruix J, Tak WY, Gasbarrini A et al. Regorafenib as second-line therapy for intermediate or advanced hepatocellular carcinoma: multicentre, open-label, Phase II safety study. Eur. J. Cancer 49(16), 3412-3419 (2013).
-
(2013)
Eur. J. Cancer
, vol.49
, Issue.16
, pp. 3412-3419
-
-
Bruix, J.1
Tak, W.Y.2
Gasbarrini, A.3
-
49
-
-
78650847886
-
Linifanib Phase II trial in 44 patients with advanced hepatocellular carcinoma (HCC)
-
Abstract 4038
-
Toh H, Chen P, Carr BI et al. Linifanib Phase II trial in 44 patients with advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 28(s15), Abstract 4038 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.S15
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
-
50
-
-
84885894561
-
Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)
-
Abstract 249
-
Cainap C, Qin S, Huang W et al. Phase III trial of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 31(Suppl. 34), Abstract 249 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, Issue.SUPPL. 34
-
-
Cainap, C.1
Qin, S.2
Huang, W.3
-
51
-
-
0030792419
-
Implications of serum basic fibroblast growth factor levels in chronic liver diseases and hepatocellular carcinoma
-
Hsu PI, Chow NH, Lai KH et al. Implications of serum basic fibroblast growth factor levels in chronic liver diseases and hepatocellular carcinoma. Anticancer Res. 17(4A), 2803-2809 (1997).
-
(1997)
Anticancer Res.
, vol.17
, Issue.4 A
, pp. 2803-2809
-
-
Hsu, P.I.1
Chow, N.H.2
Lai, K.H.3
-
52
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 8(8), 592-603 (2008).
-
(2008)
Nat. Rev. Cancer
, vol.8
, Issue.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
53
-
-
79953325932
-
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
-
Park JW, Finn RS, Kim JS et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 17, 1973-1983 (2011).
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 1973-1983
-
-
Park, J.W.1
Finn, R.S.2
Kim, J.S.3
-
54
-
-
84890274647
-
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: Results from the randomized Phase III BRISK-FL study
-
Johnson PJ, Qin S, Park JW et al. Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized Phase III BRISK-FL study. J. Clin. Oncol. 31, 3517-3524 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 3517-3524
-
-
Johnson, P.J.1
Qin, S.2
Park, J.W.3
-
55
-
-
84857008164
-
Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma
-
Finn RS, Kang YK, Mulcahy M et al. Phase II, open-label study of brivanib as second-line therapy in patients with advanced hepatocellular carcinoma. Clin. Cancer Res. 18, 2090-2098 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 2090-2098
-
-
Finn, R.S.1
Kang, Y.K.2
Mulcahy, M.3
-
56
-
-
84885587718
-
Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: Results from the randomized Phase III BRISK-PS study
-
Llovet JM, Decaens T, Raoul JL et al. Brivanib in patients with advanced hepatocellular carcinoma who were intolerant to sorafenib or for whom sorafenib failed: results from the randomized Phase III BRISK-PS study. J. Clin. Oncol. 31, 3509-3516 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 3509-3516
-
-
Llovet, J.M.1
Decaens, T.2
Raoul, J.L.3
-
57
-
-
20144370978
-
AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
-
DOI 10.1158/0008-5472.CAN-04-4409
-
Wedge SR, Kendrew J, Hennequin LF et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65, 4389-4400 (2005). (Pubitemid 40775678)
-
(2005)
Cancer Research
, vol.65
, Issue.10
, pp. 4389-4400
-
-
Wedge, S.R.1
Kendrew, J.2
Hennequin, L.F.3
Valentine, P.J.4
Barry, S.T.5
Brave, S.R.6
Smith, N.R.7
James, N.H.8
Dukes, M.9
Curwen, J.O.10
Chester, R.11
Jackson, J.A.12
Boffey, S.J.13
Kilburn, L.L.14
Barnett, S.15
Richmond, G.H.P.16
Wadsworth, P.F.17
Walker, M.18
Bigley, A.L.19
Taylor, S.T.20
Cooper, L.21
Beck, S.22
Jurgensmeier, J.M.23
Ogilvie, D.J.24
more..
-
58
-
-
84864348077
-
Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: A Phase II North Central Cancer Treatment Group clinical trial
-
Alberts SR, Fitch TR, Kim GP et al. Cediranib (AZD2171) in patients with advanced hepatocellular carcinoma: a Phase II North Central Cancer Treatment Group clinical trial. Am. J. Clin. Oncol. 35, 329-333 (2012).
-
(2012)
Am. J. Clin. Oncol.
