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Volumn 87, Issue 4, 2014, Pages 571-578

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling

Author keywords

Breast cancer; Clofazimine; In silico screening; Wnt signaling

Indexed keywords

BREAST CANCER; CLOFAZIMINE; IN SILICO SCREENING; WNT SIGNALING;

EID: 84893754602     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.12.007     Document Type: Article
Times cited : (57)

References (44)
  • 1
    • 84876888105 scopus 로고    scopus 로고
    • Challenges and opportunities of drug repositioning
    • N. Novac Challenges and opportunities of drug repositioning Trends Pharmacol Sci 34 2013 267 272
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 267-272
    • Novac, N.1
  • 2
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • M. Boolell, M.J. Allen, S.A. Ballard, S. Gepi-Attee, G.J. Muirhead, and A.M. Naylor et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction Int J Impot Res 8 1996 47 52
    • (1996) Int J Impot Res , vol.8 , pp. 47-52
    • Boolell, M.1    Allen, M.J.2    Ballard, S.A.3    Gepi-Attee, S.4    Muirhead, G.J.5    Naylor, A.M.6
  • 3
    • 0037208595 scopus 로고    scopus 로고
    • Thalidomide alone or with dexamethasone for previously untreated multiple myeloma
    • D. Weber, K. Rankin, M. Gavino, K. Delasalle, and R. Alexanian Thalidomide alone or with dexamethasone for previously untreated multiple myeloma J Clin Oncol 21 2003 16 19
    • (2003) J Clin Oncol , vol.21 , pp. 16-19
    • Weber, D.1    Rankin, K.2    Gavino, M.3    Delasalle, K.4    Alexanian, R.5
  • 4
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling: Components, mechanisms, and diseases
    • B.T. MacDonald, K. Tamai, and X. He Wnt/β-catenin signaling: components, mechanisms, and diseases Dev Cell 17 2009 9 26
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 5
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • N. Barker, and H. Clevers Mining the Wnt pathway for cancer therapeutics Nat Rev Drug Discov 5 2006 997 1014 (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 6
    • 80055040407 scopus 로고    scopus 로고
    • FZD7 has a critical role in cell proliferation in triple negative breast cancer
    • L. Yang, X. Wu, Y. Wang, K. Zhang, J. Wu, and Y.C. Yuan et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer Oncogene 30 2011 4437 4446
    • (2011) Oncogene , vol.30 , pp. 4437-4446
    • Yang, L.1    Wu, X.2    Wang, Y.3    Zhang, K.4    Wu, J.5    Yuan, Y.C.6
  • 8
    • 78651373139 scopus 로고    scopus 로고
    • New avenues to target Wnt/β-catenin signaling
    • F. Verkaar, and G.J.R. Zaman New avenues to target Wnt/β-catenin signaling Drug Discov Today 16 2011 35 41
    • (2011) Drug Discov Today , vol.16 , pp. 35-41
    • Verkaar, F.1    Zaman, G.J.R.2
  • 9
    • 84870326949 scopus 로고    scopus 로고
    • Platforms for high-throughput screening of Wnt/Frizzled antagonists
    • A. Koval, and V.L. Katanaev Platforms for high-throughput screening of Wnt/Frizzled antagonists Drug Discov Today 17 2012 1316 1322
    • (2012) Drug Discov Today , vol.17 , pp. 1316-1322
    • Koval, A.1    Katanaev, V.L.2
  • 11
    • 76149120388 scopus 로고    scopus 로고
    • AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading
    • O. Trott, and A.J. Olson AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading J Comput Chem 31 2010 455 461
    • (2010) J Comput Chem , vol.31 , pp. 455-461
