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Volumn 23, Issue 1, 2014, Pages 107-126

Two- and three-dimensional QSAR studies on a set of antimycobacterial pyrroles: CoMFA, Topomer CoMFA, and HQSAR

Author keywords

Antimycobacterial pyrroles; HQSAR; QSAR: CoMFA; Topomer CoMFA

Indexed keywords


EID: 84893706743     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0607-3     Document Type: Article
Times cited : (37)

References (42)
  • 1
    • 84912099528 scopus 로고
    • 3-D QSAR for intrinsic activity of 5-HT1 A receptor ligands by the method of comparative molecular field analysis
    • 1:CAS:528:DyaK3sXitVClu7s%3D 10.1002/jcc.540140211
    • Agarwal A, Taylor EW (1993) 3-D QSAR for intrinsic activity of 5-HT1 A receptor ligands by the method of comparative molecular field analysis. J Comput Chem 14(2):237-245
    • (1993) J Comput Chem , vol.14 , Issue.2 , pp. 237-245
    • Agarwal, A.1    Taylor, E.W.2
  • 2
    • 0034608634 scopus 로고    scopus 로고
    • 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis
    • 1:CAS:528:DC%2BD3cXktF2qt7g%3D 10866382 10.1016/S0960-894X(00)00188-8
    • Bakkestuen AK, Gundersen LL, Langli G, Liu F, Nolsøe JM (2000) 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis. Bioorg Med Chem Lett 10:1207-1210
    • (2000) Bioorg Med Chem Lett , vol.10 , pp. 1207-1210
    • Bakkestuen, A.K.1    Gundersen, L.L.2    Langli, G.3    Liu, F.4    Nolsøe, J.M.5
  • 3
    • 0034704736 scopus 로고    scopus 로고
    • 3D-QSAR CoMFA study on imidazolinergic I2 ligands: A significant model through a combined exploration of structural diversity and methodology
    • 1:CAS:528:DC%2BD3cXhsValu7Y%3D 10737743 10.1021/jm991124t
    • Baurin N, Vangrevelinghe E, Morin-Allory L, Mérour JY, Renard P, Payard M, Guillaumet G, Marot C (2000) 3D-QSAR CoMFA study on imidazolinergic I2 ligands: a significant model through a combined exploration of structural diversity and methodology. J Med Chem 43:1109-1122
    • (2000) J Med Chem , vol.43 , pp. 1109-1122
    • Baurin, N.1    Vangrevelinghe, E.2    Morin-Allory, L.3    Mérour, J.Y.4    Renard, P.5    Payard, M.6    Guillaumet, G.7    Marot, C.8
  • 4
    • 0033581568 scopus 로고    scopus 로고
    • New pyrrole derivatives as antimycobacterial agents analogs of BM212
    • 1:CAS:528:DyaK1MXntFKltbc%3D 10.1016/S0960-894X(99)00510-7
    • Biava M, Fioravanti R, Porretta GC, Deidda D, Maullu C, Pompei R (1999) New pyrrole derivatives as antimycobacterial agents analogs of BM212. Biorg Med Chem Lett 9:2983-2988
    • (1999) Biorg Med Chem Lett , vol.9 , pp. 2983-2988
    • Biava, M.1    Fioravanti, R.2    Porretta, G.C.3    Deidda, D.4    Maullu, C.5    Pompei, R.6
  • 5
    • 0037245323 scopus 로고    scopus 로고
    • Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212
    • 1:CAS:528:DC%2BD3sXlt1OksA%3D%3D 10.1016/S0968-0896(02)00455-8
    • Biava M, Cesare Porretta G, Deidda D, Pompei R, Tafi A, Manetti F (2003) Importance of the thiomorpholine introduction in new pyrrole derivatives as antimycobacterial agents analogues of BM 212 Biorg Med Chem 11:515-520
    • (2003) Biorg Med Chem , vol.11 , pp. 515-520
    • Biava, M.1    Cesare Porretta, G.2    Deidda, D.3    Pompei, R.4    Tafi, A.5    Manetti, F.6