, vol.35
, pp. 329-333
-
-
Alberts, S.R.1
Fitch, T.R.2
Kim, G.P.3
-
59
-
-
84874586305
-
Clinical, pharmacodynamic (PD), and pharmacokinetic (PK) evaluation of cediranib in advanced hepatocellular carcinoma (HCC): A Phase II study (CTEP 7147)
-
Abstract 4112
-
Zhu AX, Ancukiewicz M, Supko JG et al. Clinical, pharmacodynamic (PD), and pharmacokinetic (PK) evaluation of cediranib in advanced hepatocellular carcinoma (HCC): a Phase II study (CTEP 7147). J. Clin. Oncol. 30(s15), Abstract 4112 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.S15
-
-
Zhu, A.X.1
Ancukiewicz, M.2
Supko, J.G.3
-
60
-
-
84864459187
-
Phase I/II study of E7080 (lenvatinib), a multitargeted tyrosine kinase inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC): Initial assessment of response rate
-
Abstract 320
-
Okita K, Kumada H, Ikeda K et al. Phase I/II study of E7080 (lenvatinib), a multitargeted tyrosine kinase inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC): initial assessment of response rate. J. Clin. Oncol. 30(s4), Abstract 320 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.S4
-
-
Okita, K.1
Kumada, H.2
Ikeda, K.3
-
61
-
-
79953803472
-
A Phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma
-
Kanai F, Yoshida H, Tateishi R et al. A Phase I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma. Cancer Chemother. Pharmacol. 67, 315-324 (2011).
-
(2011)
Cancer Chemother. Pharmacol.
, vol.67
, pp. 315-324
-
-
Kanai, F.1
Yoshida, H.2
Tateishi, R.3
-
62
-
-
33750929534
-
Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group's study E1203
-
Abstract 4143
-
O'Dwyer PJ, Giantonio BJ, Levy DE, Kauh JS, Fitzgerald DB, Benson AB. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperative Oncology Group's study E1203. J. Clin. Oncol. 24(s18), Abstract 4143 (2006).
-
(2006)
J. Clin. Oncol.
, vol.24
, Issue.S18
-
-
O'Dwyer, P.J.1
Giantonio, B.J.2
Levy, D.E.3
Kauh, J.S.4
Fitzgerald, D.B.5
Benson, A.B.6
-
63
-
-
27244447373
-
Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer
-
DOI 10.1200/JCO.2005.14.696
-
Philip PA, Mahoney MR, Allmer C et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J. Clin. Oncol. 23, 6657-6663 (2005). (Pubitemid 46190260)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6657-6663
-
-
Philip, P.A.1
Mahoney, M.R.2
Allmer, C.3
Thomas, J.4
Pitot, H.C.5
Kim, G.6
Donehower, R.C.7
Fitch, T.8
Picus, J.9
Erlichman, C.10
-
64
-
-
34548150925
-
Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
-
DOI 10.1002/cncr.22886
-
Thomas MB, Chadha R, Glover K et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 110, 1059-1067 (2007). (Pubitemid 47312872)
-
(2007)
Cancer
, vol.110
, Issue.5
, pp. 1059-1067
-
-
Thomas, M.B.1
Chadha, R.2
Glover, K.3
Wang, X.4
Morris, J.5
Brown, T.6
Rashid, A.7
Dancey, J.8
Abbruzzese, J.L.9
-
65
-
-
68149164263
-
A Phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer
-
Ramanathan RK, Belani CP, Singh DA et al. A Phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother. Pharmacol. 64, 777-783 (2009).
-
(2009)
Cancer Chemother. Pharmacol.
