메뉴 건너뛰기




Volumn 68, Issue 1, 2014, Pages 132-143

Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat

Author keywords

Baicalin; Brain derived neurotrophic factor; CAMP response element binding protein; Corticosterone; Hypothalamus pituitary adrenal axis; Memory

Indexed keywords

BAICALIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CYCLIC AMP; MESSENGER RNA; CREBBP PROTEIN, RAT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FLAVONOID; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT;

EID: 84893784268     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-013-0782-z     Document Type: Article
Times cited : (34)

References (45)
  • 2
    • 77956292771 scopus 로고    scopus 로고
    • Effects of acute psychosocial stress on working memory related brain activity in men
    • Weerda R, Muehlhan M, Wolf OT, Thiel CM (2010) Effects of acute psychosocial stress on working memory related brain activity in men. Hum Brain Mapp 31:1418-1429
    • (2010) Hum Brain Mapp , vol.31 , pp. 1418-1429
    • Weerda, R.1    Muehlhan, M.2    Wolf, O.T.3    Thiel, C.M.4
  • 3
    • 3042647294 scopus 로고    scopus 로고
    • Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke
    • Marklund N, Peltonen M, Nilsson TK, Olsson T (2004) Low and high circulating cortisol levels predict mortality and cognitive dysfunction early after stroke. J Intern Med 256:15-21
    • (2004) J Intern Med , vol.256 , pp. 15-21
    • Marklund, N.1    Peltonen, M.2    Nilsson, T.K.3    Olsson, T.4
  • 4
    • 85027920819 scopus 로고    scopus 로고
    • A subchronic application period of glucocorticoids leads to rat cognitive dysfunction whereas physostigmine induces a mild neuroprotection
    • Wüppen K, Oesterle D, Lewicka S, Kopitz J, Plaschke K (2010) A subchronic application period of glucocorticoids leads to rat cognitive dysfunction whereas physostigmine induces a mild neuroprotection. J Neural Transm 117:1055-1065
    • (2010) J Neural Transm , vol.117 , pp. 1055-1065
    • Wüppen, K.1    Oesterle, D.2    Lewicka, S.3    Kopitz, J.4    Plaschke, K.5
  • 5
    • 3042597733 scopus 로고    scopus 로고
    • Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function
    • Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T (2004) Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. J Neurosci 24:5492-5499
    • (2004) J Neurosci , vol.24 , pp. 5492-5499
    • Mizoguchi, K.1    Ishige, A.2    Takeda, S.3    Aburada, M.4    Tabira, T.5
  • 6
    • 0030844427 scopus 로고    scopus 로고
    • Exposure to chronic psychosocial stress and corticosterone in the rat: Effects on spatial discrimination learning and hippocampal protein kinase C-gamma immunoreactivity
    • Krugers HJ, Douma BR, Andringa G, Bohus B, Korf J, Luiten PG (1997) Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase C-gamma immunoreactivity. Hippocampus 7:427-436
    • (1997) Hippocampus , vol.7 , pp. 427-436
    • Krugers, H.J.1    Douma, B.R.2    Andringa, G.3    Bohus, B.4    Korf, J.5    Luiten, P.G.6
  • 7
    • 29344447753 scopus 로고    scopus 로고
    • Ginkgo biloba normalizes stress- and corticosterone-induced impairment of recall in rats
    • Walesiuk A, Trofimiuk E, Braszko JJ (2006) Ginkgo biloba normalizes stress- and corticosterone-induced impairment of recall in rats. Pharmacol Res 53:123-128
    • (2006) Pharmacol Res , vol.53 , pp. 123-128
    • Walesiuk, A.1    Trofimiuk, E.2    Braszko, J.J.3
  • 8
    • 0034933917 scopus 로고    scopus 로고