    • Trott, O.1    Olson, A.J.2
  • 12
    • 78751483422 scopus 로고    scopus 로고
    • Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins
    • A. Koval, and V.L. Katanaev Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins Biochem J 433 2011 435 440
    • (2011) Biochem J , vol.433 , pp. 435-440
    • Koval, A.1    Katanaev, V.L.2
  • 13
    • 67349233100 scopus 로고    scopus 로고
    • The role of parafibromin/hyrax as a nuclear Gli/Ci-interacting protein in hedgehog target gene control
    • C. Mosimann, G. Hausmann, and K. Basler The role of parafibromin/hyrax as a nuclear Gli/Ci-interacting protein in hedgehog target gene control Mech Dev 126 2009 394 405
    • (2009) Mech Dev , vol.126 , pp. 394-405
    • Mosimann, C.1    Hausmann, G.2    Basler, K.3
  • 14
    • 0034660683 scopus 로고    scopus 로고
    • A noncommercial dual luciferase enzyme assay system for reporter gene analysis
    • DOI 10.1006/abio.2000.4605
    • B.W. Dyer, F.A. Ferrer, D.K. Klinedinst, and R. Rodriguez A noncommercial dual luciferase enzyme assay system for reporter gene analysis Anal Biochem 282 2000 158 161 (Pubitemid 30409441)
    • (2000) Analytical Biochemistry , vol.282 , Issue.1 , pp. 158-161
    • Dyer, B.W.1    Ferrer, F.A.2    Klinedinst, D.K.3    Rodriguez, R.4
  • 15
    • 0031792355 scopus 로고    scopus 로고
    • Cytoskeletal reorganization by soluble Wnt-3a protein signalling
    • DOI 10.1046/j.1365-2443.1998.00221.x
    • Shibamoto, K. Higano, R. Takada, F. Ito, M. Takeichi, and S. Takada Cytoskeletal reorganization by soluble Wnt-3a protein signalling Genes Cells 3 1998 659 670 (Pubitemid 28557207)
    • (1998) Genes to Cells , vol.3 , Issue.10 , pp. 659-670
    • Shibamoto, S.1    Higano, K.2    Takada, R.3    Ito, F.4    Takeichi, M.5    Takada, S.6
  • 16
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: A comprehensive resource for 'omics' research on drugs
    • C. Knox, V. Law, T. Jewison, P. Liu, S. Ly, and A. Frolkis et al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs Nucl Acids Res 39 2011 1035 1041
    • (2011) Nucl Acids Res , vol.39 , pp. 1035-1041
    • Knox, C.1    Law, V.2    Jewison, T.3    Liu, P.4    Ly, S.5    Frolkis, A.6
  • 17
    • 78650926798 scopus 로고    scopus 로고
    • Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis
    • B.K. Atwood, J. Lopez, J. Wager-Miller, K. Mackie, and A. Straiker Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis BMC Genomics 2011 12
    • (2011) BMC Genomics , pp. 12
    • Atwood, B.K.1    Lopez, J.2    Wager-Miller, J.3    MacKie, K.4    Straiker, A.5
  • 18
    • 84893737659 scopus 로고    scopus 로고
    • WNT/Frizzled signaling: Receptor-ligand selectivity with focus on FZD-G protein signaling and its physiological relevance
    • J.P. Dijksterhuis, J. Petersen, and G. Schulte WNT/Frizzled signaling: receptor-ligand selectivity with focus on FZD-G protein signaling and its physiological relevance Br J Pharmacol 2013 n/a n/a
    • (2013) Br J Pharmacol
    • Dijksterhuis, J.P.1    Petersen, J.2    Schulte, G.3
  • 19
    • 80054685356 scopus 로고    scopus 로고
    • Yellow submarine of the Wnt/Frizzled signaling: Submerging from the G protein harbor to the targets
    • A. Koval, V. Purvanov, D. Egger-Adam, and V.L. Katanaev Yellow submarine of the Wnt/Frizzled signaling: submerging from the G protein harbor to the targets Biochem Pharmacol 82 2011 1311 1319
