메뉴 건너뛰기




Volumn 61, Issue , 2014, Pages 191-200

Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties

Author keywords

Mechanical testing; Raloxifene; Toughness; Water

Indexed keywords

MECHANICAL TESTING; RALOXIFENE; TOUGHNESS; WATER;

EID: 84893810527     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.01.009     Document Type: Article
Times cited : (82)

References (37)
  • 1
    • 14844323000 scopus 로고    scopus 로고
    • The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management
    • Felsenberg D., Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther 2005, 27:1-11.
    • (2005) Clin Ther , vol.27 , pp. 1-11
    • Felsenberg, D.1    Boonen, S.2
  • 2
    • 79952698455 scopus 로고    scopus 로고
    • Denosumab and bisphosphonates: different mechanisms of action and effects
    • Baron R., Ferrari S., Russell R.G.G. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone 2011, 48:677-692.
    • (2011) Bone , vol.48 , pp. 677-692
    • Baron, R.1    Ferrari, S.2    Russell, R.G.G.3
  • 3
    • 0033581212 scopus 로고    scopus 로고
    • Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators
    • Ettinger B., Black D.M., Mitlak B.H., Knickerbocker R.K., Nickelsen T., Genant H.K., et al. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 1999, 282:637-645.
    • (1999) JAMA , vol.282 , pp. 637-645
    • Ettinger, B.1    Black, D.M.2    Mitlak, B.H.3    Knickerbocker, R.K.4    Nickelsen, T.5    Genant, H.K.6
  • 4
    • 0035233715 scopus 로고    scopus 로고
    • Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator*
    • Bryant H.U. Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator*. Rev Endocr Metab Disord 2001, 2:129-138.
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 129-138
    • Bryant, H.U.1
  • 5
    • 78651395974 scopus 로고    scopus 로고
    • Preventing osteoporosis in symptomatic postmenopausal women
    • Gallagher J.C., Levine J.P. Preventing osteoporosis in symptomatic postmenopausal women. Menopause 2011, 18:109-118.
    • (2011) Menopause , vol.18 , pp. 109-118
    • Gallagher, J.C.1    Levine, J.P.2
  • 6
    • 78650822592 scopus 로고    scopus 로고
    • Antifracture efficacy of currently available therapies for postmenopausal osteoporosis
    • Reginster J.-Y. Antifracture efficacy of currently available therapies for postmenopausal osteoporosis. Drugs 2011, 71:65-78.
    • (2011) Drugs , vol.71 , pp. 65-78
    • Reginster, J.-Y.1
  • 7
    • 34547091927 scopus 로고    scopus 로고
    • Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone
    • Allen M.R., Hogan H.A., Hobbs W.A., Koivuniemi A.S., Koivuniemi M.C., Burr D.B. Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone. Endocrinology 2007, 148:3908-3913.
    • (2007) Endocrinology , vol.148 , pp. 3908-3913
    • Allen, M.R.1    Hogan, H.A.2    Hobbs, W.A.3    Koivuniemi, A.S.4    Koivuniemi, M.C.5    Burr, D.B.6
  • 8
    • 33749537051 scopus 로고    scopus 로고
    • Raloxifene enhances vertebral mechanical properties independent of bone density
    • Allen M.R., Iwata K., Sato M., Burr D.B. Raloxifene enhances vertebral mechanical properties independent of bone density. Bone 2006, 39:1130-1135.
    • (2006) Bone , vol.39 , pp. 1130-1135
    • Allen, M.R.1    Iwata, K.2    Sato, M.3    Burr, D.B.4
  • 9
    • 79251509585 scopus 로고    scopus 로고
    • Effects of the combination treatment 1 of raloxifene and alendronate on the biomechanical properties of vertebral bone