  • 6
    • 0027672324 scopus 로고
    • Sample-distance partial least squares: PLS optimized for many variables, with application to CoMFA
    • 1:CAS:528:DyaK2cXis1Ghs7s%3D 8294948 10.1007/BF00124364
    • Bush BL, Nachbar RB Jr (1993) Sample-distance partial least squares: PLS optimized for many variables, with application to CoMFA. J Comput Aided Mol Des 7:587-619
    • (1993) J Comput Aided Mol des , vol.7 , pp. 587-619
    • Bush, B.L.1    Nachbar, Jr.R.B.2
  • 7
    • 0041446875 scopus 로고
    • Comparative molecular field analysis (CoMFA). 2. Toward its use with 3D-structural databases
    • 1:CAS:528:DyaK3MXhtVSmtbs%3D 10.1016/0898-5529(90)90120-W
    • Clark M, Cramer RD III, Jones DM, Patterson DE, Simeroth PE (1990) Comparative molecular field analysis (CoMFA). 2. Toward its use with 3D-structural databases. Tetrahedron Comput Methodol 3(1):47-59
    • (1990) Tetrahedron Comput Methodol , vol.3 , Issue.1 , pp. 47-59
    • Clark, M.1    Cramer III, R.D.2    Jones, D.M.3    Patterson, D.E.4    Simeroth, P.E.5
  • 8
    • 0542380422 scopus 로고    scopus 로고
    • The CoMFA steroids as a benchmark dataset for development of 3D QSAR methods
    • 10.1023/A:1017050508855
    • Coats EA (1998) The CoMFA steroids as a benchmark dataset for development of 3D QSAR methods. Perspect Drug Discov Des 12(13/14):199-213
    • (1998) Perspect Drug Discov des , vol.12 , Issue.1314 , pp. 199-213
    • Coats, E.A.1
  • 9
    • 79955996710 scopus 로고    scopus 로고
    • Rethinking 3D-QSAR
    • 1:CAS:528:DC%2BC3MXivVCktLk%3D 3051061 21110063 10.1007/s10822-010-9403-z
    • Cramer RD III (2011) Rethinking 3D-QSAR. J Comput Aided Mol Des 25:197-201
    • (2011) J Comput Aided Mol des , vol.25 , pp. 197-201
    • Cramer III, R.D.1
  • 10
    • 0016381211 scopus 로고
    • Substructural analysis. A novel approach to the problem of drug design
    • 1:CAS:528:DyaE2cXltFCgu7o%3D 4830256 10.1021/jm00251a014
    • Cramer RD III, Reld G, Berkoff CE (1974) Substructural analysis. A novel approach to the problem of drug design. J Med Chem 17:533-535
    • (1974) J Med Chem , vol.17 , pp. 533-535
    • Cramer III, R.D.1    Reld, G.2    Berkoff, C.E.3
  • 11
    • 0023751431 scopus 로고
    • Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding steroids to carrier proteins
    • 1:CAS:528:DyaL1cXltVCqsbs%3D 22148765 10.1021/ja00226a005
    • Cramer RD III, Patterson DE, Bunce JD (1988a) Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding steroids to carrier proteins. J Am Chem Soc 110:5959-5967
    • (1988) J Am Chem Soc , vol.110 , pp. 5959-5967
    • Cramer III, R.D.1    Patterson, D.E.2    Bunce, J.D.3
  • 12
    • 84987100711 scopus 로고
    • Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies
    • 10.1002/qsar.19880070105 (erratum 1988, 7:91)
    • Cramer RD III, Bunce JD, Patterson DE, Frank IE (1988b) Crossvalidation, bootstrapping, and partial least squares compared with multiple regression in conventional QSAR studies. Quant Struct Act Relat 7:18-25 (erratum 1988, 7:91)
    • (1988) Quant Struct Act Relat , vol.7 , pp. 18-25
    • Cramer III, R.D.1    Bunce, J.D.2    Patterson, D.E.3    Frank, I.E.4
  • 13
    • 0024491426 scopus 로고
    • Recent advances in comparative molecular field analysis (CoMFA)