, vol.64
, pp. 777-783
-
-
Ramanathan, R.K.1
Belani, C.P.2
Singh, D.A.3
-
66
-
-
70349443677
-
A multi-institutional Phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
-
Bekaii-Saab T, Markowitz J, Prescott N et al. A multi-institutional Phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin. Cancer Res. 15, 5895-5901 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 5895-5901
-
-
Bekaii-Saab, T.1
Markowitz, J.2
Prescott, N.3
-
67
-
-
34547102484
-
Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
-
DOI 10.1002/cncr.22829
-
Zhu AX, Stuart K, Blaszkowsky LS et al. Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 110, 581-589 (2007). (Pubitemid 47106147)
-
(2007)
Cancer
, vol.110
, Issue.3
, pp. 581-589
-
-
Zhu, A.X.1
Stuart, K.2
Blaszkowsky, L.S.3
Muzikansky, A.4
Reitberg, D.P.5
Clark, J.W.6
Enzinger, P.C.7
Bhargava, P.8
Meyerhardt, J.A.9
Horgan, K.10
Fuchs, C.S.11
Ryan, D.P.12
-
68
-
-
36348947270
-
A Phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: Final results
-
Abstract 4598
-
Gruenwald Y, Wilkens L, Gebel M et al. A Phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J. Clin. Oncol. 25(s18), Abstract 4598 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.S18
-
-
Gruenwald, Y.1
Wilkens, L.2
Gebel, M.3
-
69
-
-
84875552108
-
Targeting the HGF/c-MET pathway in hepatocellular carcinoma
-
Goyal L, Muzumdar MD, Zhu AX. Targeting the HGF/c-MET pathway in hepatocellular carcinoma. Clin. Cancer Res. 19, 2310-2318 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 2310-2318
-
-
Goyal, L.1
Muzumdar, M.D.2
Zhu, A.X.3
-
70
-
-
84875025156
-
A Phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC)
-
Abstract 4108
-
Yau T, Sukeepaisarnjaroen W, Chao Y et al. A Phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 30(s15), Abstract 4108 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.S15
-
-
Yau, T.1
Sukeepaisarnjaroen, W.2
Chao, Y.3
-
71
-
-
84872549428
-
Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a Phase II randomized discontinuation trial (RDT)
-
Abstract 4007
-
Verslype C, Cohn AL, Kelley RK et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: results from a Phase II randomized discontinuation trial (RDT). J. Clin. Oncol. 30(s15), Abstract 4007 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.S15
-
-
Verslype, C.1
Cohn, A.L.2
Kelley, R.K.3
-
72
-
-
84872600260
-
A Phase-1b study of tivantinib (ARQ 197) in adult patients with hepatocellular carcinoma and cirrhosis
-
Santoro A, Simonelli M, Rodriguez-Lope C et al. A Phase-1b study of tivantinib (ARQ 197) in adult patients with hepatocellular carcinoma and cirrhosis. Br. J. Cancer 108, 21-24 (2013).
-
(2013)
Br. J. Cancer
, vol.108
, pp. 21-24
-
-
Santoro, A.1
Simonelli, M.2
Rodriguez-Lope, C.3
-
73
-
-
84871721240
-
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled Phase 2 study
-
Santoro A, Rimassa L, Borbath I et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled Phase 2 study. Lancet Oncol. 14, 55-63 (2013).
-
(2013)
Lancet Oncol.
, vol.14
, pp. 55-63
-
-
Santoro, A.1
Rimassa, L.2
Borbath, I.3
-
74
-
-
77952085946
-
Randomized, Phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC)
-
Abstract 4587
-
Chen L, Shiah HS, Chen CY et al. Randomized, Phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients (pts) with advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 27(s15), Abstract 4587 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.S15
-
-
Chen, L.1
Shiah, H.S.2
Chen, C.Y.3
-
75
-
-
80555126830
-
Phase 1/2 study of everolimus in advanced hepatocellular carcinoma
-
Zhu AX, Abrams TA, Miksad R et al. Phase 1/2 study of everolimus in advanced hepatocellular carcinoma. Cancer 117, 5094-5102 (2011).
-
(2011)
Cancer
, vol.117
, pp. 5094-5102
-
-
Zhu, A.X.1
Abrams, T.A.2
Miksad, R.3
-
76
-
-
33846781365
-
Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma
-
DOI 10.1158/1535-7163.MCT-06-0436
-
Huynh H, Soo KC, Chow PK, Tran E. Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma. Mol. Cancer Ther. 6, 138-146 (2007). (Pubitemid 46206676)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.1
, pp. 138-146
-
-
Huynh, H.1
Soo, K.C.2
Chow, P.K.H.3
Tran, E.4
-
77
-
-
77149133090
-
AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma
-
Huynh H. AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma. Cancer 116, 1315-1325 (2010).
-
(2010)
Cancer
, vol.116
, pp. 1315-1325
-
-
Huynh, H.1
-
78
-
-
71349084002
-
AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
-
Huynh H, Ngo VC, Koong HN et al. AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC). J. Hepatol. 52, 79-87 (2010).
