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Volumn 9, Issue 1, 2014, Pages 813-822

Development of Yersinia pestis F1 antigen-loaded microspheres vaccine against plague

Author keywords

Immunological; PLGA; Protective responses

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; CAF1 PROTEIN, YERSINIA PESTIS; CYTOKINE; DRUG CARRIER; IMMUNOGLOBULIN G; MACROGOL DERIVATIVE; MICROSPHERE; NANOPARTICLE; POLY(LACTIC-GLYCOLIC ACID)-POLY(ETHYLENEGLYCOL) COPOLYMER; POLYGLACTIN;

EID: 84893814221     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S56260     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 84886025351 scopus 로고    scopus 로고
    • Plague gives surprises in the first decade of the 21st century in the United States and worldwide
    • Butler T. Plague gives surprises in the first decade of the 21st century in the United States and worldwide. Am J Trop Med Hyg. 2013;89(4): 788-793.
    • (2013) Am J Trop Med Hyg , vol.89 , Issue.4 , pp. 788-793
    • Butler, T.1
  • 2
    • 0014728212 scopus 로고
    • Effectiveness of live or killed plague vaccines in man
    • Meyer KF. Effectiveness of live or killed plague vaccines in man. Bull World Health Organ. 1970;42(5):653-666.
    • (1970) Bull World Health Organ , vol.42 , Issue.5 , pp. 653-666
    • Meyer, K.F.1
  • 4
    • 84878369905 scopus 로고    scopus 로고
    • Plague vaccines: Current developments and future perspectives
    • Feodorova VA, Motin VL. Plague vaccines: current developments and future perspectives. Emerg Microbes Infect. 2012;1(11):e36.
    • (2012) Emerg Microbes Infect , vol.1 , Issue.11
    • Feodorova, V.A.1    Motin, V.L.2
  • 5
    • 84879049312 scopus 로고    scopus 로고
    • Live-attenuated Yersinia pestis vaccines
    • Wang X, Zhang X, Zhou D, Yang R. Live-attenuated Yersinia pestis vaccines. Expert Rev Vaccines. 2013;12(6):677-686.
    • (2013) Expert Rev Vaccines , vol.12 , Issue.6 , pp. 677-686
    • Wang, X.1    Zhang, X.2    Zhou, D.3    Yang, R.4
  • 6
    • 84876792470 scopus 로고    scopus 로고
    • Multiple antigen peptide containing B and T cell epitopes of F1 antigen of Yersinia pestis showed enhanced Th1 immune response in murine model
    • Ali R, Naqvi RA, Kumar S, Bhat AA, Rao DN. Multiple antigen peptide containing B and T cell epitopes of F1 antigen of Yersinia pestis showed enhanced Th1 immune response in murine model. Scand J Immunol. 2013;77(5):361-371.
    • (2013) Scand J Immunol , vol.77 , Issue.5 , pp. 361-371
    • Ali, R.1    Naqvi, R.A.2    Kumar, S.3    Bhat, A.A.4    Rao, D.N.5
  • 7
    • 63149102052 scopus 로고    scopus 로고
    • Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by smalland large-particle aerosols
    • Thomas RJ, Webber D, Collinge A, et al. Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by smalland large-particle aerosols. Infect Immun. 2009;77(4):1315-1323.
    • (2009) Infect Immun , vol.77 , Issue.4 , pp. 1315-1323
    • Thomas, R.J.1    Webber, D.2    Collinge, A.3
  • 8
    • 0041652361 scopus 로고    scopus 로고
    • Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles
    • Sabhnani L, Manocha M, Sridevi K, Shashikiran D, Rayanade R, Rao DN. Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen of Yersinia pestis using novel delivery vehicles. FEMS Immunol Med Microbiol. 2003;38(3): 215-229.
    • (2003) FEMS Immunol Med Microbiol , vol.38 , Issue.3 , pp. 215-229
    • Sabhnani, L.1    Manocha, M.2    Sridevi, K.3    Shashikiran, D.4    Rayanade, R.5    Rao, D.N.6
  • 9
    • 84874984038 scopus 로고    scopus 로고
    • Protecting against plague: Towards a nextgeneration vaccine
    • Williamson ED, Oyston PC. Protecting against plague: towards a nextgeneration vaccine. Clin Exp Immunol. 2013;172(1):1-8.