    • Diab T., Wang J., Reienwald S., Guldberg R.E., Burr D.B. Effects of the combination treatment 1 of raloxifene and alendronate on the biomechanical properties of vertebral bone. J Bone Miner Res 2010, 26:270-276.
    • (2010) J Bone Miner Res , vol.26 , pp. 270-276
    • Diab, T.1    Wang, J.2    Reienwald, S.3    Guldberg, R.E.4    Burr, D.B.5
  • 11
    • 33846813959 scopus 로고    scopus 로고
    • The antioxidant effect of estrogen and selective estrogen receptor modulators in the inhibition of osteocyte apoptosis in vitro
    • Mann V., Huber C., Kogianni G., Collins F., Noble B. The antioxidant effect of estrogen and selective estrogen receptor modulators in the inhibition of osteocyte apoptosis in vitro. Bone 2007, 40:674-684.
    • (2007) Bone , vol.40 , pp. 674-684
    • Mann, V.1    Huber, C.2    Kogianni, G.3    Collins, F.4    Noble, B.5
  • 12
    • 0037709896 scopus 로고    scopus 로고
    • Raloxifene is a better antioxidant of low-density lipoprotein than estradiol or tamoxifen in postmenopausal women in vitro
    • Arteaga E., Villaseca P., Bianchi M., Rojas A., Marshall G. Raloxifene is a better antioxidant of low-density lipoprotein than estradiol or tamoxifen in postmenopausal women in vitro. Menopause 2003, 10:142-146.
    • (2003) Menopause , vol.10 , pp. 142-146
    • Arteaga, E.1    Villaseca, P.2    Bianchi, M.3    Rojas, A.4    Marshall, G.5
  • 13
    • 47549088812 scopus 로고    scopus 로고
    • Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway
    • Yu J., Eto M., Kozaki K., Akishita M., Okabe T., Ouchi Y. Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway. Eur J Pharmacol 2008, 589:32-36.
    • (2008) Eur J Pharmacol , vol.589 , pp. 32-36
    • Yu, J.1    Eto, M.2    Kozaki, K.3    Akishita, M.4    Okabe, T.5    Ouchi, Y.6
  • 15
    • 38949160556 scopus 로고    scopus 로고
    • Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    • Krum S.A., Miranda-Carboni G.A., Hauschka P.V., Carroll J.S., Lane T.F., Freedman L.P., et al. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J 2008, 27:535-545.
    • (2008) EMBO J , vol.27 , pp. 535-545
    • Krum, S.A.1    Miranda-Carboni, G.A.2    Hauschka, P.V.3    Carroll, J.S.4    Lane, T.F.5    Freedman, L.P.6
  • 16
    • 15644370745 scopus 로고    scopus 로고
    • Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene
    • Grese T.A., Cho S., Finley D.R., Godfrey A.G., Jones C.D., Lugar C.W., et al. Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene. J Med Chem 1997, 40:146-167.
    • (1997) J Med Chem , vol.40 , pp. 146-167
    • Grese, T.A.1    Cho, S.2    Finley, D.R.3    Godfrey, A.G.4    Jones, C.D.5    Lugar, C.W.6
  • 18
    • 84870065097 scopus 로고    scopus 로고
    • Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone
    • Horch R.A., Gochberg D.F., Nyman J.S., Does M.D. Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone. Magn Reson Med 2012, 68:1774-1784.
    • (2012) Magn Reson Med , vol.68 , pp. 1774-1784
    • Horch, R.A.1    Gochberg, D.F.2    Nyman, J.S.3    Does, M.D.4
  • 20
    • 78649449575 scopus 로고    scopus 로고
    • Qualitative and quantitative ultrashort echo time (UTE) imaging of cortical bone
    • Du J., Carl M., Bydder M., Takahashi A., Chung C.B., Bydder G.M. Qualitative and quantitative ultrashort echo time (UTE) imaging of cortical bone. J Magn Reson 2010, 207:304-311.