    • 1:CAS:528:DyaL1MXhs1Ggt7Y%3D 2726839
    • Cramer RD III, Patterson DE, Bunce JD (1989) Recent advances in comparative molecular field analysis (CoMFA). Prog Clin Biol Res 291:161-165
    • (1989) Prog Clin Biol Res , vol.291 , pp. 161-165
    • Cramer III, R.D.1    Patterson, D.E.2    Bunce, J.D.3
  • 14
    • 0029742341 scopus 로고    scopus 로고
    • Bioisosterism as a molecular diversity descriptor: Steric fields of single "topomeric" conformers
    • 1:CAS:528:DyaK28Xkt1alurw%3D 8759627 10.1021/jm960291f
    • Cramer RD III, Clark RD, Patterson DE, Ferguson AM (1996) Bioisosterism as a molecular diversity descriptor: steric fields of single "topomeric" conformers. J Med Chem 39(16):3060-3069
    • (1996) J Med Chem , vol.39 , Issue.16 , pp. 3060-3069
    • Cramer III, R.D.1    Clark, R.D.2    Patterson, D.E.3    Ferguson, A.M.4
  • 15
    • 0037294865 scopus 로고    scopus 로고
    • Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives
    • 1:CAS:528:DC%2BD3sXhs1eiu74%3D 12620665 10.1016/S0223-5234(02)01445-9
    • Dabak K, Sezer O, Akar A, Anac O (2003) Synthesis and investigation of tuberculosis inhibition activities of some 1,2,3-triazole derivatives. Eur J Med Chem 38:215-218
    • (2003) Eur J Med Chem , vol.38 , pp. 215-218
    • Dabak, K.1    Sezer, O.2    Akar, A.3    Anac, O.4
  • 16
    • 0032452982 scopus 로고    scopus 로고
    • The envelope layers of mycobacteria with reference to their pathogenicity
    • 10.1016/S0065-2911(08)60016-8 1:CAS:528:DyaK2sXnt1yiu7o%3D 9328647 10.1016/S0065-2911(08)60016-8
    • Daffe M, Draper P (1998) The envelope layers of mycobacteria with reference to their pathogenicity. Adv Microb Physiol 39:131-203. doi: 10.1016/S0065-2911(08)60016-8
    • (1998) Adv Microb Physiol , vol.39 , pp. 131-203
    • Daffe, M.1    Draper, P.2
  • 18
    • 0028291730 scopus 로고
    • Global tuberculosis incidence and mortality during 1990-2000
    • 1:STN:280:DyaK2c3msFarsA%3D%3D 2486541 8205640
    • Dolin PJ, Raviglione MC, Kochi A (1994) Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ 72:213-220
    • (1994) Bull World Health Organ , vol.72 , pp. 213-220
    • Dolin, P.J.1    Raviglione, M.C.2    Kochi, A.3
  • 19
    • 0033581124 scopus 로고    scopus 로고
    • Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
    • 10.1001/jama.282.7.677 1:STN:280:DyaK1MvksFeisg%3D%3D 10517722 10.1001/jama.282.7.677
    • Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC (1999) Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 282:677-686. doi: 10.1001/jama.282.7.677
    • (1999) JAMA , vol.282 , pp. 677-686
    • Dye, C.1    Scheele, S.2    Dolin, P.3    Pathania, V.4    Raviglione, M.C.5
  • 21
    • 0029995624 scopus 로고    scopus 로고
    • VALIDATE: A new method for the receptor-based prediction of binding affinities of novel ligands
    • 1:CAS:528:DyaK28XitVejurg%3D 10.1021/ja9539002
    • Head RD, Smythe ML, Oprea TI, Waller CL, Green SM, Marshall GR (1996) VALIDATE: a new method for the receptor-based prediction of binding affinities of novel ligands. J Am Chem Soc 118:3959-3969
    • (1996) J Am Chem Soc , vol.118 , pp. 3959-3969
    • Head, R.D.1    Smythe, M.L.2    Oprea, T.I.3    Waller, C.L.4    Green, S.M.5    Marshall, G.R.6