    • Glucocorticoids and cognitive function: From physiology to pathophysiology
    • Jameison K, Dinan TG (2001) Glucocorticoids and cognitive function: from physiology to pathophysiology. Hum Psychopharmacol 16:293-302
    • (2001) Hum Psychopharmacol , vol.16 , pp. 293-302
    • Jameison, K.1    Dinan, T.G.2
  • 9
    • 0028858985 scopus 로고
    • Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats
    • Bodnoff SR, Humphreys AG, Lehman JC, Diamond DM, Rose GM, Meaney MJ (1995) Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J Neurosci 15:61-69
    • (1995) J Neurosci , vol.15 , pp. 61-69
    • Bodnoff, S.R.1    Humphreys, A.G.2    Lehman, J.C.3    Diamond, D.M.4    Rose, G.M.5    Meaney, M.J.6
  • 11
    • 70449524441 scopus 로고    scopus 로고
    • Gingkoselect alleviates chronic corticosterone-induced spatial memory deficits in rats
    • Walesiuk A, Braszko JJ (2010) Gingkoselect alleviates chronic corticosterone-induced spatial memory deficits in rats. Fitoterapia 81:25-29
    • (2010) Fitoterapia , vol.81 , pp. 25-29
    • Walesiuk, A.1    Braszko, J.J.2
  • 12
    • 33846299160 scopus 로고    scopus 로고
    • Blocking effects of intra-hippocampal naltrexone microinjections on glucocorticoid-induced impairment of spatial memory retrieval in rats
    • Sajadi AA, Samaei SA, Rashidy-Pour A (2007) Blocking effects of intra-hippocampal naltrexone microinjections on glucocorticoid-induced impairment of spatial memory retrieval in rats. Neuropharmacology 52:347-354
    • (2007) Neuropharmacology , vol.52 , pp. 347-354
    • Sajadi, A.A.1    Samaei, S.A.2    Rashidy-Pour, A.3
  • 13
    • 46749094132 scopus 로고    scopus 로고
    • Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
    • Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, Spencer JP (2008) Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 45:295-305
    • (2008) Free Radic Biol Med , vol.45 , pp. 295-305
    • Williams, C.M.1    El Mohsen, M.A.2    Vauzour, D.3    Rendeiro, C.4    Butler, L.T.5    Ellis, J.A.6    Whiteman, M.7    Spencer, J.P.8
  • 14
    • 77955913748 scopus 로고    scopus 로고
    • Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: Reversal by procyanidins extracted from the lotus seedpod
    • Xu J, Rong S, Xie B, Sun Z, Deng Q, Wu H, Bao W, Wang D, Yao P, Huang F, Liu L (2010) Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod. J Gerontol A Biol Sci Med Sci 65:933-940
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 933-940
    • Xu, J.1    Rong, S.2    Xie, B.3    Sun, Z.4    Deng, Q.5    Wu, H.6    Bao, W.7    Wang, D.8    Yao, P.9    Huang, F.10    Liu, L.11
  • 15
    • 0242653760 scopus 로고    scopus 로고
    • Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synapticplasticity
    • Vaynman S, Ying Z, Gomez-Pinilla F (2003) Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synapticplasticity. Neuroscience 122:647-657
    • (2003) Neuroscience , vol.122 , pp. 647-657
    • Vaynman, S.1    Ying, Z.2    Gomez-Pinilla, F.3
  • 16
    • 0036742611 scopus 로고    scopus 로고
    • From acquisition to consolidation: On the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning
    • Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD (2002) From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 9:224-237
    • (2002) Learn Mem , vol.9 , pp. 224-237
    • Tyler, W.J.1    Alonso, M.2    Bramham, C.R.3    Pozzo-Miller, L.D.4
  • 18
    • 79954573504 scopus 로고    scopus 로고
    • The role of CREB signaling in Alzheimer's disease and other cognitive disorders