    • (2010) J Magn Reson , vol.207 , pp. 304-311
    • Du, J.1    Carl, M.2    Bydder, M.3    Takahashi, A.4    Chung, C.B.5    Bydder, G.M.6
  • 21
    • 51549099461 scopus 로고    scopus 로고
    • Cortical bone water: in vivo quantification with ultrashort echo-time MR Imaging1
    • Techawiboonwong A., Song H.K., Leonard M.B., Wehrli F.W. Cortical bone water: in vivo quantification with ultrashort echo-time MR Imaging1. Radiology 2008, 248:824-833.
    • (2008) Radiology , vol.248 , pp. 824-833
    • Techawiboonwong, A.1    Song, H.K.2    Leonard, M.B.3    Wehrli, F.W.4
  • 22
    • 35948963686 scopus 로고    scopus 로고
    • Ultrashort echo time spectroscopic imaging (UTESI) of cortical bone
    • Du J., Hamilton G., Takahashi A., Bydder M., Chung C.B. Ultrashort echo time spectroscopic imaging (UTESI) of cortical bone. Magn Reson Med 2007, 58:1001-1009.
    • (2007) Magn Reson Med , vol.58 , pp. 1001-1009
    • Du, J.1    Hamilton, G.2    Takahashi, A.3    Bydder, M.4    Chung, C.B.5
  • 23
    • 0036266936 scopus 로고    scopus 로고
    • Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance
    • Kemp D.C., Fan P.W., Stevens J.C. Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance. Drug Metab Dispos 2002, 30:694-700.
    • (2002) Drug Metab Dispos , vol.30 , pp. 694-700
    • Kemp, D.C.1    Fan, P.W.2    Stevens, J.C.3
  • 24
    • 33846370827 scopus 로고    scopus 로고
    • Micromechanical response of mineral and collagen phases in bone
    • Almer J., Stock S. Micromechanical response of mineral and collagen phases in bone. J Struct Biol 2007, 157:365-370.
    • (2007) J Struct Biol , vol.157 , pp. 365-370
    • Almer, J.1    Stock, S.2
  • 25
    • 84877686535 scopus 로고    scopus 로고
    • In vitro exposure to strontium improves bone material level properties
    • Cattani-Lorente M., Rizzoli R., Ammann P. In vitro exposure to strontium improves bone material level properties. Acta Biomater 2013, 9:7005-7013.
    • (2013) Acta Biomater , vol.9 , pp. 7005-7013
    • Cattani-Lorente, M.1    Rizzoli, R.2    Ammann, P.3
  • 26
    • 77951256738 scopus 로고    scopus 로고
    • Ultra-short echo-time MRI detects changes in bone mineralization and water content in OVX rat bone in response to alendronate treatment
    • Anumula S., Wehrli S.L., Magland J., Wright A.C., Wehrli F.W. Ultra-short echo-time MRI detects changes in bone mineralization and water content in OVX rat bone in response to alendronate treatment. Bone 2010, 46:1391-1399.
    • (2010) Bone , vol.46 , pp. 1391-1399
    • Anumula, S.1    Wehrli, S.L.2    Magland, J.3    Wright, A.C.4    Wehrli, F.W.5
  • 27
    • 79960558439 scopus 로고    scopus 로고
    • Effect of mineral-collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model
    • Luo Q., Nakade R., Dong X., Rong Q., Wang X. Effect of mineral-collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model. J Mech Behav Biomed Mater 2011, 4:943-952.
    • (2011) J Mech Behav Biomed Mater , vol.4 , pp. 943-952
    • Luo, Q.1    Nakade, R.2    Dong, X.3    Rong, Q.4    Wang, X.5
  • 28
    • 77951253891 scopus 로고    scopus 로고
    • Distribution of type I collagen morphologies in bone: relation to estrogen depletion
    • Wallace J.M., Erickson B., Les C.M., Orr B.G., Banaszak Holl M.M. Distribution of type I collagen morphologies in bone: relation to estrogen depletion. Bone 2010, 46:1349-1354.
    • (2010) Bone , vol.46 , pp. 1349-1354