  • 22
    • 0034669750 scopus 로고    scopus 로고
    • Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis
    • 1:CAS:528:DC%2BD3cXosFKmtro%3D 11064188 10.1111/j.1574-6968.2000.tb09375. x
    • Jackson CJ, Lamb DC, Kelly DE, Kelly SL (2000) Bactericidal and inhibitory effects of azole antifungal compounds on Mycobacterium smegmatis. FEMS Microbiol Lett 192:159-162
    • (2000) FEMS Microbiol Lett , vol.192 , pp. 159-162
    • Jackson, C.J.1    Lamb, D.C.2    Kelly, D.E.3    Kelly, S.L.4
  • 23
    • 4043157718 scopus 로고    scopus 로고
    • Topomers: A validated protocol for their self-consistent generation
    • 1:CAS:528:DC%2BD2cXktlWnur0%3D
    • Jilek RJ, Cramer RD III (2004) Topomers: a validated protocol for their self-consistent generation. J Chem Inf Comp Sci 44:1221-1227
    • (2004) J Chem Inf Comp Sci , vol.44 , pp. 1221-1227
    • Jilek, R.J.1    Cramer III, R.D.2
  • 24
    • 51149107005 scopus 로고    scopus 로고
    • Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems, a novel class of potential antibacterial and antitubercular agents
    • 1:CAS:528:DC%2BD1cXhtFens7%2FN 18207286 10.1016/j.ejmech.2007.11.016
    • Joshi SD, Vagdevi HM, Vaidya VP, Gadaginamath GS (2008) Synthesis of new 4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems, a novel class of potential antibacterial and antitubercular agents. Eur J Med Chem 43:1989-1996
    • (2008) Eur J Med Chem , vol.43 , pp. 1989-1996
    • Joshi, S.D.1    Vagdevi, H.M.2    Vaidya, V.P.3    Gadaginamath, G.S.4
  • 25
    • 84874106227 scopus 로고    scopus 로고
    • Synthesis of new 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems a novel class of potential antibacterial, antifungal and antitubercular agents
    • Joshi SD, More Y, Vagdevi HM, Vaidya VP, Gadaginamath GS, Kulkarni VH (2013) Synthesis of new 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs and some derived oxadiazole, triazole and pyrrole ring systems a novel class of potential antibacterial, antifungal and antitubercular agents. Med Chem Res 22:1073-1089
    • (2013) Med Chem Res , vol.22 , pp. 1073-1089
    • Joshi, S.D.1    More, Y.2    Vagdevi, H.M.3    Vaidya, V.P.4    Gadaginamath, G.S.5    Kulkarni, V.H.6
  • 26
    • 1842664451 scopus 로고    scopus 로고
    • Synthesis and antimycobacterial activity of 1,2,4-triazole 3-benzylsulfanyl derivatives II
    • 1:CAS:528:DC%2BD2cXjtVCnsb0%3D 15081345 10.1016/j.farmac.2004.01.006
    • Klimesova V, Zahajska L, Waisser K, Kaustova J, Mollmann U (2004) Synthesis and antimycobacterial activity of 1,2,4-triazole 3-benzylsulfanyl derivatives II. Farmaco 59:279-288
    • (2004) Farmaco , vol.59 , pp. 279-288
    • Klimesova, V.1    Zahajska, L.2    Waisser, K.3    Kaustova, J.4    Mollmann, U.5
  • 27
    • 0036501101 scopus 로고    scopus 로고
    • Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds
    • 1:CAS:528:DC%2BD38XitFWnsLg%3D 11900864 10.1016/S0223-5234(01)01326-5
    • Kucukguzel SG, Oruc EE, Rollas S, Sahin F, Ozbek A (2002) Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds. Eur J Med Chem 37:197-206
    • (2002) Eur J Med Chem , vol.37 , pp. 197-206
    • Kucukguzel, S.G.1    Oruc, E.E.2    Rollas, S.3    Sahin, F.4    Ozbek, A.5
  • 28