    • (2013) Clin Exp Immunol , vol.172 , Issue.1 , pp. 1-8
    • Williamson, E.D.1    Oyston, P.C.2
  • 10
    • 0028965278 scopus 로고
    • Molecular modeling of the steric structure of the envelope F1 antigen of Yersinia pestis
    • Zav'yalov V, Denesyuk A, Zav'yalova G, Korpela T. Molecular modeling of the steric structure of the envelope F1 antigen of Yersinia pestis. Immunol Lett. 1995;45(1-2):19-22.
    • (1995) Immunol Lett , vol.45 , Issue.1-2 , pp. 19-22
    • Zav'yalov, V.1    Denesyuk, A.2    Zav'yalova, G.3    Korpela, T.4
  • 11
    • 0038820383 scopus 로고    scopus 로고
    • Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: Preserved folding energy drives fiber formation
    • Zavialov AV, Berglund J, Pudney AF, et al. Structure and biogenesis of the capsular F1 antigen from Yersinia pestis: preserved folding energy drives fiber formation. Cell. 2003;113(5):587-596.
    • (2003) Cell , vol.113 , Issue.5 , pp. 587-596
    • Zavialov, A.V.1    Berglund, J.2    Pudney, A.F.3
  • 12
    • 26644448730 scopus 로고    scopus 로고
    • Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plague
    • Powell BS, Andrews GP, Enama JT, et al. Design and testing for a nontagged F1-V fusion protein as vaccine antigen against bubonic and pneumonic plague. Biotechnol Prog. 2005;21(5):1490-1510.
    • (2005) Biotechnol Prog , vol.21 , Issue.5 , pp. 1490-1510
    • Powell, B.S.1    Andrews, G.P.2    Enama, J.T.3
  • 14
    • 78650479446 scopus 로고    scopus 로고
    • One does not fit all: New adjuvants are needed and vaccine formulation is critical
    • Korsholm KS. One does not fit all: new adjuvants are needed and vaccine formulation is critical. Expert Rev Vaccines. 2011;10(1):45-48.
    • (2011) Expert Rev Vaccines , vol.10 , Issue.1 , pp. 45-48
    • Korsholm, K.S.1
  • 15
    • 70450221930 scopus 로고    scopus 로고
    • Biodegradable polymeric nanoparticles based drug delivery systems
    • Kumari A, Yadav SK, Yadav SC. Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces. 2010;75(1): 1-18.
    • (2010) Colloids Surf B Biointerfaces , vol.75 , Issue.1 , pp. 1-18
    • Kumari, A.1    Yadav, S.K.2    Yadav, S.C.3
  • 16
    • 77957738079 scopus 로고    scopus 로고
    • Vaccine delivery by polymeric vehicles in the mouse reproductive tract induces sustained local and systemic immunity
    • Kuo-Haller P, Cu Y, Blum J, Appleton JA, Saltzman WM. Vaccine delivery by polymeric vehicles in the mouse reproductive tract induces sustained local and systemic immunity. Mol Pharm. 2010;7(5): 1585-1595.
    • (2010) Mol Pharm , vol.7 , Issue.5 , pp. 1585-1595
    • Kuo-Haller, P.1    Cu, Y.2    Blum, J.3    Appleton, J.A.4    Saltzman, W.M.5
  • 17
    • 0036709448 scopus 로고    scopus 로고
    • Japanese encephalitis virus vaccine formulations using PLA lamellar and PLG microparticles
    • Yeh MK, Coombes AG, Chen JL, Chiang CH. Japanese encephalitis virus vaccine formulations using PLA lamellar and PLG microparticles. J Microencapsul. 2002;19(5):671-682.
    • (2002) J Microencapsul , vol.19 , Issue.5 , pp. 671-682
    • Yeh, M.K.1    Coombes, A.G.2    Chen, J.L.3    Chiang, C.H.4
  • 18
    • 55649104973 scopus 로고    scopus 로고
    • Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles
    • Wischke C, Schwendeman SP. Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. Int J Pharm. 2008;364(2): 298-327.
    • (2008) Int J Pharm , vol.364 , Issue.2 , pp. 298-327
    • Wischke, C.1    Schwendeman, S.P.2
  • 19
    • 0036151773 scopus 로고    scopus 로고
    • Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles
    • Yeht MK, Chen JL, Chiang CH. Vibrio cholerae-loaded poly(DL lactide co-glycolide) microparticles. J Microencapsul. 2002;19(2): 203-212.
