Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Brain

Volumn 137, Issue 2, 2014, Pages 537-552

  Stygelbout, Virginie ^a   Leroy, Karelle ^a   Pouillon, Valérie ^a   Ando, Kunie ^b   D'amico, Eva ^a   Jia, Yonghui ^c,d   Luo, H Robert ^c,d   Duyckaerts, Charles ^b   Erneux, Christophe ^a   Schurmans, Stéphane ^a,e   Brion, Jean Pierre ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Alzheimer pathology; inositol (1,3,4,5) tetrakisphosphate; inositol phosphates; ITPKB

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; INOSITOL TRISPHOSPHATE 3 KINASE; INOSITOL TRISPHOSPHATE 3 KINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BRAIN CORTEX; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FOREBRAIN; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEURITE; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALZHEIMER PATHOLOGY; INOSITOL (1,3,4,5) TETRAKISPHOSPHATE; INOSITOL PHOSPHATES; ITPKB;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BRAIN; CELL LINE, TUMOR; FEMALE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; NEURITES; NEUROBLASTOMA; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PLAQUE, AMYLOID;

EID: 84893828779     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awt344     Document Type: Article

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