In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection

Journal of General Virology

Volumn 93, Issue 6, 2012, Pages 1269-1277

  Tan, Kai Sen ^a,b   Olfat, Farzad ^b   Phoon, Meng Chee ^a   Hsu, Jung Pu ^a   Howe, Josephine L C ^a   Seet, Ju Ee ^c   Chin, Keh Chuang ^d   Chow, Vincent T K ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d AGENCY FOR SCIENCE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1; VIPER VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPE; GENETIC TRANSFECTION; HELA CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H1N1); INFLUENZA VIRUS A H1N1; KNOCKOUT MOUSE; LUNG EXAMINATION; LUNG INJURY; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS LOAD; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TITRATION; WILD TYPE;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; FEMALE; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEINS; VIRAL LOAD; VIRUS REPLICATION;

ANIMALIA; INFECTIOUS FLACHERIE VIRUS; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 84861133476     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.040824-0     Document Type: Article

References (38)

1. Boudinot, P., Riffault, S., Salhi, S., Carrat, C., Sedlik, C., Mahmoudi, N., Charley, B. & Benmansour, A. (2000). Vesicular stomatitis virus and pseudorabies virus induce a vig1/cig5 homologue in mouse dendritic cells via different pathways. J Gen Virol 81, 2675-2682.
2. Chin, K. C. & Cresswell, P. (2001). Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc Natl Acad Sci U S A 98, 15125-15130.
3. de Wit, E. & Fouchier, R. A. M. (2008). Emerging influenza. J Clin Virol 41, 1-6.
4. Fitzgerald, K. A. (2011). The interferon inducible gene: viperin. J Interferon Cytokine Res 31, 131-135.
5. Hale, B. G., Albrecht, R. A. & García-Sastre, A. (2010). Innate immune evasion strategies of influenza viruses. Future Microbiol 5, 23-41.
6. Helbig, K. J., Lau, D. T., Semendric, L., Harley, H. A. & Beard, M. R. (2005). Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector. Hepatology 42, 702-710.
7. Hinson, E. R. & Cresswell, P. (2009). The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic a-helix. Proc Natl Acad Sci U S A 106, 20452-20457.
8. Jiang, D., Guo, H., Xu, C., Chang, J., Gu, B., Wang, L., Block, T. M. & Guo, J. T. (2008). Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. J Virol 82, 1665-1678.
9. Karlas, A., Machuy, N., Shin, Y., Pleissner, K. P., Artarini, A., Heuer, D., Becker, D., Khalil, H., Ogilvie, L. A. & other authors (2010). Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 463, 818-822.
10. Kaushik, D. K., Gupta, M. & Basu, A. (2011). Microglial response to viral challenges: every silver lining comes with a cloud. Front Biosci 17, 2187-2205.
11. König, R., Stertz, S., Zhou, Y., Inoue, A., Hoffmann, H. H., Bhattacharyya, S., Alamares, J. G., Tscherne, D. M., Ortigoza, M. B. & other authors (2010). Human host factors required for influenza virus replication. Nature 463, 813-817.
12. Lee, V. J., Tay, J. K., Chen, M. I., Phoon, M. C., Xie, M. L., Wu, Y., Lee, C. X., Yap, J., Sakharkar, K. R. & other authors (2010). Inactivated trivalent seasonal influenza vaccine induces limited cross-reactive neutralizing antibody responses against 2009 pandemic and 1934 PR8 H1N1 strains. Vaccine 28, 6852-6857.
13. Leong, W. F. & Chow, V. T. (2006). Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell Microbiol 8, 565-580.
14. Lim, S. M., Koraka, P., Osterhaus, A. D. & Martina, B. E. (2011). West Nile virus: immunity and pathogenesis. Viruses 3, 811-828.
15. Matute-Bello, G., Winn, R. K., Jonas, M., Chi, E. Y., Martin, T. R. & Liles, W. C. (2001). Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol 158, 153-161.