    • (2011) Biochem Pharmacol , vol.82 , pp. 1311-1319
    • Koval, A.1    Purvanov, V.2    Egger-Adam, D.3    Katanaev, V.L.4
  • 21
    • 0001315351 scopus 로고
    • Cultivation of human breast carcinomas
    • E.Y. Lasfargues, and L. Ozzello Cultivation of human breast carcinomas J Nat Cancer Inst 21 1958 1131 1147
    • (1958) J Nat Cancer Inst , vol.21 , pp. 1131-1147
    • Lasfargues, E.Y.1    Ozzello, L.2
  • 22
    • 84055222589 scopus 로고    scopus 로고
    • The Wnt/β-catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer
    • T.D. King, M.J. Suto, and Y. Li The Wnt/β-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer J Cell Biochem 113 2012 13 18
    • (2012) J Cell Biochem , vol.113 , pp. 13-18
    • King, T.D.1    Suto, M.J.2    Li, Y.3
  • 23
    • 7544247898 scopus 로고    scopus 로고
    • Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid
    • DOI 10.1016/j.tube.2004.04.001, PII S1472979204000526
    • D.E. Nix, R.D. Adam, B. Auclair, T.S. Krueger, P.G. Godo, and C.A. Peloquin Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid Tuberculosis 84 2004 365 373 (Pubitemid 39451903)
    • (2004) Tuberculosis , vol.84 , Issue.6 , pp. 365-373
    • Nix, D.E.1    Adam, R.D.2    Auclair, B.3    Krueger, T.S.4    Godo, P.G.5    Peloquin, C.A.6
  • 24
    • 0016283694 scopus 로고
    • Tissue concentrations of clofazimine (B663) in man
    • R.E. Mansfield Tissue concentrations of clofazimine (B663) in man Am J Trop Med Hyg 23 1974 1116 1119
    • (1974) Am J Trop Med Hyg , vol.23 , pp. 1116-1119
    • Mansfield, R.E.1
  • 26
    • 81155148160 scopus 로고    scopus 로고
    • Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells
    • M.Y. Sherman, L. Meng, M. Stampfer, V.L. Gabai, and J.A. Yaglom Oncogenes induce senescence with incomplete growth arrest and suppress the DNA damage response in immortalized cells Aging Cell 10 2011 949 961
    • (2011) Aging Cell , vol.10 , pp. 949-961
    • Sherman, M.Y.1    Meng, L.2    Stampfer, M.3    Gabai, V.L.4    Yaglom, J.A.5
  • 28
    • 0033613394 scopus 로고    scopus 로고
    • Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response
    • DOI 10.1038/sj.onc.1202985
    • A. Gazit, A. Yaniv, A. Bafico, T. Pramila, M. Igarashi, and J. Kitajewski et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response Oncogene 18 1999 5959 5966 (Pubitemid 29535007)
    • (1999) Oncogene , vol.18 , Issue.44 , pp. 5959-5966
    • Gazit, A.1    Yaniv, A.2    Bafico, A.3    Pramila, T.4    Igarashi, M.5    Kitajewski, J.6    Aaronson, S.A.7
  • 29
    • 18344389705 scopus 로고    scopus 로고
    • Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling
    • H.G. Pálmer, J.M. González-Sancho, J. Espada, M.T. Berciano, I. Puig, and J. Baulida et al. Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling J Cell Biol 154 2001 369 388
    • (2001) J Cell Biol , vol.154 , pp. 369-388
    • Pálmer, H.G.1    González-Sancho, J.M.2    Espada, J.3    Berciano, M.T.4    Puig, I.5    Baulida, J.6
  • 31
    • 84856051012 scopus 로고    scopus 로고
    • Sorafenib: Complexities of Raf-dependent and Raf-independent signaling are now unveiled
    • Y. Matsuda, and M. Fukumoto Sorafenib: complexities of Raf-dependent and Raf-independent signaling are now unveiled Med Mol Morphol 44 2011 183 189
    • (2011) Med Mol Morphol , vol.44 , pp. 183-189
    • Matsuda, Y.1    Fukumoto, M.2
  • 32
    • 84866532501 scopus 로고    scopus 로고
