Raloxifene enhances material-level mechanical properties of femoral cortical and trabecular bone

Endocrinology

Volumn 148, Issue 8, 2007, Pages 3908-3913

  Allen, Matthew R ^a   Hogan, Harry A ^c   Hobbs, Wesley A ^c   Koivuniemi, Andrew S ^a   Koivuniemi, Mark C ^a   Burr, David B ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Indiana University Purdue University Indianapolis   (United States)

^c Texas AandM University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RALOXIFENE;

ANALYTIC METHOD; ARTICLE; BIOMECHANICS; BONE MATURATION; BONE STRENGTH; BONE STRESS; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; DOG; FEMALE; FEMUR; FEMUR NECK; NONHUMAN; PRIORITY JOURNAL; RELAXATION TRAINING; STATISTICAL ANALYSIS; TRABECULAR BONE;

ANIMALS; BIOMECHANICS; BONE DENSITY CONSERVATION AGENTS; DOGS; FEMALE; FEMUR NECK; FRACTURES, BONE; RALOXIFENE; TRABECULAR MESHWORK;

EID: 34547091927     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2007-0275     Document Type: Article

References (27)

1. Currey JD 2001 Bone strength: what are we trying to measure? Calcif Tissue Int 68:205-210
2. Burr DB, Turner CH 2003 Biomechanics of bone. In: Favus M, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. Washington, DC: American Society for Bone and Mineral Research; 58-64
3. Allen MR, Iwata K, Sato M, Burr DB 2006 Raloxifene enhances vertebral mechanical properties independent of bone density. Bone 39:1130-1135
4. Ettinger B, Black DM, Mitlak BH, Knickerbocker RK, Nickelsen T, Genant HK, Christiansen C, Delmas PD, Zanchetta JR, Stakkestad J, Gluer CC, Krueger K, Cohen FJ, Eckert S, Ensrud KE, Avioli LV, Lips P, Cummings SR 1999 Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. JAMA 282:637-645
5. Siris ES, Harris ST, Eastell R, Zanchetta JR, Goemaere S, Diez-Perez A, Stock JL, Song J, Qu Y, Kulkarni PM, Siddhanti SR, Wong M, Cummings SR 2005 Skeletal effects of raloxifene after 8 years: results from the continuing outcomes relevant to Evista (CORE) study. J Bone Miner Res 20:1514-1524
6. Delmas PD, Ensrud KE, Adachi JD, Harper KD, Sarkar S, Gennari C, Reginster JY, Pols HA, Recker RR, Harris ST, Wu W, Genant HK, Black DM, Eastell R 2002 Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial. J Clin Endocrinol Metab 87:3609-3617
7. Sarkar S, Mitlak BH, Wong M, Stock JL, Black DM, Harper KD 2002 Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy. J Bone Miner Res 17:1-10
8. Delmas PD 2000 How does antiresorptive therapy decrease the risk of fracture in women with osteoporosis? Bone 27:1-3
9. Riggs BL, Melton 3rd LJ 2002 Bone turnover matters: the raloxifene treatment paradox of dramatic decreases in vertebral fractures without commensurate increases in bone density. J Bone Miner Res 17:11-14
10. Day JS, Ding M, Bednarz P, van der Linden JC, Mashiba T, Hirano T, Johnston CC, Burr DB, Hvid I, Sumner DR, Weinans H 2004 Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties. J Orthop Res 22:465-471
11. Guo XE, Kim CH 2002 Mechanical consequence of trabecular bone loss and its treatment: a three-dimensional model simulation. Bone 30:404-411
12. Hernandez CJ, Gupta A, Keaveny TM 2006 A biomechanical analysis of the effects of resorption cavities on cancellous bone strength. J Bone Miner Res 21:1248-1255
13. Eriksen E, Axelrod D, Melsen F 1994 Bone histomorphometry. New York: Raven Press
14. Hogan H, Ruhmann S, Sampson H 2000 The mechanical properties of cancellous bone in the proximal tibia of ovariectomized rats. J Bone Miner Res 15:284-292
15. Turner CH, Burr DB 1993 Basic biomechanical measurements of bone: a tutorial. Bone 14:595-608
16. Tommasini SM, Nasser P, Schaffler MB, Jepsen KJ 2005 Relationship between bone morphology and bone quality in male tibias: implications for stress fracture risk. J Bone Miner Res 20:1372-1380
17. Garetto LP, Tricker ND, Remodeling of bone surrounding the implant interface. In: Garetto LP, Turner CH, Duncan RL, Burr DB, eds. Bridging the gap between dental, orthopaedic implants. 3rd Annual Indiana Conference, Indianapolis, IN, 1998, pp 89-100
18. Allen MR, Follet H, Khurana M, Burr DB 2006 Anti-remodeling agents influence osteoblast activity differently in modeling- and remodeling- associated bone formation. Calcif Tissue Int 79:255-261
19. Burstein AH, Currey JD, Frankel VH, Reilly DT 1972 The ultimate properties of bone tissue: the effects of yielding. J Biomech 5:35-44
20. Burr D 2002 The contribution of the organic matrix to bone's material properties. Bone 31:8-11
21. Viguet-Carrin S, Garnero P, Delmas PD 2006 The role of collagen in bone strength. Osteoporos Int 17:319-336
22. Fantner GE, Birkedal H, Kindt JH, Hassenkam T, Weaver JC, Cutroni JA, Bosma BL, Bawazer L, Finch MM, Cidade GA, Morse DE, Stucky GD, Hansma PK 2004 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone. Bone 35:1013-1022
23. Gineyts E, Allen MR, Burr DB, Delmas PD 2006 Effects of antiresorptive therapy on the bone tissue concentration of enzymatic mature collagen crosslinks and pentosidine. J Bone Miner Res 21(Suppl 1):M344
24. Banse X, Sims TJ, Bailey AJ 2002 Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links. J Bone Miner Res 17:1621-1628
25. Mann V, Huber C, Kogianni G, Collins F, Noble B 2007 The antioxidant effect of estrogen and selective estrogen receptor modulators in the inhibition of osteocyte apoptosis in vitro. Bone 40:674-684
26. Jepsen KJ, Schaffler MB, Kuhn JL, Goulet RW, Bonadio J, Goldstein SA 1997 Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue. J Biomech 30:1141-1147
27. Delmas PD, Genant HK, Crans GG, Stock JL, Wong M, Siris E, Adachi JD 2003 Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial. Bone 33:522-532