    • (2002) J Microencapsul , vol.19 , Issue.2 , pp. 203-212
    • Yeht, M.K.1    Chen, J.L.2    Chiang, C.H.3
  • 20
    • 0030453147 scopus 로고    scopus 로고
    • Improving protein delivery from microparticles using blends of poly(DL lactide co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers
    • Yeh MK, Davis SS, Coombes AG. Improving protein delivery from microparticles using blends of poly(DL lactide co-glycolide) and poly(ethylene oxide)-poly(propylene oxide) copolymers. Pharm Res. 1996;13(11):1693-1698.
    • (1996) Pharm Res , vol.13 , Issue.11 , pp. 1693-1698
    • Yeh, M.K.1    Davis, S.S.2    Coombes, A.G.3
  • 21
    • 38349154138 scopus 로고    scopus 로고
    • Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives
    • Mundargi RC, Babu VR, Rangaswamy V, Patel P, Aminabhavi TM. Nano/micro technologies for delivering macromolecular therapeutics using poly(D,L-lactide-co-glycolide) and its derivatives. J Control Release. 2008;125(3):193-209.
    • (2008) J Control Release , vol.125 , Issue.3 , pp. 193-209
    • Mundargi, R.C.1    Babu, V.R.2    Rangaswamy, V.3    Patel, P.4    Aminabhavi, T.M.5
  • 23
    • 79954996814 scopus 로고    scopus 로고
    • Encapsulation of water-soluble drugs by an o/o/o-solvent extraction microencapsulation method
    • Elkharraz K, Ahmed AR, Dashevsky A, Bodmeier R. Encapsulation of water-soluble drugs by an o/o/o-solvent extraction microencapsulation method. Int J Pharm. 2011;409(1-2):89-95.
    • (2011) Int J Pharm , vol.409 , Issue.1-2 , pp. 89-95
    • Elkharraz, K.1    Ahmed, A.R.2    Dashevsky, A.3    Bodmeier, R.4
  • 24
    • 12144285274 scopus 로고    scopus 로고
    • The mechanism of surface-indented protein-loaded PLGA microparticle formation: The effects of salt (NaCl) on the solidification process
    • Chen JL, Yeh MK, Chiang CH. The mechanism of surface-indented protein-loaded PLGA microparticle formation: the effects of salt (NaCl) on the solidification process. J Microencapsul. 2004;21(8): 877-888.
    • (2004) J Microencapsul , vol.21 , Issue.8 , pp. 877-888
    • Chen, J.L.1    Yeh, M.K.2    Chiang, C.H.3
  • 25
    • 79960154421 scopus 로고    scopus 로고
    • The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review
    • Fredenberg S, Wahlgren M, Reslow M, Axelsson A. The mechanisms of drug release in poly(lactic-co-glycolic acid)-based drug delivery systems-a review. Int J Pharm. 2011;415(1-2):34-52.
    • (2011) Int J Pharm , vol.415 , Issue.1-2 , pp. 34-52
    • Fredenberg, S.1    Wahlgren, M.2    Reslow, M.3    Axelsson, A.4
  • 26
    • 11844259383 scopus 로고    scopus 로고
    • Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology
    • Freitas S, Merkle HP, Gander B. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. J Control Release. 2005;102(2):313-332.
    • (2005) J Control Release , vol.102 , Issue.2 , pp. 313-332
    • Freitas, S.1    Merkle, H.P.2    Gander, B.3
  • 27
    • 79551538254 scopus 로고    scopus 로고
    • Adjuvants and delivery systems in veterinary vaccinology: Current state and future developments
    • Heegaard PM, Dedieu L, Johnson N, et al. Adjuvants and delivery systems in veterinary vaccinology: current state and future developments. Arch Virol. 2011;156(2):183-202.
    • (2011) Arch Virol , vol.156 , Issue.2 , pp. 183-202
    • Heegaard, P.M.1    Dedieu, L.2    Johnson, N.3
  • 28
    • 0842303577 scopus 로고    scopus 로고
    • Inactive Vibrio cholerae whole-cell vaccine-loaded biodegradable microparticles: In vitro release and oral vaccination
    • Yeh M, Chiang C. Inactive Vibrio cholerae whole-cell vaccine-loaded biodegradable microparticles: in vitro release and oral vaccination. J Microencapsul. 2004;21(1):91-106.
    • (2004) J Microencapsul , vol.21 , Issue.1 , pp. 91-106
    • Yeh, M.1    Chiang, C.2
  • 29
    • 0032584076 scopus 로고    scopus 로고
    • The control of protein release from poly(DL-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method
    • Coombes AG, Yeh MK, Lavelle EC, Davis SS. The control of protein release from poly(DL-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method. J Control Release. 1998;52(3):311-320.
