Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo

Molecular Medicine Reports

Volumn 9, Issue 1, 2014, Pages 51-56

  Tan, Kai Sen ^a,b   Ng, Wai Chii ^a   Seet, Ju Ee ^c   Olfat, Farzad ^b   Engelward, Bevin P ^b,d   Chow, Vincent T K ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d Massachusetts Institute of Technology   (United States)

Author keywords

Bisphosphonate; Farnesyl pyrophosphate synthase; Influenza; Lipid rafts; Pamidronate; Prophylaxis; Viperin

Indexed keywords

ANIMALS; ANTIVIRAL AGENTS; DIPHOSPHONATES; GERANYLTRANSTRANSFERASE; HELA CELLS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MYELOID DIFFERENTIATION FACTOR 88; ORTHOMYXOVIRIDAE INFECTIONS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84893850068     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1750     Document Type: Article

References (24)

1. Poland GA, Jacobson RM and Targonski PV: Avian and pandemic influenza: an overview. Vaccine 25: 3057-3061, 2007
2. de Wit E and Fouchier RA: Emerging influenza. J Clin Virol 41: 1-6, 2008
3. Memoli MJ, Morens DM and Taubenberger JK: Pandemic and seasonal influenza: therapeutic challenges. Drug Discov Today 13: 590-595, 2008
4. Rothberg MB, Haessler SD and Brown RB: Complications of viral influenza. Am J Med 121: 258-264, 2008
5. Watanabe T, Watanabe S and Kawaoka Y: Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 7: 427-439, 2010
6. Karlas A, Machuy N, Shin Y, et al: Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 463: 818-822, 2010
7. Stertz S and Shaw ML: Uncovering the global host cell requirements for influenza virus replication via RNAi screening. Microbes Infect 13: 516-525, 2011
8. König R, Stertz S, Zhou Y, et al: Human host factors required for influenza virus replication. Nature 463: 813-817, 2010
9. Fitzgerald KA: The interferon inducible gene: Viperin. J Interferon Cytokine Res 31: 131-135, 2011.
10. Gerber SA and Pober JS: IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells. J Immunol 181: 1052-1062, 2008.
11. Wang X, Hinson ER and Cresswell P: The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe 2: 96-105, 2007.
12. Simons K and Ehehalt R: Cholesterol, lipid rafts, and disease. J Clin Invest 110: 597-603, 2002.
13. Reilly JF, Martinez SD, Mickey G and Maher PA: A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction. Biochem J 366: 501-510, 2002.
14. Nayak DP, Balogun RA, Yamada H, Zhou ZH and Barman S: Influenza virus morphogenesis and budding. Virus Res 143: 147-161, 2009.
15. Ono A and Freed EO: Role of lipid rafts in virus replication. Adv Virus Res 64: 311-358, 2005.
16. van Beek E, Pieterman E, Cohen L, Löwik C and Papapoulos S: Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates. Biochem Biophys Res Commun 264: 108-111, 1999.
17. Kavanagh KL, Guo K, Dunford JE, et al: The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci USA 103: 7829-7834, 2006.
18. Guo RT, Cao R, Liang PH, et al: Bisphosphonates target multiple sites in both cis-and trans-prenyltransferases. Proc Natl Acad Sci USA 104: 10022-10027, 2007.
19. Tan KS, Olfat F, Phoon MC, et al: In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection. J Gen Virol 93: 1269-1277, 2012.
20. Matute-Bello G, Winn RK, Jonas M, Chi EY, Martin TR and Liles WC: Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol 158: 153-161, 2001.
21. Yardley V, Khan AA, Martin MB, et al: In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother 46: 929-931, 2002.
22. Rossini M, Adami S, Viapiana O, et al: Long-term effects of amino-bisphosphonates on circulating γδ T cells. Calcif Tissue Int 91: 395-399, 2012.
23. Tu W, Zheng J, Liu Y, et al: The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice. J Exp Med 208: 1511-1522, 2011.
24. Szretter KJ, Brien JD, Thackray LB, Virgin HW, Cresswell P and Diamond MS: The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J Virol 85: 11557-11566, 2011.