    • 0035833072 scopus 로고    scopus 로고
    • Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials
    • 10.1016/S0960-894X(01)00283-9
    • Kuçukguzel I, Kuçukguzel SG, Rollas S, Kiraz M (2001) Some 3-thioxo/alkylthio-1,2,4-triazoles with a substituted thiourea moiety as possible antimycobacterials. Biorg Med Chem Lett 11:1703-1707
    • (2001) Biorg Med Chem Lett , vol.11 , pp. 1703-1707
    • Kuçukguzel, I.1    Kuçukguzel, S.G.2    Rollas, S.3    Kiraz, M.4
  • 29
    • 0034065350 scopus 로고    scopus 로고
    • Computational methods for the structural alignment of molecules
    • 1:CAS:528:DC%2BD3cXitlCktro%3D 10756477 10.1023/A:1008194019144
    • Lemmen C, Lengauer T (2000) Computational methods for the structural alignment of molecules. J Comput Aided Mol Des 14:215-232
    • (2000) J Comput Aided Mol des , vol.14 , pp. 215-232
    • Lemmen, C.1    Lengauer, T.2
  • 31
    • 0037397783 scopus 로고    scopus 로고
    • Synthesis and antifungal activity of (±)-1-(5-aryl-3-pyridin-2-yl- 4,5-dihydro-pyrazol-1-yl)-2-imidazol-1-yl-ethanone derivatives
    • 1:CAS:528:DC%2BD3sXjt1Kgu7s%3D 10.1016/S0014-827X(02)00006-X
    • Mamolo MG, Zampieri D, Falagiani V, Vio L, Banfi E (2003) Synthesis and antifungal activity of (±)-1-(5-aryl-3-pyridin-2-yl-4,5-dihydro-pyrazol- 1-yl)-2-imidazol-1-yl-ethanone derivatives. II Farmaco 58:315-322
    • (2003) II Farmaco , vol.58 , pp. 315-322
    • Mamolo, M.G.1    Zampieri, D.2    Falagiani, V.3    Vio, L.4    Banfi, E.5
  • 32
    • 0037367439 scopus 로고    scopus 로고
    • Synthesis and antifungal activity of new 1-halogenobenzyl-3- imidazolylmethylindole derivatives
    • 1:CAS:528:DC%2BD3sXht1yqtrs%3D 12593918 10.1016/S0223-5234(02)00005-3
    • Na YM, Le Borgne M, Pagniez F, Le Baut G, Le Pape P (2003) Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives. Eur J Med Chem 38:75-87
    • (2003) Eur J Med Chem , vol.38 , pp. 75-87
    • Na, Y.M.1    Le Borgne, M.2    Pagniez, F.3    Le Baut, G.4    Le Pape, P.5
  • 33
    • 0034091543 scopus 로고    scopus 로고
    • Synthesis and antitubercular activity of 3-aryl substituted-2-[1H(2H) benzotriazol-1(2)-yl]acrylonitriles
    • 1:CAS:528:DC%2BD3cXkt1ais7g%3D 10889332 10.1016/S0223-5234(00)00144-6
    • Sanna P, Carta A, Nikookar ME (2000) Synthesis and antitubercular activity of 3-aryl substituted-2-[1H(2H)benzotriazol-1(2)-yl]acrylonitriles. Eur J Med Chem 35:535-543
    • (2000) Eur J Med Chem , vol.35 , pp. 535-543
    • Sanna, P.1    Carta, A.2    Nikookar, M.E.3
  • 34
    • 1542284725 scopus 로고    scopus 로고
    • Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2-oxazolidinone analogues of PNU-100480
    • 1:CAS:528:DC%2BD2cXhvV2itb0%3D 10.1016/j.bmcl.2004.01.010
    • Sbardella G, Mai A, Artico M, Loddo R, Setzu MG, La Colla P (2004) Synthesis and in vitro antimycobacterial activity of novel 3-(1H-pyrrol-1-yl)-2- oxazolidinone analogues of PNU-100480. Biorg Med Chem Lett 14:1537-1541
    • (2004) Biorg Med Chem Lett , vol.14 , pp. 1537-1541
    • Sbardella, G.1    Mai, A.2    Artico, M.3    Loddo, R.4    Setzu, M.G.5    La Colla, P.6
  • 35
    • 30444445995 scopus 로고    scopus 로고
    • Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain
    • 1:CAS:528:DC%2BD2MXht12rtbjO 16392788 10.1021/jm051060o
