In vitro inhibitory effects of antioxidants on cytotoxicity of T-2 toxin

Toxicology

Volumn 146, Issue 2-3, 2000, Pages 171-176

  Shokri, F ^a,c   Heidari, M ^a,b   Gharagozloo, S ^a   Ghazi Khansari, M ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Antioxidant; Cell culture; Cytotoxicity; In vitro; T 2 toxin

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; FUNGUS TOXIN T 2; MYCOTOXIN; SELENIUM; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL TRANSFORMATION; DRUG CYTOTOXICITY; FUSARIUM; HUMAN; HUMAN CELL; LIPID PEROXIDATION; PRIORITY JOURNAL; REGULATORY MECHANISM; TOXIN ANALYSIS;

ANTIOXIDANTS; ASCORBIC ACID; CELL LINE; CYTOTOXINS; FIBROBLASTS; HUMANS; LETHAL DOSE 50; SELENIUM; T-2 TOXIN; TUMOR CELLS, CULTURED; VITAMIN E;

FUNGI; FUSARIUM;

EID: 0034608003     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00172-4     Document Type: Article

References (32)

1. Abramson, D., Mills, J.T., Marquardt, R.R., Frohlich, A.A., 1997. Mycotoxins in fungal contaminated samples of animal feed from western Canada, 1982-1994. Can. J. Vet. Res. 61, 49-52.
2. Atroshi, F., Rizzo, A., Biese, I., Veijalainen, P., Antila, E., Westermark, T., 1997. T-2 toxin-induced DNA damage in mouse liver: the effect of pretreatment with coenzyme Q10 and alpha-ocopherol. Mol. Aspects Med. 18 (Suppl), S255-S258.
3. Babich, H., Borenfreund, E., 1991a. Application of the neutral red cytotoxicity assay to in vitro toxicology. ATLA 18, 129-144.
4. Babich, H., Borenfreund, E., 1991b. Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay. Appl. Environ. Microbiol. 57, 2101-2103.
5. Blaylock, B.L., Kouchi, Y., Comment, C.E., Pollack, P.L., Luster, M.I., 1993. Topical application of T-2 toxin inhibits the contact hypersensitivity response in Balb/c mice. J. Immunol. 150, 5135-5143.
6. Bus, J.S., 1979. Lipid peroxidation and its role in toxicology. In: Hodgson, E., Lester, M. (Eds.), Reviews in Biochemical Toxicology. Elsevier, North Holland, pp. 125-149.
7. Frick, R.F., Robert, F., Poggenga, R.H., Robert, H., 1989. Treatment and prophylaxis for trichothecene mycotoxicosis. In: Beasley, V.R. (Ed.), Trichothecene Mycotoxicosis: Pathophysiologic Effects. CRC Press, Boca Raton, FL, pp. 40-168.
8. Gheshlaghi Azar, N., Heidari, M., Samadi Bahrami, Z., Shokri, F., 2000. In vitro cytotoxicity of a new epoxy resin root canal sealer. J. Endodontics, in press.
9. Gynogyossy-Issa, M.I.C., Khanna, V., Khachatourians, G., 1986. Changes induced by T-2 toxin in the erythrocyte membrane. Food Chem. Toxicol. 24, 311-317.
10. Hayes, A.W., 1980. Mycotoxin: a review of biological effects and their role in human disease. Clin. Toxicol. 17, 45-83.
11. Hoehler, D., Marquardt, R.R., 1996. Influence of vitamins E and C on the toxin effects of ochratoxin A and T-2 toxin in chicks. Poultry Sci. 75, 1508-1515.
12. Holladay, S.D., Blaylock, B.L., Comment, C.E., Heindel, J.J., Leuster, M.I., 1993. Fetal thymic atrophy after exposure to T-2 toxin: selectivity for lymphoid progenitor cells. Toxicol. Appl. Pharmacol. 121, 8-14.