    • (1998) J Control Release , vol.52 , Issue.3 , pp. 311-320
    • Coombes, A.G.1    Yeh, M.K.2    Lavelle, E.C.3    Davis, S.S.4
  • 30
    • 84882687280 scopus 로고    scopus 로고
    • Evaluation of protective efficacy using a nonstructural protein NS1 in DNA vaccine-loaded microspheres against dengue 2 virus
    • Huang SS, Li IH, Hong PD, Yeh MK. Evaluation of protective efficacy using a nonstructural protein NS1 in DNA vaccine-loaded microspheres against dengue 2 virus. Int J Nanomedicine. 2013;8:3161-3169.
    • (2013) Int J Nanomedicine , vol.8 , pp. 3161-3169
    • Huang, S.S.1    Li, I.H.2    Hong, P.D.3    Yeh, M.K.4
  • 31
    • 84862787965 scopus 로고    scopus 로고
    • Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors
    • Wang Y, Hao J, Li Y, et al. Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors. Biomaterials. 2012;33(18):4741-4751.
    • (2012) Biomaterials , vol.33 , Issue.18 , pp. 4741-4751
    • Wang, Y.1    Hao, J.2    Li, Y.3
  • 32
    • 10744224004 scopus 로고    scopus 로고
    • Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice
    • Wu SF, Liao CL, Lin YL, et al. Evaluation of protective efficacy and immune mechanisms of using a non-structural protein NS1 in DNA vaccine against dengue 2 virus in mice. Vaccine. 2003;21(25-26): 3919-3929.
    • (2003) Vaccine , vol.21 , Issue.25-26 , pp. 3919-3929
    • Wu, S.F.1    Liao, C.L.2    Lin, Y.L.3
  • 33
    • 53649110120 scopus 로고    scopus 로고
    • A nasal interleukin-12 DNA vaccine coexpressing Yersinia pestis F1-V fusion protein confers protection against pneumonic plague
    • Yamanaka H, Hoyt T, Yang X, et al. A nasal interleukin-12 DNA vaccine coexpressing Yersinia pestis F1-V fusion protein confers protection against pneumonic plague. Infect Immun. 2008;76(10): 4564-4573.
    • (2008) Infect Immun , vol.76 , Issue.10 , pp. 4564-4573
    • Yamanaka, H.1    Hoyt, T.2    Yang, X.3
  • 34
    • 0032077280 scopus 로고    scopus 로고
    • Comparison of the immunological and protective responses elicited by microencapsulated formulations of the F1 antigen from Yersinia pestis
    • Reddin KM, Easterbrook TJ, Eley SM, et al. Comparison of the immunological and protective responses elicited by microencapsulated formulations of the F1 antigen from Yersinia pestis. Vaccine. 1998;16(8): 761-767.
    • (1998) Vaccine , vol.16 , Issue.8 , pp. 761-767
    • Reddin, K.M.1    Easterbrook, T.J.2    Eley, S.M.3
  • 35
    • 0029053808 scopus 로고
    • Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence
    • Florence AT, Hillery AM, Hussain N, Jani PU. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. J Drug Target. 1995;3(1):65-70.
    • (1995) J Drug Target , vol.3 , Issue.1 , pp. 65-70
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 36
    • 77956494575 scopus 로고    scopus 로고
    • Nano-microparticles as immune adjuvants: Correlating particle sizes and the resultant immune responses
    • Oyewumi MO, Kumar A, Cui Z. Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses. Expert Rev Vaccines. 2010;9(9):1095-1107.
    • (2010) Expert Rev Vaccines , vol.9 , Issue.9 , pp. 1095-1107
    • Oyewumi, M.O.1    Kumar, A.2    Cui, Z.3
  • 38
    • 68649083210 scopus 로고    scopus 로고
    • Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses
    • Thomas C, Gupta V, Ahsan F. Influence of surface charge of PLGA particles of recombinant hepatitis B surface antigen in enhancing systemic and mucosal immune responses. Int J Pharm. 2009;379(1): 41-50.
    • (2009) Int J Pharm , vol.379 , Issue.1 , pp. 41-50
    • Thomas, C.1    Gupta, V.2    Ahsan, F.3
  • 39
    • 80051784753 scopus 로고    scopus 로고
    • Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    • He J, Feng M, Zhou X, et al. Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer. Int J Pharm. 2011;416(1):69-76.