    • Somu RV, Boshoff H, Qiao C, Bennett EM, Barry CE 3rd, Aldrich CC (2006) Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain. J Med Chem 49:31-34
    • (2006) J Med Chem , vol.49 , pp. 31-34
    • Somu, R.V.1    Boshoff, H.2    Qiao, C.3    Bennett, E.M.4    Barry III, C.E.5    Aldrich, C.C.6
  • 36
    • 0002368625 scopus 로고    scopus 로고
    • Intra molecular interactions encoded in lipophilicity
    • V. Pliska B. Testa H. Van der Waterbeemd (eds) Wiley Weinheim
    • Testa B, Carrupt PA, Gaillard P, Tasai RS (1997) Intra molecular interactions encoded in lipophilicity. In: Pliska V, Testa B, Van der Waterbeemd H (eds) Lipophilicity in drug action and toxicology. Wiley, Weinheim, p 49
    • (1997) Lipophilicity in Drug Action and Toxicology , pp. 49
    • Testa, B.1    Carrupt, P.A.2    Gaillard, P.3    Tasai, R.S.4
  • 37
    • 33749242759 scopus 로고    scopus 로고
    • Contribution of conformer focusing on the uncertainty in predicting free energies for protein-ligand binding
    • 1:CAS:528:DC%2BD28Xptl2hsLk%3D 17004703 10.1021/jm060763i
    • Tirado-Rives J, Jorgensen W (2006) Contribution of conformer focusing on the uncertainty in predicting free energies for protein-ligand binding. J Med Chem 49:5880-5884
    • (2006) J Med Chem , vol.49 , pp. 5880-5884
    • Tirado-Rives, J.1    Jorgensen, W.2
  • 38
    • 0032109698 scopus 로고    scopus 로고
    • Evaluation of quantitative structure-activity relationship methods for large-scale prediction of chemicals binding to the estrogen descriptor
    • 1:CAS:528:DyaK1cXkt1Whur8%3D 9722424 10.1021/ci980008g
    • Tong W, Lowis DR, Perkins R, Chen Y, Welsh WJ, Goddette DW, Hetitage TW, Sheehan DM (1998) Evaluation of quantitative structure-activity relationship methods for large-scale prediction of chemicals binding to the estrogen descriptor. J Chem Inf Comput Sci 38:669-677
    • (1998) J Chem Inf Comput Sci , vol.38 , pp. 669-677
    • Tong, W.1    Lowis, D.R.2    Perkins, R.3    Chen, Y.4    Welsh, W.J.5    Goddette, D.W.6    Hetitage, T.W.7    Sheehan, D.M.8
  • 39
    • 84879042929 scopus 로고    scopus 로고
    • Tripos International Tripos International, St. Louis, MO
    • Tripos International (2012) Sybyl-X 2.0, Tripos International, St. Louis, MO
    • (2012) Sybyl-X 2.0
  • 40
    • 0035663918 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of some 1,2,4-triazole-3- mercaptoacetic acid derivatives
    • 1:CAS:528:DC%2BD3MXpt1artLY%3D 10.1016/S0014-827X(01)01128-4
    • Ulusoy N, Gursoy A, Otuk G (2001) Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivatives. II Farmaco 56:947-952
    • (2001) II Farmaco , vol.56 , pp. 947-952
    • Ulusoy, N.1    Gursoy, A.2    Otuk, G.3
  • 42
    • 0242437861 scopus 로고    scopus 로고
    • Mode of action of pyrazinamide: Disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid
    • 14563891 10.1093/jac/dkg446
    • Zhang Y, Wade MM, Scorpio A, Zhang H, Sun Z (2003) Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J Antimicrob Chemother 52:790-795
    • (2003) J Antimicrob Chemother , vol.52 , pp. 790-795
    • Zhang, Y.1    Wade, M.M.2    Scorpio, A.3    Zhang, H.4    Sun, Z.5


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