13. Ihara, T., Sugamata, M., Sekijima, M., Okumura, H., Yoshino, N., Ueno, Y., 1997. Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis. Nat. Toxins 5, 141-145.
14. International program on chemical safety, 1990. Environmental Health Criteria for Selected Mycotoxins: Ochratoxin, Trichothecenes and Ergot, World Health Organization (WHO), Geneva, p. 163.
15. Iwahashi, M., 1982. Mechanism of cytotoxic effect of T-2 toxin on a protozoa. Proc. Assoc. Jpn. Mycotoxin 4, 23-30.
16. Juranic, Z., Stojiljkovic, M.P., Bocarov-Stancic, A., Kilibarada, V., Milovanovic, S.R., Juranic, I., Bijelogrlic, S., Vuletic, N., Radulovic, S., 1998. T-2 toxin affects proliferation of three different neoplastic cell lines. J. Exp. Clin. Cancer Res. 17, 33-40.
17. Krachenco, L.V., 1989. Biochemical changes in subacute mycotoxicosis induced by T-2 toxin in rats. Toxicology 42, 77-83.
18. Marin, M.L., Murtha, J., Dong, W., Pestka, J., 1996. Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. J. Toxicol. Environ. Health 48, 379-396.
19. Maurice, O.M., 1983. Mycotoxins. Mycol. Res. 100, 513-523.
20. Miller, K., 1986. The in vitro effects of trichothecenes on the immune system. Food Chem. Toxicol. 24, 545-549.
21. Pace, J.G., 1988. T-2 mycotoxin inhibits mitochondrial protein synthesis. Toxicon 26, 77-85.
22. Parent, M.D., Fuselier, R., Thouvenot, D., 1994. In vitro toxicity of trichothecenes on human hematopoietic progenitors. Food Additives Contam. 11, 441-447.
23. Rio, B., Lautriaite, S., Parent, M.D., 1997. In vitro toxicity of trichothecenes on human erythroblastic progenitors. Human Exp. Toxicol. 23, 67-72.
24. Rizzo, A.F., Atroshi, F., Ahotupa, M., Sankari, S., Elovara, E., 1994. Protective effect of antioxidants against free radical-mediated lipid peroxidation induced by DON or T-2 toxin. Zentralblatt Fur Veterinarmedizine 41, 81-90.
25. Rosenstein, Y., Lafarge, F.C., 1983. Inhibitory effect of Fusarium T-2 toxin on lymphoid DNA and protein synthesis. Toxicol. Appl. Pharmacol. 70, 283-288.
26. Sharma, R.P., 1993. Immunotoxicity of mycotoxins. J. Dairy Sci. 76, 892-897.
27. Shinozuka, J., Li, G., Kiatipattanasakul, W., Uetsuka, K., Nakayama, H., Doi, K., 1997. T-2 toxin-induced apoptosis in lymphoid organs of mice. Exp. Toxicol. Pathol. 49, 387-392.
28. Smith, B.J., Holladay, S.D., Blaylock, B.L., 1994. Hematopoietic alterations after exposure to T-2 mycotoxin. Toxicon 32, 1115-1123.
29. Tutelyan, V.A., Kravchenko, L.V., Kuzmina, E.E., Avrenieva, L.I., Kumpularinen, J.T., 1990. Dietary selenium protects against acute toxicity of T-2 toxin in rats. Food Additives Contam. 7, 821-827.
30. Ueno, Y., 1984. Trichothecenes as environmental toxicants. J. Toxicol. 5, 1-15.
31. Yazdanpanah, H., Roshanzamir, F., Shafaghi, B., Faizi, M., Elhami, M., Rasekh, H.R., 1997. Assessment of possible protective role of selenium, zinc and cis-stilbene oxide against acute T-2 toxin poisoning: in preliminary report. Nat. Toxins 5, 133-135.
32. Yoshino, N., Takizawa, M., Akiba, H., Okumura, H., Tashiro, F., Honda, M., Ueno, Y., 1996. Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin-induced apoptosis in human promyelotic cell line HL-60. Nat. Toxins 4, 234-241.