The association of four common polymorphisms from four candidate genes (COX-1, COX-2, ITGA2B, ITGA2) with aspirin insensitivity: A meta-analysis

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Weng, Zhiyuan ^a   Li, Xiaobo ^b   Li, Yuqiong ^b   Lin, Jinxiu ^a   Peng, Feng ^a   Niu, Wenquan ^b  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASIAN CONTINENTAL ANCESTRY GROUP; ASPIRIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; INTEGRIN ALPHA2; PLATELET COUNT; POLYMORPHISM, GENETIC; RISK FACTORS;

EID: 84893664451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078093     Document Type: Article

References (38)

1. Buchanan MR, Verma S (2006) Biological basis and clinical implications of acetylsalicylic acid resistance. The Canadian journal of cardiology 22: 149.
2. Grinstein J, Cannon CP (2012) Aspirin resistance: current status and role of tailored therapy. Clin Cardiol 35: 673-681.
3. Kim SH, Sanak M, Park HS (2013) Genetics of hypersensitivity to aspirin and nonsteroidal anti-inflammatory drugs. Immunol Allergy Clin North Am 33: 177-194.
4. Palikhe NS, Kim SH, Park HS (2008) What do we know about the genetics of aspirin intolerance? J Clin Pharm Ther 33: 465-472.
5. Lev EI, Patel RT, Guthikonda S, Lopez D, Bray PF, et al. (2007) Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. Thromb Res 119: 355-360. (Pubitemid 44918095)
6. Kunicki TJ, Williams SA, Nugent DJ, Harrison P, Segal HC, et al. (2009) Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease. Thromb Haemost 101: 123-133.
7. Kranzhofer R, Ruef J (2006) Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. Platelets 17: 163-169. (Pubitemid 43791628)
8. Fontana P, Nolli S, Reber G, de Moerloose P (2006) Biological effects of aspirin and clopidogrel in a randomized cross-over study in 96 healthy volunteers. J Thromb Haemost 4: 813-819.
9. Cambria-Kiely JA, Gandhi PJ (2002) Aspirin resistance and genetic polymorphisms. J Thromb Thrombolysis 14: 51-58. (Pubitemid 36277691)
10. Niu W, Liu Y, Qi Y, Wu Z, Zhu D, et al. (2012) Association of interleukin-6 circulating levels with coronary artery disease: a meta-analysis implementing mendelian randomization approach. Int J Cardiol 157: 243-252.
11. Niu W, Qi Y (2012) Matrix metalloproteinase family gene polymorphisms and risk for coronary artery disease: systematic review and meta-analysis. Heart 98: 1483-1491.
12. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38: 904-909. (Pubitemid 44141658)
13. Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151: 264-269.
14. Wang Y, Ni P, Yang R, Wu J, Wu F (2012) Relationship between single nucleotide polymorphisms in promoter region of cyclooxygenase-2 gene and aspirin resistance in the elderly. Journal of Shanghai Jiaotong University (Medical Science): 301-306.
15. Wang B, Tan S, Hu J (2012) Platelet glycoprotein III a gene platelet antigen T/C polymorphisms and aspirin resistance in aged patients. Chinese Journal of Geriatric Heart Brain and Vessel Diseases 14: 3.
16. Li XL, Cao J, Fan L, Wang Q, Ye L, et al. (2012) Genetic Polymorphisms of HO-1 and COX-1 Are Associated With Aspirin Resistance Defined by Light Transmittance Aggregation in Chinese Han Patients. Clin Appl Thromb Hemost: May 19. [Epub ahead of print].
17. Zhao Y, Wang J, Sun H, Wang C, Li Y, et al. (2011) Cyclooxygenase-2 Gene-765G.C Polymorphism is NOT Associated with Aspirin Resistance in Elderly Patients with Metabolic Syndrome. Molecular Cardiology of China: 164-168.
