Reversal of the DNA-binding-induced loop L1 conformational switch in an engineered human p53 protein

Journal of Molecular Biology

Volumn 426, Issue 4, 2014, Pages 936-944

  Emamzadah, Soheila ^a   Tropia, Laurence ^a   Vincenti, Ilena ^a   Falquet, Benoît ^a   Halazonetis, Thanos D ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

conformational selection; crystallography; DNA binding; induced fit; p53

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; OLIGONUCLEOTIDE; PROTEIN P53; TETRAMER; DNA; STREPTAVIDIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DNA BINDING; DNA SEQUENCE; DNA STRUCTURE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SURFACE PLASMON RESONANCE; ANISOTROPY; CAENORHABDITIS ELEGANS; CRYSTALLOGRAPHY; HUMAN; OLIGOMERIZATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTEIN TARGETING; THERMOSTABILITY;

CONFORMATIONAL SELECTION; CRYSTALLOGRAPHY; DNA BINDING; INDUCED FIT; P53; RESPONSE UNIT; RU; SPR; SURFACE PLASMON RESONANCE;

AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA; HALF-LIFE; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; SURFACE PLASMON RESONANCE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84893676311     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.12.020     Document Type: Article

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