    • Saura CA, Valero J (2011) The role of CREB signaling in Alzheimer's disease and other cognitive disorders. Rev Neurosci 22:153-169
    • (2011) Rev Neurosci , vol.22 , pp. 153-169
    • Saura, C.A.1    Valero, J.2
  • 19
    • 84862965142 scopus 로고    scopus 로고
    • Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats
    • Lee B, Sur BJ, Kwon S, Jung E, Shim I, Lee H, Hahm DH (2012) Acupuncture stimulation alleviates corticosterone-induced impairments of spatial memory and cholinergic neurons in rats. Evid Based Complement Alternat Med 2012:670536
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 670536
    • Lee, B.1    Sur, B.J.2    Kwon, S.3    Jung, E.4    Shim, I.5    Lee, H.6    Hahm, D.H.7
  • 20
    • 33646048297 scopus 로고    scopus 로고
    • Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress
    • Song L, Che W, Min-Wei W, Murakami Y, Matsumoto K (2006) Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress. Pharmacol Biochem Behav 83:186-193
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 186-193
    • Song, L.1    Che, W.2    Min-Wei, W.3    Murakami, Y.4    Matsumoto, K.5
  • 21
    • 77956612277 scopus 로고    scopus 로고
    • Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease
    • Alkadhi KA, Srivareerat M, Tran TT (2010) Intensification of long-term memory deficit by chronic stress and prevention by nicotine in a rat model of Alzheimer's disease. Mol Cell Neurosci 45(3):289-296
    • (2010) Mol Cell Neurosci , vol.45 , Issue.3 , pp. 289-296
    • Alkadhi, K.A.1    Srivareerat, M.2    Tran, T.T.3
  • 22
    • 84864622269 scopus 로고    scopus 로고
    • Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis
    • Cheng O, Li Z, Han Y, Jiang Q, Yan Y, Cheng K (2012) Baicalin improved the spatial learning ability of global ischemia/reperfusion rats by reducing hippocampal apoptosis. Brain Res 1470:111-118
    • (2012) Brain Res , vol.1470 , pp. 111-118
    • Cheng, O.1    Li, Z.2    Han, Y.3    Jiang, Q.4    Yan, Y.5    Cheng, K.6
  • 23
    • 79960199325 scopus 로고    scopus 로고
    • Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways
    • Cao Y, Mao X, Sun C, Zheng P, Gao J, Wang X, Min D, Sun H, Xie N, Cai J (2011) Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways. Brain Res Bull 85:396-402
    • (2011) Brain Res Bull , vol.85 , pp. 396-402
    • Cao, Y.1    Mao, X.2    Sun, C.3    Zheng, P.4    Gao, J.5    Wang, X.6    Min, D.7    Sun, H.8    Xie, N.9    Cai, J.10
  • 25
    • 58749114381 scopus 로고    scopus 로고
    • New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin
    • Li-Weber M (2009) New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev 35:57-68
    • (2009) Cancer Treat Rev , vol.35 , pp. 57-68
    • Li-Weber, M.1
  • 26
    • 78049302588 scopus 로고    scopus 로고
    • Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo
    • Li H, Hu J, Ma L, Yuan Z, Wang Y, Wang X, Xing D, Lei F, Du L (2010) Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo. Eur J Pharmacol 649:92-99
    • (2010) Eur J Pharmacol , vol.649 , pp. 92-99
    • Li, H.1    Hu, J.2    Ma, L.3    Yuan, Z.4    Wang, Y.5    Wang, X.6    Xing, D.7    Lei, F.8    Du, L.9
  • 27
    • 77957258387 scopus 로고    scopus 로고
    • Neuroprotective effect of baicalin on compression spinal cord injury in rats
    • Cao Y, Li G, Wang YF, Fan ZK, Yu DS, Wang ZD, Bi YL (2010) Neuroprotective effect of baicalin on compression spinal cord injury in rats. Brain Res 1357:115-123