-
(2010)
J. Hepatol.
, vol.52
, pp. 79-87
-
-
Huynh, H.1
Ngo, V.C.2
Koong, H.N.3
-
79
-
-
34748917797
-
AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma
-
DOI 10.1158/1535-7163.MCT-07-0162
-
Huynh H, Chow PK, Soo KC. AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma. Mol. Cancer Ther. 6, 2468-2476 (2007). (Pubitemid 47480412)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.9
, pp. 2468-2476
-
-
Huynh, H.1
Chow, P.K.H.2
Soo, K.-C.3
-
80
-
-
79959214127
-
Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma
-
O'Neil BH, Goff LW, Kauh JS et al. Phase II study of the mitogen-activated protein kinase 1/2 inhibitor selumetinib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 29, 2350-2356 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 2350-2356
-
-
O'Neil, B.H.1
Goff, L.W.2
Kauh, J.S.3
-
81
-
-
84876277951
-
A Phase II trial of MEK inhibitor BAY 86-9766 in combination with sorafenib as first-line systemic treatment for patients with unresectable hepatocellular carcinoma (HCC)
-
Abstract 4103
-
Lim HY, Yen CJ, Tak WY et al. A Phase II trial of MEK inhibitor BAY 86-9766 in combination with sorafenib as first-line systemic treatment for patients with unresectable hepatocellular carcinoma (HCC). J. Clin. Oncol. 30(s15), Abstract 4103 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, Issue.S15
-
-
Lim, H.Y.1
Yen, C.J.2
Tak, W.Y.3
-
82
-
-
84866758581
-
Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: A multicenter Phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group
-
Yeo W, Chung HC, Chan SL et al. Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter Phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group. J. Clin. Oncol. 30, 3361-3367 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 3361-3367
-
-
Yeo, W.1
Chung, H.C.2
Chan, S.L.3
-
83
-
-
58949092553
-
A Phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma
-
Palmer DH, Midgley RS, Mirza M et al. A Phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology 49, 124-132 (2009).
-
(2009)
Hepatology
, vol.49
, pp. 124-132
-
-
Palmer, D.H.1
Midgley, R.S.2
Mirza, M.3
-
84
-
-
0034596475
-
Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: A randomised trial
-
Takayama T, Sekine T, Makuuchi M et al. Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomised trial. Lancet 356, 802-807 (2000).
-
(2000)
Lancet
, vol.356
, pp. 802-807
-
-
Takayama, T.1
Sekine, T.2
Makuuchi, M.3
-
85
-
-
84875225339
-
Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer
-
Heo J, Reid T, Ruo L et al. Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer. Nat. Med. 19, 329-336 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 329-336
-
-
Heo, J.1
Reid, T.2
Ruo, L.3
-
86
-
-
84879141840
-
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C
-
Sangro B, Gomez-Martin C, de la Mata M et al. A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. J. Hepatol. 59, 81-88 (2013).
-
(2013)
J. Hepatol.
, vol.59
, pp. 81-88
-
-
Sangro, B.1
Gomez-Martin, C.2
De La Mata, M.3
-
87
-
-
84864019956
-
Management of hepatocellular carcinoma: Beyond sorafeni
-
Chan SL, Mok T, Ma BB. Management of hepatocellular carcinoma: beyond sorafenib. Curr. Oncol. Rep. 14, 257-266 (2012).
-
(2012)
Curr. Oncol. Rep.
, vol.14
, pp. 257-266
-
-
Chan, S.L.1
Mok, T.2
Ma, B.B.3
-
88
-
-
78349298645
-
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
-
Abou-Alfa GK, Johnson P, Knox JJ et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 304, 2154-2160 (2010).
-
(2010)
JAMA
, vol.304
, pp. 2154-2160
-
-
Abou-Alfa, G.K.1
Johnson, P.2
Knox, J.J.3
-
89
-
-
84984578313
-
Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
-
Hsu CH, Yang TS, Hsu C et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br. J. Cancer 102, 981-986 (2010).
-
(2010)
Br. J. Cancer
, vol.102
, pp. 981-986
-
-
Hsu, C.H.1
Yang, T.S.2
Hsu, C.3
-
90
-
-
79959978255
-
Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma
-
Sun W, Sohal D, Haller DG et al. Phase 2 trial of bevacizumab, capecitabine, and oxaliplatin in treatment of advanced hepatocellular carcinoma. Cancer 117, 3187-3192 (2011).
-
(2011)
Cancer
, vol.117
, pp. 3187-3192
-
-
Sun, W.1
Sohal, D.2
Haller, D.G.3
-
91
-
-
33646351795
-
Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
-
DOI 10.1200/JCO.2005.04.9130
-
Zhu AX, Blaszkowsky LS, Ryan DP et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 24, 1898-1903 (2006). (Pubitemid 46638989)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.12
, pp. 1898-1903
-
-
Zhu, A.X.1
Blaszkowsky, L.S.2
Ryan, D.P.3
Clark, J.W.4
Muzikansky, A.5
Horgan, K.6
Sheehan, S.7
Hale, K.E.8
Enzinger, P.C.9
Bhargava, P.10
Stuart, K.11
-
92
-
-
84856294957
-
Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101
-
Chiorean EG, Ramasubbaiah R, Yu M et al. Phase II trial of erlotinib and docetaxel in advanced and refractory hepatocellular and biliary cancers: Hoosier Oncology Group GI06-101. Oncologist 17, 13 (2012).