18. Mao X, Yan X, Han L, Huang X, Guan C, et al. (2011) The relationship of aspirin resistance and platelet glycoproteinIIIa gene polymorphism. Modern Practical Medicine 23: 18-21.
19. Li C, Wei L, Yang Z, Liu Z, Hou Q (2011) Relationship Between the Gene Polymorphisms of Platelet Glycoprotein III aPLA and I a807C/T with Aspirin Resistance. Progress in Modern Biomedicine 11: 2324-2327.
20. Zhou Q (2010) The clinical study in both aspirin resistance and cyclooxygenase-1 C50T single nucleotide polymorphism: Wenzhou Medical College P12-13.
21. Zhang J, Wang J, Zhao Y, Li Y, Liu C, et al. (2009) Relation between cyclooxygenase-2 gene polymorphism and aspirin resistance in patients with CHD. Chinese Journal of Geriatric Heart Brain and Vessel Diseases 11: 3.
22. Xin X, Zhang Y, Jing Y, Li J, Bi L (2009) Study of Platelet Membrane Glycoprotein Ia Polymorphism C807T and Aspirin Resistance. Journal of Modern Laboratory Medicine 24: 3.
23. Su G, Wang Z, Ding Y, Liu X (2007) Association of the Platelet Membrane Glycoprotein I a C807T Gene Poly-morphism with Aspirin Resistance. Chinese Journal of Hemorheology: 43-45.
24. Wu W (2006) The Clinical Factors of Aspirin Resisitance and the Association of the Cyclooxygenase-2 Gene Polymorphism with Aspirin Resistance: Tianjin Medical University.
25. Li A, Zhang J, Wang J (2010) The Relationship between COX-2 gene765G.C Polymorphism and Aspirin Resistance. Shandong Medical Journal: 80-81.
26. Papp E, Havasi V, Bene J, Komlosi K, Czopf L, et al. (2005) Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation? Ann Pharmacother 39: 1013-1018. (Pubitemid 40695965)
27. Pamukcu B, Oflaz H, Nisanci Y (2005) The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis. Am Heart J 149: 675-680.
28. Macchi L, Christiaens L, Brabant S, Sorel N, Ragot S, et al. (2003) Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol 42: 1115-1119. (Pubitemid 37108603)
29. Gonzalez-Conejero R, Rivera J, Corral J, Acuna C, Guerrero JA, et al. (2005) Biological assessment of aspirin efficacy on healthy individuals: heterogeneous response or aspirin failure? Stroke 36: 276-280. (Pubitemid 40170808)
30. Bernardo E, Angiolillo DJ, Ramirez C, Cavallari U, Trabetti E, et al. (2006) Lack of association between gene sequence variations of platelet membrane receptors and aspirin responsiveness detected by the PFA-100 system in patients with coronary artery disease. Platelets 17: 586-590. (Pubitemid 44837729)
31. Krasopoulos G, Brister SJ, Beattie WS, Buchanan MR (2008) Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 336: 195-198. (Pubitemid 351212675)
32. (2002) Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324: 71-86.
33. Kuliczkowski W, Witkowski A, Polonski L, Watala C, Filipiak K, et al. (2009) Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J 30: 426-435.
34. Niu W, Qi Y, Wu Z, Liu Y, Zhu D, et al. (2012) A meta-analysis of receptor for advanced glycation end products gene: four well-evaluated polymorphisms with diabetes mellitus. Mol Cell Endocrinol 358: 9-17.
35. Nissen SE (2012) Cox-2 inhibitors and cardiovascular disease: considerable heat, but not much light. Eur Heart J 33: 2631-2633.
36. Cannon CP, Cannon PJ (2012) Physiology. COX-2 inhibitors and cardiovascular risk. Science 336: 1386-1387.
37. Munafo MR, Flint J (2004) Meta-analysis of genetic association studies. Trends Genet 20: 439-444. (Pubitemid 39094573)
38. Tang TT, Yuan J, Zhu ZF, Zhang WC, Xiao H, et al. (2012) Regulatory T cells ameliorate cardiac remodeling after myocardial infarction. Basic Res Cardiol 107: 232.