Biochemical and cellular specificity of peptide inhibitors of g protein-coupled receptor kinases

International Journal of Peptide Research and Therapeutics

Volumn 20, Issue 1, 2014, Pages 1-12

  Baameur, Faiza ^a   Hammitt, Richard A ^b   Friedman, Jacqueline ^a   McMurray, John S ^b   Clark, Richard B ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Cell penetrating peptide; GPCRs; GRKs; Peptide inhibitors

Indexed keywords

EID: 84893815351     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-013-9357-9     Document Type: Article

References (34)

1. Aris L, Gilchrist A, Rens-Domiano S, Meyer C, Schatz PJ, Dratz EA et al (2001) Structural requirements for the stabilization of metarhodopsin II by the C terminus of the alpha subunit of transducin. J Biol Chem 276(4):2333-2339
2. Arshady R, Atherton E, Clive DL, Sheppard RC (1981) Peptide synthesis. Part 1. Preparation and use of polar supports based on poly(dimethylacrylamide). J Chem Soc Perkin Trans 1:529-537
3. Baameur F, Morgan DH, Yao H, Tran TM, Hammitt RA, Sabui S et al (2010) Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation. Mol Pharmacol 77(3):405-415
4. Benovic JL (1991) Purification and characterization of beta-adrenergic receptor kinase. Methods Enzymol 200:351-362
5. Benovic JL, Onorato J, Lohse MJ, Dohlman HG, Staniszewski C, Caron MG et al (1990) Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. Br J Clin Pharmacol 30(Suppl 1):3S-12S
6. Boguth CA, Singh P, Huang CC, Tesmer JJ (2010) Molecular basis for activation of G protein-coupled receptor kinases. EMBO J 29(19):3249-3259
7. Clark RB, Goka TJ, Proll MA, Friedman J (1986) Homologous desensitization of beta-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein. Biochem J 235(2):399-405
8. Fawell S, Seery J, Daikh Y, Moore C, Chen LL, Pepinsky B et al (1994) Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 91(2):664-668
9. Green DA, Clark RB (1981) Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells. J Biol Chem 256(5):2105-2108
10. Gurevich EV, Tesmer JJ, Mushegian A, Gurevich VV (2012) G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther 133(1):40-69
11. Hamm HE, Deretic D, Arendt A, Hargrave PA, Koenig B, Hofmann KP (1988) Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science 241(4867):832-835
12. Homan KT, Glukhova A, Tesmer JJ (2013) Regulation of G protein-coupled receptor kinases by phospholipids. Curr Med Chem 20(1):39-46
13. Huang CC, Yoshino-Koh K, Tesmer JJ (2009) A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases. J Biol Chem 284(25):17206-17215
14. Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ (2011) Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry 50(11):1940-1949
15. Kunkel MW, Friedman J, Shenolikar S, Clark RB (1989) Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase. FASEB J 3(9):2067-2074
16. Lodowski DT, Barnhill JF, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ (2003) Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. Acta Crystallogr D 59(Pt 5):936-939
17. Lodowski DT, Tesmer VM, Benovic JL, Tesmer JJ (2006) The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. J Biol Chem 281(24):16785-16793
18. Martin EL, Rens-Domiano S, Schatz PJ, Hamm HE (1996) Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library. J Biol Chem 271(1):361-366
19. Noble B, Kallal LA, Pausch MH, Benovic JL (2003) Development of a yeast bioassay to characterize G protein-coupled receptor kinases. Identification of an NH2-terminal region essential for receptor phosphorylation. J Biol Chem 278(48):47466-47476
20. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL (1991) Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry 30(21):5118-5125
21. Pao CS, Barker BL, Benovic JL (2009) Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation. Biochemistry 48(30):7325-7333
22. Richard JP, Melikov K, Brooks H, Prevot P, Lebleu B, Chernomordik LV (2005) Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors. J Biol Chem 280(15):15300-15306
23. Ridge KD, Marino JP, Ngo T, Ramon E, Brabazon DM, Abdulaev NG (2006) NMR analysis of rhodopsin-transducin interactions. Vis Res 46(27):4482-4492
24. Sanders WS, Johnston CI, Bridges SM, Burgess SC, Willeford KO (2011) Prediction of cell penetrating peptides by support vector machines. PLoS Comput Biol 7(7):e1002101
25. Sarko D, Beijer B, Garcia Boy R, Nothelfer EM, Leotta K, Eisenhut M et al (2010) The pharmacokinetics of cell-penetrating peptides. Mol Pharm 7(6):2224-2231
26. Scheerer P, Park JH, Hildebrand PW, Kim YJ, Krauss N, Choe HW et al (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature 455(7212):497-502
27. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ (2008) Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem 283(20):14053-14062
28. Sterne-Marr R, Leahey PA, Bresee JE, Dickson HM, Ho W, Ragusa MJ et al (2009) GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail. Biochemistry 48(20):4285-4293
29. Tran TM, Friedman J, Qunaibi E, Baameur F, Moore RH, Clark RB (2004) Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol 65(1):196-206
30. Tran TM, Friedman J, Baameur F, Knoll BJ, Moore RH, Clark RB (2007a) Characterization of beta2-adrenergic receptor dephosphorylation: comparison with the rate of resensitization. Mol Pharmacol 71(1):47-60
31. Tran TM, Jorgensen R, Clark RB (2007b) Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5. Biochemistry 46(50):14438-14449
32. Winstel R, Ihlenfeldt HG, Jung G, Krasel C, Lohse MJ (2005) Peptide inhibitors of G protein-coupled receptor kinases. Biochem Pharmacol 70(7):1001-1008
33. Xin W, Tran TM, Richter W, Clark RB, Rich TC (2008) Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling. J Gen Physiol 131(4):349-364
34. Yu QM, Cheng ZJ, Gan XQ, Bao GB, Li L, Pei G (1999) The amino terminus with a conserved glutamic acid of G protein-coupled receptor kinases is indispensable for their ability to phosphorylate photoactivated rhodopsin. J Neurochem 73(3):1222-1227