    • Wallace, J.M.1    Erickson, B.2    Les, C.M.3    Orr, B.G.4    Banaszak Holl, M.M.5
  • 29
    • 78649906076 scopus 로고    scopus 로고
    • Nanoscale morphology of Type I collagen is altered in the Brtl mouse model of Osteogenesis Imperfecta
    • Wallace J.M., Orr B.G., Marini J.C., Holl M.M.B. Nanoscale morphology of Type I collagen is altered in the Brtl mouse model of Osteogenesis Imperfecta. J Struct Biol 2011, 173:146-152.
    • (2011) J Struct Biol , vol.173 , pp. 146-152
    • Wallace, J.M.1    Orr, B.G.2    Marini, J.C.3    Holl, M.M.B.4
  • 30
    • 44649194388 scopus 로고    scopus 로고
    • Fracture toughness and work of fracture of hydrated, dehydrated, and ashed bovine bone
    • Yan J., Daga A., Kumar R., Mecholsky J.J. Fracture toughness and work of fracture of hydrated, dehydrated, and ashed bovine bone. J Biomech 2008, 41:1929-1936.
    • (2008) J Biomech , vol.41 , pp. 1929-1936
    • Yan, J.1    Daga, A.2    Kumar, R.3    Mecholsky, J.J.4
  • 31
    • 32644452256 scopus 로고    scopus 로고
    • The influence of water removal on the strength and toughness of cortical bone
    • Nyman J.S., Roy A., Shen X., Acuna R.L., Tyler J.H., Wang X. The influence of water removal on the strength and toughness of cortical bone. J Biomech 2006, 39:931-938.
    • (2006) J Biomech , vol.39 , pp. 931-938
    • Nyman, J.S.1    Roy, A.2    Shen, X.3    Acuna, R.L.4    Tyler, J.H.5    Wang, X.6
  • 32
    • 37349054707 scopus 로고    scopus 로고
    • Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone
    • Nyman J.S., Ni Q., Nicolella D.P., Wang X. Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. Bone 2008, 42:193-199.
    • (2008) Bone , vol.42 , pp. 193-199
    • Nyman, J.S.1    Ni, Q.2    Nicolella, D.P.3    Wang, X.4
  • 33
    • 0036313364 scopus 로고    scopus 로고
    • Age-related changes in the collagen network and toughness of bone
    • Wang X., Shen X., Li X., Mauli Agrawal C. Age-related changes in the collagen network and toughness of bone. Bone 2002, 31:1-7.
    • (2002) Bone , vol.31 , pp. 1-7
    • Wang, X.1    Shen, X.2    Li, X.3    Mauli, A.C.4
  • 34
    • 0031973823 scopus 로고    scopus 로고
    • Changes in the stiffness, strength, and toughness of human cortical bone with age
    • Zioupos P., Currey J. Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 1998, 22:57-66.
    • (1998) Bone , vol.22 , pp. 57-66
    • Zioupos, P.1    Currey, J.2
  • 35
    • 84863397896 scopus 로고    scopus 로고
    • Quantitative ultrashort echo time (UTE) MRI of human cortical bone: correlation with porosity and biomechanical properties
    • Bae W.C., Chen P.C., Chung C.B., Masuda K., D'Lima D., Du J. Quantitative ultrashort echo time (UTE) MRI of human cortical bone: correlation with porosity and biomechanical properties. J Bone Miner Res 2012, 27:848-857.
    • (2012) J Bone Miner Res , vol.27 , pp. 848-857
    • Bae, W.C.1    Chen, P.C.2    Chung, C.B.3    Masuda, K.4    D'Lima, D.5    Du, J.6
  • 37
    • 75149182867 scopus 로고    scopus 로고
    • Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial
    • Jacobsen D.E., Samson M.M., Emmelot-Vonk M.H., Verhaar H.J. Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial. Eur J Endocrinol 2010, 162:371-376.
    • (2010) Eur J Endocrinol , vol.162 , pp. 371-376
    • Jacobsen, D.E.1    Samson, M.M.2    Emmelot-Vonk, M.H.3    Verhaar, H.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.