    • (2010) Brain Res , vol.1357 , pp. 115-123
    • Cao, Y.1    Li, G.2    Wang, Y.F.3    Fan, Z.K.4    Yu, D.S.5    Wang, Z.D.6    Bi, Y.L.7
  • 28
    • 84864329642 scopus 로고    scopus 로고
    • The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats
    • Liu YF, Gao F, Li XW, Jia RH, Meng XD, Zhao R, Jing YY, Wang Y, Jiang W (2012) The anticonvulsant and neuroprotective effects of baicalin on pilocarpine-induced epileptic model in rats. Neurochem Res 37:1670-1680
    • (2012) Neurochem Res , vol.37 , pp. 1670-1680
    • Liu, Y.F.1    Gao, F.2    Li, X.W.3    Jia, R.H.4    Meng, X.D.5    Zhao, R.6    Jing, Y.Y.7    Wang, Y.8    Jiang, W.9
  • 29
    • 84867897745 scopus 로고    scopus 로고
    • Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: Involving the inhibition of cyclooxygenase-2 in rat brain
    • Li YC, Shen JD, Li J, Wang R, Jiao S, Yi LT (2013) Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: involving the inhibition of cyclooxygenase-2 in rat brain. Prog Neuropsychopharmacol Biol Psychiatry 40:138-143
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.40 , pp. 138-143
    • Li, Y.C.1    Shen, J.D.2    Li, J.3    Wang, R.4    Jiao, S.5    Yi, L.T.6
  • 30
    • 79551569169 scopus 로고    scopus 로고
    • Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin
    • Li M, Tsang KS, Choi ST, Li K, Shaw PC, Lau KF (2011) Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin. ChemBioChem 12:449-456
    • (2011) ChemBioChem , vol.12 , pp. 449-456
    • Li, M.1    Tsang, K.S.2    Choi, S.T.3    Li, K.4    Shaw, P.C.5    Lau, K.F.6
  • 31
    • 80055017674 scopus 로고    scopus 로고
    • Effect of baicalin on matrix metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral ischemia in rats
    • Tu XK, Yang WZ, Liang RS, Shi SS, Chen JP, Chen CM, Wang CH, Xie HS, Chen Y, Ouyang LQ (2011) Effect of baicalin on matrix metalloproteinase-9 expression and blood-brain barrier permeability following focal cerebral ischemia in rats. Neurochem Res 36:2022-2028
    • (2011) Neurochem Res , vol.36 , pp. 2022-2028
    • Tu, X.K.1    Yang, W.Z.2    Liang, R.S.3    Shi, S.S.4    Chen, J.P.5    Chen, C.M.6    Wang, C.H.7    Xie, H.S.8    Chen, Y.9    Ouyang, L.Q.10
  • 33
    • 84868214343 scopus 로고    scopus 로고
    • Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration
    • Yi LT, Li J, Li HC, Zhou Y, Su BF, Yang KF, Jiang M, Zhang YT (2012) Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration. J Ethnopharmacol 144:328-334
    • (2012) J Ethnopharmacol , vol.144 , pp. 328-334
    • Yi, L.T.1    Li, J.2    Li, H.C.3    Zhou, Y.4    Su, B.F.5    Yang, K.F.6    Jiang, M.7    Zhang, Y.T.8
  • 34
    • 79952899810 scopus 로고    scopus 로고
    • Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats
    • Huang Z, Zhong XM, Li ZY, Feng CR, Pan AJ, Mao QQ (2011) Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats. Neurosci Lett 493:145-148
    • (2011) Neurosci Lett , vol.493 , pp. 145-148
    • Huang, Z.1    Zhong, X.M.2    Li, Z.Y.3    Feng, C.R.4    Pan, A.J.5    Mao, Q.Q.6
  • 35
    • 2942666062 scopus 로고    scopus 로고
    • Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
    • Nacher J, Pham K, Gil-Fernandez V, McEwen BS (2004) Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex. Neuroscience 126:503-509
    • (2004) Neuroscience , vol.126 , pp. 503-509
    • Nacher, J.1    Pham, K.2    Gil-Fernandez, V.3    McEwen, B.S.4
  • 36
    • 0029555525 scopus 로고
