Perfusion of ischemic brain in young and aged animals a laser speckle flowmetry study

Stroke

Volumn 45, Issue 2, 2014, Pages 571-578

  Manwani, Bharti ^a   Friedler, Brett ^a   Verma, Rajkumar ^a   Venna, Venugopal Reddy ^a   McCullough, Louise D ^a   Liu, Fudong ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Aging; Brain ischemia; Infarction; Microcirculation; Middle cerebral artery occlusion; Perfusion; Regional blood flow

Indexed keywords

CD31 ANTIGEN; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN PERFUSION; CEREBROVASCULAR ACCIDENT; DENSITY; DYNAMICS; EXTRAVASATION; FLOW MEASUREMENT; IMMUNOHISTOCHEMISTRY; LASER; LASER SPECKLE FLOWMETRY; MALE; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STAINING; TISSUE PERFUSION;

AGING; BRAIN ISCHEMIA; INFARCTION; MICROCIRCULATION; MIDDLE CEREBRAL ARTERY OCCLUSION; PERFUSION; REGIONAL BLOOD FLOW;

AGING; ANIMALS; ANTIGENS, CD31; BENZOXAZINES; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CAPILLARIES; CEREBROVASCULAR CIRCULATION; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; FUNCTIONAL LATERALITY; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; LASER-DOPPLER FLOWMETRY; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE;

EID: 84893749944     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.002944     Document Type: Article

References (41)

1. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008;117:e25-146.
2. Knoflach M, Matosevic B, Rücker M, Furtner M, Mair A, Wille G, et al; Austrian Stroke Unit Registry Collaborators. Functional recovery after ischemic stroke-a matter of age: data from the Austrian Stroke Unit Registry. Neurology. 2012;78:279-285.
3. Rojas JI, Zurrú MC, Romano M, Patrucco L, Cristiano E. Acute ischemic stroke and transient ischemic attack in the very old-risk factor profile and stroke subtype between patients older than 80 years and patients aged less than 80 years. Eur J Neurol. 2007;14:895-899.
4. Yuan M, Siegel C, Zeng Z, Li J, Liu F, McCullough LD. Sex differences in the response to activation of the poly (ADP-ribose) polymerase pathway after experimental stroke. Exp Neurol. 2009;217:210-218.
5. Liu F, Benashski SE, Persky R, Xu Y, Li J, McCullough LD. Age-related changes in AMP-activated protein kinase after stroke. Age (Dordr). 2012;34:157-168.
6. Manwani B, Liu F, Xu Y, Persky R, Li J, McCullough LD. Functional recovery in aging mice after experimental stroke. Brain Behav Immun. 2011;25:1689-1700.
7. Agarwal S, Scoffings DJ, Jones PS, Marrapu ST, Barry PJ, O'Brien EW, et al. Interaction of age with the ischaemic penumbra, leptomeningeal collateral circulation and haemodynamic variables in acute stroke: a pilot study. J Neurol Neurosurg Psychiatry. 2013;84:271-276.
8. Petcu EB, Smith RA, Miroiu RI, Opris MM. Angiogenesis in old- aged subjects after ischemic stroke: a cautionary note for investigators. J Angiogenes Res. 2010;2:26.
9. Gupta A, Nair S, Schweitzer AD, Kishore S, Johnson CE, Comunale JP, et al. Neuroimaging of cerebrovascular disease in the aging brain. Aging Dis. 2012;3:414-425.
10. Dunn AK, Bolay H, Moskowitz MA, Boas DA. Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab. 2001;21:195-201.
11. McCullough LD, Zeng Z, Blizzard KK, Debchoudhury I, Hurn PD. Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection. J Cereb Blood Flow Metab. 2005;25:502-512.
12. Liu F, Benashski SE, Xu Y, Siegel M, McCullough LD. Effects of chronic and acute oestrogen replacement therapy in aged animals after experimental stroke. J Neuroendocrinol. 2012;24:319-330.
13. Bake S, Friedman JA, Sohrabji F. Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins. Microvasc Res. 2009;78:413-424.
14. Richmon JD, Fukuda K, Maida N, Sato M, Bergeron M, Sharp FR, et al. Induction of heme oxygenase-1 after hyperosmotic opening of the blood- brain barrier. Brain Res. 1998;780:108-118.
15. Hoffmann A, Bredno J, Wendland M, Derugin N, Ohara P, Wintermark M. High and low molecular weight fluorescein isothiocyanate ( FITC)-dextrans to assess blood-brain barrier disruption: technical considerations. Transl Stroke Res. 2011;2:106-111.
16. Liu F, Akella P, Benashski SE, Xu Y, McCullough LD. Expression of Na-K-Cl cotransporter and edema formation are age dependent after ischemic stroke. Exp Neurol. 2010;224:356-361.
17. Manwani B, McCullough LD. Sexual dimorphism in ischemic stroke: lessons from the laboratory. Womens Health (Lond Engl). 2011;7:319-339.
18. Liu F, Yuan R, Benashski SE, McCullough LD. Changes in experimental stroke outcome across the life span. J Cereb Blood Flow Metab. 2009;29:792-802.
19. Shapira S, Sapir M, Wengier A, Grauer E, Kadar T. Aging has a complex effect on a rat model of ischemic stroke. Brain Res. 2002;925:148-158.
20. Sieber MW, Claus RA, Witte OW, Frahm C. Attenuated inflammatory response in aged mice brains following stroke. PLoS One. 2011;6:e26288.
21. Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, et al. Tissue plasminogen activator prevents white matter damage following stroke. J Exp Med. 2011;208:1229-1242.
22. DiNapoli VA, Huber JD, Houser K, Li X, Rosen CL. Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats. Neurobiol Aging. 2008;29:753-764.
23. Wang RY, Wang PS, Yang YR. Effect of age in rats following middle cerebral artery occlusion. Gerontology. 2003;49:27-32.
24. Chen Y, Sun FY. Age-related decrease of striatal neurogenesis is associated with apoptosis of neural precursors and newborn neurons in rat brain after ischemia. Brain Res. 2007;1166:9-19.
25. Won SJ, Xie L, Kim SH, Tang H, Wang Y, Mao X, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res. 2006;1123:237-244.
26. Roussel BD, Macrez R, Jullienne A, Agin V, Maubert E, Dauphinot L, et al. Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact. Brain. 2009;132(pt 8):2219-2230.
27. Ford GA, Ahmed N, Azevedo E, Grond M, Larrue V, Lindsberg PJ, et al. Intravenous alteplase for stroke in those older than 80 years old. Stroke. 2010;41:2568-2574.
28. Machado MC, Coelho AM, Carneiro D'Albuquerque LA, Jancar S. Effect of ageing on systemic inflammatory response in acute pancreatitis. Int J Inflam. 2012;2012:270319.
29. Esler MD, Thompson JM, Kaye DM, Turner AG, Jennings GL, Cox HS, et al. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation. 1995;91:351-358.
30. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490-497.
31. Herrera MD, Mingorance C, Rodríguez-Rodríguez R, Alvarez de Sotomayor M. Endothelial dysfunction and aging: an update. Ageing Res Rev. 2010;9:142-152.
32. Cau SB, Carneiro FS, Tostes RC. Differential modulation of nitric oxide synthases in aging: therapeutic opportunities. Front Physiol. 2012;3:218.
33. Meltzer CC, Cantwell MN, Greer PJ, Ben-Eliezer D, Smith G, Frank G, et al. Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction. J Nucl Med. 2000;41:1842-1848.
34. Gendron A, Teitelbaum J, Cossette C, Nuara S, Dumont M, Geadah D, et al. Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in Wistar rats. Brain Res. 2002;955:85-97.
35. Offner H, Vandenbark AA, Hurn PD. Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression. Neuroscience. 2009;158:1098-1111.
36. Farrall AJ, Wardlaw JM. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol Aging. 2009;30:337-352.
37. Hu Q, Chen C, Khatibi NH, Li L, Yang L, Wang K, et al. Lentivirus- mediated transfer of MMP-9 shRNA provides neuroprotection following focal ischemic brain injury in rats. Brain Res. 2011;1367:347-359.
38. Romanic AM, White RF, Arleth AJ, Ohlstein EH, Barone FC. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 1998;29:1020-1030.
39. Chen J, Graham SH, Zhu RL, Simon RP. Stress proteins and tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab. 1996;16:566-577.
40. Chen JJ, Rosas HD, Salat DH. The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span. PLoS One. 2013;8:e56733.
41. Manwani B, McCullough LD. Sexual dimorphism in ischemic stroke: lessons from the laboratory. Womens Health (Lond Engl). 2011;7:319-339.