Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells

Biochemical and Biophysical Research Communications

Volumn 443, Issue 3, 2014, Pages 1035-1040

  Woo, Jeong Im ^a   Kil, Sung Hee ^a   Pan, Huiqi ^b   Lee, Yoo Jin ^a   Lim, David J ^a   Moon, Sung K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOUSE RESEARCH INSTITUTE   (United States)

Author keywords

Defensin; Inflammation; Innate immunity; Middle ear; Otitis media

Indexed keywords

BACTERIAL PROTEIN; DEFB4 PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; DNA FLANKING REGION; ENHANCER REGION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; HAEMOPHILUS INFLUENZAE; MIDDLE EAR; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MOTIF; REGULATORY MECHANISM; UPREGULATION;

BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE;

DEFENSIN; INFLAMMATION; INNATE IMMUNITY; MIDDLE EAR; OTITIS MEDIA;

ADULT; BACTERIAL TYPING TECHNIQUES; BASE SEQUENCE; BETA-DEFENSINS; BINDING SITES; ENHANCER ELEMENTS, GENETIC; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HAEMOPHILUS INFLUENZAE; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; TRANSCRIPTION FACTOR RELA;

EID: 84893701899     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.091     Document Type: Article

References (34)

1. J. Harder, J. Bartels, E. Christophers, and J.M. Schroder A peptide antibiotic from human skin Nature 387 1997 861
2. A.M. McDermott, R.L. Redfern, and B. Zhang Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea Curr. Eye Res. 22 2001 64 67
3. S.K. Moon, H.Y. Lee, J.D. Li, M. Nagura, S.H. Kang, Y.M. Chun, F.H. Linthicum, T. Ganz, A. Andalibi, and D.J. Lim Activation of a Src-dependent Raf-MEK1/2-ERK signaling pathway is required for IL-1alpha-induced upregulation of beta-defensin 2 in human middle ear epithelial cells Biochim. Biophys. Acta 1590 2002 41 51
4. E. Martin, T. Ganz, and R.I. Lehrer Defensins and other endogenous peptide antibiotics of vertebrates J. Leukocyte Biol. 58 1995 128 136
5. Y. Tsutsumi-Ishii, and I. Nagaoka Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production J. Immunol. 170 2003 4226 4236
6. C.Y. Kao, Y. Chen, P. Thai, S. Wachi, F. Huang, C. Kim, R.W. Harper, and R. Wu IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways J. Immunol. 173 2004 3482 3491
7. S.K. Moon, H.Y. Lee, H. Pan, T. Takeshita, R. Park, K. Cha, A. Andalibi, and D.J. Lim Synergistic effect of interleukin 1 alpha on nontypeable Haemophilus influenzae-induced up-regulation of human beta-defensin 2 in middle ear epithelial cells BMC Infect. Dis. 6 2006 12
8. J. Wehkamp, J. Harder, K. Wehkamp, B. Wehkamp-von Meissner, M. Schlee, C. Enders, U. Sonnenborn, S. Nuding, S. Bengmark, K. Fellermann, J.M. Schroder, and E.F. Stange NF-kappaB- and AP-1-mediated induction of human beta defensin-2 in intestinal epithelial cells by Escherichia coli Nissle 1917: a novel effect of a probiotic bacterium Infect. Immun. 72 2004 5750 5758
9. K. Ogushi, A. Wada, T. Niidome, N. Mori, K. Oishi, T. Nagatake, A. Takahashi, H. Asakura, S. Makino, H. Hojo, Y. Nakahara, M. Ohsaki, T. Hatakeyama, H. Aoyagi, H. Kurazono, J. Moss, and T. Hirayama Salmonella enteritidis FliC (flagella filament protein) induces human beta-defensin-2 mRNA production by Caco-2 cells J. Biol. Chem. 276 2001 30521 30526
10. A.M. McDermott, R.L. Redfern, B. Zhang, Y. Pei, L. Huang, and R.J. Proske Defensin expression by the cornea: multiple signalling pathways mediate IL-1beta stimulation of hBD-2 expression by human corneal epithelial cells Invest. Ophthalmol. Vis. Sci. 44 2003 1859 1865
11. W.O. Chung, S.R. Hansen, D. Rao, and B.A. Dale Protease-activated receptor signaling increases epithelial antimicrobial peptide expression J. Immunol. 173 2004 5165 5170
12. X. Wang, Z. Zhang, J.P. Louboutin, C. Moser, D.J. Weiner, and J.M. Wilson Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2 FASEB J. 17 2003 1727 1729
13. S. Krisanaprakornkit, J.R. Kimball, and B.A. Dale Regulation of human beta-defensin-2 in gingival epithelial cells: the involvement of mitogen-activated protein kinase pathways, but not the NF-kappaB transcription factor family J. Immunol. 168 2002 316 324