    • Measurement of phosphotyrosine phosphatase activity using the Folin-Ciocalteu phenol reaction
    • Gmeiner BM, Seelos CC (1995) Measurement of phosphotyrosine phosphatase activity using the Folin-Ciocalteu phenol reaction. Biochem Mol Biol Int 36:943-948
    • (1995) Biochem Mol Biol Int , vol.36 , pp. 943-948
    • Gmeiner, B.M.1    Seelos, C.C.2
  • 39
    • 84861200987 scopus 로고    scopus 로고
    • Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells
    • Zhu H, Wang Z, Xing Y, Gao Y, Ma T, Lou L, Lou J, Gao Y, Wang S, Wang Y (2012) Baicalin reduces the permeability of the blood-brain barrier during hypoxia in vitro by increasing the expression of tight junction proteins in brain microvascular endothelial cells. J Ethnopharmacol 141:714-720
    • (2012) J Ethnopharmacol , vol.141 , pp. 714-720
    • Zhu, H.1    Wang, Z.2    Xing, Y.3    Gao, Y.4    Ma, T.5    Lou, L.6    Lou, J.7    Gao, Y.8    Wang, S.9    Wang, Y.10
  • 40
    • 34547689480 scopus 로고    scopus 로고
    • Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory
    • Conrad CD, McLaughlin KJ, Harman JS, Foltz C, Wieczorek L, Lightner E, Wright RL (2007) Chronic glucocorticoids increase hippocampal vulnerability to neurotoxicity under conditions that produce CA3 dendritic retraction but fail to impair spatial recognition memory. J Neurosci 27:8278-8285
    • (2007) J Neurosci , vol.27 , pp. 8278-8285
    • Conrad, C.D.1    McLaughlin, K.J.2    Harman, J.S.3    Foltz, C.4    Wieczorek, L.5    Lightner, E.6    Wright, R.L.7
  • 41
    • 0037171762 scopus 로고    scopus 로고
    • Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory
    • Pittenger C, Huang YY, Paletzki RF, Bourtchouladze R, Scanlin H, Vronskaya S, Kandel ER (2002) Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34:447-462
    • (2002) Neuron , vol.34 , pp. 447-462
    • Pittenger, C.1    Huang, Y.Y.2    Paletzki, R.F.3    Bourtchouladze, R.4    Scanlin, H.5    Vronskaya, S.6    Kandel, E.R.7
  • 42
    • 84872724945 scopus 로고    scopus 로고
    • Angelica keiskei ameliorates scopolamine-induced memory impairments in mice
    • Oh SR, Kim SJ, Kim DH, Ryu JH, Ahn EM, Jung JW (2013) Angelica keiskei ameliorates scopolamine-induced memory impairments in mice. Biol Pharm Bull 36:82-88
    • (2013) Biol Pharm Bull , vol.36 , pp. 82-88
    • Oh, S.R.1    Kim, S.J.2    Kim, D.H.3    Ryu, J.H.4    Ahn, E.M.5    Jung, J.W.6
  • 43
    • 84860217099 scopus 로고    scopus 로고
    • CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice
    • Saura CA (2012) CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice. Neurodegener Dis 10:250-252
    • (2012) Neurodegener Dis , vol.10 , pp. 250-252
    • Saura, C.A.1
  • 44
    • 0035686083 scopus 로고    scopus 로고
    • Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology
    • Frautschy SA, Hu W, Kim P, Miller SA, Chu T, Harris-White ME, Cole GM (2001) Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 22:993-1005
    • (2001) Neurobiol Aging , vol.22 , pp. 993-1005
    • Frautschy, S.A.1    Hu, W.2    Kim, P.3    Miller, S.A.4    Chu, T.5    Harris-White, M.E.6    Cole, G.M.7
  • 45
    • 33748439924 scopus 로고    scopus 로고
    • Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats
    • Browne KD, Iwata A, Putt ME, Smith DH (2006) Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats. Exp Neurol 201:301-307
    • (2006) Exp Neurol , vol.201 , pp. 301-307
    • Browne, K.D.1    Iwata, A.2    Putt, M.E.3    Smith, D.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.