-
(2012)
Oncologist
, vol.17
, pp. 13
-
-
Chiorean, E.G.1
Ramasubbaiah, R.2
Yu, M.3
-
93
-
-
84893831663
-
Phase II trial of gemcitabine (G), oxaliplatin (O), and erlotinib (T) for the treatment of hepatocellular carcinoma (HCC) and biliary tree cancers (BTC)
-
Abstract 4153
-
Patt AD, Baron VA, Parks A et al. Phase II trial of gemcitabine (G), oxaliplatin (O), and erlotinib (T) for the treatment of hepatocellular carcinoma (HCC) and biliary tree cancers (BTC). J. Clin. Oncol. 28(s15), Abstract 4153 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.S15
-
-
Patt, A.D.1
Baron, V.A.2
Parks, A.3
-
94
-
-
46049097410
-
Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: Results of a multicenter phase 2 study
-
DOI 10.1002/cncr.23489
-
Asnacios A, Fartoux L, Romano O et al. Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma: results of a multicenter Phase 2 study. Cancer 112, 2733-2739 (2008). (Pubitemid 351969218)
-
(2008)
Cancer
, vol.112
, Issue.12
, pp. 2733-2739
-
-
Asnacios, A.1
Fartoux, L.2
Romano, O.3
Tesmoingt, C.4
Louafi S, S.5
Mansoubakht, T.6
Artru, P.7
Poynard, T.8
Rosmorduc, O.9
Hebbar, M.10
Taieb, J.11
-
95
-
-
80053012405
-
Phase II study of capecitabine, oxaliplatin, and cetuximab for advanced hepatocellular carcinoma
-
Sanoff HK, Bernard S, Goldberg RM et al. Phase II study of capecitabine, oxaliplatin, and cetuximab for advanced hepatocellular carcinoma. Gastrointest. Cancer Res. 4, 78-83 (2011).
-
(2011)
Gastrointest. Cancer Res.
, vol.4
, pp. 78-83
-
-
Sanoff, H.K.1
Bernard, S.2
Goldberg, R.M.3
-
96
-
-
72849135336
-
Palliative treatment of unresectable metastatic colorectal cancer
-
Fornaro L, Masi G, Loupakis F, Vasile E, Falcone A. Palliative treatment of unresectable metastatic colorectal cancer. Expert Opin. Pharmacother. 11, 63-77 (2010).
-
(2010)
Expert Opin. Pharmacother.
, vol.11
, pp. 63-77
-
-
Fornaro, L.1
Masi, G.2
Loupakis, F.3
Vasile, E.4
Falcone, A.5
-
97
-
-
60849124241
-
Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinom
-
Thomas MB, Morris JS, Chadha R et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J. Clin. Oncol. 27, 843-850 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 843-850
-
-
Thomas, M.B.1
Morris, J.S.2
Chadha, R.3
-
98
-
-
84860224913
-
Phase 2 study of bevacizumab plus erlotinib in patients with advanced hepatocellular cancer
-
Philip PA, Mahoney MR, Holen KD et al. Phase 2 study of bevacizumab plus erlotinib in patients with advanced hepatocellular cancer. Cancer 118, 2424-2430 (2012).
-
(2012)
Cancer
, vol.118
, pp. 2424-2430
-
-
Philip, P.A.1
Mahoney, M.R.2
Holen, K.D.3
-
99
-
-
84872301160
-
SEARCH: A Phase III, randomized, doubleblind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC)
-
Abstract LBA2
-
Zhu AX, Rosmorduc O, Evans J et al. SEARCH: a Phase III, randomized, doubleblind, placebo-controlled trial of sorafenib plus erlotinib in patients with hepatocellular carcinoma (HCC). Ann. Oncol. 23(Suppl. 9), Abstract LBA2 (2012).
-
(2012)
Ann. Oncol.
, vol.23
, Issue.SUPPL. 9
-
-
Zhu, A.X.1
Rosmorduc, O.2
Evans, J.3
-
100
-
-
84859217727
-
Phase i study of everolimus in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC)
-
Abstract 4074
-
Finn RS, Poon RTP, Yau T et al. Phase I study of everolimus in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC). J. Clin. Oncol. 29(Suppl. 15), Abstract 4074 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.SUPPL. 15
-
-
Finn, R.S.1
Rtp, P.2
Yau, T.3
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