C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 6, 2014, Pages 2164-2169

  Ye, Xuan ^a   Zeng, Huiqing ^a   Ning, Gang ^b   Reiter, Jeremy F ^c   Liu, Aimin ^a,b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bbs4; Centrosome; Ciliopathy; Ofd1

Indexed keywords

BBS4; CENTROSOME; CILIOPATHY; OFD1;

ANIMALS; CELLS, CULTURED; CENTRIOLES; CILIA; HEDGEHOG PROTEINS; MICE; MICROTUBULES; RNA INTERFERENCE;

EID: 84893834826     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318737111     Document Type: Article

References (33)

1. Gerdes JM, Davis EE, Katsanis N (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137(1):32-45.
2. Gerdes JM, Katsanis N (2008) Ciliary function and Wnt signal modulation. Curr Top Dev Biol 85:175-195.
3. Schneider L, et al. (2005) PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol 15(20):1861-1866.
4. Habbig S, et al. (2011) NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway. J Cell Biol 193(4):633-642.
5. Inglis PN, Boroevich KA, Leroux MR (2006) Piecing together a ciliome. Trends Genet 22(9):491-500.
6. Gherman A, Davis EE, Katsanis N (2006) The ciliary proteome database: An integrated community resource for the genetic and functional dissection of cilia. Nat Genet 38(9):961-962.
7. Bornens M (2012) The centrosome in cells and organisms. Science 335(6067):422-426.
8. Sorokin S (1962) Centrioles and the formation of rudimentary cilia by fibroblasts and smooth muscle cells. J Cell Biol 15:363-377.
9. Tanos BE, et al. (2013) Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev 27(2):163-168.
10. Goetz SC, Liem KF, Jr., Anderson KV (2012) The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell 151(4):847-858.
11. Wei Q, et al. (2013) Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes. Nat Commun 4:2750.
12. Joo K, et al. (2013) CCDC41 is required for ciliary vesicle docking to the mother centriole. Proc Natl Acad Sci USA 110(15):5987-5992.
13. Schmidt KN, et al. (2012) Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. J Cell Biol 199(7):1083-1101.
14. Sillibourne JE, et al. (2013) Primary ciliogenesis requires the distal appendage component Cep123. Biol Open 2(6):535-545.
15. Pedersen LB, Rosenbaum JL (2008) Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling. Curr Top Dev Biol 85:23-61.
16. Bärenz F, Mayilo D, Gruss OJ (2011) Centriolar satellites: Busy orbits around the centrosome. Eur J Cell Biol 90(12):983-989.
17. Kubo A, Sasaki H, Yuba-Kubo A, Tsukita S, Shiina N (1999) Centriolar satellites: Molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J Cell Biol 147(5):969-980.
18. Nachury MV, et al. (2007) A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 129(6):1201-1213.
19. Kim J, Krishnaswami SR, Gleeson JG (2008) CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium. Hum Mol Genet 17(23):3796-3805.
20. Lopes CA, et al. (2011) Centriolar satellites are assembly points for proteins implicated in human ciliopathies, including oral-facial-digital syndrome. J Cell Sci 124(Pt 4): 600-612
21. Jin H, et al. (2010) The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 141(7):1208-1219.
22. Tang Z, et al. (2013) Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. Nature 502(7470):254-257.
23. Singla V, Romaguera-Ros M, Garcia-Verdugo JM, Reiter JF (2010) Ofd1, a human disease gene, regulates the length and distal structure of centrioles. Dev Cell 18(3): 410-424.
24. Hoover AN, et al. (2008) C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 135(24):4049-4058.
25. Schroer TA (2004) Dynactin. Annu Rev Cell Dev Biol 20:759-779.
26. Echeverri CJ, Paschal BM, Vaughan KT, Vallee RB (1996) Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol 132(4):617-633.
27. Tsang WY, et al. (2008) CP110 suppresses primary cilia formation through its interaction with CEP290, a protein deficient in human ciliary disease. Dev Cell 15(2): 187-197.
28. Spektor A, Tsang WY, Khoo D, Dynlacht BD (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130(4):678-690.
29. Liu A, Wang B, Niswander LA (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132(13):3103-3111.
30. Dammermann A, Merdes A (2002) Assembly of centrosomal proteins and microtubule organization depends on PCM-1. J Cell Biol 159(2):255-266.
31. Balestra FR, Strnad P, Flückiger I, Gönczy P (2013) Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev Cell 25(6): 555-571.
32. Wang C, Low WC, Liu A, Wang B (2013) Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem 288(41):29518-29529.
33. Jia J, et al. (2009) Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev Biol 330(2):452-460.