    • Wnt-Pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib
    • A. Lachenmayer, C. Alsinet, R. Savic, L. Cabellos, S. Toffanin, and Y. Hoshida et al. Wnt-Pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib Clin Cancer Res 18 2012 4997 5007
    • (2012) Clin Cancer Res , vol.18 , pp. 4997-5007
    • Lachenmayer, A.1    Alsinet, C.2    Savic, R.3    Cabellos, L.4    Toffanin, S.5    Hoshida, Y.6
  • 34
    • 12344307170 scopus 로고    scopus 로고
    • Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells
    • DOI 10.1210/en.2004-1064
    • P. Thomas, Y. Pang, E.J. Filardo, and J. Dong Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells Endocrinology 146 2005 624 632 (Pubitemid 40129818)
    • (2005) Endocrinology , vol.146 , Issue.2 , pp. 624-632
    • Thomas, P.1    Pang, Y.2    Filardo, E.J.3    Dong, J.4
  • 36
    • 0242390079 scopus 로고    scopus 로고
    • Breast cancer and hormonal contraceptives: Collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies
    • Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53 297 women with breast cancer and 100 239 women without breast cancer from 54 epidemiological studies. Lancet 1996; 347:1713-27.
    • (1996) Lancet , vol.347 , pp. 1713-1727
  • 37
  • 39
    • 0030887404 scopus 로고    scopus 로고
    • Riminophenazine compounds: Pharmacology and anti-neoplastic potential
    • DOI 10.1016/S1040-8428(96)00229-6, PII S1040842896002296
    • C.E.J. Van Rensburg, R. Anderson, and J.F. O'Sullivan Riminophenazine compounds: pharmacology and anti-neoplastic potential Crit Rev Oncol/Hematol 25 1997 55 67 (Pubitemid 27138048)
    • (1997) Critical Reviews in Oncology/Hematology , vol.25 , Issue.1 , pp. 55-67
    • Van Rensburg, C.E.J.1    Anderson, R.2    O'Sullivan, J.F.3
  • 40
    • 0029594566 scopus 로고
    • The pharmacology, metabolism, and chemistry of clofazimine
    • R. O'Connor, J.F. O'Sullivan, and R. O'Kennedy The pharmacology, metabolism, and chemistry of clofazimine Drug Metab Rev 27 1995 591 614 (Pubitemid 26032119)
    • (1995) Drug Metabolism Reviews , vol.27 , Issue.4 , pp. 591-614
    • O'Connor, R.1    O'Sullivan, J.F.2    O'Kennedy, R.3
  • 41
    • 0027530702 scopus 로고
    • 2-mediated oxidative and nonoxidative mechanisms
    • C.E. Van Rensburg, A.M. Van Staden, and R. Anderson The riminophenazine agents clofazimine and B669 inhibit the proliferation of cancer cell lines in vitro by phospholipase A2-mediated oxidative and nonoxidative mechanisms Cancer Res 53 1993 318 323 (Pubitemid 23031843)
    • (1993) Cancer Research , vol.53 , Issue.2 , pp. 318-323
    • Van Rensburg, C.E.J.1    Van Staden, A.M.2    Anderson, R.3
  • 42
    • 0028218451 scopus 로고
    • Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo
    • R.M. Sri-Pathmanathan, J.A. Plumb, and K.C. Fearon Clofazimine alters the energy metabolism and inhibits the growth rate of a human lung-cancer cell line in vitro and in vivo Int J Cancer 56 1994 900 905 (Pubitemid 24102760)
    • (1994) International Journal of Cancer , vol.56 , Issue.6 , pp. 900-905
    • Sri-Pathmanathan, R.M.1    Plumb, J.A.2    Fearon, K.C.H.3
  • 43
    • 3142590865 scopus 로고    scopus 로고
    • Wnt signaling and breast cancer
    • L.R. Howe, and A.M.C. Brown Wnt signaling and breast cancer Cancer Biol Ther 3 2004 36 41
    • (2004) Cancer Biol Ther , vol.3 , pp. 36-41
    • Howe, L.R.1    Brown, A.M.C.2
  • 44


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