    • (2011) Int J Pharm , vol.416 , Issue.1 , pp. 69-76
    • He, J.1    Feng, M.2    Zhou, X.3
  • 40
    • 80053567503 scopus 로고    scopus 로고
    • Investigation on structural integrity of PLGA during ammonolysis-based microencapsulation process
    • Heo S, Lee M, Lee S, Sah H. Investigation on structural integrity of PLGA during ammonolysis-based microencapsulation process. Int J Pharm. 2011;419(1-2):60-70.
    • (2011) Int J Pharm , vol.419 , Issue.1-2 , pp. 60-70
    • Heo, S.1    Lee, M.2    Lee, S.3    Sah, H.4
  • 41
    • 51649129933 scopus 로고    scopus 로고
    • Microencapsulation by solvent evaporation: State of the art for process engineering approaches
    • Li M, Rouaud O, Poncelet D. Microencapsulation by solvent evaporation: state of the art for process engineering approaches. Int J Pharm. 2008;363(1-2):26-39.
    • (2008) Int J Pharm , vol.363 , Issue.1-2 , pp. 26-39
    • Li, M.1    Rouaud, O.2    Poncelet, D.3
  • 42
    • 79960336687 scopus 로고    scopus 로고
    • Archaeosomes with encapsulated antigens for oral vaccine delivery
    • Li Z, Zhang L, Sun W, Ding Q, Hou Y, Xu Y. Archaeosomes with encapsulated antigens for oral vaccine delivery. Vaccine. 2011;29(32): 5260-5266.
    • (2011) Vaccine , vol.29 , Issue.32 , pp. 5260-5266
    • Li, Z.1    Zhang, L.2    Sun, W.3    Ding, Q.4    Hou, Y.5    Xu, Y.6
  • 43
    • 80052030876 scopus 로고    scopus 로고
    • Enhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate
    • Mata E, Igartua M, Patarroyo ME, Pedraz JL, Hernández RM. Enhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate. Eur J Pharm Sci. 2011;44(1-2): 32-40.
    • (2011) Eur J Pharm Sci , vol.44 , Issue.1-2 , pp. 32-40
    • Mata, E.1    Igartua, M.2    Patarroyo, M.E.3    Pedraz, J.L.4    Hernández, R.M.5
  • 44
    • 84876156655 scopus 로고    scopus 로고
    • Particulate adjuvant and innate immunity: Past achievements, present findings, and future prospects
    • Kuroda E, Coban C, Ishii KJ. Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects. Int Rev Immunol. 2013;32(2):209-220.
    • (2013) Int Rev Immunol , vol.32 , Issue.2 , pp. 209-220
    • Kuroda, E.1    Coban, C.2    Ishii, K.J.3
  • 45
    • 27744528495 scopus 로고    scopus 로고
    • Cell-mediated protection against pulmonary Yersinia pestis infection
    • Parent MA, Berggren KN, Kummer LW, et al. Cell-mediated protection against pulmonary Yersinia pestis infection. Infect Immun. 2005;73(11): 7304-7310.
    • (2005) Infect Immun , vol.73 , Issue.11 , pp. 7304-7310
    • Parent, M.A.1    Berggren, K.N.2    Kummer, L.W.3
  • 46
    • 33644831362 scopus 로고    scopus 로고
    • Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles
    • Shen H, Ackerman AL, Cody V, et al. Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles. Immunology. 2006;117(1): 78-88.
    • (2006) Immunology , vol.117 , Issue.1 , pp. 78-88
    • Shen, H.1    Ackerman, A.L.2    Cody, V.3
  • 47
    • 80052648088 scopus 로고    scopus 로고
    • CD8-dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo
    • Schliehe C, Redaelli C, Engelhardt S, et al. CD8-dendritic cells and macrophages cross-present poly(D,L-lactate-co-glycolate) acid microsphere-encapsulated antigen in vivo. J Immunol. 2011;187(5): 2112-2121.
    • (2011) J Immunol , vol.187 , Issue.5 , pp. 2112-2121
    • Schliehe, C.1    Redaelli, C.2    Engelhardt, S.3
  • 48
    • 78651515340 scopus 로고    scopus 로고
    • Improved immunogenicity of biodegradable polymer particles entrapped rotavirus vaccine
    • Nayak B, Ray AR, Panda AK, Ray P. Improved immunogenicity of biodegradable polymer particles entrapped rotavirus vaccine. J Biomater Appl. 2011;25(5):469-496.
    • (2011) J Biomater Appl , vol.25 , Issue.5 , pp. 469-496
    • Nayak, B.1    Ray, A.R.2    Panda, A.K.3    Ray, P.4


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