16. Memoli, M. J., Morens, D. M. & Taubenberger, J. K. (2008). Pandemic and seasonal influenza: therapeutic challenges. Drug Discov Today 13, 590-595.
17. Moltedo, B., López, C. B., Pazos, M., Becker, M. I., Hermesh, T. & Moran, T. M. (2009). Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. J Immunol 183, 3569-3573.
18. Narasaraju, T., Yang, E., Samy, R. P., Ng, H. H., Poh, W. P., Liew, A. A., Phoon, M. C., van Rooijen, N. & Chow, V. T. (2011). Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am J Pathol 179, 199-210.
19. Nayak, D. P., Balogun, R. A., Yamada, H., Zhou, Z. H. & Barman, S. (2009). Influenza virus morphogenesis and budding. Virus Res 143, 147-161.
20. Ono, A. & Freed, E. O. (2005). Role of lipid rafts in virus replication. Adv Virus Res 64, 311-358.
21. Patrozou, E. & Mermel, L. A. (2009). Does influenza transmission occur from asymptomatic infection or prior to symptom onset? Public Health Rep 124, 193-196.
22. Phoon, M. C., Desbordes, C., Howe, J. & Chow, V. T. (2001). Linoleic and linolelaidic acids differentially influence proliferation and apoptosis of MOLT-4 leukaemia cells. Cell Biol Int 25, 777-784.
23. Qiu, L. Q., Cresswell, P. & Chin, K. C. (2009). Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kB and AP-1. Blood 113, 3520-3529.
24. Reilly, J. F., Martinez, S. D., Mickey, G. & Maher, P. A. (2002). A novel role for farnesyl pyrophosphate synthase in fibroblast growth factormediated signal transduction. Biochem J 366, 501-510.
25. Saitoh, T., Satoh, T., Yamamoto, N., Uematsu, S., Takeuchi, O., Kawai, T. & Akira, S. (2011). Antiviral protein viperin promotes Toll-like receptor 7- and Toll-like receptor 9 mediated type I interferon production in plasmacytoid dendritic cells. Immunity 34, 352-363.
26. Sanders, C. J., Doherty, P. C. & Thomas, P. G. (2011). Respiratory epithelial cells in innate immunity to influenza virus infection. Cell Tissue Res 343, 13-21.
27. Schmolke, M. & García-Sastre, A. (2010). Evasion of innate and adaptive immune responses by influenza A virus. Cell Microbiol 12, 873-880.
28. Severa, M., Coccia, E. M. & Fitzgerald, K. A. (2006). Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1. J Biol Chem 281, 26188-26195.
29. Shaveta, G., Shi, J., Chow, V. T. & Song, J. (2010). Structural characterization reveals that viperin is a radical S-adenosyl-Lmethionine (SAM) enzyme. Biochem Biophys Res Commun 391, 1390-1395.
30. Stertz, S. & Shaw, M. L. (2011). Uncovering the global host cell requirements for influenza virus replication via RNAi screening. Microbes Infect 13, 516-525.
31. Stirnweiss, A., Ksienzyk, A., Klages, K., Rand, U., Grashoff, M., Hauser, H. & Kröger, A. (2010). IFN regulatory factor-1 bypasses IFNmediated antiviral effects through viperin gene induction. J Immunol 184, 5179-5185.
32. Szretter, K. J., Brien, J. D., Thackray, L. B., Virgin, H. W., Cresswell, P. & Diamond, M. S. (2011). The interferon-inducible gene viperin restricts West Nile virus pathogenesis. J Virol 85, 11557-11566.
33. Waheed, A. A. & Freed, E. O. (2007). Influenza virus not cRAFTy enough to dodge viperin. Cell Host Microbe 2, 71-72.
34. Wang, X., Hinson, E. R. & Cresswell, P. (2007). The interferoninducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe 2, 96-105.
35. Watanabe, T., Watanabe, S. & Kawaoka, Y. (2010). Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 7, 427-439.
36. Whitsett, J. A. (2002). Intrinsic and innate defenses in the lung: intersection of pathways regulating lung morphogenesis, host defense, and repair. J Clin Invest 109, 565-569.
37. Wu, S., Metcalf, J. P. & Wu, W. (2011). Innate immune response to influenza virus. Curr Opin Infect Dis 24, 235-240.
38. Zhang, Y., Burke, C. W., Ryman, K. D. & Klimstra, W. B. (2007). Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J Virol 81, 11246-11255.