14. A. Wada, K. Ogushi, T. Kimura, H. Hojo, N. Mori, S. Suzuki, A. Kumatori, M. Se, Y. Nakahara, M. Nakamura, J. Moss, and T. Hirayama Helicobacter pylori-mediated transcriptional regulation of the human beta-defensin 2 gene requires NF-kappaB Cell Microbiol. 3 2001 115 123
15. K. Wehkamp, L. Schwichtenberg, J.M. Schroder, and J. Harder Pseudomonas aeruginosa- and IL-1beta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1 J. Invest. Dermatol. 126 2006 121 127
16. Y. Tsutsumi-Ishii, and I. Nagaoka NF-kappa B-mediated transcriptional regulation of human beta-defensin-2 gene following lipopolysaccharide stimulation J. Leukocyte Biol. 71 2002 154 162
17. S. Maxson, and T. Yamauchi Acute otitis media Pediatr. Rev. 17 1996 191 195 quiz 196
18. B.W. Gibson, W. Melaugh, N.J. Phillips, M.A. Apicella, A.A. Campagnari, and J.M. Griffiss Investigation of the structural heterogeneity of lipooligosaccharides from pathogenic Haemophilus and Neisseria species and of R-type lipopolysaccharides from Salmonella typhimurium by electrospray mass spectrometry J. Bacteriol. 175 1993 2702 2712
19. A.R. Foxwell, J.M. Kyd, and A.W. Cripps Nontypeable Haemophilus influenzae: pathogenesis and prevention Microbiol. Mol. Biol. Rev. 62 1998 294 308
20. T.F. Murphy Bacterial otitis media: pathogenetic considerations Pediatr. Infect. Dis. J. 19 2000 S9 S15 discussion S15-S16
21. T. Shuto, H. Xu, B. Wang, J. Han, H. Kai, X.X. Gu, T.F. Murphy, D.J. Lim, and J.D. Li Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells Proc. Natl. Acad. Sci. USA 98 2001 8774 8779
22. J.C. Chow, D.W. Young, D.T. Golenbock, W.J. Christ, and F. Gusovsky Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction J. Biol. Chem. 274 1999 10689 10692
23. H.Y. Lee, T. Takeshita, J. Shimada, A. Akopyan, J.I. Woo, H. Pan, S.K. Moon, A. Andalibi, R.K. Park, S.H. Kang, S.S. Kang, R. Gellibolian, and D.J. Lim Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells BMC Infect. Dis. 8 2008 87
24. H.Y. Lee, A. Andalibi, P. Webster, S.K. Moon, K. Teufert, S.H. Kang, J.D. Li, M. Nagura, T. Ganz, and D.J. Lim Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae BMC Infect. Dis. 4 2004 12
25. S.K. Moon, J.I. Woo, H.Y. Lee, R. Park, J. Shimada, H. Pan, R. Gellibolian, and D.J. Lim Toll-like receptor 2-dependent NF-kappaB activation is involved in nontypeable Haemophilus influenzae-induced monocyte chemotactic protein 1 up-regulation in the spiral ligament fibrocytes of the inner ear Infect. Immun. 75 2007 3361 3372
26. S.J. Barenkamp, and E. Leininger Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutinin of Bordetella pertussis Infect. Immun. 60 1992 1302 1313
27. G. Diamond, V. Kaiser, J. Rhodes, J.P. Russell, and C.L. Bevins Transcriptional regulation of beta-defensin gene expression in tracheal epithelial cells Infect. Immun. 68 2000 113 119
28. M.A. Suico, Z. Lu, T. Shuto, T. Koga, T. Uchikawa, H. Yoshida, K. Matsuzaki, M. Nakao, J.D. Li, and H. Kai The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid Elf-1-like factor) is enhanced by promyelocytic leukemia protein J. Pharmacol. Sci. 95 2004 466 470
29. L.O. Bakaletz, and S.J. Barenkamp Localization of high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae by immunoelectron microscopy Infect. Immun. 62 1994 4460 4468
30. C.S. Berenson, T.F. Murphy, C.T. Wrona, and S. Sethi Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines Infect. Immun. 73 2005 2728 2735
31. H. Ishinaga, H. Jono, J.H. Lim, S.M. Kweon, H. Xu, U.H. Ha, H. Xu, T. Koga, C. Yan, X.H. Feng, L.F. Chen, and J.D. Li TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation EMBO J. 26 2007 1150 1162
32. N. Miyamoto, and L.O. Bakaletz Selective adherence of non-typeable Haemophilus influenzae (NTHi) to mucus or epithelial cells in the chinchilla eustachian tube and middle ear Microb. Pathog. 21 1996 343 356
33. T.H. Flo, L. Ryan, E. Latz, O. Takeuchi, B.G. Monks, E. Lien, O. Halaas, S. Akira, G. Skjak-Braek, D.T. Golenbock, and T. Espevik Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers J. Biol. Chem. 277 2002 35489 35495
34. R. Adamo, S. Sokol, G. Soong, M.I. Gomez, and A. Prince Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5 Am. J. Respir. Cell Mol. Biol. 30 2004 627 634